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The map label for this gene is ndhA [H]

Identifier: 124024379

GI number: 124024379

Start: 2374037

End: 2375191

Strand: Reverse

Name: ndhA [H]

Synonym: P9303_26911

Alternate gene names: 124024379

Gene position: 2375191-2374037 (Counterclockwise)

Preceding gene: 124024380

Following gene: 124024378

Centisome position: 88.54

GC content: 54.46

Gene sequence:

>1155_bases
ATGGTGACCACCTTTGCCACTGCAACCTCAGGCTTGGTGAGTTCTGGCCTTGATCTGGAGTTGAGCTTTAGTCAGTCATT
ACAAGGGCTGGGACTTTCCCCTCAGATGGCCCATCTCATTTGGTTGCCGCTGCCGATGCTGTTGGTGTTGACCGCGGCGA
TGGTGGGCGTTTTGGTCACCGTGTGGCTGGAGCGGAAGATTTCGGCGGCAGTTCAGCAGCGGATCGGACCGGAATACGCA
GGAGCTCTCGGCGTGTTGCAGCCGATGGCCGATGGCTTGAAGTTGCTGGTGAAGGAAGACGTGATCCCTGTCAGGGCGGA
TGGCCTGCTGTTCACTCTTGGTCCGGTCCTGGTGCTTGTGCCTGTGATCCTCTCCTGGCTGATCGTGCCTTTTGGTCAAA
ATCTGCTGATCAGCAATGTGGGGATAGGGATTTTCCTCTGGATCTCCCTCAGCAGCATTCAGCCCATTGGCCTATTGATG
AGTGGCTATGCCTCCAATAACAAGTACTCACTCTTGGGTGGGCTGAGGGCTGCAGCTCAATCGATCAGTTATGAAATCCC
TCTTGCCTTGGCTGTTCTGGCAGTGGTGATGATGAGCAATTCGCTCAGCACGGTCGACATTGTTGCCCAACAAAATGGTG
CTGGCTTGCTGAGCTGGAATGTGTGGCGGCAGCCTGTGGGCTTTTTGATCTTTTGGATCTGTGCGCTGGCCGAGTGCGAA
CGACTTCCTTTCGATCTCCCTGAAGCGGAGGAAGAGCTGGTGGCGGGTTATCAGACCGAGTACGCAGGGATGAAGTTTGC
CCTGTTTTATCTCGGTAGTTACATCAACCTTGTGCTTTCGTCCTTGTTGGTCGCAGTGCTCTACCTAGGGGGATGGGGCT
TCCCCATCCCGGTGGAATGGTTGGCTGGTTGGCTTGGTCAGTCGGTTGATGCTCCCTTGGTGCAGGTGATCACTGGCTCC
GTTGGCATTGTGATGACAGTGCTGAAGGCTTATCTGCTGGTGTTCTTAGCCATCTTGTTGCGCTGGACTACTCCACGCGT
ACGCATTGATCAATTGCTTGATTTGGGCTGGAAGTTTCTTTTGCCGATCGCGCTTGGAAATCTGCTGATCACCGCTGCTC
TTAAGTTGGCTTTCCCTGTTGCCTTTGGCGGTTGA

Upstream 100 bases:

>100_bases
TTCGCAGATTTACACAGGTGCTCAGAACAGAACTTGGATCCCTAGTGATGAGCGTGTCTCTTCTACGGGCGCCTAAGTTG
CAGCCAGCTCAGCCATCACC

Downstream 100 bases:

>100_bases
TGCAGCCAAAGCGCTTGAAGGTGCTGGATCTCGCCCTGGGAAGGCTAAGCACTTTTACTTATCCTGGCTAAAAAGCTTGT
AGGATTTCTGTAATGCTCCT

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MVTTFATATSGLVSSGLDLELSFSQSLQGLGLSPQMAHLIWLPLPMLLVLTAAMVGVLVTVWLERKISAAVQQRIGPEYA
GALGVLQPMADGLKLLVKEDVIPVRADGLLFTLGPVLVLVPVILSWLIVPFGQNLLISNVGIGIFLWISLSSIQPIGLLM
SGYASNNKYSLLGGLRAAAQSISYEIPLALAVLAVVMMSNSLSTVDIVAQQNGAGLLSWNVWRQPVGFLIFWICALAECE
RLPFDLPEAEEELVAGYQTEYAGMKFALFYLGSYINLVLSSLLVAVLYLGGWGFPIPVEWLAGWLGQSVDAPLVQVITGS
VGIVMTVLKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFLLPIALGNLLITAALKLAFPVAFGG

