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The map label for this gene is pgl [H]

Identifier: 124023390

GI number: 124023390

Start: 1477199

End: 1477909

Strand: Direct

Name: pgl [H]

Synonym: P9303_16881

Alternate gene names: 124023390

Gene position: 1477199-1477909 (Clockwise)

Preceding gene: 124023389

Following gene: 124023392

Centisome position: 55.06

GC content: 55.13

Gene sequence:

>711_bases
ATGACGACCTACAAAGTTGAGCGAGGGAGCGACCCTGAGGATCTTGCACGTCGTGCCGCCCAGAGAATCGCATCTCATAT
TGATCTGGTACTTGATCAGCGTGATCGCGTTCAGATTGCTCTCTCGGGAGGGACCACACCCGCTATTGCCTATAGGTTGC
TTGGTCAGGAGCGACTGCCCTGGGATCGTGTTGATGTTTTCCTGGGCGATGAGCGCTGGGTTGATGCCAGTGATGACGCC
AGTAACGCCCGCATGCTTCGTACGACACTTCTTGCTGAAGGCCCAGGATCGCAGGCTGCATTTCATCCCGTGCCAACGGT
GGAGCTGCCAGACCCTGAGGCCAGTGCCGAGGCCTACGCGAAGATCATTCAGGAAAGCTGTGCAGGTGATCCACCGGTAT
TTGATCTAATGGTTTTAGGACTTGGTGAAGATGGCCATACAGCCTCTCTTTTTCCAGGAACGGAAGCCCCCTCCGTTGTT
GATCGCTGGGCTACTGTCGGCAGAGGGAAGGGTCTAGAGAGAATCACTCTCACAGCTCCTGTGCTCAGCTCAGCACGCGA
AGTGATCTTTCTTGTAAGTGGTGTAGGGAAGCAACTTGCCCTGAAGAGGCTATTGGATTCTGCTGAATCAGCTGAACGCA
CGCCTGCCCGCTTGGTTCAACCTCGTTCACCGATTTTGGTCTTGGCAGATGAGGCCGCCTTACTCGGCTGA

Upstream 100 bases:

>100_bases
TTGGTGCAGGCCATGCGCGATTGCTTCGGCTCACATACCTACCAACGGGTTGACAAAGAAGGAACCTTCCATACTGAGTG
GCTGGACTGAGGAGATCGTG

Downstream 100 bases:

>100_bases
TGAAGGCCTCTTGACAAGTATTCTTGTTCATTATTACTTGCATTATCTTCCAGTATCTGCAAATATAAATTCATCAAAAA
TTGCAGATCAATTATTGTAT

Product: 6-phosphogluconolactonase (DevB, Pgl)

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTTYKVERGSDPEDLARRAAQRIASHIDLVLDQRDRVQIALSGGTTPAIAYRLLGQERLPWDRVDVFLGDERWVDASDDA
SNARMLRTTLLAEGPGSQAAFHPVPTVELPDPEASAEAYAKIIQESCAGDPPVFDLMVLGLGEDGHTASLFPGTEAPSVV
DRWATVGRGKGLERITLTAPVLSSAREVIFLVSGVGKQLALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG

Sequences:

>Translated_236_residues
MTTYKVERGSDPEDLARRAAQRIASHIDLVLDQRDRVQIALSGGTTPAIAYRLLGQERLPWDRVDVFLGDERWVDASDDA
SNARMLRTTLLAEGPGSQAAFHPVPTVELPDPEASAEAYAKIIQESCAGDPPVFDLMVLGLGEDGHTASLFPGTEAPSVV
DRWATVGRGKGLERITLTAPVLSSAREVIFLVSGVGKQLALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
>Mature_235_residues
TTYKVERGSDPEDLARRAAQRIASHIDLVLDQRDRVQIALSGGTTPAIAYRLLGQERLPWDRVDVFLGDERWVDASDDAS
NARMLRTTLLAEGPGSQAAFHPVPTVELPDPEASAEAYAKIIQESCAGDPPVFDLMVLGLGEDGHTASLFPGTEAPSVVD
RWATVGRGKGLERITLTAPVLSSAREVIFLVSGVGKQLALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=231, Percent_Identity=37.6623376623377, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI52145310, Length=239, Percent_Identity=30.9623430962343, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115533058, Length=243, Percent_Identity=30.4526748971193, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115533060, Length=243, Percent_Identity=30.4526748971193, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321687, Length=217, Percent_Identity=30.8755760368664, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324362, Length=198, Percent_Identity=29.7979797979798, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321957, Length=209, Percent_Identity=28.7081339712919, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319918, Length=188, Percent_Identity=29.7872340425532, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24641119, Length=231, Percent_Identity=29.4372294372294, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25356; Mature: 25225

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYKVERGSDPEDLARRAAQRIASHIDLVLDQRDRVQIALSGGTTPAIAYRLLGQERLP
CCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
WDRVDVFLGDERWVDASDDASNARMLRTTLLAEGPGSQAAFHPVPTVELPDPEASAEAYA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KIIQESCAGDPPVFDLMVLGLGEDGHTASLFPGTEAPSVVDRWATVGRGKGLERITLTAP
HHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEHH
VLSSAREVIFLVSGVGKQLALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
HHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCHHHCC
>Mature Secondary Structure 
TTYKVERGSDPEDLARRAAQRIASHIDLVLDQRDRVQIALSGGTTPAIAYRLLGQERLP
CCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCC
WDRVDVFLGDERWVDASDDASNARMLRTTLLAEGPGSQAAFHPVPTVELPDPEASAEAYA
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
KIIQESCAGDPPVFDLMVLGLGEDGHTASLFPGTEAPSVVDRWATVGRGKGLERITLTAP
HHHHHHHCCCCCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEHH
VLSSAREVIFLVSGVGKQLALKRLLDSAESAERTPARLVQPRSPILVLADEAALLG
HHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]