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The map label for this gene is lldD [H]

Identifier: 124265553

GI number: 124265553

Start: 395603

End: 396715

Strand: Reverse

Name: lldD [H]

Synonym: Mpe_A0360

Alternate gene names: 124265553

Gene position: 396715-395603 (Counterclockwise)

Preceding gene: 124265554

Following gene: 124265552

Centisome position: 9.81

GC content: 69.81

Gene sequence:

>1113_bases
ATGTTCTACGACTACGCCGACTCGGGCTCCTGGACCGAGGGCACCTACCGCGCCAACGAGACCGACTTCGCCCGCATCCT
GCTGCGCCAGCGCGTGGCGGTGAACATGGAGGGCCGCTCGCTGCGCACCACCCTGGCCGGCCAGGACTGCGCCATGCCGG
TCGTGATCGCCCCCACCGGCCTGACCGGCATGCAGCACGCCGACGGCGAGATCCTGGGCGCGCGCGCGGCCGAGGCCTTC
GGGGTGCCGTTCACGCTGTCGACGATGAGCATCTGCTCGATCGAGGACATCGCCGCGCACACGAAGGCGCCGTTCTGGTT
CCAGCTGTACTGGATGCGCGACCGCGATTTCATGGAGCGGCTGATCGAGCGAGCCAAGGCGGCACGCTGCTCGGCGCTGG
TGCTGACGCTGGACCTGCAGGTGCTGGGGCAGCGCCACAAGGATCTGAAGAACGGCATGACGGCGCCGCCCAAGCCGACG
CTGGCGAACCTGATCAACCTGGCGATGAAGCCGCGCTGGTGCCTGGGGATGGCCGGGACGCGGCGCCACAGCTTCGGCAA
CCTGGTGGGGCATGCCAAGGGGGTGAGCGACATGTCTTCGCTGGGGACGTGGACGAAGGAGCAGTTCGATCCGCGGCTGA
GCTGGGACGATGTGGCGTGGATCAAGCAGCGCTGGGGCGGCCGGCTGATCCTGAAGGGGATCATGGAGGTGGCCGACGCG
AAGCTGGCGGCCGACAGCGGGGCCGACGCGATCGTGGTGTCGAACCACGGGGGGAGGCAGCTCGATGGGGCGCCGTCCTC
GATCGCGGCGCTGCCGGCGATCGCCGAGGCGGTGGGCGACCGGATCGAGGTGTGGATGGACGGGGGGATCCGCTCGGGCC
AGGACGTGCTCAAGGCGGTGGCCCTGGGAGCGCGCGGCACGATGATCGGGCGGGCCTTCCTGTACGGGCTGGGCGCGATG
GGCCAGGCCGGCGTGACACGCGCCCTCGAGATCATCCGCAACGAGCTCGACATCACCATGGCCTTCACCGGCCATACCGA
TATCAGACGGGTGGGGCGCGAGATCCTGCTGAACGCGCCGACGCCGCCTGTCCGCACGGACCGAGGGAGGTGA

Upstream 100 bases:

>100_bases
TGCCGGACCGCGCACGCCCCGCCACTGCGACGCCACTCCCATGCCCGTGATCACCTGCATCGAAGACCTGAGGGTTCTGG
CCCGGCGCCGGGTGCCGAGG

Downstream 100 bases:

>100_bases
GCCCGCCCTCGATCCCGACGCACGCACACCCCACCGACAAAAGACACACCGGCCGCCCGGCCCCCGACGGGCGCATGCGG
CCGCGCATCGAACACCAACA

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MFYDYADSGSWTEGTYRANETDFARILLRQRVAVNMEGRSLRTTLAGQDCAMPVVIAPTGLTGMQHADGEILGARAAEAF
GVPFTLSTMSICSIEDIAAHTKAPFWFQLYWMRDRDFMERLIERAKAARCSALVLTLDLQVLGQRHKDLKNGMTAPPKPT
LANLINLAMKPRWCLGMAGTRRHSFGNLVGHAKGVSDMSSLGTWTKEQFDPRLSWDDVAWIKQRWGGRLILKGIMEVADA
KLAADSGADAIVVSNHGGRQLDGAPSSIAALPAIAEAVGDRIEVWMDGGIRSGQDVLKAVALGARGTMIGRAFLYGLGAM
GQAGVTRALEIIRNELDITMAFTGHTDIRRVGREILLNAPTPPVRTDRGR

Sequences:

