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The map label for this gene is pepP [H]

Identifier: 124265447

GI number: 124265447

Start: 275036

End: 276400

Strand: Reverse

Name: pepP [H]

Synonym: Mpe_A0254

Alternate gene names: 124265447

Gene position: 276400-275036 (Counterclockwise)

Preceding gene: 124265449

Following gene: 124265445

Centisome position: 6.83

GC content: 72.67

Gene sequence:

>1365_bases
ATGAGCCCCTCCGTCTATGCCGAGCGCCGCGCACGCCTGAGCACCGCGCTGCGCGAGGCCGGTGGCGGCATCGCCGTGCT
GCCGACCGCGCCGGAGCGCACCCGCAACGCCGACAGCGAACACCCTTATCGCCACGACAGCGCGTTCTACTACCTGACCG
GGTTCTCCGAGCCGGGCGCGCTGCTCGTCCTCGACGCCGCCGGTCGCAGCCTGCTGCTGTGCCGCCCGAAGGACGAGGAA
CGCGAGATCTGGGACGGCTACCGGCTCGGCCCCGAATCGGCGCCCGCCGCGCTGGGCATCGACGAGGCGATGCCGATCGA
GGCGCTGGACACGGTGTTGCCGCAGCGGCTCGCCAACTGCCCGGCGGTGTGGTTCCCGTTCGGCGGACACGACGGGCTCG
CGTCGCGCGTCGCCGGCTGGCTGGACAACGTGCGTGCGCGTTCACGCGCCGGCATCGAGTCGCCGACGCAGCAGCGCGAC
CTGGCTCGGTTGATCGACGAAATGCGCCTGTTCAAGGACCCGCACGAGGTGGCGCTGATGCGCCGCGCCGGCGAAATCGG
CGCGGCCGGGCATGTGCGCGCCATGCAGGCCTGCCGGCCCGGCCTGCGTGAGTACCAGCTCGAGGCCGAACTGCTGCACG
AGTTCCGCCGCAGTGGCGCCAGCGGCCCGGCCTACACGAGCATCGTCGCCGCGGGCCGCAACGCCTGCGTGCTGCACTAC
GCTGCCGGCGACGCTGAGCTGCGGCCCGGCGAGCTGTGCCTGATCGACGCCGGCTGCGAATACGGCAGCTATGCGAGCGA
CATCACGCGCAGCTTTCCGGTCGACGGCCGCTACACGGCGCCGCAACGTGCGCTCTATGAACTGGTGCTGGCCGCCCAGG
AGGCCGCGATCGCCCACACCCGGCCCGGCGCCCGCAAGACCGACAGCCACTGGGCTGCGGTGCGCGCGCTGAGCGTCGGC
CTGCTGGACCTGGGTCTGCTCGACCGCGACCGGCACGGCACGGTCGACGACGTGGTGGCCAGCGCCGCCTACAGGCGCTT
CTACATGCACGGCACCGGCCACTGGCTGGGGCTGGACGTGCATGATGCCGGCGAGTACCTCGCCCTCGACGAGGCGCCGA
TCGAGCAGCCCGACGGGCTCGGCGGCCTCACCATCAAGAAGCCCTCGCGCCGTCTGCAGCCGGGCATGGTGGTCACGATC
GAGCCCGGGCTCTACGTGCGGCCGGCCCCCGACGTGCCGGAGTGCTACTGGCACCTCGGCATCCGCATCGAGGACGACGC
GCTCGTCACGCCCGACGGCTGCGAGCTGCTGAGCCGGGGCGTGCCGGTGCGGCCCGACGAGATCGAGGCGCTGATGCGCG
GCTGA

Upstream 100 bases:

>100_bases
GAGGGACTCCTGGTCTTCGATGATCGGTACCGCGCGCGGCGGGCACCTTGCCCCTGCCGCGCTCACTACACTGCAAGCGT
ACCCAGAACCGCATCGCCCC

Downstream 100 bases:

>100_bases
GTGCCGCGCGCCGCGCCGGGGGCTATTGCAGTTGCCCGGGTGCGCGGTGCCACAGCCGCTGGGCGGCTTCGGCCGGATCG
ACACCGACGGCATCCGCGAC

Product: putative Xaa-Pro aminopeptidase (aminopeptidase P II) protein

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSPSVYAERRARLSTALREAGGGIAVLPTAPERTRNADSEHPYRHDSAFYYLTGFSEPGALLVLDAAGRSLLLCRPKDEE
REIWDGYRLGPESAPAALGIDEAMPIEALDTVLPQRLANCPAVWFPFGGHDGLASRVAGWLDNVRARSRAGIESPTQQRD
LARLIDEMRLFKDPHEVALMRRAGEIGAAGHVRAMQACRPGLREYQLEAELLHEFRRSGASGPAYTSIVAAGRNACVLHY
AAGDAELRPGELCLIDAGCEYGSYASDITRSFPVDGRYTAPQRALYELVLAAQEAAIAHTRPGARKTDSHWAAVRALSVG
LLDLGLLDRDRHGTVDDVVASAAYRRFYMHGTGHWLGLDVHDAGEYLALDEAPIEQPDGLGGLTIKKPSRRLQPGMVVTI
EPGLYVRPAPDVPECYWHLGIRIEDDALVTPDGCELLSRGVPVRPDEIEALMRG

Sequences:

>Translated_454_residues
MSPSVYAERRARLSTALREAGGGIAVLPTAPERTRNADSEHPYRHDSAFYYLTGFSEPGALLVLDAAGRSLLLCRPKDEE
REIWDGYRLGPESAPAALGIDEAMPIEALDTVLPQRLANCPAVWFPFGGHDGLASRVAGWLDNVRARSRAGIESPTQQRD
LARLIDEMRLFKDPHEVALMRRAGEIGAAGHVRAMQACRPGLREYQLEAELLHEFRRSGASGPAYTSIVAAGRNACVLHY
AAGDAELRPGELCLIDAGCEYGSYASDITRSFPVDGRYTAPQRALYELVLAAQEAAIAHTRPGARKTDSHWAAVRALSVG
LLDLGLLDRDRHGTVDDVVASAAYRRFYMHGTGHWLGLDVHDAGEYLALDEAPIEQPDGLGGLTIKKPSRRLQPGMVVTI
EPGLYVRPAPDVPECYWHLGIRIEDDALVTPDGCELLSRGVPVRPDEIEALMRG
>Mature_453_residues
SPSVYAERRARLSTALREAGGGIAVLPTAPERTRNADSEHPYRHDSAFYYLTGFSEPGALLVLDAAGRSLLLCRPKDEER
EIWDGYRLGPESAPAALGIDEAMPIEALDTVLPQRLANCPAVWFPFGGHDGLASRVAGWLDNVRARSRAGIESPTQQRDL
ARLIDEMRLFKDPHEVALMRRAGEIGAAGHVRAMQACRPGLREYQLEAELLHEFRRSGASGPAYTSIVAAGRNACVLHYA
AGDAELRPGELCLIDAGCEYGSYASDITRSFPVDGRYTAPQRALYELVLAAQEAAIAHTRPGARKTDSHWAAVRALSVGL
LDLGLLDRDRHGTVDDVVASAAYRRFYMHGTGHWLGLDVHDAGEYLALDEAPIEQPDGLGGLTIKKPSRRLQPGMVVTIE
PGLYVRPAPDVPECYWHLGIRIEDDALVTPDGCELLSRGVPVRPDEIEALMRG

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=467, Percent_Identity=32.9764453961456, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI149589008, Length=480, Percent_Identity=33.125, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI260593665, Length=312, Percent_Identity=38.1410256410256, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI260593663, Length=291, Percent_Identity=36.426116838488, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789275, Length=456, Percent_Identity=44.2982456140351, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788728, Length=276, Percent_Identity=32.2463768115942, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790282, Length=324, Percent_Identity=29.6296296296296, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508215, Length=479, Percent_Identity=32.5678496868476, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=374, Percent_Identity=28.8770053475936, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321118, Length=465, Percent_Identity=31.6129032258064, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320922, Length=465, Percent_Identity=28.3870967741935, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19920384, Length=472, Percent_Identity=34.9576271186441, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI21357079, Length=445, Percent_Identity=30.7865168539326, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49524; Mature: 49392

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSVYAERRARLSTALREAGGGIAVLPTAPERTRNADSEHPYRHDSAFYYLTGFSEPGA
CCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCC
LLVLDAAGRSLLLCRPKDEEREIWDGYRLGPESAPAALGIDEAMPIEALDTVLPQRLANC
EEEEECCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PAVWFPFGGHDGLASRVAGWLDNVRARSRAGIESPTQQRDLARLIDEMRLFKDPHEVALM
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
RRAGEIGAAGHVRAMQACRPGLREYQLEAELLHEFRRSGASGPAYTSIVAAGRNACVLHY
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEE
AAGDAELRPGELCLIDAGCEYGSYASDITRSFPVDGRYTAPQRALYELVLAAQEAAIAHT
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RPGARKTDSHWAAVRALSVGLLDLGLLDRDRHGTVDDVVASAAYRRFYMHGTGHWLGLDV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEEE
HDAGEYLALDEAPIEQPDGLGGLTIKKPSRRLQPGMVVTIEPGLYVRPAPDVPECYWHLG
ECCCCEEEECCCCCCCCCCCCCEEECCCHHHCCCCEEEEECCCEEECCCCCCCHHHEEEC
IRIEDDALVTPDGCELLSRGVPVRPDEIEALMRG
EEECCCCEECCCHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SPSVYAERRARLSTALREAGGGIAVLPTAPERTRNADSEHPYRHDSAFYYLTGFSEPGA
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCCCCCCCCEEEEEEECCCCCC
LLVLDAAGRSLLLCRPKDEEREIWDGYRLGPESAPAALGIDEAMPIEALDTVLPQRLANC
EEEEECCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PAVWFPFGGHDGLASRVAGWLDNVRARSRAGIESPTQQRDLARLIDEMRLFKDPHEVALM
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
RRAGEIGAAGHVRAMQACRPGLREYQLEAELLHEFRRSGASGPAYTSIVAAGRNACVLHY
HHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEE
AAGDAELRPGELCLIDAGCEYGSYASDITRSFPVDGRYTAPQRALYELVLAAQEAAIAHT
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RPGARKTDSHWAAVRALSVGLLDLGLLDRDRHGTVDDVVASAAYRRFYMHGTGHWLGLDV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEECCCCCEEEEEE
HDAGEYLALDEAPIEQPDGLGGLTIKKPSRRLQPGMVVTIEPGLYVRPAPDVPECYWHLG
ECCCCEEEECCCCCCCCCCCCCEEECCCHHHCCCCEEEEECCCEEECCCCCCCHHHEEEC
IRIEDDALVTPDGCELLSRGVPVRPDEIEALMRG
EEECCCCEECCCHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]