Click here to switch to the map view.

The map label for this gene is purM

Identifier: 124023942

GI number: 124023942

Start: 1988368

End: 1989405

Strand: Direct

Name: purM

Synonym: P9303_22491

Alternate gene names: 124023942

Gene position: 1988368-1989405 (Clockwise)

Preceding gene: 124023939

Following gene: 124023943

Centisome position: 74.12

GC content: 54.91

Gene sequence:

>1038_bases
ATGGACTACAAGACCGCGGGCGTTGACGTCCAAGCAGGCAGGGCATTCATCGAGCGAATCAGATCTAGCGTCGAAGCCAC
CCACCGCCCAGAGGTGATCGGTGGGCTGGGAGGGTTTGGAGGCTTGATACGCCTCCCCGCAGGGCTAAACAAGCCTCTGC
TTGTCGCAGGAACTGATGGAGTCGGCACCAAGCTCGAACTAGCTCAGCAACATCAAGCCCACTACGGAGTAGGGCTGGAC
CTGGTTGGAATGTGTGTCAACGACGTCATCACCAGTGGCGCTGAACCCCTCTTTTTCCTCGACTACATCGCCACCGGAAC
CCTCAGCCCAGAGGCCATGGCACAAGTTGTGGAGGGAATTGCAGAGGGCTGTCGCCGCAGCGGCTGCGCCCTCCTAGGAG
GAGAAACCGCCGAGATGCCTGGGTTTTACGACCCAGGTTGCTACGACCTAGCCGGCTTTTGCGTAGCAGTGGTAGAAGAA
GACGAGATGATTGACGGTCGCAAGATCAAGCCTGGAGATCAGATTATCGGTGTGGCAAGCAGTGGCGTTCATAGCAACGG
GTTCAGTTTGGTGCGCAAAGTGCTCGCTCTTACTGAAGCCAATAAGAACACTCGCTTCGGATGCGACAACAAACCTCTAA
TCGAGACCCTGCTAACCCCTACCACCCTTTACGGCCAGCTGGTAAGAAACCTCCTAGAAGCAAAAGTGCCACTCCACGGC
ATGGCACATATCACCGGTGGAGGCCTACCAGAGAATCTTCCCCGATGTTGTCCAAAAGACTTAGTTACCGTCATAGATCC
AAGCAGCTGGACCAGACCAGAACTTTTTCAATGGCTCCAAGATGCTGGCCAGATTCCAGAGCATGACCTCTGGCACACAT
TCAATCTTGGAGTGGGTTTCTGCCTAGTGGTCGCAGAAGAAGCAGTACGTGATGTCCTGCAGGTTTGCAAAGAACAAGCT
CTTCAAGCTTGGCCTATTGGTCAAGTCGAAACTGCCTCTCCCTCAACCGGGGAGAGATTACGAGGGCTACCCAGCTAA

Upstream 100 bases:

>100_bases
TGATGCCATCCACAGGCCCCGCTAATGCAAGACAGGACAATCACGACATTGGCTGAATGGAGGGCGGCAGAGGAGGATCT
AGGGAGGGCCAGTCGAAACC

Downstream 100 bases:

>100_bases
AGCATTGCATCGCAAGGGCTCTTGAGTCGCAAGATCTCTCTGACTAATTACATCGGTCTTGTACGAGCCTATTCTCGAGC
CGATGTTTAGACACGTCCTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEAVRDVLQVCKEQA
LQAWPIGQVETASPSTGERLRGLPS

Sequences:

>Translated_345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEAVRDVLQVCKEQA
LQAWPIGQVETASPSTGERLRGLPS
>Mature_345_residues
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDGVGTKLELAQQHQAHYGVGLD
LVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGIAEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEE
DEMIDGRKIKPGDQIIGVASSGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHG
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGFCLVVAEEAVRDVLQVCKEQA
LQAWPIGQVETASPSTGERLRGLPS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=46.5465465465465, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=46.5465465465465, Blast_Score=294, Evalue=7e-80,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=46.5465465465465, Blast_Score=294, Evalue=7e-80,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=51.5060240963855, Blast_Score=344, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=40.2298850574713, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=45.5357142857143, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24582400, Length=277, Percent_Identity=42.9602888086643, Blast_Score=221, Evalue=5e-58,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_PROM3 (A2CBX4)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001018249.1
- ProteinModelPortal:   A2CBX4
- SMR:   A2CBX4
- STRING:   A2CBX4
- GeneID:   4778428
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_22491
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36830; Mature: 36830

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEECCCCCCCCEEEECCCC
VGTKLELAQQHQAHYGVGLDLVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEEDEMIDGRKIKPGDQIIGVAS
HHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEC
SGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGF
CCEECCCCCCCHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEHHCCHHH
CLVVAEEAVRDVLQVCKEQALQAWPIGQVETASPSTGERLRGLPS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MDYKTAGVDVQAGRAFIERIRSSVEATHRPEVIGGLGGFGGLIRLPAGLNKPLLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEECCCCCCCCEEEECCCC
VGTKLELAQQHQAHYGVGLDLVGMCVNDVITSGAEPLFFLDYIATGTLSPEAMAQVVEGI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AEGCRRSGCALLGGETAEMPGFYDPGCYDLAGFCVAVVEEDEMIDGRKIKPGDQIIGVAS
HHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEEC
SGVHSNGFSLVRKVLALTEANKNTRFGCDNKPLIETLLTPTTLYGQLVRNLLEAKVPLHG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCCCCC
MAHITGGGLPENLPRCCPKDLVTVIDPSSWTRPELFQWLQDAGQIPEHDLWHTFNLGVGF
CCEECCCCCCCHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEHHCCHHH
CLVVAEEAVRDVLQVCKEQALQAWPIGQVETASPSTGERLRGLPS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA