| Definition | Prochlorococcus marinus str. MIT 9303, complete genome. |
|---|---|
| Accession | NC_008820 |
| Length | 2,682,675 |
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The map label for this gene is murE [H]
Identifier: 124023806
GI number: 124023806
Start: 1874582
End: 1876198
Strand: Reverse
Name: murE [H]
Synonym: P9303_21131
Alternate gene names: 124023806
Gene position: 1876198-1874582 (Counterclockwise)
Preceding gene: 124023807
Following gene: 124023795
Centisome position: 69.94
GC content: 57.51
Gene sequence:
>1617_bases TTGGGGGGGAAGGACTGTTCAGGTGGTTGCAACAGGCCTGCACCAAGGCGCTTGGATCGGACTAGAACGGCTCCATTCAT GGGCGGGCCTGGAATGACCCAGATGCTCCATTCATTGTTGCGGGCTGTAGGACTACCTGTGCCGGAGGGATTGGCGAATC CCTGTCTTGCAATGGTTAGCTGTGATTCCCGTGCGGTTGCTCGAGGCTGTTTATTCCTTGGCTTACCTGGTGAACAGGTT GATGGCGGCAGCTTTTGGCGTCAGGCTTTGGCCGCTGGTGCAGAGGCGGCGGTGATTGGTCCGGCAGCAGCAGCCTTGCG GCCGCCTGGGCCTAAAGATGCGGTAGTGGTGGTATCGGAGCCGGTTGCAGCATGGGTTGGACAGCTGGCAGCGGCCTTTT GGCAGCAGCCCTCCTCGAGACTTGCTCTGATCGGGGTAACGGGGACGAATGGCAAAACCACCACCACCCATCTGATTGAG CATCTCAGTGTGGCTGTGGGCAGATCAACTGCCTTGTTCGGCACCCTCGTGAATCGCTGGCCTAATTACAGCGTTCCCGC AACGCATACCACGGCCTTTGCTGATCGCCTTCAGGCTCAGTTGGCGCAAGCGGTTGAGGCCGGTGCTGAGTTGGGAGCGA TGGAGGTGAGTTCTCATGCCCTTGAACAACAACGGGTGGCGGGATGTCGTTTTGCTGGTGCCGTGTTTACCAACCTCACT CAAGATCATCTTGACTATCACTCTTCGATGGAGGCTTACTTCGAGGCCAAGGCGCAGCTGTTTGCACCACCGTTGCTGGA ATCTGGATCAGCCAAGGCGGTGGTGAATATTGATGGCCCCTGGGGCGCACGATTGGCTCAGCGTCTCGGCGATACCTGTT GGCGCAGTTCTCTTGCCGAGGGTGTTTTGCAGCGAGCTGATGCTGAACTGACAATGACGGAGCTGACGATGAGCTCCGCT GGGGTTCAAGGTCGCCTGATCAGCCCTTGTGGTGAGGGCTGGTTTGACTCTCCATTACTGGGTCGCTTCAACTTGATGAA CCTGCTTCAGGCGGTTGGGGTCTTGTTGCAACAAGGCTTGCCCTTGCCGTTGTTGTTGAAAGCGATCGCAGACTTCCGCG GCGTACCTGGGCGGATGGAGCGTGTGTTGATCCCTGCAGCTGATGCCAGTCAAGTGCCCACTGTGTTGGTGGATTACGCC CACACCCCTGATGGTTTGGAGAATGCCTTGACGGCTTCCAGGCCGTTCACCAGTAAAAACTTGTGTTGCGTATTTGGTTG TGGAGGAGACCGAGACCGTGGCAAGCGCTCTCAGATGGCTGCGATTGCAGCGCGGTTGGCCGATCGAGTGGTGGTGACCT CAGACAATCCCCGCACAGAAGATCCCCAGCAAATACTGGTTGATGTGGTGGCTGGAATCCCTCAAGGCACAGCCTTAACT GTGGAGGTTGACCGGGCGGTGGCGATTGCGCTTGCGATTGCCGAGGCAGGTCCTGGTGATGTGGTGTTGGTGGCAGGCAA GGGCCATGAGGATTATCAGATCCTCGGAACCAGCAAAGTGCATTTTGATGATCGCGAGGAAGCTGAGCGGGCGCTTAAGC AACGCTTAGATGGCTAA
Upstream 100 bases:
>100_bases GCCAGTATCCGCGACCATTACGACTTGCAGGTTCCTGTTTTGGTGTTGGTTGAACTGGAGCAACAGTTTTCGCTAGAGCT GCCGCGGGTGTCGCCGCGGC
Downstream 100 bases:
>100_bases CAAGTTTTGTTGGTATGAGTTGGTTTTGATCAGGCTGGTTGTTTAGTAATTGCCAGCATGGCTATGGCTGTGTTGAGCAG GGTTGATACTAAAATCTTTT
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 538; Mature: 537
Protein sequence:
>538_residues MGGKDCSGGCNRPAPRRLDRTRTAPFMGGPGMTQMLHSLLRAVGLPVPEGLANPCLAMVSCDSRAVARGCLFLGLPGEQV DGGSFWRQALAAGAEAAVIGPAAAALRPPGPKDAVVVVSEPVAAWVGQLAAAFWQQPSSRLALIGVTGTNGKTTTTHLIE HLSVAVGRSTALFGTLVNRWPNYSVPATHTTAFADRLQAQLAQAVEAGAELGAMEVSSHALEQQRVAGCRFAGAVFTNLT QDHLDYHSSMEAYFEAKAQLFAPPLLESGSAKAVVNIDGPWGARLAQRLGDTCWRSSLAEGVLQRADAELTMTELTMSSA GVQGRLISPCGEGWFDSPLLGRFNLMNLLQAVGVLLQQGLPLPLLLKAIADFRGVPGRMERVLIPAADASQVPTVLVDYA HTPDGLENALTASRPFTSKNLCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILVDVVAGIPQGTALT VEVDRAVAIALAIAEAGPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG
Sequences:
>Translated_538_residues MGGKDCSGGCNRPAPRRLDRTRTAPFMGGPGMTQMLHSLLRAVGLPVPEGLANPCLAMVSCDSRAVARGCLFLGLPGEQV DGGSFWRQALAAGAEAAVIGPAAAALRPPGPKDAVVVVSEPVAAWVGQLAAAFWQQPSSRLALIGVTGTNGKTTTTHLIE HLSVAVGRSTALFGTLVNRWPNYSVPATHTTAFADRLQAQLAQAVEAGAELGAMEVSSHALEQQRVAGCRFAGAVFTNLT QDHLDYHSSMEAYFEAKAQLFAPPLLESGSAKAVVNIDGPWGARLAQRLGDTCWRSSLAEGVLQRADAELTMTELTMSSA GVQGRLISPCGEGWFDSPLLGRFNLMNLLQAVGVLLQQGLPLPLLLKAIADFRGVPGRMERVLIPAADASQVPTVLVDYA HTPDGLENALTASRPFTSKNLCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILVDVVAGIPQGTALT VEVDRAVAIALAIAEAGPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG >Mature_537_residues GGKDCSGGCNRPAPRRLDRTRTAPFMGGPGMTQMLHSLLRAVGLPVPEGLANPCLAMVSCDSRAVARGCLFLGLPGEQVD GGSFWRQALAAGAEAAVIGPAAAALRPPGPKDAVVVVSEPVAAWVGQLAAAFWQQPSSRLALIGVTGTNGKTTTTHLIEH LSVAVGRSTALFGTLVNRWPNYSVPATHTTAFADRLQAQLAQAVEAGAELGAMEVSSHALEQQRVAGCRFAGAVFTNLTQ DHLDYHSSMEAYFEAKAQLFAPPLLESGSAKAVVNIDGPWGARLAQRLGDTCWRSSLAEGVLQRADAELTMTELTMSSAG VQGRLISPCGEGWFDSPLLGRFNLMNLLQAVGVLLQQGLPLPLLLKAIADFRGVPGRMERVLIPAADASQVPTVLVDYAH TPDGLENALTASRPFTSKNLCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILVDVVAGIPQGTALTV EVDRAVAIALAIAEAGPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=482, Percent_Identity=42.9460580912863, Blast_Score=295, Evalue=5e-81, Organism=Escherichia coli, GI1786274, Length=332, Percent_Identity=29.2168674698795, Blast_Score=73, Evalue=4e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 56625; Mature: 56494
Theoretical pI: Translated: 6.35; Mature: 6.35
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.0 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 2.0 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MGGKDCSGGCNRPAPRRLDRTRTAPFMGGPGMTQMLHSLLRAVGLPVPEGLANPCLAMVS CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEHC CDSRAVARGCLFLGLPGEQVDGGSFWRQALAAGAEAAVIGPAAAALRPPGPKDAVVVVSE CCCHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCEEEEECC PVAAWVGQLAAAFWQQPSSRLALIGVTGTNGKTTTTHLIEHLSVAVGRSTALFGTLVNRW HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC PNYSVPATHTTAFADRLQAQLAQAVEAGAELGAMEVSSHALEQQRVAGCRFAGAVFTNLT CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH QDHLDYHSSMEAYFEAKAQLFAPPLLESGSAKAVVNIDGPWGARLAQRLGDTCWRSSLAE HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH GVLQRADAELTMTELTMSSAGVQGRLISPCGEGWFDSPLLGRFNLMNLLQAVGVLLQQGL HHHHHCCCCEEHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC PLPLLLKAIADFRGVPGRMERVLIPAADASQVPTVLVDYAHTPDGLENALTASRPFTSKN CHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCC LCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILVDVVAGIPQGTALT EEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEE VEVDRAVAIALAIAEAGPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG EEECHHEEEHHHEECCCCCCEEEEECCCCCCEEEEECCEECCCCHHHHHHHHHHHCCC >Mature Secondary Structure GGKDCSGGCNRPAPRRLDRTRTAPFMGGPGMTQMLHSLLRAVGLPVPEGLANPCLAMVS CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEEHC CDSRAVARGCLFLGLPGEQVDGGSFWRQALAAGAEAAVIGPAAAALRPPGPKDAVVVVSE CCCHHHHCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCEEEEECC PVAAWVGQLAAAFWQQPSSRLALIGVTGTNGKTTTTHLIEHLSVAVGRSTALFGTLVNRW HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC PNYSVPATHTTAFADRLQAQLAQAVEAGAELGAMEVSSHALEQQRVAGCRFAGAVFTNLT CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH QDHLDYHSSMEAYFEAKAQLFAPPLLESGSAKAVVNIDGPWGARLAQRLGDTCWRSSLAE HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH GVLQRADAELTMTELTMSSAGVQGRLISPCGEGWFDSPLLGRFNLMNLLQAVGVLLQQGL HHHHHCCCCEEHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC PLPLLLKAIADFRGVPGRMERVLIPAADASQVPTVLVDYAHTPDGLENALTASRPFTSKN CHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCC LCCVFGCGGDRDRGKRSQMAAIAARLADRVVVTSDNPRTEDPQQILVDVVAGIPQGTALT EEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEE VEVDRAVAIALAIAEAGPGDVVLVAGKGHEDYQILGTSKVHFDDREEAERALKQRLDG EEECHHEEEHHHEECCCCCCEEEEECCCCCCEEEEECCEECCCCHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12917642 [H]