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The map label for this gene is comEC [H]

Identifier: 124023739

GI number: 124023739

Start: 1798841

End: 1800976

Strand: Reverse

Name: comEC [H]

Synonym: P9303_20431

Alternate gene names: 124023739

Gene position: 1800976-1798841 (Counterclockwise)

Preceding gene: 124023741

Following gene: 124023737

Centisome position: 67.13

GC content: 57.07

Gene sequence:

>2136_bases
TTGCTTGTTGCAGGCTTGGCCCTGACAGCACTAGTGCTTGGTGCCCAACCATTGCCTTTTCAAGCAATGGTTGTCGTTGC
TGTGGTGTTGCTGATCACTGCTCGTTTCTACTTGATTCGTCTCGGCATTACCCAAAGCAGGGCTACAGCATTGGCGTTGA
TGTTGCCATTGTTGTTGGCATGGGCTTGCTGGTGGGGGCAGCCGAGGCCTGGACCTTTGGACCCTGTGCGTTTGTTGGCG
AGTGCCGGTTCTTTTGATCGTTCCTCACGCCTACCGCTTCGCAGCAGCCTCGAAGGCCGGCTGCTGAGTGATAGCCGATT
GCTTCGTGATAGCAGCTTTGTGGCTGATAGTTGCCGTGCATTGTTGGCGGTGAACCGGATCAATGGCCTGCCGAGACATG
GCCGTAGTGAAGTTCAGCTAAGACCTTGCCCTCAGCTTTTGCAGCAGGGTTGGCGAATCCGTGTGCATGGTCAGTTGCGC
GCTCCTGCTCTCGGGCCTCATTCGCTACTGCCTGGGCCAGCGGAGCGGCTTCAGCAGCAGGGAAGTTGGAGCCAATTCTG
GGGTGATCAGGTTGAGGTGTTGCAACGCCCCTGGACGCCCATCGCCGATGCTCGCCGTGGGGTCGCCTTGCGCTTACAGC
AACTGGCAGGTCCACGTTCGGGAGGATTGCTGGCGGCTTTGGTGTTGGGTCGTGCCCAAGTTGATCTGCCGCTTGATTTG
GTTAAGGCGTTCCGCGTTGCTGGCCTTTCCCATGCCTTGGCGGCTTCGGGCTTTCATCTTTCTGTGCTGTTGGGAGCGTC
GCTGGGGATTGCTCGGTTGTTGCCAAGGCCCTTTCGTTTGACGTTTGCTGCAATGGCACTGATCAGCTTTTTGATGCTGG
CCGGACCACAACCGTCGGTTGTGAGAGCTGTCTTGATGGGTAGCACGGTGTTGTTGATCAACGAGGGCGGAGGCCGCAGT
CGTCCTCTAGGGGTCTTGCTAGCGACGTTGGTGCTCATGTTGTTGGTGAATCCCGCCTGGGCGCGTTCGATTGGTTTTCA
ATTGAGTGCGGCAGCTACAGCCGGATTGGTCGTCACAGCAGGTCCCCTAGAGCAGGCTCTCTCCAAGCGTCTACCTACAT
GGCTTCGAGGGTTGGCACCGGCGCTGGCTGTTCCTTTGGCCGCAATCGTCTGGACGCTGCCACTACAGATTGTTCATTTT
GGATCCACTCCTGTCTATGCCCTATTGGCGAATCTGCTGGCTGCTCCTGTGTTGGTGCTGCTCACCCTCTCAGCGATGGC
GTTGGCCTGGTTGTGTTTGCTCTTGCCTGCTGGCTTGCTGACTCCATTGCTGAACTGGATCAGTTGGCCGATCCAGCAGT
TGGCTGGGTTATTGATTGCTCTGGTGCGTTGGATCTGCACTTGGCCAATGGCGCAGTTGTTCACCGGTCATCCCCAGCCT
TGGTTGGTGCTGTTGTTGGTGTTGGGATTGCTGCCTTGGTTGGTAGCGGGATTGCGTCACTGGCGTTACTGGGGAGTGGT
TGCGTTGTTGGTTTGTTCGTTATCGCAGGCTGTTGTACAGATGGGTGATGGATTCGTGGTGGTGCATCAGCGCAGTCGTC
AATGGTTACTAGCTAGGCATGGTGGGCGGGCGGTTTTGGTTAGTACGCATGGAGATGGTCGTAGCTGTTGGCAGGCTCAT
CGGCTGAGTGAAGCGTTTGGCCATGCCCGTCTTGATTGGGCGATGGTCTTGGATCCGGTTGCCAGTGAGGCGGCGTCCTG
TTGGCGAAATCTGGCCCATACCGTGCTGGCTGAGCATCAGGGTGTGATGCCTTTGCAGGTTGGACAGCGGTTAGTCAGTC
CTGGCCTGGAGGTGAGACCAATCGCTGCAGCAGAGCAGAGTTTGCAGTTGCGAGCTGGTCGTTTGCGTTGGCATCTGTTG
CCAACGCGTCAGGCCTATTGGAGTTGGCGTGATCGTCAGGGTTTGGATGGCGTGGAGCGTCAACCTTTAGTCAAATCAGA
GGGTTTGACAGGGGTATGGCTTGGCTTTGTCCCAACCTCTCTTGAGCGGCGATGGTTGCTACAACACACTGCAGGGCGGC
TTTGGGTCAGTGGTAGAGCCAGCGGCTCCTTCAGCATGGTGGCCTCAGCGTTTTAA

Upstream 100 bases:

>100_bases
CTTTGCAAGGTTCTTCCTCGAACCCTGCAGACTGCGAAGCGCAGAGAGGGGAATTCTCGAGATAGTCGTTTGAGTTTGTT
TGCGAGGGTTTTCTTCGCCT

Downstream 100 bases:

>100_bases
AGTTGCTTTGCGTCTTTACGGGCGTCTGGAGAGGTGGCTGAGTGGTCGAAAGCGAACGACTCGAAATCGTTTGACGGGCA
ACCGTCCGTGGGTTCGAATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MLVAGLALTALVLGAQPLPFQAMVVVAVVLLITARFYLIRLGITQSRATALALMLPLLLAWACWWGQPRPGPLDPVRLLA
SAGSFDRSSRLPLRSSLEGRLLSDSRLLRDSSFVADSCRALLAVNRINGLPRHGRSEVQLRPCPQLLQQGWRIRVHGQLR
APALGPHSLLPGPAERLQQQGSWSQFWGDQVEVLQRPWTPIADARRGVALRLQQLAGPRSGGLLAALVLGRAQVDLPLDL
VKAFRVAGLSHALAASGFHLSVLLGASLGIARLLPRPFRLTFAAMALISFLMLAGPQPSVVRAVLMGSTVLLINEGGGRS
RPLGVLLATLVLMLLVNPAWARSIGFQLSAAATAGLVVTAGPLEQALSKRLPTWLRGLAPALAVPLAAIVWTLPLQIVHF
GSTPVYALLANLLAAPVLVLLTLSAMALAWLCLLLPAGLLTPLLNWISWPIQQLAGLLIALVRWICTWPMAQLFTGHPQP
WLVLLLVLGLLPWLVAGLRHWRYWGVVALLVCSLSQAVVQMGDGFVVVHQRSRQWLLARHGGRAVLVSTHGDGRSCWQAH
RLSEAFGHARLDWAMVLDPVASEAASCWRNLAHTVLAEHQGVMPLQVGQRLVSPGLEVRPIAAAEQSLQLRAGRLRWHLL
PTRQAYWSWRDRQGLDGVERQPLVKSEGLTGVWLGFVPTSLERRWLLQHTAGRLWVSGRASGSFSMVASAF

Sequences:

>Translated_711_residues
MLVAGLALTALVLGAQPLPFQAMVVVAVVLLITARFYLIRLGITQSRATALALMLPLLLAWACWWGQPRPGPLDPVRLLA
SAGSFDRSSRLPLRSSLEGRLLSDSRLLRDSSFVADSCRALLAVNRINGLPRHGRSEVQLRPCPQLLQQGWRIRVHGQLR
APALGPHSLLPGPAERLQQQGSWSQFWGDQVEVLQRPWTPIADARRGVALRLQQLAGPRSGGLLAALVLGRAQVDLPLDL
VKAFRVAGLSHALAASGFHLSVLLGASLGIARLLPRPFRLTFAAMALISFLMLAGPQPSVVRAVLMGSTVLLINEGGGRS
RPLGVLLATLVLMLLVNPAWARSIGFQLSAAATAGLVVTAGPLEQALSKRLPTWLRGLAPALAVPLAAIVWTLPLQIVHF
GSTPVYALLANLLAAPVLVLLTLSAMALAWLCLLLPAGLLTPLLNWISWPIQQLAGLLIALVRWICTWPMAQLFTGHPQP
WLVLLLVLGLLPWLVAGLRHWRYWGVVALLVCSLSQAVVQMGDGFVVVHQRSRQWLLARHGGRAVLVSTHGDGRSCWQAH
RLSEAFGHARLDWAMVLDPVASEAASCWRNLAHTVLAEHQGVMPLQVGQRLVSPGLEVRPIAAAEQSLQLRAGRLRWHLL
PTRQAYWSWRDRQGLDGVERQPLVKSEGLTGVWLGFVPTSLERRWLLQHTAGRLWVSGRASGSFSMVASAF
>Mature_711_residues
MLVAGLALTALVLGAQPLPFQAMVVVAVVLLITARFYLIRLGITQSRATALALMLPLLLAWACWWGQPRPGPLDPVRLLA
SAGSFDRSSRLPLRSSLEGRLLSDSRLLRDSSFVADSCRALLAVNRINGLPRHGRSEVQLRPCPQLLQQGWRIRVHGQLR
APALGPHSLLPGPAERLQQQGSWSQFWGDQVEVLQRPWTPIADARRGVALRLQQLAGPRSGGLLAALVLGRAQVDLPLDL
VKAFRVAGLSHALAASGFHLSVLLGASLGIARLLPRPFRLTFAAMALISFLMLAGPQPSVVRAVLMGSTVLLINEGGGRS
RPLGVLLATLVLMLLVNPAWARSIGFQLSAAATAGLVVTAGPLEQALSKRLPTWLRGLAPALAVPLAAIVWTLPLQIVHF
GSTPVYALLANLLAAPVLVLLTLSAMALAWLCLLLPAGLLTPLLNWISWPIQQLAGLLIALVRWICTWPMAQLFTGHPQP
WLVLLLVLGLLPWLVAGLRHWRYWGVVALLVCSLSQAVVQMGDGFVVVHQRSRQWLLARHGGRAVLVSTHGDGRSCWQAH
RLSEAFGHARLDWAMVLDPVASEAASCWRNLAHTVLAEHQGVMPLQVGQRLVSPGLEVRPIAAAEQSLQLRAGRLRWHLL
PTRQAYWSWRDRQGLDGVERQPLVKSEGLTGVWLGFVPTSLERRWLLQHTAGRLWVSGRASGSFSMVASAF

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 77263; Mature: 77263

Theoretical pI: Translated: 12.14; Mature: 12.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVAGLALTALVLGAQPLPFQAMVVVAVVLLITARFYLIRLGITQSRATALALMLPLLLA
CEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WACWWGQPRPGPLDPVRLLASAGSFDRSSRLPLRSSLEGRLLSDSRLLRDSSFVADSCRA
HHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHHCCHHHHHHHHH
LLAVNRINGLPRHGRSEVQLRPCPQLLQQGWRIRVHGQLRAPALGPHSLLPGPAERLQQQ
HHHHHHHCCCCCCCCCCCEECCCHHHHHCCCEEEEECEECCCCCCCCCCCCCHHHHHHHC
GSWSQFWGDQVEVLQRPWTPIADARRGVALRLQQLAGPRSGGLLAALVLGRAQVDLPLDL
CCHHHHCCHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHH
VKAFRVAGLSHALAASGFHLSVLLGASLGIARLLPRPFRLTFAAMALISFLMLAGPQPSV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHH
VRAVLMGSTVLLINEGGGRSRPLGVLLATLVLMLLVNPAWARSIGFQLSAAATAGLVVTA
HHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEEHHHHCCEEEEC
GPLEQALSKRLPTWLRGLAPALAVPLAAIVWTLPLQIVHFGSTPVYALLANLLAAPVLVL
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHH
LTLSAMALAWLCLLLPAGLLTPLLNWISWPIQQLAGLLIALVRWICTWPMAQLFTGHPQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCH
WLVLLLVLGLLPWLVAGLRHWRYWGVVALLVCSLSQAVVQMGDGFVVVHQRSRQWLLARH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEC
GGRAVLVSTHGDGRSCWQAHRLSEAFGHARLDWAMVLDPVASEAASCWRNLAHTVLAEHQ
CCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVMPLQVGQRLVSPGLEVRPIAAAEQSLQLRAGRLRWHLLPTRQAYWSWRDRQGLDGVER
CCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCCCCCC
QPLVKSEGLTGVWLGFVPTSLERRWLLQHTAGRLWVSGRASGSFSMVASAF
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCC
>Mature Secondary Structure
MLVAGLALTALVLGAQPLPFQAMVVVAVVLLITARFYLIRLGITQSRATALALMLPLLLA
CEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WACWWGQPRPGPLDPVRLLASAGSFDRSSRLPLRSSLEGRLLSDSRLLRDSSFVADSCRA
HHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHHCCHHHHHHHHH
LLAVNRINGLPRHGRSEVQLRPCPQLLQQGWRIRVHGQLRAPALGPHSLLPGPAERLQQQ
HHHHHHHCCCCCCCCCCCEECCCHHHHHCCCEEEEECEECCCCCCCCCCCCCHHHHHHHC
GSWSQFWGDQVEVLQRPWTPIADARRGVALRLQQLAGPRSGGLLAALVLGRAQVDLPLDL
CCHHHHCCHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHH
VKAFRVAGLSHALAASGFHLSVLLGASLGIARLLPRPFRLTFAAMALISFLMLAGPQPSV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHH
VRAVLMGSTVLLINEGGGRSRPLGVLLATLVLMLLVNPAWARSIGFQLSAAATAGLVVTA
HHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCEEEHHHHCCEEEEC
GPLEQALSKRLPTWLRGLAPALAVPLAAIVWTLPLQIVHFGSTPVYALLANLLAAPVLVL
CHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHH
LTLSAMALAWLCLLLPAGLLTPLLNWISWPIQQLAGLLIALVRWICTWPMAQLFTGHPQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCH
WLVLLLVLGLLPWLVAGLRHWRYWGVVALLVCSLSQAVVQMGDGFVVVHQRSRQWLLARH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEC
GGRAVLVSTHGDGRSCWQAHRLSEAFGHARLDWAMVLDPVASEAASCWRNLAHTVLAEHQ
CCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVMPLQVGQRLVSPGLEVRPIAAAEQSLQLRAGRLRWHLLPTRQAYWSWRDRQGLDGVER
CCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCEEEEEECCHHHHHCCCCCCCCCCCCC
QPLVKSEGLTGVWLGFVPTSLERRWLLQHTAGRLWVSGRASGSFSMVASAF
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]