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The map label for this gene is uvrD [H]

Identifier: 124024248

GI number: 124024248

Start: 2252348

End: 2254756

Strand: Reverse

Name: uvrD [H]

Synonym: P9303_25591

Alternate gene names: 124024248

Gene position: 2254756-2252348 (Counterclockwise)

Preceding gene: 124024249

Following gene: 124024247

Centisome position: 84.05

GC content: 52.93

Gene sequence:

>2409_bases
GTGAGTTTTCTTGCTGGCCTTAATGATGCTCAGCGCAAGGCTGTCGACCATCATCAGGGACCTCTGTTGGTGGTTGCAGG
AGCTGGTAGTGGCAAGACGCGTGCACTGACGCATCGCATCGCTCACTTGATTGGAGCGCATGGTGCCGATCCGGCTCAGA
TTTTGGCTGTGACCTTTACGAACAAGGCCGCGCGCGAGATGAAGGATCGTTTGGAGCTGTTATTGGCTCAGCGGCTTGCT
GAGAGTCAATACGGCCAACCATGGAGCACTCTGCCGCCGGTGGACCAGCGCCAGCTGCGGGGTCGAATTTTTCGAGAGGT
GACCAAAGAGTTGTGGATTGGCACATTTCACTCTTTATTTGCTCGCTTGCTTCGCTTTGACATCGACAAGTTTCGTGATG
CAGAAGGACTGAGTTGGACGCGTCAGTTTTCGATTTACGACGAGGCCGATGCCCAGAGTTTGGTGAAGGAGATTGTGACT
CAGGAGCTGCAGCTCGATCCCAAGCGCTTTGAGCCTAAGAAGGTGCGCTGGGCGATTAGTAACGCCAAAAATCAAGGCTG
GTTGCCTGATCAATTGGCAGCCCAGGTCGATGGTCAGCGAGGCAAGCTCACGGTTGAGACGTATCGGCGTTATCGCAAGG
CATTAGCGGCGAACAATGCACTGGATTTCGACGACCTGCTGTTATTGCCCGTCCAGTTACTTCAGCAGAACGAGCAGATA
CGACGTTATTGGCATAATCGTTTTCGGCATGTGTTAGTTGATGAATACCAAGACACCAATCGCACTCAGTACGAGTTGAT
CAAGTTGTTGGTTACCGATGGTCGGGAACCTGAAATCTTTGATGATTGGCAGGGCCGTTCAGTTTTTGTGGTCGGTGATG
CAGATCAAAGCATCTACAGCTTCCGTGCGGCTGATTTCACGATCTTAATGGGCTTTCAGGACGACTTTGGCGACAAAGCA
TCAGACGATGCCACTCGCACCATGGTGAAGTTGGAGGAGAATTATCGCTCTACCTCAACAATTCTGGAGGCAGCCAATGC
CTTGATCGCTAACAATACAGAGCGGATTGACAAGGTATTGCGAGCTACCCGTGGCGAGGGGGAGTTGATCACCCTTACCC
GCTGTGACGATGAGATCGCAGAAGCTGAAGCTGTAGTGCATCGAATGCGCATGCTGGAAGCTGCTCATCCAGAACTTCGC
TGGGGCGATGTGGCAGTGCTGTATCGCACCAATGCCCAGTCCAGGGCGATTGAGGAGTCGTTGGTGCGTTGGCGTATTCC
TTACATTGTCGTGGGCGGACTACGTTTTTATGACAGGCGTGAAATCAAGGATGTTTTGGCCTATTTACGCTTATTGGTCA
ACCCCGCCGATACGGTGAGCCTGCTCAGAGTCATCAATGTGCCCAAGCGAGGCATTGGCAAGACCACCTTGCAGAGACTT
GCTGATGCTGCCAATCAACTTGGGATTCCTTTGTGGGATGTGGTGAGTGATGCCGAAGCAGTGCGCTCACTAGGAGGCAG
ATCGGCGAAGGGGTTGTTGCAGTTCTGTGAATTGATCAATGATTTGCAACGCTCGATTCAAGATCAGATTCCTTCGGAGA
TGATTCAGCAGGTGATGGAGAAGAGTGGCTATATCAGTGAGTTGATCGCTGAAGCTACCGATGAGGCAGAGGAGAGGCGA
CGCAATTTGCAAGAACTTGTGAATGCTGCTTTGCAATACCAGGAAGAAAATGAAGAGGGCAATCTTGAGGGCTTCTTAGC
CTCCGCTGCGTTGGCTAGCGATGCTGATAGCAAAGATACGGCTGCTGATCGGGTGACGTTAATGACTTTGCATAGCAGTA
AGGGGCTGGAGTTTCCCTTGGTCTTTCTGGTTGGTATGGAGCAGGGGCTTTTCCCTAGCTATCGCTCCCTTGATGATCCA
TCCTCTTTGGAGGAAGAACGACGCCTTTGCTATGTGGGGATGACGCGTGCCAAAGAACGTTTGTTTTTGTCTCATGCCAG
TGAGCGAAGACTTTGGGGTGGCATGCGACAGCCTGCTGTTCCCTCACTATTTCTTGCTGAGTTGCCCGAGGGTTTGGTGC
AGGGTGATCTCCCTCAAATTGGTGGTGTGGCATTACGGCGTGAGCGACGGCTGGACCGTTTGACGCGGGTTGATCGCGAT
GACAATCAACGGATCAAAGCGGGTGGTGTGAGCGGAGCCCCTAGCAATGCAGTGCGGCGGCGGCAGGCTGGGCCCGCTCC
AGGCAAGGCATGGGTCGTGGGTGATCGGGTCGTGCATTCCAGCTTTGGCGAAGGGGAGATCACCCATACCTTCGGCAGTG
GCGAGAAAGTGTCGATTGCTGTCAAGTTTGTCGGTATGGGGCCAAAGATTCTTGATCCACGTTTGGCCCCGATTGAGCCT
TTGGAGTAG

Upstream 100 bases:

>100_bases
GATTTGCTATGCACCACTGTCATCAGAGGGGCTTTCGCTATGACAGTTCTTTGTCGAGTCGTATGGCGACGAGGGCTTGG
CCAATTGTGAGATCTAAAGC

Downstream 100 bases:

>100_bases
GCCTGAGGTGATGGCACGTAAAAAACTGCTCCTGATCCGTGGCTTGGGCCATAGCGGCACCACCATTCTCGATTTGGCGT
TGGGGAGCCACCCAAGCATG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 802; Mature: 801

Protein sequence:

>802_residues
MSFLAGLNDAQRKAVDHHQGPLLVVAGAGSGKTRALTHRIAHLIGAHGADPAQILAVTFTNKAAREMKDRLELLLAQRLA
ESQYGQPWSTLPPVDQRQLRGRIFREVTKELWIGTFHSLFARLLRFDIDKFRDAEGLSWTRQFSIYDEADAQSLVKEIVT
QELQLDPKRFEPKKVRWAISNAKNQGWLPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPEIFDDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKA
SDDATRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPELR
WGDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQRSIQDQIPSEMIQQVMEKSGYISELIAEATDEAEERR
RNLQELVNAALQYQEENEEGNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDP
SSLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRD
DNQRIKAGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFVGMGPKILDPRLAPIEP
LE

Sequences:

>Translated_802_residues
MSFLAGLNDAQRKAVDHHQGPLLVVAGAGSGKTRALTHRIAHLIGAHGADPAQILAVTFTNKAAREMKDRLELLLAQRLA
ESQYGQPWSTLPPVDQRQLRGRIFREVTKELWIGTFHSLFARLLRFDIDKFRDAEGLSWTRQFSIYDEADAQSLVKEIVT
QELQLDPKRFEPKKVRWAISNAKNQGWLPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPEIFDDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKA
SDDATRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPELR
WGDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQRSIQDQIPSEMIQQVMEKSGYISELIAEATDEAEERR
RNLQELVNAALQYQEENEEGNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDP
SSLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRD
DNQRIKAGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFVGMGPKILDPRLAPIEP
LE
>Mature_801_residues
SFLAGLNDAQRKAVDHHQGPLLVVAGAGSGKTRALTHRIAHLIGAHGADPAQILAVTFTNKAAREMKDRLELLLAQRLAE
SQYGQPWSTLPPVDQRQLRGRIFREVTKELWIGTFHSLFARLLRFDIDKFRDAEGLSWTRQFSIYDEADAQSLVKEIVTQ
ELQLDPKRFEPKKVRWAISNAKNQGWLPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQIR
RYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPEIFDDWQGRSVFVVGDADQSIYSFRAADFTILMGFQDDFGDKAS
DDATRTMVKLEENYRSTSTILEAANALIANNTERIDKVLRATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPELRW
GDVAVLYRTNAQSRAIEESLVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRLA
DAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQRSIQDQIPSEMIQQVMEKSGYISELIAEATDEAEERRR
NLQELVNAALQYQEENEEGNLEGFLASAALASDADSKDTAADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDPS
SLEEERRLCYVGMTRAKERLFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRDD
NQRIKAGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIAVKFVGMGPKILDPRLAPIEPL
E

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=803, Percent_Identity=38.3561643835616, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI48994965, Length=694, Percent_Identity=39.7694524495677, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787196, Length=374, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=781, Percent_Identity=27.6568501920615, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324477, Length=723, Percent_Identity=23.2365145228216, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 90293; Mature: 90162

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLAGLNDAQRKAVDHHQGPLLVVAGAGSGKTRALTHRIAHLIGAHGADPAQILAVTFT
CCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHEEEEEEC
NKAAREMKDRLELLLAQRLAESQYGQPWSTLPPVDQRQLRGRIFREVTKELWIGTFHSLF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLLRFDIDKFRDAEGLSWTRQFSIYDEADAQSLVKEIVTQELQLDPKRFEPKKVRWAIS
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEC
NAKNQGWLPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
CCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHH
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPEIFDDWQGRSVFVVGDADQSIYS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHH
FRAADFTILMGFQDDFGDKASDDATRTMVKLEENYRSTSTILEAANALIANNTERIDKVL
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPELRWGDVAVLYRTNAQSRAIEES
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
LVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQRSIQDQIPSEMIQQVME
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KSGYISELIAEATDEAEERRRNLQELVNAALQYQEENEEGNLEGFLASAALASDADSKDT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDPSSLEEERRLCYVGMTRAKER
HHCEEEEEEEECCCCCCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHHHHHH
LFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRD
HHHHHCHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
DNQRIKAGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIA
CCCEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECHHHHCCCCCCCEEEECCCCCEEEEE
VKFVGMGPKILDPRLAPIEPLE
EEEECCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
SFLAGLNDAQRKAVDHHQGPLLVVAGAGSGKTRALTHRIAHLIGAHGADPAQILAVTFT
CCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHEEEEEEC
NKAAREMKDRLELLLAQRLAESQYGQPWSTLPPVDQRQLRGRIFREVTKELWIGTFHSLF
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLLRFDIDKFRDAEGLSWTRQFSIYDEADAQSLVKEIVTQELQLDPKRFEPKKVRWAIS
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEC
NAKNQGWLPDQLAAQVDGQRGKLTVETYRRYRKALAANNALDFDDLLLLPVQLLQQNEQI
CCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHH
RRYWHNRFRHVLVDEYQDTNRTQYELIKLLVTDGREPEIFDDWQGRSVFVVGDADQSIYS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHH
FRAADFTILMGFQDDFGDKASDDATRTMVKLEENYRSTSTILEAANALIANNTERIDKVL
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RATRGEGELITLTRCDDEIAEAEAVVHRMRMLEAAHPELRWGDVAVLYRTNAQSRAIEES
HHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
LVRWRIPYIVVGGLRFYDRREIKDVLAYLRLLVNPADTVSLLRVINVPKRGIGKTTLQRL
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHH
ADAANQLGIPLWDVVSDAEAVRSLGGRSAKGLLQFCELINDLQRSIQDQIPSEMIQQVME
HHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
KSGYISELIAEATDEAEERRRNLQELVNAALQYQEENEEGNLEGFLASAALASDADSKDT
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AADRVTLMTLHSSKGLEFPLVFLVGMEQGLFPSYRSLDDPSSLEEERRLCYVGMTRAKER
HHCEEEEEEEECCCCCCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHEEHHHHHHHHHH
LFLSHASERRLWGGMRQPAVPSLFLAELPEGLVQGDLPQIGGVALRRERRLDRLTRVDRD
HHHHHCHHHHHHCCCCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
DNQRIKAGGVSGAPSNAVRRRQAGPAPGKAWVVGDRVVHSSFGEGEITHTFGSGEKVSIA
CCCEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECHHHHCCCCCCCEEEECCCCCEEEEE
VKFVGMGPKILDPRLAPIEPLE
EEEECCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]