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The map label for this gene is wzb [C]

Identifier: 124023939

GI number: 124023939

Start: 1985440

End: 1985919

Strand: Direct

Name: wzb [C]

Synonym: P9303_22461

Alternate gene names: 124023939

Gene position: 1985440-1985919 (Clockwise)

Preceding gene: 124023937

Following gene: 124023942

Centisome position: 74.01

GC content: 55.83

Gene sequence:

>480_bases
ATGAATCATCGGCTGCTGTTCGTTTGCCTCGGCAACATCTGTCGCTCCCCCGCTGCAGAAGGGGTTTTCTTGCATCAACT
CAAAAGCCAAGACATGGAGAAGCACTTCGTGGTGGATTCCGCCGGCACCGGTGGATGGCACGTTGGCAGGCCAGCGGATT
CGCGCATGCGTAGTGCTGCCCAGCAGCGAGGGATCCTTCTACCCAGCCGAGCGAGACAGATCACCCTCGAGGATCTGCAG
ACTTTTGATCTAATCCTGACCATGGACGCAGATAATTTGGCGACTGTTCAGAGCCTGGCCACCGAAGTCGGCCCTATGGC
AACTGCCAGGATCGAGCCCATGCTCAGCTATGCCACCAAAACATCACTTGAAGAGGTCCCAGACCCTTATTACGGAGGAG
ATGCAGGCTTCGAGAAAGTTCTCGATCTGCTTGAAGACGCCTGTGAAGGCCTACTGATTGCACTCAGCTCCCAGGTGTAG

Upstream 100 bases:

>100_bases
CAAGCCATCAATAGACTTACAGACCCTTGCTAGTGCAATCAAAGATGCCTCAGTGGTATGCAAAGCGATTCACGCTCATC
CCGCAACGCTTGGAGTCTGA

Downstream 100 bases:

>100_bases
GCCAAACCTCCTCGGGAACCTGCACTCGAAACAGATCGATCAAAGTCTCAATCACCTCCTCAATCGACATACCGTCACTG
ATCAACTCAGTGGCATCTTC

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MNHRLLFVCLGNICRSPAAEGVFLHQLKSQDMEKHFVVDSAGTGGWHVGRPADSRMRSAAQQRGILLPSRARQITLEDLQ
TFDLILTMDADNLATVQSLATEVGPMATARIEPMLSYATKTSLEEVPDPYYGGDAGFEKVLDLLEDACEGLLIALSSQV

Sequences:

>Translated_159_residues
MNHRLLFVCLGNICRSPAAEGVFLHQLKSQDMEKHFVVDSAGTGGWHVGRPADSRMRSAAQQRGILLPSRARQITLEDLQ
TFDLILTMDADNLATVQSLATEVGPMATARIEPMLSYATKTSLEEVPDPYYGGDAGFEKVLDLLEDACEGLLIALSSQV
>Mature_159_residues
MNHRLLFVCLGNICRSPAAEGVFLHQLKSQDMEKHFVVDSAGTGGWHVGRPADSRMRSAAQQRGILLPSRARQITLEDLQ
TFDLILTMDADNLATVQSLATEVGPMATARIEPMLSYATKTSLEEVPDPYYGGDAGFEKVLDLLEDACEGLLIALSSQV

Specific function: Unknown

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=148, Percent_Identity=43.2432432432432, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI6005988, Length=148, Percent_Identity=42.5675675675676, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI96304457, Length=101, Percent_Identity=39.6039603960396, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87081812, Length=146, Percent_Identity=35.6164383561644, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788375, Length=159, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325330, Length=133, Percent_Identity=33.0827067669173, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78711846, Length=150, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI78706766, Length=153, Percent_Identity=36.6013071895425, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78706768, Length=153, Percent_Identity=36.6013071895425, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78706764, Length=131, Percent_Identity=38.1679389312977, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI78706770, Length=149, Percent_Identity=32.8859060402685, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78706772, Length=149, Percent_Identity=32.8859060402685, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17334; Mature: 17334

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRLLFVCLGNICRSPAAEGVFLHQLKSQDMEKHFVVDSAGTGGWHVGRPADSRMRSAA
CCCCEEEEEHHHHHCCCCCCCHHHHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHHH
QQRGILLPSRARQITLEDLQTFDLILTMDADNLATVQSLATEVGPMATARIEPMLSYATK
HHCCCCCCCCCCEEEHHHHCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TSLEEVPDPYYGGDAGFEKVLDLLEDACEGLLIALSSQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNHRLLFVCLGNICRSPAAEGVFLHQLKSQDMEKHFVVDSAGTGGWHVGRPADSRMRSAA
CCCCEEEEEHHHHHCCCCCCCHHHHHHHHCCCHHHEEEECCCCCCCCCCCCHHHHHHHHH
QQRGILLPSRARQITLEDLQTFDLILTMDADNLATVQSLATEVGPMATARIEPMLSYATK
HHCCCCCCCCCCEEEHHHHCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TSLEEVPDPYYGGDAGFEKVLDLLEDACEGLLIALSSQV
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]