Click here to switch to the map view.

The map label for this gene is adk

Identifier: 124024015

GI number: 124024015

Start: 2044418

End: 2044966

Strand: Direct

Name: adk

Synonym: P9303_23221

Alternate gene names: 124024015

Gene position: 2044418-2044966 (Clockwise)

Preceding gene: 124024014

Following gene: 124024016

Centisome position: 76.21

GC content: 52.09

Gene sequence:

>549_bases
ATGAAGCAACGTCTCCTCTTCCTAGGACCCCCCGGAGCAGGCAAAGGGACCCAGGCTGAACGTCTCTGCGCAGCCCATGA
ATTAATGCACCTATCGACGGGCGATCTACTGCGTGCTGAGGTCGGCGCCAAAACACCCCTTGGTCAGGAGGCTGCTGCTG
TTATGAACCGAGGCGAGCTGGTCAGCGATGAGTTGGTGCTCGCCATCGTCGAAAACCAACTCAAGAACCAAAGTGGTGGT
TGGCTCTTGGATGGTTTTCCACGCACCTTGATCCAAGCCACAGCACTCGAACCCTTACTTGAAGAACTCAAGCAACCAAT
TGAGGCTGTTGTACTACTGGAACTCAACGATGCAGTGTTAATTGAACGGTTAATTTCCCGAGGCCGCAGTGATGACAACG
AAAGCGTGATTCGTAATCGCCTTGAGGTCTACCGCGAAAAAACAGCCCCCCTTATCGACCATTACCGCCAACAAGGACTG
CTACAAACGGTGGAAGCACAGGGCAGTATCGAATCAATCGCTATCAGCATCGAAAAATCCTTATGTTGA

Upstream 100 bases:

>100_bases
GCAAAACAAGTTCAGACCTACGTGATCTCTCAACGCTACGAAGGCCTTGTCCGCCAATGAACGATTCTCCACTTCGCCTC
AAAGCCCTTTTTTGCCATCC

Downstream 100 bases:

>100_bases
CCTACGTGGTATGGTTGCCGTTTGGAAATTTGGAGAGCCACACTCCATGAAGGTGCGTGCCTCGGTCAAGAAAATGTGTG
AGAAATGCCGGGTGATCCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQSGG
WLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAQGSIESIAISIEKSLC

Sequences:

>Translated_182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQSGG
WLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAQGSIESIAISIEKSLC
>Mature_182_residues
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGELVSDELVLAIVENQLKNQSGG
WLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVLIERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGL
LQTVEAQGSIESIAISIEKSLC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=36.5740740740741, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI7524346, Length=207, Percent_Identity=37.1980676328502, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=38.2513661202186, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI19923437, Length=193, Percent_Identity=32.1243523316062, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI7706497, Length=187, Percent_Identity=31.0160427807487, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=31.5217391304348, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=31.5217391304348, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI310110345, Length=188, Percent_Identity=33.5106382978723, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI53832003, Length=188, Percent_Identity=33.5106382978723, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI8051579, Length=188, Percent_Identity=33.5106382978723, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI53832001, Length=188, Percent_Identity=33.5106382978723, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=34.0425531914894, Blast_Score=113, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=36.3636363636364, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=37.2881355932203, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=32.620320855615, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=175, Percent_Identity=32.5714285714286, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=26.046511627907, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147457, Length=179, Percent_Identity=22.3463687150838, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=34.5177664974619, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=32.7956989247312, Blast_Score=112, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=32.3232323232323, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI22026816, Length=206, Percent_Identity=36.4077669902913, Blast_Score=136, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=31.1827956989247, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=31.1827956989247, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=31.1881188118812, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=31.1881188118812, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=29.5698924731183, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=29.5698924731183, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PROM3 (A2CC47)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018322.1
- ProteinModelPortal:   A2CC47
- SMR:   A2CC47
- STRING:   A2CC47
- GeneID:   4776973
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_23221
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK14531
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19956; Mature: 19956

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGEL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCC
VSDELVLAIVENQLKNQSGGWLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVL
HHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHH
IERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGLLQTVEAQGSIESIAISIEKS
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
LC
CC
>Mature Secondary Structure
MKQRLLFLGPPGAGKGTQAERLCAAHELMHLSTGDLLRAEVGAKTPLGQEAAAVMNRGEL
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCC
VSDELVLAIVENQLKNQSGGWLLDGFPRTLIQATALEPLLEELKQPIEAVVLLELNDAVL
HHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHH
IERLISRGRSDDNESVIRNRLEVYREKTAPLIDHYRQQGLLQTVEAQGSIESIAISIEKS
HHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
LC
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA