Click here to switch to the map view.

The map label for this gene is mrdB [H]

Identifier: 124023962

GI number: 124023962

Start: 2003673

End: 2004956

Strand: Direct

Name: mrdB [H]

Synonym: P9303_22691

Alternate gene names: 124023962

Gene position: 2003673-2004956 (Clockwise)

Preceding gene: 124023961

Following gene: 124023963

Centisome position: 74.69

GC content: 56.23

Gene sequence:

>1284_bases
ATGCTTTCAAGCCAGAGGCGGCGACGCAATGGTGGCAAGTCCTTCCGTTCTAAGGGGCATCTACGCAGATGGTGGAAAGA
ACTGGATCAAGTCCTCTGGGGGGTGCCAGTGGCCATGGTGATCCTTGCGGGCGTTCTGATCGCCAGCACTCAAAGACAGG
CTGATTACGCCGACTGGTATCACCACTGGATCACCGCTGGATTGGGATGCTTGGTCGCTCTGTTGCTGGCCCGATTGCCA
CTCCAGAGACTTCGGCCGCTATTAATTCCCCTCTACGCACTCACGGTTCTGAGCCTGGTAGCCGTTCGCCTAATCGGCAC
CTCCGCCCTAGGCGCTCAGCGGTGGATCAGCATCGCTGGGGTGAATGTTCAGCCATCTGAATTCGCAAAACTGGCAGCAA
TCCTCCTTTTGGCAGCAGTACTCGACCGCCACCCGATAGAACGCCCCATCGACCTGATGAGGCCTTTGGCCGTGATTTCT
GTGCCCTGGACACTGGTCTTCCTGCAACCGGATCTCGGCAGTTCACTCGTGTTCGGCGCCTTGCTAGTGACAATGCTCTA
TTGGGCTGACATGCCCTGGGAATGGGTCCTGTTGCTCCTATCACCTCTAGCCACAGCACTCCTTGCAGGGCTATGGCCTT
GGACTCTCTGCGCATGGCTCCCTCTGATGGGTTTCCTGGCCTATCGCTCACTGCCATGGAAACGCCTGGCCGCTTCGCTC
ACTTTGGCGCTGCAAGGAATCGTGGCTGTTACCACCCCTTGGCTTTGGTTGCATGGCCTCAAGGACTATCAAAGAGAACG
GCTGGTGCTGTTTCTCGATCCCACCAAAGACCCCCTAGGTGGTGGCTATCACCTCCTGCAAAGCACTGTGGGCATTGGGT
CTGGCGGGCTATTTGGCACAGGGCTGCTGCAAGGTCAACTCACCAAGCTACGTTTCATCCCCGAGCAGCACACCGATTTC
ATCTTCAGTGCCCTAGGGGAAGAAACTGGCTTCATCGGGACCATCCTTGTCGTAACAGGCTTCGCGCTACTAATGGGACG
CCTACTACAAGTTGCCAGAGAAGCCCGCAGTGACTTCGAATCACTGGTTGTCATAGGCGTCGCCACGATGGTGATGTTCC
AAGTGGTCGTGAACATCTTTATGACCATTGGCCTTGGTCCTGTAACTGGTATCCCCTTACCATTTATGAGCTATGGCCGC
TCAGCAATGGTGGTGAACTTCGTAGCACTTGGACTCTGCCTTTCGGTGGCACGCCGAGGCCACACAAGACTCAACAACTG
GTGA

Upstream 100 bases:

>100_bases
GTAGCCCCATCGTTCATAGCCGACCCGAATCAGTGAGTGCCAAAGCCTTCAAACAATTAGCCAAACAAGTTCTGGATTGC
GCCTCCCAGGCCAGCTGACC

Downstream 100 bases:

>100_bases
GCGATTCCATCTCGCTCACCACGATCCAACAACGGCTTGCAGAAGGTGTCCCTCCTGGTCGGGTCGATGAAGCCACCGTT
CGACGTCTGTGGTGGGCAGC

Product: cell division membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLSSQRRRRNGGKSFRSKGHLRRWWKELDQVLWGVPVAMVILAGVLIASTQRQADYADWYHHWITAGLGCLVALLLARLP
LQRLRPLLIPLYALTVLSLVAVRLIGTSALGAQRWISIAGVNVQPSEFAKLAAILLLAAVLDRHPIERPIDLMRPLAVIS
VPWTLVFLQPDLGSSLVFGALLVTMLYWADMPWEWVLLLLSPLATALLAGLWPWTLCAWLPLMGFLAYRSLPWKRLAASL
TLALQGIVAVTTPWLWLHGLKDYQRERLVLFLDPTKDPLGGGYHLLQSTVGIGSGGLFGTGLLQGQLTKLRFIPEQHTDF
IFSALGEETGFIGTILVVTGFALLMGRLLQVAREARSDFESLVVIGVATMVMFQVVVNIFMTIGLGPVTGIPLPFMSYGR
SAMVVNFVALGLCLSVARRGHTRLNNW

Sequences:

>Translated_427_residues
MLSSQRRRRNGGKSFRSKGHLRRWWKELDQVLWGVPVAMVILAGVLIASTQRQADYADWYHHWITAGLGCLVALLLARLP
LQRLRPLLIPLYALTVLSLVAVRLIGTSALGAQRWISIAGVNVQPSEFAKLAAILLLAAVLDRHPIERPIDLMRPLAVIS
VPWTLVFLQPDLGSSLVFGALLVTMLYWADMPWEWVLLLLSPLATALLAGLWPWTLCAWLPLMGFLAYRSLPWKRLAASL
TLALQGIVAVTTPWLWLHGLKDYQRERLVLFLDPTKDPLGGGYHLLQSTVGIGSGGLFGTGLLQGQLTKLRFIPEQHTDF
IFSALGEETGFIGTILVVTGFALLMGRLLQVAREARSDFESLVVIGVATMVMFQVVVNIFMTIGLGPVTGIPLPFMSYGR
SAMVVNFVALGLCLSVARRGHTRLNNW
>Mature_427_residues
MLSSQRRRRNGGKSFRSKGHLRRWWKELDQVLWGVPVAMVILAGVLIASTQRQADYADWYHHWITAGLGCLVALLLARLP
LQRLRPLLIPLYALTVLSLVAVRLIGTSALGAQRWISIAGVNVQPSEFAKLAAILLLAAVLDRHPIERPIDLMRPLAVIS
VPWTLVFLQPDLGSSLVFGALLVTMLYWADMPWEWVLLLLSPLATALLAGLWPWTLCAWLPLMGFLAYRSLPWKRLAASL
TLALQGIVAVTTPWLWLHGLKDYQRERLVLFLDPTKDPLGGGYHLLQSTVGIGSGGLFGTGLLQGQLTKLRFIPEQHTDF
IFSALGEETGFIGTILVVTGFALLMGRLLQVAREARSDFESLVVIGVATMVMFQVVVNIFMTIGLGPVTGIPLPFMSYGR
SAMVVNFVALGLCLSVARRGHTRLNNW

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=350, Percent_Identity=34.5714285714286, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1786277, Length=365, Percent_Identity=28.4931506849315, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 47209; Mature: 47209

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSSQRRRRNGGKSFRSKGHLRRWWKELDQVLWGVPVAMVILAGVLIASTQRQADYADWY
CCCCHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HHWITAGLGCLVALLLARLPLQRLRPLLIPLYALTVLSLVAVRLIGTSALGAQRWISIAG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNVQPSEFAKLAAILLLAAVLDRHPIERPIDLMRPLAVISVPWTLVFLQPDLGSSLVFGA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LLVTMLYWADMPWEWVLLLLSPLATALLAGLWPWTLCAWLPLMGFLAYRSLPWKRLAASL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
TLALQGIVAVTTPWLWLHGLKDYQRERLVLFLDPTKDPLGGGYHLLQSTVGIGSGGLFGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHH
GLLQGQLTKLRFIPEQHTDFIFSALGEETGFIGTILVVTGFALLMGRLLQVAREARSDFE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVVIGVATMVMFQVVVNIFMTIGLGPVTGIPLPFMSYGRSAMVVNFVALGLCLSVARRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
HTRLNNW
CCCCCCC
>Mature Secondary Structure
MLSSQRRRRNGGKSFRSKGHLRRWWKELDQVLWGVPVAMVILAGVLIASTQRQADYADWY
CCCCHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
HHWITAGLGCLVALLLARLPLQRLRPLLIPLYALTVLSLVAVRLIGTSALGAQRWISIAG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VNVQPSEFAKLAAILLLAAVLDRHPIERPIDLMRPLAVISVPWTLVFLQPDLGSSLVFGA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHH
LLVTMLYWADMPWEWVLLLLSPLATALLAGLWPWTLCAWLPLMGFLAYRSLPWKRLAASL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
TLALQGIVAVTTPWLWLHGLKDYQRERLVLFLDPTKDPLGGGYHLLQSTVGIGSGGLFGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHH
GLLQGQLTKLRFIPEQHTDFIFSALGEETGFIGTILVVTGFALLMGRLLQVAREARSDFE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLVVIGVATMVMFQVVVNIFMTIGLGPVTGIPLPFMSYGRSAMVVNFVALGLCLSVARRG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
HTRLNNW
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]