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The map label for this gene is hemB [H]

Identifier: 124265499

GI number: 124265499

Start: 332520

End: 333551

Strand: Reverse

Name: hemB [H]

Synonym: Mpe_A0306

Alternate gene names: 124265499

Gene position: 333551-332520 (Counterclockwise)

Preceding gene: 124265511

Following gene: 124265498

Centisome position: 8.25

GC content: 69.48

Gene sequence:

>1032_bases
GTGCCCCTCCACCCGGTCACGCCCGTGAGCTCCTACCCCCAACGCTTCCCCGCCACGCGCGCGCGCCGCCTGCGCCGAGA
CGACTTCACCCGTGCGCTGGTGCGCGAGCACGCCCTCACCGCGTCGGACCTGATCCTGCCGGTGTTCGTGCTCGACGGCA
GCAACCAGGTGCACGACGTGGCCTCGATGCCCGGCGTGCAGCGCCTGAGTCTGGACCGGTTGCTGCCGCTGGCCGAGGCC
TGTGTGCGCGAACGCATTCCGGTGATGGCGCTGTTCCCGGTGATCGACGCGGCGAAGAAGACCGAGGACGGCCGCGAAGC
GATGAACCCCGAGGGCCTGGTGCCCACCGTCGTGCGTGAGCTCAAGCGCCGCTTCCCGGAGCTGGGCGTGCTGACCGATG
TGGCGCTCGACCCCTTCACCACGCACGGCCAGGACGGCCTGCTGGACGCCACCGGCTACATCCTCAACGACGAGACGGTG
GCCGTGCTGACGCAGCAGGCCCTGGTGCAAGCCGAGGCCGGCGTCGACATCGTCGCGCCGAGCGACATGATGGATGGCCG
CATCGGCGCGATCCGCGACGCGCTGGAGGCCCGGGGCCTGATCCACACCCGCATCATGGCGTACAGCGCCAAGTATGCGA
GCGCCTTCTACGGCCCGTTCCGCGACGCCGTCGGCTCGGCCGGCAACTTGGGCAAGAGCAACAAGAAGGTCTACCAGATG
GATCCGGGCAACACCAACGAGGCGCTGCGCGAGGTGGCGTTGGACCTCGCCGAAGGCGCCGACATGGTGATGGTCAAGCC
CGGGATGCCCTATCTCGACATCGTGCGGCGTGTGAAGGAAGAGTTCCGCGTGCCCACCTTCGCCTACCAGGTGAGCGGCG
AGTACGCGATGCTGAAGGCCGCCGCCGCCAACGGCTGGCTCGATGGCGAGGCAGTGATGATGGAGTCGCTGCTGGCCTTC
AAGCGGGCCGGTGCCGACGGGGTGCTGAGCTACTTCGCGCTCGACGCCGCGCGGGCCCTGAACGCGCGGTGA

Upstream 100 bases:

>100_bases
TTCGACGAGAATTTTAGCAGCGCCCGGCCGGCGTTTTCCTGTCAGATGCGCTCTGCGCGCGGGCCGCTCTCGATCGACGC
CACACCCTTCCTTCGGCCTT

Downstream 100 bases:

>100_bases
CGGCGCGATGCGGATCTTCCACGTCGGCACGGACCAGTTCACCGAGCTGAGCGAGCTGCCCGACACGCTGCCGACCGCAG
GCTACCTCTGGATCGGCAGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPLHPVTPVSSYPQRFPATRARRLRRDDFTRALVREHALTASDLILPVFVLDGSNQVHDVASMPGVQRLSLDRLLPLAEA
CVRERIPVMALFPVIDAAKKTEDGREAMNPEGLVPTVVRELKRRFPELGVLTDVALDPFTTHGQDGLLDATGYILNDETV
AVLTQQALVQAEAGVDIVAPSDMMDGRIGAIRDALEARGLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKSNKKVYQM
DPGNTNEALREVALDLAEGADMVMVKPGMPYLDIVRRVKEEFRVPTFAYQVSGEYAMLKAAAANGWLDGEAVMMESLLAF
KRAGADGVLSYFALDAARALNAR

Sequences:

>Translated_343_residues
MPLHPVTPVSSYPQRFPATRARRLRRDDFTRALVREHALTASDLILPVFVLDGSNQVHDVASMPGVQRLSLDRLLPLAEA
CVRERIPVMALFPVIDAAKKTEDGREAMNPEGLVPTVVRELKRRFPELGVLTDVALDPFTTHGQDGLLDATGYILNDETV
AVLTQQALVQAEAGVDIVAPSDMMDGRIGAIRDALEARGLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKSNKKVYQM
DPGNTNEALREVALDLAEGADMVMVKPGMPYLDIVRRVKEEFRVPTFAYQVSGEYAMLKAAAANGWLDGEAVMMESLLAF
KRAGADGVLSYFALDAARALNAR
>Mature_342_residues
PLHPVTPVSSYPQRFPATRARRLRRDDFTRALVREHALTASDLILPVFVLDGSNQVHDVASMPGVQRLSLDRLLPLAEAC
VRERIPVMALFPVIDAAKKTEDGREAMNPEGLVPTVVRELKRRFPELGVLTDVALDPFTTHGQDGLLDATGYILNDETVA
VLTQQALVQAEAGVDIVAPSDMMDGRIGAIRDALEARGLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKSNKKVYQMD
PGNTNEALREVALDLAEGADMVMVKPGMPYLDIVRRVKEEFRVPTFAYQVSGEYAMLKAAAANGWLDGEAVMMESLLAFK
RAGADGVLSYFALDAARALNAR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=296, Percent_Identity=44.9324324324324, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=46.2264150943396, Blast_Score=245, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=38.4364820846906, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=41.2371134020619, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37401; Mature: 37269

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHPVTPVSSYPQRFPATRARRLRRDDFTRALVREHALTASDLILPVFVLDGSNQVHDV
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCHHHH
ASMPGVQRLSLDRLLPLAEACVRERIPVMALFPVIDAAKKTEDGREAMNPEGLVPTVVRE
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCHHHCCCCCCHHHHHHH
LKRRFPELGVLTDVALDPFTTHGQDGLLDATGYILNDETVAVLTQQALVQAEAGVDIVAP
HHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEECC
SDMMDGRIGAIRDALEARGLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKSNKKVYQM
CHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPGNTNEALREVALDLAEGADMVMVKPGMPYLDIVRRVKEEFRVPTFAYQVSGEYAMLKA
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHEEEH
AAANGWLDGEAVMMESLLAFKRAGADGVLSYFALDAARALNAR
HHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLHPVTPVSSYPQRFPATRARRLRRDDFTRALVREHALTASDLILPVFVLDGSNQVHDV
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCCCCHHHH
ASMPGVQRLSLDRLLPLAEACVRERIPVMALFPVIDAAKKTEDGREAMNPEGLVPTVVRE
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCHHHCCCCCCHHHHHHH
LKRRFPELGVLTDVALDPFTTHGQDGLLDATGYILNDETVAVLTQQALVQAEAGVDIVAP
HHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCEEECC
SDMMDGRIGAIRDALEARGLIHTRIMAYSAKYASAFYGPFRDAVGSAGNLGKSNKKVYQM
CHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPGNTNEALREVALDLAEGADMVMVKPGMPYLDIVRRVKEEFRVPTFAYQVSGEYAMLKA
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHEEEH
AAANGWLDGEAVMMESLLAFKRAGADGVLSYFALDAARALNAR
HHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]