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The map label for this gene is ubiH [H]

Identifier: 124265438

GI number: 124265438

Start: 265387

End: 266622

Strand: Reverse

Name: ubiH [H]

Synonym: Mpe_A0245

Alternate gene names: 124265438

Gene position: 266622-265387 (Counterclockwise)

Preceding gene: 124265445

Following gene: 124265435

Centisome position: 6.59

GC content: 74.76

Gene sequence:

>1236_bases
ATGGCAGCAGAACTTTCACTCGCGGTGGTCGGCGCCGGTCCGGTGGGGCTGGCGCTGGCGCTGCACGCGGCGCGCGCGCT
GCCTGAGGCCCGCGTGCACGTGTTCGACGCGCGGCCCGCCGACCTGGACGTGTCGCGCGATCCGCGCACGCTGGCGCTCT
CGCTCGGCAGCGTGCAGGAGTTCGAGCGCCTGGGCGTCTGGCCGAGCATCGCGCCGGCCAGCACGGCGATCACCGCGGTG
CACGTGTCGCAGCAGCAGCCCGCGCTGCTGATGAATGGCCTGGCCTCGGTGCTGCGTCTGCCGCCACCCGAGCTGCTGCT
GACGGCGACCGAGTGCGGCGTCGACCAGCTCGGCGCAGTGGCCAGCTACGGTGCGATCGTCGCGCCGCTGCAGGCCGCCT
GGTTCGAGGCCGTGGCCAAGGAGCCGCGGCGGCTGTCGGCCCGCTTCGGCACGCCGGTCGCGGCGCTCAAGCCGGCTGCG
GGGGGTGTGGAGGTCGACGCCGGCATCGCCGAGCTGCACGACCTGGCGGTGGTGGCCGAAGGCGGCGTGTTCTCGACGCA
GGCGCGCAAGGCACTGGCGCACGACTACCGCCAGACCGCCTGGGTCGGCCAGGTCACGCTGGCCGGCCCGGGCGCCCCGG
CGACGGCCGGCACCGCCTACGAGCGCTTCACCCCGCAGGGTCCGGCGGCGCTGCTGCCGCTGCCGCCGCTCGATGGCGCC
GCGCGCGCGGCGCTCGTATGGTGCGTCGATGCCGCCGACGACCCGGTGCACGATCTCGACGACGCGCAGCGCCTCGCGGT
GCTGAACCAGGTGTTCCCTCCTCGCGTCGGCCGCCTCGTGGCGATCACGCCGCTCAAGCGCTTCGCGCTCGGGCTCAATG
CCGAGCGCACGCTGGTCGAGGGCCGCACGGTGCGCATCGGCAATGCGGCCCAGACGCTGCACCCGGTGGCCGGCCAGGGA
CTGAACCTCGGGCTGCGCGACGCGCATGCGCTGGTCGCCGCGCTGCAGGCGGCACCGGCCGCGGCGGGCGACTTCGATGC
CGTACTGAAGCGGGTGGAATGGCAACGTGCCCCGGATCGCTGGGCACTGATCGCCGCCACCGACTTCCTGGCCCGCAGCT
TCACCTGGCCGCTGCCCGGCCTGGCCAGCGCCCGCGGGCTGGGTCTGGCGGCGCTGCAGGCGTTGTCGCCGGCCAAGCGA
CTGCTGGCTCGGCAGATGATGTTCGGCTGGCGCTGA

Upstream 100 bases:

>100_bases
GAGGGAAGCGAACACAATAGCGGCGGGATCATAGACCGCGGTCCGGGTCGCGCCGCCCCTCTTCCGGGGGCGTGCCGGCT
GGCCGCCAGCAGGGCGGGTC

Downstream 100 bases:

>100_bases
CGCGGCCGCGTGCAGCGGCGCTACAGCACGCGGTGCTGCAGCGCAGGCAGTTGCGCGCGCACCTGCGCCATGCGGGCAGC
GTCGAGGCTCGCGATCACCA

Product: putative 2-octaprenyl-6-methoxyphenol hydroxylase oxidoreductase protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MAAELSLAVVGAGPVGLALALHAARALPEARVHVFDARPADLDVSRDPRTLALSLGSVQEFERLGVWPSIAPASTAITAV
HVSQQQPALLMNGLASVLRLPPPELLLTATECGVDQLGAVASYGAIVAPLQAAWFEAVAKEPRRLSARFGTPVAALKPAA
GGVEVDAGIAELHDLAVVAEGGVFSTQARKALAHDYRQTAWVGQVTLAGPGAPATAGTAYERFTPQGPAALLPLPPLDGA
ARAALVWCVDAADDPVHDLDDAQRLAVLNQVFPPRVGRLVAITPLKRFALGLNAERTLVEGRTVRIGNAAQTLHPVAGQG
LNLGLRDAHALVAALQAAPAAAGDFDAVLKRVEWQRAPDRWALIAATDFLARSFTWPLPGLASARGLGLAALQALSPAKR
LLARQMMFGWR

