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The map label for this gene is fabG [C]

Identifier: 124265423

GI number: 124265423

Start: 246446

End: 247231

Strand: Reverse

Name: fabG [C]

Synonym: Mpe_A0230

Alternate gene names: 124265423

Gene position: 247231-246446 (Counterclockwise)

Preceding gene: 124265424

Following gene: 124265422

Centisome position: 6.11

GC content: 70.87

Gene sequence:

>786_bases
GTGTCCCTGAATCCCCCCCTTACCGAGTGGTCCGGCCAGCTCGCCTGGCTGGTCGGCGCCTCCAGCGGCATCGGTCGCGC
CACCGCGTCGGCGCTGCATGCGCAGGGGGCGACCGTGGTGGTGTCGGCCCGCAAGGCGGCGGACCTCGAGCGCTTCGTGC
AGGAGCATCCCGGCAGCCATGCGGTGGTGCTCGACGCGACCGACCGTGCCGCGATGCAGGCCGCCGCGCGCCGCGTGCGG
GGCCTGATGGGTCGTATCGATCTCGCGATGTACTGCGCGGGCCACTACAAGCCGCAGCGCGCCACGGCCTTCGACCTCGA
CGAGATGCTGCTGCACCAGCAGGTCAACTATGTCGGCGCGCTGCATCTGGTCGACGCGGTGCTGCCCGGGCTGCTCGAGC
AGGCCGCGGCCGGCTCGGGAGGGCACTTGAGCCTGGTCGGCAGCGTGGCCGGCTACCGCGGACTGCCGAACTCGCTGGCC
TACGGGCCGACGAAGGCGGCGCTGATCAACCTGGCGCAGACGCTCTACCTCGACCTGCACGCGAAGGGCATCGGCGTGTC
GATCGTCAACCCCGGCTTCGTCGAGTCGCCGCTGACGGCGCAGAACGACTTCGCGATGCCGGCGCTGCTGACCCCCGAGC
AGGCGGCGCAGGCCATTCTCGCGGGCTGGGCCTCGGGCGTCTTCGAGCTGCACTTCCCGAAGCGCTTCACGCTGTGGATG
AAGTTGCTGAGCCACGTGGGTGACGGCCTGTACTTCAAGGCGGTGCGCCGCGCCACGGGTCTGTGA

Upstream 100 bases:

>100_bases
CCTGATGGACGAGCGCGTGATGCTGAACAAGGCAGTGATGAGCAAGTTCGGTGTCCGCCTCGGCGAGGTCACGTTGTCCT
TCTACAAGCGCTGAGCCTCC

Downstream 100 bases:

>100_bases
TGTCCGCATCCACCGACGACTCCCGCGTCGCACGCGTGATCGCACGCTTCGAGCACCTCACCCGCGCGGACCTGCCGCGC
CTGGGCGAGATCTACACCGA

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSLNPPLTEWSGQLAWLVGASSGIGRATASALHAQGATVVVSARKAADLERFVQEHPGSHAVVLDATDRAAMQAAARRVR
GLMGRIDLAMYCAGHYKPQRATAFDLDEMLLHQQVNYVGALHLVDAVLPGLLEQAAAGSGGHLSLVGSVAGYRGLPNSLA
YGPTKAALINLAQTLYLDLHAKGIGVSIVNPGFVESPLTAQNDFAMPALLTPEQAAQAILAGWASGVFELHFPKRFTLWM
KLLSHVGDGLYFKAVRRATGL

Sequences:

>Translated_261_residues
MSLNPPLTEWSGQLAWLVGASSGIGRATASALHAQGATVVVSARKAADLERFVQEHPGSHAVVLDATDRAAMQAAARRVR
GLMGRIDLAMYCAGHYKPQRATAFDLDEMLLHQQVNYVGALHLVDAVLPGLLEQAAAGSGGHLSLVGSVAGYRGLPNSLA
YGPTKAALINLAQTLYLDLHAKGIGVSIVNPGFVESPLTAQNDFAMPALLTPEQAAQAILAGWASGVFELHFPKRFTLWM
KLLSHVGDGLYFKAVRRATGL
>Mature_260_residues
SLNPPLTEWSGQLAWLVGASSGIGRATASALHAQGATVVVSARKAADLERFVQEHPGSHAVVLDATDRAAMQAAARRVRG
LMGRIDLAMYCAGHYKPQRATAFDLDEMLLHQQVNYVGALHLVDAVLPGLLEQAAAGSGGHLSLVGSVAGYRGLPNSLAY
GPTKAALINLAQTLYLDLHAKGIGVSIVNPGFVESPLTAQNDFAMPALLTPEQAAQAILAGWASGVFELHFPKRFTLWMK
LLSHVGDGLYFKAVRRATGL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=27.9187817258883, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI7706318, Length=211, Percent_Identity=31.7535545023697, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI210032110, Length=239, Percent_Identity=22.5941422594142, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI7705925, Length=188, Percent_Identity=32.4468085106383, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI66933014, Length=200, Percent_Identity=27, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=27.4611398963731, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=29.2307692307692, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1787820, Length=229, Percent_Identity=26.6375545851528, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786701, Length=240, Percent_Identity=27.5, Blast_Score=64, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=229, Percent_Identity=29.6943231441048, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=200, Percent_Identity=31.5, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=202, Percent_Identity=28.7128712871287, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=227, Percent_Identity=27.7533039647577, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=200, Percent_Identity=31, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=203, Percent_Identity=26.6009852216749, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=34.0314136125654, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007236, Length=228, Percent_Identity=25.8771929824561, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580925, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643142, Length=197, Percent_Identity=30.9644670050761, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=200, Percent_Identity=28, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27597; Mature: 27466

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNPPLTEWSGQLAWLVGASSGIGRATASALHAQGATVVVSARKAADLERFVQEHPGSH
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCE
AVVLDATDRAAMQAAARRVRGLMGRIDLAMYCAGHYKPQRATAFDLDEMLLHQQVNYVGA
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LHLVDAVLPGLLEQAAAGSGGHLSLVGSVAGYRGLPNSLAYGPTKAALINLAQTLYLDLH
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEE
AKGIGVSIVNPGFVESPLTAQNDFAMPALLTPEQAAQAILAGWASGVFELHFPKRFTLWM
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHH
KLLSHVGDGLYFKAVRRATGL
HHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLNPPLTEWSGQLAWLVGASSGIGRATASALHAQGATVVVSARKAADLERFVQEHPGSH
CCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCE
AVVLDATDRAAMQAAARRVRGLMGRIDLAMYCAGHYKPQRATAFDLDEMLLHQQVNYVGA
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LHLVDAVLPGLLEQAAAGSGGHLSLVGSVAGYRGLPNSLAYGPTKAALINLAQTLYLDLH
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEE
AKGIGVSIVNPGFVESPLTAQNDFAMPALLTPEQAAQAILAGWASGVFELHFPKRFTLWM
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHH
KLLSHVGDGLYFKAVRRATGL
HHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA