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The map label for this gene is srpG [H]

Identifier: 124023813

GI number: 124023813

Start: 1880227

End: 1881213

Strand: Direct

Name: srpG [H]

Synonym: P9303_21201

Alternate gene names: 124023813

Gene position: 1880227-1881213 (Clockwise)

Preceding gene: 124023812

Following gene: 124023816

Centisome position: 70.09

GC content: 55.02

Gene sequence:

>987_bases
ATGTCCCGCATTTACGAAGACAACAGCCAGGCAATCGGCAACACTCCACTGGTCAAACTGCACGCCGTCAGCAAAAACGC
CAAAGCAACTGTTCTCGCAAAGATTGAAGGCCGCAATCCCGCCTACAGCGTGAAATGCCGCATTGGCGCCAACATGATCT
GGGATGCCGAAAAGCGCGGCTTACTGAGCAAAGAACGCACGATCATTGAGCCCACCTCTGGCAACACAGGTATCGCTCTG
GCCTTCACAGCAGCAGCCCGCGGCTACAAACTGATCCTCACCATGCCCGAATCAATGTCGCTAGAACGGCGGCGGGTGAT
GGCAGTGCTTGGTGCAGAACTCATCCTCACAGAAGCAGCCAAGGGGATGCCAGGCGCCATTGCCAAGGCAAAAGAGATCG
CCGAAAGCGATCCCCAGAAATACTTCATGCCCGGTCAGTTTGAGAATCCGGCCAATCCCGACATCCACAGCAAAACAACC
GGTCCAGAAATCTGGAACGACTGTGATGGCGCCATTGATGTGCTCGTGGCTGGCGTAGGCACCGGCGGCACGATCACCGG
TGTGTCCCGCTACATCAAGCAGGAGAAAGGCAAATCCATCGTTTCTGTAGCCGTCGAACCAACCCATAGCCCGGTCATCA
GCCAAACCCTCAACGGGGAAGACGTCAAACCTGGTCCTCACAAAATCCAGGGCATTGGAGCCGGCTTTATTCCCAAAAAC
CTCGATCTTGCGTTAGTGGATCGTGTTGAGCAGGTCAGCAATGATGAATCCATCGCCATGGCCCTGCGCTTGGCAAATGA
AGAAGGTCTACTGGTGGGCATCTCCAGTGGTGCGGCAGTTGCAGCGGCTATTCGTCTGGCAGAACAACCCGAATTTGCAG
GCAAAACCATCGTGGTAGTTCTGCCAGACATGGCCGAGCGTTATCTCTCCTCAGTGATGTTTGAGAGTGTGCCCACAGGC
ATCATTCAGGACCCTGTAGCTGCCTAA

Upstream 100 bases:

>100_bases
CTAACCGTAAGCAACCCATCACATGGTCGTCACAACAGATCATCGTCCTCACCAATAGAGCCAAATTCCAGCTAATGATG
TGGTCGATTCATAAGCACGC

Downstream 100 bases:

>100_bases
ATCACCTCCACCTGGAAATGATCAGCAGGGGCGGGCCGCTGGCAACACCGCCCCTGGATCAATCCACATCGCATCGCCAT
AAGAGAAAAAGCGATAGTGG

Product: O-acetylserine (thiol)-lyase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSRIYEDNSQAIGNTPLVKLHAVSKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKRGLLSKERTIIEPTSGNTGIAL
AFTAAARGYKLILTMPESMSLERRRVMAVLGAELILTEAAKGMPGAIAKAKEIAESDPQKYFMPGQFENPANPDIHSKTT
GPEIWNDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKSIVSVAVEPTHSPVISQTLNGEDVKPGPHKIQGIGAGFIPKN
LDLALVDRVEQVSNDESIAMALRLANEEGLLVGISSGAAVAAAIRLAEQPEFAGKTIVVVLPDMAERYLSSVMFESVPTG
IIQDPVAA

Sequences:

>Translated_328_residues
MSRIYEDNSQAIGNTPLVKLHAVSKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKRGLLSKERTIIEPTSGNTGIAL
AFTAAARGYKLILTMPESMSLERRRVMAVLGAELILTEAAKGMPGAIAKAKEIAESDPQKYFMPGQFENPANPDIHSKTT
GPEIWNDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKSIVSVAVEPTHSPVISQTLNGEDVKPGPHKIQGIGAGFIPKN
LDLALVDRVEQVSNDESIAMALRLANEEGLLVGISSGAAVAAAIRLAEQPEFAGKTIVVVLPDMAERYLSSVMFESVPTG
IIQDPVAA
>Mature_327_residues
SRIYEDNSQAIGNTPLVKLHAVSKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKRGLLSKERTIIEPTSGNTGIALA
FTAAARGYKLILTMPESMSLERRRVMAVLGAELILTEAAKGMPGAIAKAKEIAESDPQKYFMPGQFENPANPDIHSKTTG
PEIWNDCDGAIDVLVAGVGTGGTITGVSRYIKQEKGKSIVSVAVEPTHSPVISQTLNGEDVKPGPHKIQGIGAGFIPKNL
DLALVDRVEQVSNDESIAMALRLANEEGLLVGISSGAAVAAAIRLAEQPEFAGKTIVVVLPDMAERYLSSVMFESVPTGI
IQDPVAA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=39.5569620253165, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=39.5569620253165, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=39.5569620253165, Blast_Score=202, Evalue=3e-52,
Organism=Escherichia coli, GI1788754, Length=320, Percent_Identity=65.3125, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=42.2950819672131, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17535051, Length=317, Percent_Identity=50.4731861198738, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI115535073, Length=316, Percent_Identity=52.2151898734177, Blast_Score=273, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=326, Percent_Identity=45.0920245398773, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI32566674, Length=312, Percent_Identity=46.7948717948718, Blast_Score=266, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI17561720, Length=330, Percent_Identity=44.5454545454545, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=229, Percent_Identity=44.1048034934498, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=323, Percent_Identity=41.1764705882353, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=313, Percent_Identity=38.3386581469649, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=138, Percent_Identity=41.304347826087, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=37.4603174603175, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=33.6363636363636, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24643623, Length=313, Percent_Identity=40.2555910543131, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI20129101, Length=313, Percent_Identity=40.2555910543131, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34740; Mature: 34609

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIYEDNSQAIGNTPLVKLHAVSKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKRG
CCCEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEEEECCCEEECCHHCC
LLSKERTIIEPTSGNTGIALAFTAAARGYKLILTMPESMSLERRRVMAVLGAELILTEAA
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
KGMPGAIAKAKEIAESDPQKYFMPGQFENPANPDIHSKTTGPEIWNDCDGAIDVLVAGVG
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHCCCCHHEEEEEECCC
TGGTITGVSRYIKQEKGKSIVSVAVEPTHSPVISQTLNGEDVKPGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCC
LDLALVDRVEQVSNDESIAMALRLANEEGLLVGISSGAAVAAAIRLAEQPEFAGKTIVVV
CCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEE
LPDMAERYLSSVMFESVPTGIIQDPVAA
CCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SRIYEDNSQAIGNTPLVKLHAVSKNAKATVLAKIEGRNPAYSVKCRIGANMIWDAEKRG
CCEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEEEECCCEEECCHHCC
LLSKERTIIEPTSGNTGIALAFTAAARGYKLILTMPESMSLERRRVMAVLGAELILTEAA
CCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
KGMPGAIAKAKEIAESDPQKYFMPGQFENPANPDIHSKTTGPEIWNDCDGAIDVLVAGVG
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHCCCCHHEEEEEECCC
TGGTITGVSRYIKQEKGKSIVSVAVEPTHSPVISQTLNGEDVKPGPHKIQGIGAGFIPKN
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCC
LDLALVDRVEQVSNDESIAMALRLANEEGLLVGISSGAAVAAAIRLAEQPEFAGKTIVVV
CCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEE
LPDMAERYLSSVMFESVPTGIIQDPVAA
CCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]