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The map label for this gene is gltA [H]

Identifier: 124024380

GI number: 124024380

Start: 2375216

End: 2376406

Strand: Reverse

Name: gltA [H]

Synonym: P9303_26921

Alternate gene names: 124024380

Gene position: 2376406-2375216 (Counterclockwise)

Preceding gene: 124024381

Following gene: 124024379

Centisome position: 88.58

GC content: 55.92

Gene sequence:

>1191_bases
GTGGGGCAGGAGCAGGTTGGGGAGATTCGCCACGATCGCAGTGGCATCAGCTTTCGTCCGGGGCTGGAGGGAGTGCCAGT
AACCCAATCCGCCATCTGTGATATCGATGGAATGCAGGGGCGGCTTGCTTATCGGGGTTATCCAATTGCGGAGCTCTCAG
CGCATAGCAGCTTTTTGGAAACCACCTATCTGTTGATCTGGGGCGATCTGCCCAGCCCACAGCAACTTCGTGATTTCGAA
GCTGAGGTGCAGATGCACCGTCGCGTGAGTTTCCGGGTACGCGACATGATGAAGTGCTTCCCAGCTTCGGGGCACCCGAT
GGATGCACTTCAGTCGAGTGCAGCATCCCTGGGGCTGTTCTATTCCCGTCGAGCCATCGATGACCCGAAGTACGTCTATA
ACGCCGTGGTGAGGCTGATCGCCAAGATTCCCACGATGGTGGCGGCCTTCAAGTTGATTCGCAAAGGGCAAGATCCCATT
CAGCCTCGTGACGACCTGGCCTACTCAGCCAATTTCCTCTACATGCTCACCGAGCGTGAACCGGACCCTTTGGCGGCAAG
GGTTCTTGATCGCTGCTTGATCCTGCATGCGGAACACAGTCTGAATGCCAGTACTTTTAGTGCTCGCGTGACCGCCAGTA
CGCTCACAGACCCTTATGCAGTGGTGGCCTCCGCAGTGGGCACCCTTGCAGGACCTCTACATGGTGGTGCCAATGAGGAT
GTTTTGGCGATGCTCGAAGAGATCGGCAGCCCAGAGCATGCTGGTGATTACTTGGATGAAGCGATTGCTTCTAAGCGCAA
GGTGATGGGCTTTGGTCATCGGGAATATCGGGTCAAGGATCCTCGCGCTGTGATCCTTCAGGGTCTTGCAGAGGAGTTGT
TTGCCCGATTCGGTACCGATGAGATGTACGACGTGGCCAAGGCGTTGGAGGCGGCGGCGGCTACCCGTTTAGGCCCTAAA
GGGATCTATCCGAATGTGGACTTCTATTCCGGTCTTGTGTATCGCAAGCTTGGAATTCCACGCGATCTTTTTACTCCTGT
GTTTGCCATCTCACGGGTGGCCGGTTGGCTGGCTCATTGGCGAGAGCAACTTGGCGCGAATCGGATTTTCAGGCCTTCGC
AGATTTACACAGGTGCTCAGAACAGAACTTGGATCCCTAGTGATGAGCGTGTCTCTTCTACGGGCGCCTAA

Upstream 100 bases:

>100_bases
AAACGCAGCCCTGCTGGTAGGGCAACGCTGCAGGTGTTGTTGAGGCCGTCGGTGTTGTTGCCCTGTTCCGCTTAGGTTGC
CAAGCAGTTGTCGAGATGCG

Downstream 100 bases:

>100_bases
GTTGCAGCCAGCTCAGCCATCACCATGGTGACCACCTTTGCCACTGCAACCTCAGGCTTGGTGAGTTCTGGCCTTGATCT
GGAGTTGAGCTTTAGTCAGT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MGQEQVGEIRHDRSGISFRPGLEGVPVTQSAICDIDGMQGRLAYRGYPIAELSAHSSFLETTYLLIWGDLPSPQQLRDFE
AEVQMHRRVSFRVRDMMKCFPASGHPMDALQSSAASLGLFYSRRAIDDPKYVYNAVVRLIAKIPTMVAAFKLIRKGQDPI
QPRDDLAYSANFLYMLTEREPDPLAARVLDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANED
VLAMLEEIGSPEHAGDYLDEAIASKRKVMGFGHREYRVKDPRAVILQGLAEELFARFGTDEMYDVAKALEAAAATRLGPK
GIYPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYTGAQNRTWIPSDERVSSTGA

Sequences:

>Translated_396_residues
MGQEQVGEIRHDRSGISFRPGLEGVPVTQSAICDIDGMQGRLAYRGYPIAELSAHSSFLETTYLLIWGDLPSPQQLRDFE
AEVQMHRRVSFRVRDMMKCFPASGHPMDALQSSAASLGLFYSRRAIDDPKYVYNAVVRLIAKIPTMVAAFKLIRKGQDPI
QPRDDLAYSANFLYMLTEREPDPLAARVLDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANED
VLAMLEEIGSPEHAGDYLDEAIASKRKVMGFGHREYRVKDPRAVILQGLAEELFARFGTDEMYDVAKALEAAAATRLGPK
GIYPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYTGAQNRTWIPSDERVSSTGA
>Mature_395_residues
GQEQVGEIRHDRSGISFRPGLEGVPVTQSAICDIDGMQGRLAYRGYPIAELSAHSSFLETTYLLIWGDLPSPQQLRDFEA
EVQMHRRVSFRVRDMMKCFPASGHPMDALQSSAASLGLFYSRRAIDDPKYVYNAVVRLIAKIPTMVAAFKLIRKGQDPIQ
PRDDLAYSANFLYMLTEREPDPLAARVLDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEDV
LAMLEEIGSPEHAGDYLDEAIASKRKVMGFGHREYRVKDPRAVILQGLAEELFARFGTDEMYDVAKALEAAAATRLGPKG
IYPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHWREQLGANRIFRPSQIYTGAQNRTWIPSDERVSSTGA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=398, Percent_Identity=29.1457286432161, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786939, Length=381, Percent_Identity=38.0577427821522, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=33.5135135135135, Blast_Score=231, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17555174, Length=330, Percent_Identity=30, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319850, Length=377, Percent_Identity=25.7294429708223, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=344, Percent_Identity=26.453488372093, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324328, Length=382, Percent_Identity=24.6073298429319, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24640124, Length=395, Percent_Identity=28.3544303797468, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24640126, Length=395, Percent_Identity=28.3544303797468, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21356863, Length=408, Percent_Identity=26.7156862745098, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 43837; Mature: 43706

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQEQVGEIRHDRSGISFRPGLEGVPVTQSAICDIDGMQGRLAYRGYPIAELSAHSSFLE
CCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHH
TTYLLIWGDLPSPQQLRDFEAEVQMHRRVSFRVRDMMKCFPASGHPMDALQSSAASLGLF
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YSRRAIDDPKYVYNAVVRLIAKIPTMVAAFKLIRKGQDPIQPRDDLAYSANFLYMLTERE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEEECCC
PDPLAARVLDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANED
CCHHHHHHHHHHHHHHCCCCCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
VLAMLEEIGSPEHAGDYLDEAIASKRKVMGFGHREYRVKDPRAVILQGLAEELFARFGTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
EMYDVAKALEAAAATRLGPKGIYPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHW
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
REQLGANRIFRPSQIYTGAQNRTWIPSDERVSSTGA
HHHHCCCCCCCCHHHEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQEQVGEIRHDRSGISFRPGLEGVPVTQSAICDIDGMQGRLAYRGYPIAELSAHSSFLE
CHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHH
TTYLLIWGDLPSPQQLRDFEAEVQMHRRVSFRVRDMMKCFPASGHPMDALQSSAASLGLF
HEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YSRRAIDDPKYVYNAVVRLIAKIPTMVAAFKLIRKGQDPIQPRDDLAYSANFLYMLTERE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEEECCC
PDPLAARVLDRCLILHAEHSLNASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANED
CCHHHHHHHHHHHHHHCCCCCCCHHHHHEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHH
VLAMLEEIGSPEHAGDYLDEAIASKRKVMGFGHREYRVKDPRAVILQGLAEELFARFGTD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCH
EMYDVAKALEAAAATRLGPKGIYPNVDFYSGLVYRKLGIPRDLFTPVFAISRVAGWLAHW
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
REQLGANRIFRPSQIYTGAQNRTWIPSDERVSSTGA
HHHHCCCCCCCCHHHEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]