Sequences:

>Translated_384_residues
MVTTFATATSGLVSSGLDLELSFSQSLQGLGLSPQMAHLIWLPLPMLLVLTAAMVGVLVTVWLERKISAAVQQRIGPEYA
GALGVLQPMADGLKLLVKEDVIPVRADGLLFTLGPVLVLVPVILSWLIVPFGQNLLISNVGIGIFLWISLSSIQPIGLLM
SGYASNNKYSLLGGLRAAAQSISYEIPLALAVLAVVMMSNSLSTVDIVAQQNGAGLLSWNVWRQPVGFLIFWICALAECE
RLPFDLPEAEEELVAGYQTEYAGMKFALFYLGSYINLVLSSLLVAVLYLGGWGFPIPVEWLAGWLGQSVDAPLVQVITGS
VGIVMTVLKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFLLPIALGNLLITAALKLAFPVAFGG
>Mature_384_residues
MVTTFATATSGLVSSGLDLELSFSQSLQGLGLSPQMAHLIWLPLPMLLVLTAAMVGVLVTVWLERKISAAVQQRIGPEYA
GALGVLQPMADGLKLLVKEDVIPVRADGLLFTLGPVLVLVPVILSWLIVPFGQNLLISNVGIGIFLWISLSSIQPIGLLM
SGYASNNKYSLLGGLRAAAQSISYEIPLALAVLAVVMMSNSLSTVDIVAQQNGAGLLSWNVWRQPVGFLIFWICALAECE
RLPFDLPEAEEELVAGYQTEYAGMKFALFYLGSYINLVLSSLLVAVLYLGGWGFPIPVEWLAGWLGQSVDAPLVQVITGS
VGIVMTVLKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFLLPIALGNLLITAALKLAFPVAFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=34.9673202614379, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1788618, Length=315, Percent_Identity=39.3650793650794, Blast_Score=224, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: 1.6.5.3

Molecular weight: Translated: 41304; Mature: 41304

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTFATATSGLVSSGLDLELSFSQSLQGLGLSPQMAHLIWLPLPMLLVLTAAMVGVLVT
CCEEEHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWLERKISAAVQQRIGPEYAGALGVLQPMADGLKLLVKEDVIPVRADGLLFTLGPVLVLV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
PVILSWLIVPFGQNLLISNVGIGIFLWISLSSIQPIGLLMSGYASNNKYSLLGGLRAAAQ
HHHHHHHHHHCCCCEEHHHCCHHHEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
SISYEIPLALAVLAVVMMSNSLSTVDIVAQQNGAGLLSWNVWRQPVGFLIFWICALAECE
HCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
RLPFDLPEAEEELVAGYQTEYAGMKFALFYLGSYINLVLSSLLVAVLYLGGWGFPIPVEW
CCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAGWLGQSVDAPLVQVITGSVGIVMTVLKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFL
HHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LPIALGNLLITAALKLAFPVAFGG
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVTTFATATSGLVSSGLDLELSFSQSLQGLGLSPQMAHLIWLPLPMLLVLTAAMVGVLVT
CCEEEHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWLERKISAAVQQRIGPEYAGALGVLQPMADGLKLLVKEDVIPVRADGLLFTLGPVLVLV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
PVILSWLIVPFGQNLLISNVGIGIFLWISLSSIQPIGLLMSGYASNNKYSLLGGLRAAAQ
HHHHHHHHHHCCCCEEHHHCCHHHEEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHH
SISYEIPLALAVLAVVMMSNSLSTVDIVAQQNGAGLLSWNVWRQPVGFLIFWICALAECE
HCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
RLPFDLPEAEEELVAGYQTEYAGMKFALFYLGSYINLVLSSLLVAVLYLGGWGFPIPVEW
CCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LAGWLGQSVDAPLVQVITGSVGIVMTVLKAYLLVFLAILLRWTTPRVRIDQLLDLGWKFL
HHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LPIALGNLLITAALKLAFPVAFGG
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA