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The map label for this gene is ybhO [H]

Identifier: 124265240

GI number: 124265240

Start: 44687

End: 45937

Strand: Reverse

Name: ybhO [H]

Synonym: Mpe_A0047

Alternate gene names: 124265240

Gene position: 45937-44687 (Counterclockwise)

Preceding gene: 124265241

Following gene: 124265239

Centisome position: 1.14

GC content: 71.22

Gene sequence:

>1251_bases
GTGAGCGCGCCACGCTGGGTCGACGGCAACCGCTTCACGCTGCTGGAGAACGGCGAGGCCTACTTCCCGCGCGTGTTCGA
GGCCATCGCCGCGGCGCGCCACGAGGTGTTGCTGGAGACCTTCATCCTGTTCGAGGACAAGGTCGGGCTCGCGCTGCATG
CCGCGCTGCTGTCGGCGGCACGCAATGGCGCGAAGGTCGACATCACGATCGACGGCTTCGGCTCGCCCGACCTGTCGCCG
GCCTTCATCGGCGCGCTCACCGAGGCCGGCGTGCGCGTGCACGTGTTCGACCCCGGCACGCGGCTGTTCGGCTGGCGCAC
CAACCTGTTCCGCCGCATGCACCGCAAGATCGTGGTGGTGGACGGCGAGCGCGCCTTCGTCGGCGGCATCAACTATTCGG
CCGATCACCTGGCCGACTTCGGGCCCGAGGCCAAGCAGGACTACGCGGTGGAGCTGGAAGGCCCGCTGGTGGCGCACATC
CAGCGCTTCGTGCAGCAGGCCATCGTCGAAGGGCGCCCGGGCCGGTCCTCCTCGGAGCGCCGCTGGTTCCGACGTCGCGC
ACCGCCGTCGGCGCTGCCGCCGCAGGCCGCCGCCGGCGCCGCCCAGGCGATGTTCGTCACGCGCGACAACCGCGAGCACC
CGCAGGACATCGAGCGCCACTACCGCGCCGTGATCCGCGCCGCGCGCCACCGTCTGGTGATCGCCAATGCCTACTTCTTC
CCCGGCTACCGGTTGCTGAGGGAGCTGCGCCGGGCGGCGCGGCGGGGCGTGCAGGTCTCGCTGATCCTGCAGGGCGAGCC
CGACATGGCCATCGTCAAGAGCGCCGCGGAGATGCTGTACCACCACCTGCTGCGCGCCGGCGTGCACATCTACGAGTACT
GCGAGCGCCCGCTGCACGGCAAGGTGGCAGTGGCCGACGACGAGTGGTCCACCGTGGGCTCCAGCAACCTCGATCCGCTG
AGCCTGTCGCTCAACCTCGAGGCCAACGTGATGATCCGCGACCGGGACTTCAACCGCCAGCTGGGCGAGCGGCTCGATCA
CCTGATGGCCCACTGCTGCAAGCGCATCGAGGCCACCGACCTGCAGGAGTCCAGCCTGTGGCGGCTGGTGCGCAGCTTCT
TCGTCTTCCACTTCCTGCGCCGCTACCCGGCGTGGGCCGGCTGGCTGCCGGCGCATGCGCCCCGGCTCAGCTCGGTGTCG
CACGCGCCGGCCGCCGGCGCCGAGCGGCTCACCGAGCCGGCGCGGAGCTGA

Upstream 100 bases:

>100_bases
TCTACGTGCGCAACGCCGCGGTGCACGCACCCATGGTGCTGCCGCGCAGGCCGTGGTCGCACCTGTCGGACCATGCGCCG
CTGGCAGCGGAGATCTCGCT

Downstream 100 bases:

>100_bases
CGGCGGTGGCGGCCGGGCCGGCCTCCGCGACGGCGATGCCCCGGCGCACCGCGGCCGGACCGCGCCACGCTGCGGGCGGG
CGACGCGGCCTCACGTCGCG

Product: cardiolipin synthase 2

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSAPRWVDGNRFTLLENGEAYFPRVFEAIAAARHEVLLETFILFEDKVGLALHAALLSAARNGAKVDITIDGFGSPDLSP
AFIGALTEAGVRVHVFDPGTRLFGWRTNLFRRMHRKIVVVDGERAFVGGINYSADHLADFGPEAKQDYAVELEGPLVAHI
QRFVQQAIVEGRPGRSSSERRWFRRRAPPSALPPQAAAGAAQAMFVTRDNREHPQDIERHYRAVIRAARHRLVIANAYFF
PGYRLLRELRRAARRGVQVSLILQGEPDMAIVKSAAEMLYHHLLRAGVHIYEYCERPLHGKVAVADDEWSTVGSSNLDPL
SLSLNLEANVMIRDRDFNRQLGERLDHLMAHCCKRIEATDLQESSLWRLVRSFFVFHFLRRYPAWAGWLPAHAPRLSSVS
HAPAAGAERLTEPARS

Sequences:

>Translated_416_residues
MSAPRWVDGNRFTLLENGEAYFPRVFEAIAAARHEVLLETFILFEDKVGLALHAALLSAARNGAKVDITIDGFGSPDLSP
AFIGALTEAGVRVHVFDPGTRLFGWRTNLFRRMHRKIVVVDGERAFVGGINYSADHLADFGPEAKQDYAVELEGPLVAHI
QRFVQQAIVEGRPGRSSSERRWFRRRAPPSALPPQAAAGAAQAMFVTRDNREHPQDIERHYRAVIRAARHRLVIANAYFF
PGYRLLRELRRAARRGVQVSLILQGEPDMAIVKSAAEMLYHHLLRAGVHIYEYCERPLHGKVAVADDEWSTVGSSNLDPL
SLSLNLEANVMIRDRDFNRQLGERLDHLMAHCCKRIEATDLQESSLWRLVRSFFVFHFLRRYPAWAGWLPAHAPRLSSVS
HAPAAGAERLTEPARS
>Mature_415_residues
SAPRWVDGNRFTLLENGEAYFPRVFEAIAAARHEVLLETFILFEDKVGLALHAALLSAARNGAKVDITIDGFGSPDLSPA
FIGALTEAGVRVHVFDPGTRLFGWRTNLFRRMHRKIVVVDGERAFVGGINYSADHLADFGPEAKQDYAVELEGPLVAHIQ
RFVQQAIVEGRPGRSSSERRWFRRRAPPSALPPQAAAGAAQAMFVTRDNREHPQDIERHYRAVIRAARHRLVIANAYFFP
GYRLLRELRRAARRGVQVSLILQGEPDMAIVKSAAEMLYHHLLRAGVHIYEYCERPLHGKVAVADDEWSTVGSSNLDPLS
LSLNLEANVMIRDRDFNRQLGERLDHLMAHCCKRIEATDLQESSLWRLVRSFFVFHFLRRYPAWAGWLPAHAPRLSSVSH
APAAGAERLTEPARS

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=397, Percent_Identity=56.4231738035265, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1787502, Length=386, Percent_Identity=27.720207253886, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 46829; Mature: 46698

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRWVDGNRFTLLENGEAYFPRVFEAIAAARHEVLLETFILFEDKVGLALHAALLSAA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RNGAKVDITIDGFGSPDLSPAFIGALTEAGVRVHVFDPGTRLFGWRTNLFRRMHRKIVVV
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEE
DGERAFVGGINYSADHLADFGPEAKQDYAVELEGPLVAHIQRFVQQAIVEGRPGRSSSER
ECCEEEECCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHH
RWFRRRAPPSALPPQAAAGAAQAMFVTRDNREHPQDIERHYRAVIRAARHRLVIANAYFF
HHHHHCCCCCCCCCCHHCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEEEEEEC
PGYRLLRELRRAARRGVQVSLILQGEPDMAIVKSAAEMLYHHLLRAGVHIYEYCERPLHG
CCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCC
KVAVADDEWSTVGSSNLDPLSLSLNLEANVMIRDRDFNRQLGERLDHLMAHCCKRIEATD
CEEEECCCCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
LQESSLWRLVRSFFVFHFLRRYPAWAGWLPAHAPRLSSVSHAPAAGAERLTEPARS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SAPRWVDGNRFTLLENGEAYFPRVFEAIAAARHEVLLETFILFEDKVGLALHAALLSAA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RNGAKVDITIDGFGSPDLSPAFIGALTEAGVRVHVFDPGTRLFGWRTNLFRRMHRKIVVV
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEE
DGERAFVGGINYSADHLADFGPEAKQDYAVELEGPLVAHIQRFVQQAIVEGRPGRSSSER
ECCEEEECCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHH
RWFRRRAPPSALPPQAAAGAAQAMFVTRDNREHPQDIERHYRAVIRAARHRLVIANAYFF
HHHHHCCCCCCCCCCHHCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEEEEEEC
PGYRLLRELRRAARRGVQVSLILQGEPDMAIVKSAAEMLYHHLLRAGVHIYEYCERPLHG
CCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCC
KVAVADDEWSTVGSSNLDPLSLSLNLEANVMIRDRDFNRQLGERLDHLMAHCCKRIEATD
CEEEECCCCCCCCCCCCCCEEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
LQESSLWRLVRSFFVFHFLRRYPAWAGWLPAHAPRLSSVSHAPAAGAERLTEPARS
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]