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The map label for this gene is hemF [H]

Identifier: 124023960

GI number: 124023960

Start: 2001390

End: 2002463

Strand: Reverse

Name: hemF [H]

Synonym: P9303_22671

Alternate gene names: 124023960

Gene position: 2002463-2001390 (Counterclockwise)

Preceding gene: 124023969

Following gene: 124023957

Centisome position: 74.64

GC content: 53.45

Gene sequence:

>1074_bases
ATGGTTCCTACTTTGATTGGCAAGGTTATGGGTGCTTCTGAGAATGTTGGCCAAGGTCCTCCTCCTCACTCGCGCGAACG
TGTACGTGAATTGGTACTCGGATTGCAAGATGAGATCAGTAATGAACTGGAGAGTCTTGATGGTGGCCAATCTTTTAGAA
CTGATAGTTGGGAGCGGCCTGAAGGGGGTGGTGGGCGATCCAAGGTGATGCGTGAGGGCCGAGTTTTTGAACAGGGCGGC
GTTAATTTCTCTGAGGTGCACGGCGAGGAGTTGCCTCCGTCGATTCTGAATCAGCGACCTGAGGCAAAGGGGCATCCCTG
GTTCGCTACCGGCACTTCGATGGTGCTACACCCGCGCAATCCCTATGTGCCTACGATCCACCTTAATTACCGCTATTTCG
AGGCGGGGCCGGTGTGGTGGTTTGGCGGTGGCGCTGACCTCACGCCGTTTTATCCCTACCTGGAAGATGCCCGCCATTTT
CATCGCGTTCACAAGCAGGCTTGCGATACGGTTGGACCTGAGCTCCATAAGGTCTTTAAACCTTGGTGTGACGAATATTT
CTATCTGAAGCACCGTGGTGAGACCCGTGGTGTGGGTGGGATTTTTTACGACTACCAGGATGGATCTGGAGTGCTTTACA
AAGGTCAAAACCCTGAGGGTCCAGCTGCACAGGTCTCACGGGAGTTAGGGCCTCATCCGAAGAGCTGGGAACAGTTATTT
GAGCTGGCCAAGGCTTGTGGGAAGGCTTTCTTGCCGGCTTATGTGCCGATTGTGGAGAAACGTCAGCAGCAGGCCTATGG
CGATCGAGAACGTCAATTCCAGTTGTATCGCCGTGGGCGATATGCGGAGTTCAATCTGGTCTGGGATCGGGGCACGATTT
TCGGATTGCAAACCAATGGCCGAACGGAGTCGATCTTGATGTCTTTGCCACCACTGGCTCGTTGGGAGTATGGATATGCC
GCACCAGCTGATTCAAGGGAGGCTTTGCTCACTGATTTGTTTACTCGACCTCAGAATTGGTTTGAGGATTCGACGTTGGA
TGAGCGTTGTCGACCACACCAGGCGGTGGATTAG

Upstream 100 bases:

>100_bases
GTGGACTCTCGTGAGAGTTCTCAAGGGCGATATCTGAAAAGACACAAAAACAGAGCTGTTCTGGCGCAAAATACAACGCA
ATTCTATTACTGTTGTCTGC

Downstream 100 bases:

>100_bases
AAGACGTCTTTCCACGTACTCCCAGCATCAAAGCGTCGGTGACTTGAAGGGCGATGGCTTGAATGGTTGCTTCTCTGGTT
TTGGGGTTGCGGAGATTGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MVPTLIGKVMGASENVGQGPPPHSRERVRELVLGLQDEISNELESLDGGQSFRTDSWERPEGGGGRSKVMREGRVFEQGG
VNFSEVHGEELPPSILNQRPEAKGHPWFATGTSMVLHPRNPYVPTIHLNYRYFEAGPVWWFGGGADLTPFYPYLEDARHF
HRVHKQACDTVGPELHKVFKPWCDEYFYLKHRGETRGVGGIFYDYQDGSGVLYKGQNPEGPAAQVSRELGPHPKSWEQLF
ELAKACGKAFLPAYVPIVEKRQQQAYGDRERQFQLYRRGRYAEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYA
APADSREALLTDLFTRPQNWFEDSTLDERCRPHQAVD

Sequences:

>Translated_357_residues
MVPTLIGKVMGASENVGQGPPPHSRERVRELVLGLQDEISNELESLDGGQSFRTDSWERPEGGGGRSKVMREGRVFEQGG
VNFSEVHGEELPPSILNQRPEAKGHPWFATGTSMVLHPRNPYVPTIHLNYRYFEAGPVWWFGGGADLTPFYPYLEDARHF
HRVHKQACDTVGPELHKVFKPWCDEYFYLKHRGETRGVGGIFYDYQDGSGVLYKGQNPEGPAAQVSRELGPHPKSWEQLF
ELAKACGKAFLPAYVPIVEKRQQQAYGDRERQFQLYRRGRYAEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYA
APADSREALLTDLFTRPQNWFEDSTLDERCRPHQAVD
>Mature_357_residues
MVPTLIGKVMGASENVGQGPPPHSRERVRELVLGLQDEISNELESLDGGQSFRTDSWERPEGGGGRSKVMREGRVFEQGG
VNFSEVHGEELPPSILNQRPEAKGHPWFATGTSMVLHPRNPYVPTIHLNYRYFEAGPVWWFGGGADLTPFYPYLEDARHF
HRVHKQACDTVGPELHKVFKPWCDEYFYLKHRGETRGVGGIFYDYQDGSGVLYKGQNPEGPAAQVSRELGPHPKSWEQLF
ELAKACGKAFLPAYVPIVEKRQQQAYGDRERQFQLYRRGRYAEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYA
APADSREALLTDLFTRPQNWFEDSTLDERCRPHQAVD

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=333, Percent_Identity=43.2432432432432, Blast_Score=278, Evalue=5e-75,
Organism=Escherichia coli, GI1788777, Length=319, Percent_Identity=51.41065830721, Blast_Score=323, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6320249, Length=342, Percent_Identity=42.9824561403509, Blast_Score=263, Evalue=5e-71,
Organism=Drosophila melanogaster, GI17864388, Length=336, Percent_Identity=46.1309523809524, Blast_Score=291, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 40671; Mature: 40671

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPTLIGKVMGASENVGQGPPPHSRERVRELVLGLQDEISNELESLDGGQSFRTDSWERP
CCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
EGGGGRSKVMREGRVFEQGGVNFSEVHGEELPPSILNQRPEAKGHPWFATGTSMVLHPRN
CCCCCHHHHHHCCCCHHCCCCCHHHHCCCCCCHHHHCCCCCCCCCCEEECCCEEEEECCC
PYVPTIHLNYRYFEAGPVWWFGGGADLTPFYPYLEDARHFHRVHKQACDTVGPELHKVFK
CCCCEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PWCDEYFYLKHRGETRGVGGIFYDYQDGSGVLYKGQNPEGPAAQVSRELGPHPKSWEQLF
HHHHHEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHH
ELAKACGKAFLPAYVPIVEKRQQQAYGDRERQFQLYRRGRYAEFNLVWDRGTIFGLQTNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCEEEEEECCC
RTESILMSLPPLARWEYGYAAPADSREALLTDLFTRPQNWFEDSTLDERCRPHQAVD
CCHHHHEECCCCHHCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MVPTLIGKVMGASENVGQGPPPHSRERVRELVLGLQDEISNELESLDGGQSFRTDSWERP
CCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
EGGGGRSKVMREGRVFEQGGVNFSEVHGEELPPSILNQRPEAKGHPWFATGTSMVLHPRN
CCCCCHHHHHHCCCCHHCCCCCHHHHCCCCCCHHHHCCCCCCCCCCEEECCCEEEEECCC
PYVPTIHLNYRYFEAGPVWWFGGGADLTPFYPYLEDARHFHRVHKQACDTVGPELHKVFK
CCCCEEEEEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PWCDEYFYLKHRGETRGVGGIFYDYQDGSGVLYKGQNPEGPAAQVSRELGPHPKSWEQLF
HHHHHEEEEEECCCCCCCCEEEEEEECCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHH
ELAKACGKAFLPAYVPIVEKRQQQAYGDRERQFQLYRRGRYAEFNLVWDRGTIFGLQTNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCEEEEEECCC
RTESILMSLPPLARWEYGYAAPADSREALLTDLFTRPQNWFEDSTLDERCRPHQAVD
CCHHHHEECCCCHHCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]