Sequences:

>Translated_411_residues
MAAELSLAVVGAGPVGLALALHAARALPEARVHVFDARPADLDVSRDPRTLALSLGSVQEFERLGVWPSIAPASTAITAV
HVSQQQPALLMNGLASVLRLPPPELLLTATECGVDQLGAVASYGAIVAPLQAAWFEAVAKEPRRLSARFGTPVAALKPAA
GGVEVDAGIAELHDLAVVAEGGVFSTQARKALAHDYRQTAWVGQVTLAGPGAPATAGTAYERFTPQGPAALLPLPPLDGA
ARAALVWCVDAADDPVHDLDDAQRLAVLNQVFPPRVGRLVAITPLKRFALGLNAERTLVEGRTVRIGNAAQTLHPVAGQG
LNLGLRDAHALVAALQAAPAAAGDFDAVLKRVEWQRAPDRWALIAATDFLARSFTWPLPGLASARGLGLAALQALSPAKR
LLARQMMFGWR
>Mature_410_residues
AAELSLAVVGAGPVGLALALHAARALPEARVHVFDARPADLDVSRDPRTLALSLGSVQEFERLGVWPSIAPASTAITAVH
VSQQQPALLMNGLASVLRLPPPELLLTATECGVDQLGAVASYGAIVAPLQAAWFEAVAKEPRRLSARFGTPVAALKPAAG
GVEVDAGIAELHDLAVVAEGGVFSTQARKALAHDYRQTAWVGQVTLAGPGAPATAGTAYERFTPQGPAALLPLPPLDGAA
RAALVWCVDAADDPVHDLDDAQRLAVLNQVFPPRVGRLVAITPLKRFALGLNAERTLVEGRTVRIGNAAQTLHPVAGQGL
NLGLRDAHALVAALQAAPAAAGDFDAVLKRVEWQRAPDRWALIAATDFLARSFTWPLPGLASARGLGLAALQALSPAKRL
LARQMMFGWR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=244, Percent_Identity=29.9180327868852, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI32967307, Length=244, Percent_Identity=29.9180327868852, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789274, Length=417, Percent_Identity=33.0935251798561, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786883, Length=411, Percent_Identity=28.9537712895377, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI25146631, Length=455, Percent_Identity=25.0549450549451, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321694, Length=137, Percent_Identity=31.3868613138686, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 42876; Mature: 42745

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAELSLAVVGAGPVGLALALHAARALPEARVHVFDARPADLDVSRDPRTLALSLGSVQE
CCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHH
FERLGVWPSIAPASTAITAVHVSQQQPALLMNGLASVLRLPPPELLLTATECGVDQLGAV
HHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEHHCCHHHHHHH
ASYGAIVAPLQAAWFEAVAKEPRRLSARFGTPVAALKPAAGGVEVDAGIAELHDLAVVAE
HHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCEEECCCHHHHHHEEEEEC
GGVFSTQARKALAHDYRQTAWVGQVTLAGPGAPATAGTAYERFTPQGPAALLPLPPLDGA
CCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCC
ARAALVWCVDAADDPVHDLDDAQRLAVLNQVFPPRVGRLVAITPLKRFALGLNAERTLVE
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCCCCEEEC
GRTVRIGNAAQTLHPVAGQGLNLGLRDAHALVAALQAAPAAAGDFDAVLKRVEWQRAPDR
CCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
WALIAATDFLARSFTWPLPGLASARGLGLAALQALSPAKRLLARQMMFGWR
EEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAELSLAVVGAGPVGLALALHAARALPEARVHVFDARPADLDVSRDPRTLALSLGSVQE
CCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEECCCHHH
FERLGVWPSIAPASTAITAVHVSQQQPALLMNGLASVLRLPPPELLLTATECGVDQLGAV
HHHCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEEHHCCHHHHHHH
ASYGAIVAPLQAAWFEAVAKEPRRLSARFGTPVAALKPAAGGVEVDAGIAELHDLAVVAE
HHCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHCCCCCCCEEECCCHHHHHHEEEEEC
GGVFSTQARKALAHDYRQTAWVGQVTLAGPGAPATAGTAYERFTPQGPAALLPLPPLDGA
CCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCC
ARAALVWCVDAADDPVHDLDDAQRLAVLNQVFPPRVGRLVAITPLKRFALGLNAERTLVE
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCCCCEEEC
GRTVRIGNAAQTLHPVAGQGLNLGLRDAHALVAALQAAPAAAGDFDAVLKRVEWQRAPDR
CCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
WALIAATDFLARSFTWPLPGLASARGLGLAALQALSPAKRLLARQMMFGWR
EEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]