>Translated_370_residues
MFYDYADSGSWTEGTYRANETDFARILLRQRVAVNMEGRSLRTTLAGQDCAMPVVIAPTGLTGMQHADGEILGARAAEAF
GVPFTLSTMSICSIEDIAAHTKAPFWFQLYWMRDRDFMERLIERAKAARCSALVLTLDLQVLGQRHKDLKNGMTAPPKPT
LANLINLAMKPRWCLGMAGTRRHSFGNLVGHAKGVSDMSSLGTWTKEQFDPRLSWDDVAWIKQRWGGRLILKGIMEVADA
KLAADSGADAIVVSNHGGRQLDGAPSSIAALPAIAEAVGDRIEVWMDGGIRSGQDVLKAVALGARGTMIGRAFLYGLGAM
GQAGVTRALEIIRNELDITMAFTGHTDIRRVGREILLNAPTPPVRTDRGR
>Mature_370_residues
MFYDYADSGSWTEGTYRANETDFARILLRQRVAVNMEGRSLRTTLAGQDCAMPVVIAPTGLTGMQHADGEILGARAAEAF
GVPFTLSTMSICSIEDIAAHTKAPFWFQLYWMRDRDFMERLIERAKAARCSALVLTLDLQVLGQRHKDLKNGMTAPPKPT
LANLINLAMKPRWCLGMAGTRRHSFGNLVGHAKGVSDMSSLGTWTKEQFDPRLSWDDVAWIKQRWGGRLILKGIMEVADA
KLAADSGADAIVVSNHGGRQLDGAPSSIAALPAIAEAVGDRIEVWMDGGIRSGQDVLKAVALGARGTMIGRAFLYGLGAM
GQAGVTRALEIIRNELDITMAFTGHTDIRRVGREILLNAPTPPVRTDRGR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=360, Percent_Identity=34.7222222222222, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI54234014, Length=354, Percent_Identity=35.8757062146893, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7705393, Length=354, Percent_Identity=35.8757062146893, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI1790033, Length=360, Percent_Identity=44.1666666666667, Blast_Score=313, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI193208036, Length=354, Percent_Identity=38.135593220339, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI32566217, Length=271, Percent_Identity=35.4243542435424, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=363, Percent_Identity=31.6804407713499, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281363140, Length=346, Percent_Identity=37.8612716763006, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI78707190, Length=346, Percent_Identity=37.8612716763006, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI78707188, Length=346, Percent_Identity=37.8612716763006, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 40308; Mature: 40308

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYDYADSGSWTEGTYRANETDFARILLRQRVAVNMEGRSLRTTLAGQDCAMPVVIAPTG
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCC
LTGMQHADGEILGARAAEAFGVPFTLSTMSICSIEDIAAHTKAPFWFQLYWMRDRDFMER
CCCCCCCCCCEEECHHHHHCCCCEEECHHHHHCHHHHHHHCCCCEEEEEEEECCHHHHHH
LIERAKAARCSALVLTLDLQVLGQRHKDLKNGMTAPPKPTLANLINLAMKPRWCLGMAGT
HHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEECCCCC
RRHSFGNLVGHAKGVSDMSSLGTWTKEQFDPRLSWDDVAWIKQRWGGRLILKGIMEVADA
CCCHHHHHHHHHCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
KLAADSGADAIVVSNHGGRQLDGAPSSIAALPAIAEAVGDRIEVWMDGGIRSGQDVLKAV
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
ALGARGTMIGRAFLYGLGAMGQAGVTRALEIIRNELDITMAFTGHTDIRRVGREILLNAP
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEECCC
TPPVRTDRGR
CCCCCCCCCC
>Mature Secondary Structure
MFYDYADSGSWTEGTYRANETDFARILLRQRVAVNMEGRSLRTTLAGQDCAMPVVIAPTG
CCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEECCC
LTGMQHADGEILGARAAEAFGVPFTLSTMSICSIEDIAAHTKAPFWFQLYWMRDRDFMER
CCCCCCCCCCEEECHHHHHCCCCEEECHHHHHCHHHHHHHCCCCEEEEEEEECCHHHHHH
LIERAKAARCSALVLTLDLQVLGQRHKDLKNGMTAPPKPTLANLINLAMKPRWCLGMAGT
HHHHHHHHHHEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEECCCCC
RRHSFGNLVGHAKGVSDMSSLGTWTKEQFDPRLSWDDVAWIKQRWGGRLILKGIMEVADA
CCCHHHHHHHHHCCHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
KLAADSGADAIVVSNHGGRQLDGAPSSIAALPAIAEAVGDRIEVWMDGGIRSGQDVLKAV
HHCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHH
ALGARGTMIGRAFLYGLGAMGQAGVTRALEIIRNELDITMAFTGHTDIRRVGREILLNAP
HHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEECCC
TPPVRTDRGR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA