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The map label for this gene is cobW [H]

Identifier: 124023398

GI number: 124023398

Start: 1483276

End: 1484421

Strand: Direct

Name: cobW [H]

Synonym: P9303_16961

Alternate gene names: 124023398

Gene position: 1483276-1484421 (Clockwise)

Preceding gene: 124023397

Following gene: 124023403

Centisome position: 55.29

GC content: 51.31

Gene sequence:

>1146_bases
TTGATCCCCAACCCGCATAGGCCTGCCTTGATTTCAAAGCGTCTGCCCGTCACGGTTTTGACTGGTTTCCTTGGAGCTGG
AAAGACCACCCTGCTACGTCATCTGCTCACTCATGGGGGGCAGCGTTTAGCGGTCATGGTCAATGAATTTGGCACGATTG
GTCTTGATGGCGATTTAATCCGTAGCTGTGGCTTTTGTCCGGAGGAGGAGTTGGATGGTCGAGTCGTTGAGCTCAATAAC
GGTTGTCTCTGCTGCACAGTGCAGGAAGACTTTTTACCCACCATGGAGACCTTGCTGAAACAGGCGGATAAGTTGGATGG
AATTATCGTTGAAACCAGTGGACTTGCTCTTCCCCGCCCCCTCTTGAAAGCGCTCGACTGGCCTGCCGTACGCACTCGAG
TTTATGTGAATGGAGTGGTCACAATGGTGGATGGTGAAGCCCTCGCAGCGGGTAGCCCCGTTGGGGATCCTGCCGGGTTG
GAACGGCAGCGACAGGAGGATCCAAGCCTTGATCATCTCAGTGCTGTTGAAGACTTGTTCACTGATCAATTGGAAGCTGC
TGATTTGGTGTTGATCAGTCGAGCGGATGTTGTCTCCAATGTCGACCTCCGCAAGCTCAAGAGCGAACTTGCTGAACAGG
TACGCCTTGGCACGTCAATGATGCCCATCAGTCATGGCCAAGTTGATCCAGCTGTGGTATTGGGTCTCAGTACTGCAGAC
AATGGCTACCAACAAAAGAGCTCGCCTAAACAATTTGGCGATGACCTAATCGACGATACTTCCATTGATGTCGATCATCA
TGAAGATGATCATCATCATGACCACAACCATGTGGAGATGGTGAGTGGGAATGTACGTTTTGAAGGTTCTGTTGATCGGG
CTACGGTTGAAGCACTTCTGCCTGAGTTGGCAACACTTCATCAGGTTGTACGCCTAAAAGGTCGCTTATGGCTACCGGGC
AAAGCTTTACCCCTTCAGCTGCAGATGGTTGGCCCAAGGCTTAGCAGTTGGTTTGAGGCTGCTCCAGAGAACGCCTGGCA
TCCTGAGGAGGCGGGCGTTGATCTGGTGGTGCTTAGTTTTGAAGAGCAAGCAGCTGAAGCAATTCGCTTTGGTCTTGAAA
GCTCTTTGATGTCAGATATTGTCTAA

Upstream 100 bases:

>100_bases
CTGTGCTTGATCGTCGCCAGCAGAATGAGCTTTGCTCCAGAGCAAATGGCACCAATGCCGTTAGCGGCTCCAACACTATT
GACAGCCTTGGCTGTCGTTC

Downstream 100 bases:

>100_bases
GGGAAGTCAACTGATTAAGCAGCTCAAGAGCTGAGCGGGTGGTTATGGTTTGGCTTCTCTATCTTTCGGCTCTTGCATAG
TGCCGTTCATCCAGTAGTCA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIPNPHRPALISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNN
GCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGL
ERQRQEDPSLDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEQVRLGTSMMPISHGQVDPAVVLGLSTAD
NGYQQKSSPKQFGDDLIDDTSIDVDHHEDDHHHDHNHVEMVSGNVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPG
KALPLQLQMVGPRLSSWFEAAPENAWHPEEAGVDLVVLSFEEQAAEAIRFGLESSLMSDIV

