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The map label for this gene is yfhR [C]

Identifier: 124023478

GI number: 124023478

Start: 1554295

End: 1556340

Strand: Reverse

Name: yfhR [C]

Synonym: P9303_17781

Alternate gene names: 124023478

Gene position: 1556340-1554295 (Counterclockwise)

Preceding gene: 124023482

Following gene: 124023475

Centisome position: 58.01

GC content: 45.8

Gene sequence:

>2046_bases
ATGAGAAGATTTTCTTTGCTTAGAGCAACTTTAGCTCTGCAATGCCTGTTAACCACTATTGCTTTACCGATAAGACTTTC
CTCTCCTGCTTTCGCAGATACCCTCCCTCAGCGGGAGGTTCCGCTGATTCCACGTGAAGTCTTGTTGGGCAACCCTGAGG
TGAGTGGGGTTACCTTGAGTCCAGATGGTAAGCAGATTGTTTTTCTGGCGCCCCATCGTGGAGTGCTCAATCTTTGGGCT
CAAGAGCTTGAAGCGGGATCTAAACCACGCCTGCTTACAAACAGCACGAATCGTCCCACTAGGCCTGCTAGTTGGAGCGT
TGATGGGCGATATCTAATCACTAGCCGCGATAGCTATGGCGATGAAAACACTGTTCTGATTCGAATCGATCCAACGACTG
GCGAGGCGATTGATCTCACACCAGGTAAGGGTGTCAAAGCTGCTATCTGGGGTGATGACCAAGACGTCCCCGACGAGTTG
GTCATCGGCCTAAATGATCGCGATCCTCGCTATCACGATCTCTGGGTAATCAATCTAGAGACTGGTGAGCGTCGCTTACT
GTATGAAGCCAATGATGGCCATTTGGTCTCTGTCGACTGGATTGACGGTGATTGGCAGTTGGTTCTGCGAAACCGGATAC
AACCAGATGGTGGCAGTACTTATGACCTTCGTCTGCCTGGCCAAAAAGGTTGGAAACCATTTTTAAGTTTCAGCTTTGAA
GAAAGTCAGGCTGGATCAGCACCTCTTGGGTTCGATAGAAATGCAACTTGGTTGTATGGGTTTCTGAATATCAAAGATGG
TTTGCCTTGCTTGGTGCGCTGGCGCACCGAAGCTCTGCAGAGTTGTAAAGAAGATTGCCCTTATGAGCTCGTGTACCAGT
CTAAAAGTGGAACACTTGGAGTTGAACTATCTGACCCTAAAACTCATGCGCCACAAATTTTGATTGAAACTGACTTGCGA
AGTCGCAAGATTATCATAGATCAGGAACTTGTGAATGATCTGAGTGCTCTTAAACAACTTGCTAAAGATCGTGAATTTTA
CATCGTTAATGATGATGTCGATTCAATGACATGGCTAGTGAGCTTATATTCCGACACCCACTCACCACAGTATTGGATAT
GGAATCGTAATCATAAAAAGGGCCAAAAACTCTTCTCAGTTAATCCTTCGCTTGATAAATACAAGCTTTCAGCAATGGAA
AGCATTGAATTACGTGCTCGTGATGGTTTGCGTCTCCCTTCTTACCTAACACGCTCAACTCTAAATCAATCGGGCCCTCA
ACCTTTTGTGCTGTTGGTGCATGGTGGCCCTCAGGCTCGTGATTATTGGGGTCTTCATTCAGTACATCAACTTTTAGCAA
ATCGCGGATACCATGTATTGAGTGTCAATTACAGAGGTTCGACTGGTTTCGGTAAAAGACATTTGCTAGCTGGTGAAGGT
CAGTGGTATGCCGCTATGCAGGATGACCTTGTTGATGCTGTTCAATGGGCTGTTGATGAAGGTATTGCCGACCCCAAGAA
GATTGTGATTATGGGGGGCTCTTATGGTGGTTATGCTGCTTTGGCTGGGCTCACGCGTGACCCAGAATTATTTGCTGCTG
CTGTGGATATAGTTGGGCCTTCTAATGTAGAAACCTTGCTAGAATCTATTCCTCCTTATTGGGAGCCCATCCGTAAACCT
TGGGAGAGAATGGTAGGTGTTGGCCGTGTTGATTTGGCAGCTATTTCACCACTAACTTATGCCAACCGTATCCAGCGTCC
TTTATTGATTGTACATGGTGCTAATGATGTACGAGTTAAGTTGTCTGAGAGTGAATCAATTGTGGCGGCTATGCATTCCA
ATAATTTGCCTGTTGACTTTATTGTTTTTCCAGACGAAGGTCATGGGATTGAAGACCCGAGAAACTCACTAGCCCTTTAT
GCAGTTATTGAGAAGTTTCTTGCTAAACAACTTGGTGGAAGGTTTGAACCAATTGGCGAAGCAATTCAAGATTCATCTAT
GCAATGGCGAAGCAAGTCCGGTGCTGGAGGTATGATCAATAAGTAA

Upstream 100 bases:

>100_bases
TAGGTTATATGCAATTTGCAGTGTGAGATGTTATTTGAAAGCGGCTGCTTCTCTTTATGAGTAACTCTGGTCACACTGAT
CAAAGAACGATTAATGATCA

Downstream 100 bases:

>100_bases
ATAGAATTATTGCCAAAATTCTTAGAATGCCATGGATGTGGAAATGCTAGGAAGTTACTTATGGCCTGTCAGTTGTGATC
ATGTAAATATTTTAGAATGC

Product: hypothetical protein

Products: NA

Alternate protein names: AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MRRFSLLRATLALQCLLTTIALPIRLSSPAFADTLPQREVPLIPREVLLGNPEVSGVTLSPDGKQIVFLAPHRGVLNLWA
QELEAGSKPRLLTNSTNRPTRPASWSVDGRYLITSRDSYGDENTVLIRIDPTTGEAIDLTPGKGVKAAIWGDDQDVPDEL
VIGLNDRDPRYHDLWVINLETGERRLLYEANDGHLVSVDWIDGDWQLVLRNRIQPDGGSTYDLRLPGQKGWKPFLSFSFE
ESQAGSAPLGFDRNATWLYGFLNIKDGLPCLVRWRTEALQSCKEDCPYELVYQSKSGTLGVELSDPKTHAPQILIETDLR
SRKIIIDQELVNDLSALKQLAKDREFYIVNDDVDSMTWLVSLYSDTHSPQYWIWNRNHKKGQKLFSVNPSLDKYKLSAME
SIELRARDGLRLPSYLTRSTLNQSGPQPFVLLVHGGPQARDYWGLHSVHQLLANRGYHVLSVNYRGSTGFGKRHLLAGEG
QWYAAMQDDLVDAVQWAVDEGIADPKKIVIMGGSYGGYAALAGLTRDPELFAAAVDIVGPSNVETLLESIPPYWEPIRKP
WERMVGVGRVDLAAISPLTYANRIQRPLLIVHGANDVRVKLSESESIVAAMHSNNLPVDFIVFPDEGHGIEDPRNSLALY
AVIEKFLAKQLGGRFEPIGEAIQDSSMQWRSKSGAGGMINK

Sequences:

>Translated_681_residues
MRRFSLLRATLALQCLLTTIALPIRLSSPAFADTLPQREVPLIPREVLLGNPEVSGVTLSPDGKQIVFLAPHRGVLNLWA
QELEAGSKPRLLTNSTNRPTRPASWSVDGRYLITSRDSYGDENTVLIRIDPTTGEAIDLTPGKGVKAAIWGDDQDVPDEL
VIGLNDRDPRYHDLWVINLETGERRLLYEANDGHLVSVDWIDGDWQLVLRNRIQPDGGSTYDLRLPGQKGWKPFLSFSFE
ESQAGSAPLGFDRNATWLYGFLNIKDGLPCLVRWRTEALQSCKEDCPYELVYQSKSGTLGVELSDPKTHAPQILIETDLR
SRKIIIDQELVNDLSALKQLAKDREFYIVNDDVDSMTWLVSLYSDTHSPQYWIWNRNHKKGQKLFSVNPSLDKYKLSAME
SIELRARDGLRLPSYLTRSTLNQSGPQPFVLLVHGGPQARDYWGLHSVHQLLANRGYHVLSVNYRGSTGFGKRHLLAGEG
QWYAAMQDDLVDAVQWAVDEGIADPKKIVIMGGSYGGYAALAGLTRDPELFAAAVDIVGPSNVETLLESIPPYWEPIRKP
WERMVGVGRVDLAAISPLTYANRIQRPLLIVHGANDVRVKLSESESIVAAMHSNNLPVDFIVFPDEGHGIEDPRNSLALY
AVIEKFLAKQLGGRFEPIGEAIQDSSMQWRSKSGAGGMINK
>Mature_681_residues
MRRFSLLRATLALQCLLTTIALPIRLSSPAFADTLPQREVPLIPREVLLGNPEVSGVTLSPDGKQIVFLAPHRGVLNLWA
QELEAGSKPRLLTNSTNRPTRPASWSVDGRYLITSRDSYGDENTVLIRIDPTTGEAIDLTPGKGVKAAIWGDDQDVPDEL
VIGLNDRDPRYHDLWVINLETGERRLLYEANDGHLVSVDWIDGDWQLVLRNRIQPDGGSTYDLRLPGQKGWKPFLSFSFE
ESQAGSAPLGFDRNATWLYGFLNIKDGLPCLVRWRTEALQSCKEDCPYELVYQSKSGTLGVELSDPKTHAPQILIETDLR
SRKIIIDQELVNDLSALKQLAKDREFYIVNDDVDSMTWLVSLYSDTHSPQYWIWNRNHKKGQKLFSVNPSLDKYKLSAME
SIELRARDGLRLPSYLTRSTLNQSGPQPFVLLVHGGPQARDYWGLHSVHQLLANRGYHVLSVNYRGSTGFGKRHLLAGEG
QWYAAMQDDLVDAVQWAVDEGIADPKKIVIMGGSYGGYAALAGLTRDPELFAAAVDIVGPSNVETLLESIPPYWEPIRKP
WERMVGVGRVDLAAISPLTYANRIQRPLLIVHGANDVRVKLSESESIVAAMHSNNLPVDFIVFPDEGHGIEDPRNSLALY
AVIEKFLAKQLGGRFEPIGEAIQDSSMQWRSKSGAGGMINK

Specific function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9C family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=219, Percent_Identity=27.8538812785388, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI194394146, Length=260, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=669, Percent_Identity=33.1838565022422, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI25144540, Length=446, Percent_Identity=36.5470852017937, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI25144543, Length=563, Percent_Identity=31.7939609236234, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17552908, Length=235, Percent_Identity=30.6382978723404, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI25149159, Length=234, Percent_Identity=27.3504273504274, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550825, Length=214, Percent_Identity=29.4392523364486, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553511, Length=214, Percent_Identity=29.4392523364486, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45551969, Length=214, Percent_Identity=29.4392523364486, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR001375
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.4.19.1 [H]

Molecular weight: Translated: 75959; Mature: 75959

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFSLLRATLALQCLLTTIALPIRLSSPAFADTLPQREVPLIPREVLLGNPEVSGVTLS
CCHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHCCCCCCCCCCCHHHHCCCCCCCEEEEC
PDGKQIVFLAPHRGVLNLWAQELEAGSKPRLLTNSTNRPTRPASWSVDGRYLITSRDSYG
CCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCC
DENTVLIRIDPTTGEAIDLTPGKGVKAAIWGDDQDVPDELVIGLNDRDPRYHDLWVINLE
CCCEEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEEEEEC
TGERRLLYEANDGHLVSVDWIDGDWQLVLRNRIQPDGGSTYDLRLPGQKGWKPFLSFSFE
CCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHEEEEC
ESQAGSAPLGFDRNATWLYGFLNIKDGLPCLVRWRTEALQSCKEDCPYELVYQSKSGTLG
CCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCEEE
VELSDPKTHAPQILIETDLRSRKIIIDQELVNDLSALKQLAKDREFYIVNDDVDSMTWLV
EEECCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
SLYSDTHSPQYWIWNRNHKKGQKLFSVNPSLDKYKLSAMESIELRARDGLRLPSYLTRST
HHHCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHEEEECCCCCCCCHHHHHHH
LNQSGPQPFVLLVHGGPQARDYWGLHSVHQLLANRGYHVLSVNYRGSTGFGKRHLLAGEG
HHCCCCCCEEEEEECCCCCCHHCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCC
QWYAAMQDDLVDAVQWAVDEGIADPKKIVIMGGSYGGYAALAGLTRDPELFAAAVDIVGP
CEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCHHHEEEEEEECCC
SNVETLLESIPPYWEPIRKPWERMVGVGRVDLAAISPLTYANRIQRPLLIVHGANDVRVK
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHCCCCEEEEECCCCEEEE
LSESESIVAAMHSNNLPVDFIVFPDEGHGIEDPRNSLALYAVIEKFLAKQLGGRFEPIGE
ECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
AIQDSSMQWRSKSGAGGMINK
HHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRFSLLRATLALQCLLTTIALPIRLSSPAFADTLPQREVPLIPREVLLGNPEVSGVTLS
CCHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHCCCCCCCCCCCHHHHCCCCCCCEEEEC
PDGKQIVFLAPHRGVLNLWAQELEAGSKPRLLTNSTNRPTRPASWSVDGRYLITSRDSYG
CCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCC
DENTVLIRIDPTTGEAIDLTPGKGVKAAIWGDDQDVPDELVIGLNDRDPRYHDLWVINLE
CCCEEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCEEEEEEEEEC
TGERRLLYEANDGHLVSVDWIDGDWQLVLRNRIQPDGGSTYDLRLPGQKGWKPFLSFSFE
CCCEEEEEECCCCEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHEEEEC
ESQAGSAPLGFDRNATWLYGFLNIKDGLPCLVRWRTEALQSCKEDCPYELVYQSKSGTLG
CCCCCCCCCCCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCEEE
VELSDPKTHAPQILIETDLRSRKIIIDQELVNDLSALKQLAKDREFYIVNDDVDSMTWLV
EEECCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHH
SLYSDTHSPQYWIWNRNHKKGQKLFSVNPSLDKYKLSAMESIELRARDGLRLPSYLTRST
HHHCCCCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHEEEECCCCCCCCHHHHHHH
LNQSGPQPFVLLVHGGPQARDYWGLHSVHQLLANRGYHVLSVNYRGSTGFGKRHLLAGEG
HHCCCCCCEEEEEECCCCCCHHCCHHHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCC
QWYAAMQDDLVDAVQWAVDEGIADPKKIVIMGGSYGGYAALAGLTRDPELFAAAVDIVGP
CEEEHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCHHHEEEEEEECCC
SNVETLLESIPPYWEPIRKPWERMVGVGRVDLAAISPLTYANRIQRPLLIVHGANDVRVK
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHCCCCEEEEECCCCEEEE
LSESESIVAAMHSNNLPVDFIVFPDEGHGIEDPRNSLALYAVIEKFLAKQLGGRFEPIGE
ECCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHH
AIQDSSMQWRSKSGAGGMINK
HHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966; 12037315 [H]