Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 124023656

GI number: 124023656

Start: 1720047

End: 1721531

Strand: Reverse

Name: ffh [H]

Synonym: P9303_19561

Alternate gene names: 124023656

Gene position: 1721531-1720047 (Counterclockwise)

Preceding gene: 124023657

Following gene: 124023655

Centisome position: 64.17

GC content: 56.09

Gene sequence:

>1485_bases
ATGTTTGAAGAACTTTCAGCCCGCTTTGAAGATGCAGTTAAGGGGCTGAGAGGCCAGGCAAAGATCAGCGACACCAATGT
TGAGGATGCTCTTAAGCAGGTGCGACGTGCCCTTTTAGGGGCTGATGTGAGTCTTGAGGTCGTGCGCGAGTTTGTCGACG
AGGTGCGGCAGAAGGCAGTTGGTGCCGAAGTGGTGCGAGGTGTCACTCCTGATCAGAAGTTTGTTCAGGTGGTGCATCAG
CAGCTGGTGGAGGTGATGGGTGGTGATAACGCTCCCATGGCTGAGGCTAAAGATTCACCAACGGTGGTGCTGATGGCTGG
ATTGCAGGGGGCTGGCAAAACCACTGCAACAGCGAAGCTTGGACTTCACCTTAAAGATCAGGGTCAGCGGCCACTGATGG
TGGCTGCTGATGTCTATCGGCCGGCTGCCATTGATCAGCTCCGCACCCTTGGTGAGCAGATCGGAGTTGATGTATTCAGC
CTCGGAGACGATGTCAAGCCTGAGGAGATCGCGGCAGCAGGACTTGCCAAGGCTCGTGAGGAAGGTTTTGACACCTTGCT
AGTGGATACGGCAGGTCGGCTGCAGATCGATACCGAGATGATGGAGGAAATGGTGCGGATTCGTTCTGCCGTAGAGCCCG
ATGAAGTGCTCTTGGTGGTGGATTCGATGATCGGTCAGGAGGCGGCTGAACTCACGCGGGCCTTCCACGACAAGGTTGGT
ATCACTGGATCTGTTCTCACCAAGCTGGATGGTGATTCCCGCGGTGGGGCTGCGCTTTCGATTCGCAAGGTGAGTGGTCA
GCCGATCAAGTTCATCGGTACTGGAGAAAAAGTTGAGGCTTTACAGCCTTTTCATCCGGAACGCATGGCCAGCCGCATCC
TCGGGATGGGCGATGTGCTCACCCTGGTGGAGAAAGCTCAGAAGGAGGTAGAGCTCGCTGATGTTGAGAAGATGCAGAAG
AAGCTGCAGGAAGCCTCGTTTGATTTCTCGGATTTCCTGCAACAGACGCGACTGATCAAACGGATGGGTTCCCTCGGTGG
TTTGATCAAGATGATGCCGGGCATGAACAAGCTGGATGACGGCATGCTCAAACAAGGAGAGCAGCAGCTCAAGCGCATCG
AGGCCATGATTGGCTCGATGACTGCTGATGAGCGCAAGCAGCCTGAATTGCTTGCTTCACAGCCTTCTCGTCGTCGTCGT
ATCGCTGGTGGGAGTGGCCATAGCCCCGCTGACGTGGACAAAGTTTTGGCTGATTTTCAGAAAATGCGTGGCTTCATGCA
GCAGATGAGTAAGGGCGGTGGCATGCCTGGAATGCCAGGCATGCCTGGCATGGGTGGAGGGTTGCCCGGTATGGGGGGGG
CTGGTGGTGGCATGCCTGGCATGGGAGGAGCAGGCATGCCAGAGCCAGCTTCAGGTGGTCGCGGTGGTGGATCCCCCAGG
CGTCAGCGACCGGTGAAAAAGAAGAAGGGGTTTGGAGAGTTGTAA

Upstream 100 bases:

>100_bases
GCGCCTGCATGAATACATCAGCGGCAAATAATCACTGTTTTGCCTAAGGGCTAGCCATCGCTTTTTACGATGAGCTCAAA
GCCCTTGGCACGTAGGCACC

Downstream 100 bases:

>100_bases
TTGGCGGCAGGCTATGGTTGTTGTTTGGCGTGTGTTTAAAACACCGCTGAACCATCCACCTTTTACGAACTTAGGGCCAC
GATGATCAAGCTCCGCCTGA

Product: signal recognition particle protein (SRP54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVDEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAKDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQTRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERKQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMGGGLPGMGGAGGGMPGMGGAGMPEPASGGRGGGSPR
RQRPVKKKKGFGEL

Sequences:

>Translated_494_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVDEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAKDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQTRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERKQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMGGGLPGMGGAGGGMPGMGGAGMPEPASGGRGGGSPR
RQRPVKKKKGFGEL
>Mature_494_residues
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVDEVRQKAVGAEVVRGVTPDQKFVQVVHQ
QLVEVMGGDNAPMAEAKDSPTVVLMAGLQGAGKTTATAKLGLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFS
LGDDVKPEEIAAAGLAKAREEGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADVEKMQK
KLQEASFDFSDFLQQTRLIKRMGSLGGLIKMMPGMNKLDDGMLKQGEQQLKRIEAMIGSMTADERKQPELLASQPSRRRR
IAGGSGHSPADVDKVLADFQKMRGFMQQMSKGGGMPGMPGMPGMGGGLPGMGGAGGGMPGMGGAGMPEPASGGRGGGSPR
RQRPVKKKKGFGEL

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=31.6742081447964, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI226371618, Length=383, Percent_Identity=32.6370757180157, Blast_Score=222, Evalue=8e-58,
Organism=Homo sapiens, GI89061728, Length=158, Percent_Identity=39.2405063291139, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI23308697, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI295424842, Length=313, Percent_Identity=28.4345047923323, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1788963, Length=456, Percent_Identity=47.8070175438597, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=271, Percent_Identity=32.8413284132841, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=443, Percent_Identity=30.9255079006772, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=298, Percent_Identity=30.8724832214765, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325345, Length=454, Percent_Identity=30.6167400881057, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=22.9299363057325, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=31.9004524886878, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24641198, Length=323, Percent_Identity=25.077399380805, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 52771; Mature: 52771

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVDEVRQKAV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAEVVRGVTPDQKFVQVVHQQLVEVMGGDNAPMAEAKDSPTVVLMAGLQGAGKTTATAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHC
GLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFSLGDDVKPEEIAAAGLAKARE
CEEECCCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
EGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCC
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVL
CCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVELADVEKMQKKLQEASFDFSDFLQQTRLIKRMGSLGGLIKMMPGMNKLDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GMLKQGEQQLKRIEAMIGSMTADERKQPELLASQPSRRRRIAGGSGHSPADVDKVLADFQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRGFMQQMSKGGGMPGMPGMPGMGGGLPGMGGAGGGMPGMGGAGMPEPASGGRGGGSPR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RQRPVKKKKGFGEL
HCCCCHHHCCCCCC
>Mature Secondary Structure
MFEELSARFEDAVKGLRGQAKISDTNVEDALKQVRRALLGADVSLEVVREFVDEVRQKAV
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAEVVRGVTPDQKFVQVVHQQLVEVMGGDNAPMAEAKDSPTVVLMAGLQGAGKTTATAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHC
GLHLKDQGQRPLMVAADVYRPAAIDQLRTLGEQIGVDVFSLGDDVKPEEIAAAGLAKARE
CEEECCCCCCCEEEEHHHHCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
EGFDTLLVDTAGRLQIDTEMMEEMVRIRSAVEPDEVLLVVDSMIGQEAAELTRAFHDKVG
CCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHCC
ITGSVLTKLDGDSRGGAALSIRKVSGQPIKFIGTGEKVEALQPFHPERMASRILGMGDVL
CCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCHHHHHHHHHCCHHHH
TLVEKAQKEVELADVEKMQKKLQEASFDFSDFLQQTRLIKRMGSLGGLIKMMPGMNKLDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GMLKQGEQQLKRIEAMIGSMTADERKQPELLASQPSRRRRIAGGSGHSPADVDKVLADFQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHH
KMRGFMQQMSKGGGMPGMPGMPGMGGGLPGMGGAGGGMPGMGGAGMPEPASGGRGGGSPR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RQRPVKKKKGFGEL
HCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]