Sequences:

>Translated_381_residues
MIPNPHRPALISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNN
GCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGL
ERQRQEDPSLDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEQVRLGTSMMPISHGQVDPAVVLGLSTAD
NGYQQKSSPKQFGDDLIDDTSIDVDHHEDDHHHDHNHVEMVSGNVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPG
KALPLQLQMVGPRLSSWFEAAPENAWHPEEAGVDLVVLSFEEQAAEAIRFGLESSLMSDIV
>Mature_381_residues
MIPNPHRPALISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLIRSCGFCPEEELDGRVVELNN
GCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRPLLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGL
ERQRQEDPSLDHLSAVEDLFTDQLEAADLVLISRADVVSNVDLRKLKSELAEQVRLGTSMMPISHGQVDPAVVLGLSTAD
NGYQQKSSPKQFGDDLIDDTSIDVDHHEDDHHHDHNHVEMVSGNVRFEGSVDRATVEALLPELATLHQVVRLKGRLWLPG
KALPLQLQMVGPRLSSWFEAAPENAWHPEEAGVDLVVLSFEEQAAEAIRFGLESSLMSDIV

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=323, Percent_Identity=30.3405572755418, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI126722884, Length=323, Percent_Identity=30.3405572755418, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI148727351, Length=323, Percent_Identity=30.030959752322, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI146231952, Length=231, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223941779, Length=200, Percent_Identity=34.5, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223941776, Length=312, Percent_Identity=29.4871794871795, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI119120938, Length=136, Percent_Identity=38.9705882352941, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI87082430, Length=360, Percent_Identity=27.2222222222222, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788499, Length=215, Percent_Identity=29.3023255813954, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=226, Percent_Identity=29.646017699115, Blast_Score=93, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 41501; Mature: 41501

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPNPHRPALISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLI
CCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
RSCGFCPEEELDGRVVELNNGCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRP
HHCCCCCCHHHCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHH
LLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPSLDHLSAVEDLF
HHHHCCCCHHHEEEEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHH
TDQLEAADLVLISRADVVSNVDLRKLKSELAEQVRLGTSMMPISHGQVDPAVVLGLSTAD
HHHHHHCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCC
NGYQQKSSPKQFGDDLIDDTSIDVDHHEDDHHHDHNHVEMVSGNVRFEGSVDRATVEALL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEECCCCHHHHHHHHH
PELATLHQVVRLKGRLWLPGKALPLQLQMVGPRLSSWFEAAPENAWHPEEAGVDLVVLSF
HHHHHHHHHHHHCCCEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEEC
EEQAAEAIRFGLESSLMSDIV
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPNPHRPALISKRLPVTVLTGFLGAGKTTLLRHLLTHGGQRLAVMVNEFGTIGLDGDLI
CCCCCCCCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
RSCGFCPEEELDGRVVELNNGCLCCTVQEDFLPTMETLLKQADKLDGIIVETSGLALPRP
HHCCCCCCHHHCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHH
LLKALDWPAVRTRVYVNGVVTMVDGEALAAGSPVGDPAGLERQRQEDPSLDHLSAVEDLF
HHHHCCCCHHHEEEEEEEEEEEECCCEEECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHH
TDQLEAADLVLISRADVVSNVDLRKLKSELAEQVRLGTSMMPISHGQVDPAVVLGLSTAD
HHHHHHCCEEEEECCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCC
NGYQQKSSPKQFGDDLIDDTSIDVDHHEDDHHHDHNHVEMVSGNVRFEGSVDRATVEALL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCEEECCCCHHHHHHHHH
PELATLHQVVRLKGRLWLPGKALPLQLQMVGPRLSSWFEAAPENAWHPEEAGVDLVVLSF
HHHHHHHHHHHHCCCEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEEEEC
EEQAAEAIRFGLESSLMSDIV
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]