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The map label for this gene is ppnK [H]

Identifier: 124023633

GI number: 124023633

Start: 1702129

End: 1703037

Strand: Reverse

Name: ppnK [H]

Synonym: P9303_19331

Alternate gene names: 124023633

Gene position: 1703037-1702129 (Counterclockwise)

Preceding gene: 124023634

Following gene: 124023632

Centisome position: 63.48

GC content: 55.78

Gene sequence:

>909_bases
GTGCCCTGTGTCGGACTGATCGTTAATGACGGCAAAGAGTTGGCGGTAGAGACCGCATTGACCCTTCAGTCGCGGCTTGA
ACAGGCTGGTATCGAAGTGGTCAGAGCAAGTAGTTCTGGCGGAATGGTTGGCTTTGCCAATCCAGATCAGCATTTGCGCC
TGCTTGGTTACAACGCGTGCGTTCCTGAGGGATTCGATGCCTCGATGGCACTGGCGATTGTCCTGGGTGGTGATGGCACC
GTGCTTTCGGCGGCACGGCAGACAGCTCCTGTGCAGGTGCCAATCCTCACCATCAACACCGGACACCTTGGCTTCCTAGC
GGAGGCCTATTTGGCTGATCTCGATCGGGTGATTGAGCAGGTTGTTAACAAGCAGTGGACGATTGAGGTGCGTTGCACCC
TGGTGGTGAGAGTGTTGCGTGGTGATCAGTGCCGCTGGGAGGCACTCTCTTTGAATGAAATGGCCTTGCATCGTGAACCG
CTCACGAGCATGTGTCATTTCGAAGTCGCGATCGGTCGTCATGCGCCGGTGGATATCTCTGCTGATGGCGTGATCCTTTC
AACTCCTACGGGATCAACGGCTTATGCACTCAGTGCAGGAGGCCCGGTGATTACACCTGAGTGCCCGGTGCTGCAGCTTG
CACCGATTGCCCCTCATTCGCTGGCGTCAAGAGCGCTGGTTTTCAGCGACCAGGAGCCAGTGACTGTGTTCCCAGCGACG
GCTGATCGCTTGATGATGGTGGTTGATGGCAGTGCGGGTTGTTATGTGTGGCCGGAAGATCGAGTACTGATTCGTCGTAG
TGATCATCCTGTGAGATTTGTGCGCTTGGCAGATCACGAGTTCTTCCAGGTGTTGCGCAACAAGTTGGGCTGGGGTTTGC
CGCATGTTGCTAAACCTGATCGAGTATGA

Upstream 100 bases:

>100_bases
CGATAGCCGATCGTGCACTGGATGAAGCATCGCCGCGTTGCTGCATCCAAAAACAGCTGAATCCCCATAAAGTGAGGTCG
TTGTTTGCTTCATTCGATCG

Downstream 100 bases:

>100_bases
GCGGCAGGGTCCTCTGCTTGCAGTGGGGGAAGAGATTGCGGTTTCCTTTGCTCTGGGGAGGGCTGGCGGTAGGTCTCAGC
GTTCTTTCATCTATTGGGGT

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase 1 [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGT
VLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVVNKQWTIEVRCTLVVRVLRGDQCRWEALSLNEMALHREP
LTSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRV

Sequences:

>Translated_302_residues
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGT
VLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVVNKQWTIEVRCTLVVRVLRGDQCRWEALSLNEMALHREP
LTSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRV
>Mature_301_residues
PCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNACVPEGFDASMALAIVLGGDGTV
LSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQVVNKQWTIEVRCTLVVRVLRGDQCRWEALSLNEMALHREPL
TSMCHFEVAIGRHAPVDISADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPATA
DRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPDRV

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=251, Percent_Identity=28.2868525896414, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788968, Length=222, Percent_Identity=35.1351351351351, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6320794, Length=251, Percent_Identity=29.0836653386454, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325068, Length=160, Percent_Identity=33.75, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322509, Length=250, Percent_Identity=28.8, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28573828, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573830, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077047, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573832, Length=246, Percent_Identity=27.2357723577236, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573826, Length=246, Percent_Identity=27.2357723577236, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 32584; Mature: 32453

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNAC
CCEEEEEEECCCEEEHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCC
VPEGFDASMALAIVLGGDGTVLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQ
CCCCCCCCEEEEEEECCCCCEEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
VVNKQWTIEVRCTLVVRVLRGDQCRWEALSLNEMALHREPLTSMCHFEVAIGRHAPVDIS
HHCCCEEEEEEEEEEEEECCCCCCEEEEECCHHHHHHHCCHHHHHEEEEEECCCCCCEEC
ADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
CCCEEEECCCCCEEEEEECCCCEECCCCCCEEECCCCCHHHHCEEEEECCCCCEEEEECC
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPD
CCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
RV
CC
>Mature Secondary Structure 
PCVGLIVNDGKELAVETALTLQSRLEQAGIEVVRASSSGGMVGFANPDQHLRLLGYNAC
CEEEEEEECCCEEEHHHHHHHHHHHHHCCEEEEEECCCCCEEEECCCCCEEEEEECCCC
VPEGFDASMALAIVLGGDGTVLSAARQTAPVQVPILTINTGHLGFLAEAYLADLDRVIEQ
CCCCCCCCEEEEEEECCCCCEEEHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
VVNKQWTIEVRCTLVVRVLRGDQCRWEALSLNEMALHREPLTSMCHFEVAIGRHAPVDIS
HHCCCEEEEEEEEEEEEECCCCCCEEEEECCHHHHHHHCCHHHHHEEEEEECCCCCCEEC
ADGVILSTPTGSTAYALSAGGPVITPECPVLQLAPIAPHSLASRALVFSDQEPVTVFPAT
CCCEEEECCCCCEEEEEECCCCEECCCCCCEEECCCCCHHHHCEEEEECCCCCEEEEECC
ADRLMMVVDGSAGCYVWPEDRVLIRRSDHPVRFVRLADHEFFQVLRNKLGWGLPHVAKPD
CCEEEEEEECCCCEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]