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The map label for this gene is fabG [C]

Identifier: 124265229

GI number: 124265229

Start: 36088

End: 36786

Strand: Direct

Name: fabG [C]

Synonym: Mpe_A0036

Alternate gene names: 124265229

Gene position: 36088-36786 (Clockwise)

Preceding gene: 124265228

Following gene: 124265231

Centisome position: 0.89

GC content: 72.39

Gene sequence:

>699_bases
ATGAAGATCAAGGACTCCGTCGCGCTGGTCACCGGCGCCAACCGCGGCCTCGGCCGTGCCTTCGCCGCCGCGCTGCTGGC
CGGTGGCGCCCGCAAGGTCTACGCCGCTGCGCGCGACCCGGCCAGCGTCACGCTCGCTGGCGTCACGCCGGTCCAGCTGG
ACGTGACGAACGCGCAGCAGGCGGCGGCGCTGGCGCGCGAGCTCGGCGACGTGTCGCTACTGATCAACAACGCCGGCATC
CTGCGCGGCACCGGCCTGCTGGAGGCCGGCTCGGTGGAGGCGGCGCGCGCCGAGATGGAAACGCACTTCTTCGGCCCGCT
GCAACTGAGCCAGGCCTTCGCGCCGGTGCTCGCGCGCAACGGCGGTGGCGCCATCCTCAACATCCTGTCGGTGCTGAGCT
GGATCAGCATGCCGGGCGTCAGCACCTATTGCGCGTCGAAGGCGGCCGAGTGGTCGCTGACCAACGGCCTGCGCAACGAG
CTGCGCGCGCAGGGCACGCAGGTCGTCGGCCTGCACGTGGGCTACATGGACACCGACATGGTCCGCGGTGTCGACGCCGC
GAAGTCCGCGCCGGAGGACGTGGTGCGCCAGGCGTTCGCGGTGCTCGAGTCCGGCGGCTACGAGGTGCTGGCCGACGAGA
TCAGCCGCCAGGTGCGCCAGGGCCTGTCGGCCGAGCCGGCGGTCTACGCGGGGAGCTGA

Upstream 100 bases:

>100_bases
GGGATTGAGCGCCGATCCGCAGGCGGCGCAACCCGGCTTTCGTCCGACGCATGACGGTCGTCATGCGAATTCACCCGCTC
ATCTCCTGGAAGGACACCTC

Downstream 100 bases:

>100_bases
CGGCGCGAGAGGGTGGACGCCAACCCCTGAAGGCCCTAGAAGAACCCGGCCTTGCCGGCCGCCGCCACCGCGGACTTCAC
CAGCTCGGCCACCTGCGCGT

Product: putative short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKIKDSVALVTGANRGLGRAFAAALLAGGARKVYAAARDPASVTLAGVTPVQLDVTNAQQAAALARELGDVSLLINNAGI
LRGTGLLEAGSVEAARAEMETHFFGPLQLSQAFAPVLARNGGGAILNILSVLSWISMPGVSTYCASKAAEWSLTNGLRNE
LRAQGTQVVGLHVGYMDTDMVRGVDAAKSAPEDVVRQAFAVLESGGYEVLADEISRQVRQGLSAEPAVYAGS

Sequences:

>Translated_232_residues
MKIKDSVALVTGANRGLGRAFAAALLAGGARKVYAAARDPASVTLAGVTPVQLDVTNAQQAAALARELGDVSLLINNAGI
LRGTGLLEAGSVEAARAEMETHFFGPLQLSQAFAPVLARNGGGAILNILSVLSWISMPGVSTYCASKAAEWSLTNGLRNE
LRAQGTQVVGLHVGYMDTDMVRGVDAAKSAPEDVVRQAFAVLESGGYEVLADEISRQVRQGLSAEPAVYAGS
>Mature_232_residues
MKIKDSVALVTGANRGLGRAFAAALLAGGARKVYAAARDPASVTLAGVTPVQLDVTNAQQAAALARELGDVSLLINNAGI
LRGTGLLEAGSVEAARAEMETHFFGPLQLSQAFAPVLARNGGGAILNILSVLSWISMPGVSTYCASKAAEWSLTNGLRNE
LRAQGTQVVGLHVGYMDTDMVRGVDAAKSAPEDVVRQAFAVLESGGYEVLADEISRQVRQGLSAEPAVYAGS

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=197, Percent_Identity=31.4720812182741, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706318, Length=176, Percent_Identity=30.6818181818182, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI19743808, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI150247226, Length=238, Percent_Identity=27.3109243697479, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=191, Percent_Identity=31.413612565445, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082160, Length=208, Percent_Identity=29.3269230769231, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367175, Length=192, Percent_Identity=34.8958333333333, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786701, Length=198, Percent_Identity=30.8080808080808, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=192, Percent_Identity=31.7708333333333, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=189, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571526, Length=192, Percent_Identity=32.8125, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281364494, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 23951; Mature: 23951

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKDSVALVTGANRGLGRAFAAALLAGGARKVYAAARDPASVTLAGVTPVQLDVTNAQQ
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHEEEECCCCCEEEEECCCEEEEECCCHHH
AAALARELGDVSLLINNAGILRGTGLLEAGSVEAARAEMETHFFGPLQLSQAFAPVLARN
HHHHHHHHCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
GGGAILNILSVLSWISMPGVSTYCASKAAEWSLTNGLRNELRAQGTQVVGLHVGYMDTDM
CCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
VRGVDAAKSAPEDVVRQAFAVLESGGYEVLADEISRQVRQGLSAEPAVYAGS
HHCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCC
>Mature Secondary Structure
MKIKDSVALVTGANRGLGRAFAAALLAGGARKVYAAARDPASVTLAGVTPVQLDVTNAQQ
CCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHEEEECCCCCEEEEECCCEEEEECCCHHH
AAALARELGDVSLLINNAGILRGTGLLEAGSVEAARAEMETHFFGPLQLSQAFAPVLARN
HHHHHHHHCCEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
GGGAILNILSVLSWISMPGVSTYCASKAAEWSLTNGLRNELRAQGTQVVGLHVGYMDTDM
CCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
VRGVDAAKSAPEDVVRQAFAVLESGGYEVLADEISRQVRQGLSAEPAVYAGS
HHCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA