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The map label for this gene is 124023573

Identifier: 124023573

GI number: 124023573

Start: 1634743

End: 1635900

Strand: Direct

Name: 124023573

Synonym: P9303_18731

Alternate gene names: NA

Gene position: 1634743-1635900 (Clockwise)

Preceding gene: 124023572

Following gene: 124023574

Centisome position: 60.94

GC content: 59.76

Gene sequence:

>1158_bases
ATGCAGGAGTCGTGGGATGTACTGGTGGTTGGGGCCGGTCCTGCAGGGGGGCTAGCCGCCCTGGATTGCGCAAGGCGAGG
ATTAAGGGTGTTACTGGTGGAAAAACGCGCTTTCCCCCGCTGGAAAGTGTGTGGTTGCTGCTTTAACAAACAGGCTCAGG
CGACTCTCGCATCTCTGGGACAGAACGATCTAATCATTGATCGCGGCGGCGTACGACTGCAAACCCTTCGCCTCGGCCTG
AATGGTCGTCAAACATCTCTAGCCATTCCCGATGGTTTTGCTCTCTCCAGGGAACAGTTCGATCAGGCACTGATGGACGC
GGTCGTTGAAGCTGGAGCTTCCGTTCGCTGTCAAATGAGCGCCGGGGTCGAAGAAGTCCAACCAGGCTGGCGGATTGTGC
GGCTGAAGGATCAGCGCAGCGGTCAGCAGAACCTCGTCAGGGCGCGTGTCGTGCTTGTCGCAGCTGGGCTTGCCCAGCGT
TGCTTACCCGAGCAGGATGCTGGCATCACCAGGATCCGTAGTCGTTCCAGGGTTGGAGCCGGTTGTGTTCTTGCTGATGA
TGAGAACCACTACACCGCAGGCGCCATTCACATGGCGATCGGTGAACGTGGTTATGTGGGTCTGGTGCGCCGAGAGGACG
GTTTACTCAATGTGGCAGCCGCTTTCGATCGGCAGGCGCTAGCCCATGGGCAAGGAGCGGCCGGAGCTACCCAGGATGTG
CTTATGCAGGCTGGTTTCCCACCACCTGCGGCTCTGAGACAGGGGCAATGGCAGCTGACGCCAGCTCTTAGTCGCGGCGC
TGAGGTTGTTGCCGGAGAGCGCTTTCTGGTGATGGGTGACGCAGCGGGTTATGTGGAGCCATTTACAGGAGAAGGAATTG
CCTGGGCCCTCACTGCAGGTGCCGTGGTGGCACCATTTGTTCAAGAAGGCCTCCTGCGCTGGAGCCATGATCTGGAGAAG
CGCTGGACGCGAGAGCTGAAGCTGCGGATCGGTCGTCGCCAGCGGATCTGTCGCACTCTGGCCATGGTGCTGAGGCAGCC
AAAGCCGACGAGGGCATTGTTTGAACTGAGCAGCCGCTGGCCGGCACTGTCTGAAACGATTGTTGCCAGCCTGAACCATG
TGACCCTCCCCTCCGCCGGAAGTCAGCAATGCCTCTGA

Upstream 100 bases:

>100_bases
GCGGAAATCATGGCTTTAGCCCAGCGCGCAGGTTTGGAGGGTGTTCAACTGAATCGCTGCTGGCCTGAGCGTTACCTGCT
CAGCTGGGAGCGTCATTGAG

Downstream 100 bases:

>100_bases
CCATTCGCGGCATGGGAACTGCAGTGCCGGAACAACAAGTCAATCAGATCGATTCCATGGCGCTTGCAGAGTTCGTGAGT
GCCGACAGTCCCGAACGAGC

Product: NAD binding site

Products: NA

Alternate protein names: DGGGPL reductase; 2,3-di-O-geranylgeranylglyceryl phosphate reductase; Geranylgeranyl reductase; GGR [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MQESWDVLVVGAGPAGGLAALDCARRGLRVLLVEKRAFPRWKVCGCCFNKQAQATLASLGQNDLIIDRGGVRLQTLRLGL
NGRQTSLAIPDGFALSREQFDQALMDAVVEAGASVRCQMSAGVEEVQPGWRIVRLKDQRSGQQNLVRARVVLVAAGLAQR
CLPEQDAGITRIRSRSRVGAGCVLADDENHYTAGAIHMAIGERGYVGLVRREDGLLNVAAAFDRQALAHGQGAAGATQDV
LMQAGFPPPAALRQGQWQLTPALSRGAEVVAGERFLVMGDAAGYVEPFTGEGIAWALTAGAVVAPFVQEGLLRWSHDLEK
RWTRELKLRIGRRQRICRTLAMVLRQPKPTRALFELSSRWPALSETIVASLNHVTLPSAGSQQCL

Sequences:

>Translated_385_residues
MQESWDVLVVGAGPAGGLAALDCARRGLRVLLVEKRAFPRWKVCGCCFNKQAQATLASLGQNDLIIDRGGVRLQTLRLGL
NGRQTSLAIPDGFALSREQFDQALMDAVVEAGASVRCQMSAGVEEVQPGWRIVRLKDQRSGQQNLVRARVVLVAAGLAQR
CLPEQDAGITRIRSRSRVGAGCVLADDENHYTAGAIHMAIGERGYVGLVRREDGLLNVAAAFDRQALAHGQGAAGATQDV
LMQAGFPPPAALRQGQWQLTPALSRGAEVVAGERFLVMGDAAGYVEPFTGEGIAWALTAGAVVAPFVQEGLLRWSHDLEK
RWTRELKLRIGRRQRICRTLAMVLRQPKPTRALFELSSRWPALSETIVASLNHVTLPSAGSQQCL
>Mature_385_residues
MQESWDVLVVGAGPAGGLAALDCARRGLRVLLVEKRAFPRWKVCGCCFNKQAQATLASLGQNDLIIDRGGVRLQTLRLGL
NGRQTSLAIPDGFALSREQFDQALMDAVVEAGASVRCQMSAGVEEVQPGWRIVRLKDQRSGQQNLVRARVVLVAAGLAQR
CLPEQDAGITRIRSRSRVGAGCVLADDENHYTAGAIHMAIGERGYVGLVRREDGLLNVAAAFDRQALAHGQGAAGATQDV
LMQAGFPPPAALRQGQWQLTPALSRGAEVVAGERFLVMGDAAGYVEPFTGEGIAWALTAGAVVAPFVQEGLLRWSHDLEK
RWTRELKLRIGRRQRICRTLAMVLRQPKPTRALFELSSRWPALSETIVASLNHVTLPSAGSQQCL

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: NA

Molecular weight: Translated: 41595; Mature: 41595

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQESWDVLVVGAGPAGGLAALDCARRGLRVLLVEKRAFPRWKVCGCCFNKQAQATLASLG
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHCC
QNDLIIDRGGVRLQTLRLGLNGRQTSLAIPDGFALSREQFDQALMDAVVEAGASVRCQMS
CCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEC
AGVEEVQPGWRIVRLKDQRSGQQNLVRARVVLVAAGLAQRCLPEQDAGITRIRSRSRVGA
CCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
GCVLADDENHYTAGAIHMAIGERGYVGLVRREDGLLNVAAAFDRQALAHGQGAAGATQDV
CEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCHHHH
LMQAGFPPPAALRQGQWQLTPALSRGAEVVAGERFLVMGDAAGYVEPFTGEGIAWALTAG
HHHCCCCCHHHHHCCCEEECHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCEEEEEHHH
AVVAPFVQEGLLRWSHDLEKRWTRELKLRIGRRQRICRTLAMVLRQPKPTRALFELSSRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PALSETIVASLNHVTLPSAGSQQCL
CHHHHHHHHHCCCEECCCCCCCCCC
>Mature Secondary Structure
MQESWDVLVVGAGPAGGLAALDCARRGLRVLLVEKRAFPRWKVCGCCFNKQAQATLASLG
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHCC
QNDLIIDRGGVRLQTLRLGLNGRQTSLAIPDGFALSREQFDQALMDAVVEAGASVRCQMS
CCCEEEECCCCEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEC
AGVEEVQPGWRIVRLKDQRSGQQNLVRARVVLVAAGLAQRCLPEQDAGITRIRSRSRVGA
CCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
GCVLADDENHYTAGAIHMAIGERGYVGLVRREDGLLNVAAAFDRQALAHGQGAAGATQDV
CEEEECCCCCEEEEEEEEEECCCCCEEEEECCCCCEEHHHHHHHHHHHCCCCCCCCHHHH
LMQAGFPPPAALRQGQWQLTPALSRGAEVVAGERFLVMGDAAGYVEPFTGEGIAWALTAG
HHHCCCCCHHHHHCCCEEECHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCEEEEEHHH
AVVAPFVQEGLLRWSHDLEKRWTRELKLRIGRRQRICRTLAMVLRQPKPTRALFELSSRW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PALSETIVASLNHVTLPSAGSQQCL
CHHHHHHHHHCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]