Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 124023389

GI number: 124023389

Start: 1475770

End: 1477188

Strand: Direct

Name: gnd [H]

Synonym: P9303_16871

Alternate gene names: 124023389

Gene position: 1475770-1477188 (Clockwise)

Preceding gene: 124023388

Following gene: 124023390

Centisome position: 55.01

GC content: 52.29

Gene sequence:

>1419_bases
ATGTCCAAGGCACATTTCGGTTTAATCGGTCTTGGCGTGATGGGTGAAAACCTAGTGCTCAATGCAGAGCGCAATGGTTT
CTCTAGTGTCGTTTACAACCGCACCTACGCCAAAACAGAGGAGTTCCTCAAAGGGCGTGGAGCTGACAAAGCCATTCAGG
GTGCCAAGGACCTTCAAGATTTCGTCGACAAGCTCGAACGACCCCGTCGAATTCTGATGATGATCAAGGCAGGTTCGGCT
ATTGATGCTGTTATTGAGCAGATCTCCCCTTATCTGCAGGAGGGTGATCTACTAATCGATGGTGGAAATTCTGAATTTCG
TGATACCGAGCGACGTGTCGCCGAGTTAGAGAGCAAAAGCTTTGGATATATCGGGATGGGTGTCTCCGGTGGAGCTAAGG
GGGCACTTGAAGGGCCGAGCATGATGCCTGGCGGAACGAAAACCTCCTATGAGGCGATTGAGAGCCTTGTTTGCAAGATG
GCTGCCCAAGTGGAGGATGGTCCCTGTGTGACCTACATCGGTCCTGGAGGTTCTGGGCATTTCGTTAAAACCGTCCACAA
CGGTATCGAGTACGGCATTGAGCAGATTCTTGCCGAGGCCTATGACCTAATGAAGCGCGTTGGTGGCATGACCGGTACCC
AGATGGCTGATGTCTTTGCGCATTGGAATGCCACAGAAGAGCTCACTTCTTATCTGGTTGAAATCACCGAAGTGTGTTTA
CGCACCAAGGATCCTGACGATGGAAGTGACCTTGTTGAGAAAATTTTGGATAAGGCAGGCCAAAAGGGAACTGGTCTATG
GACCGTTGTCAGTGCCTTGGAGTTAGGAGCCTCAGTGCCAACCATTTACGCCTCTCTGAATGGCCGTGTGATGAGCTCGA
TGAAGCCTCAAAGGATTGCCGCTGAGCAGATTTTGCATGGGTCAGCAATCAGACCATTTGATCTTGGTAGTTCCGCAGAT
GGCATGGCGCCGCTCATGGACGCCGTCGTGTTGTCTTGCATGGCTAGTTACGCGCAGGGCATGGAGCTACTGCGTATAGC
GTCTGCTGAATACAACTACAACTTGCATTTGCCCTCCATCGCGCAGATTTGGAAGGGTGGCTGCATCATCAGGTCCCGTC
TGCTGCAGCGCATCCAGGATGCCTTTAATGCTGACCCTCAGCTTTCCAATTTGTTGATCGATCCTTGGTTTGCCGAGCAA
GTGAACCGTCGCCTGCCGGGCCTAGCAAAGGTGGTAGCCGGCGCAGCTGAAGCCGGTATCCCAGTGCCTTGCTTCAGCAG
CACTCTCGATTACATCAATAGCTATCGCACGGCACGCTTACCCCAGAATTTGGTGCAGGCCATGCGCGATTGCTTCGGCT
CACATACCTACCAACGGGTTGACAAAGAAGGAACCTTCCATACTGAGTGGCTGGACTGA

Upstream 100 bases:

>100_bases
ATGTACAACGAGGATGGTTCAACCCTGACATAGCTGTACAGATCACAGCAGATTGGAGTTGCTGTGGTCACACTGACGCC
AGTTGATCATTTCACTGGCG

Downstream 100 bases:

>100_bases
GGAGATCGTGATGACGACCTACAAAGTTGAGCGAGGGAGCGACCCTGAGGATCTTGCACGTCGTGCCGCCCAGAGAATCG
CATCTCATATTGATCTGGTA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVYNRTYAKTEEFLKGRGADKAIQGAKDLQDFVDKLERPRRILMMIKAGSA
IDAVIEQISPYLQEGDLLIDGGNSEFRDTERRVAELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYEAIESLVCKM
AAQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVGGMTGTQMADVFAHWNATEELTSYLVEITEVCL
RTKDPDDGSDLVEKILDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKPQRIAAEQILHGSAIRPFDLGSSAD
GMAPLMDAVVLSCMASYAQGMELLRIASAEYNYNLHLPSIAQIWKGGCIIRSRLLQRIQDAFNADPQLSNLLIDPWFAEQ
VNRRLPGLAKVVAGAAEAGIPVPCFSSTLDYINSYRTARLPQNLVQAMRDCFGSHTYQRVDKEGTFHTEWLD

Sequences:

>Translated_472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVYNRTYAKTEEFLKGRGADKAIQGAKDLQDFVDKLERPRRILMMIKAGSA
IDAVIEQISPYLQEGDLLIDGGNSEFRDTERRVAELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYEAIESLVCKM
AAQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVGGMTGTQMADVFAHWNATEELTSYLVEITEVCL
RTKDPDDGSDLVEKILDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKPQRIAAEQILHGSAIRPFDLGSSAD
GMAPLMDAVVLSCMASYAQGMELLRIASAEYNYNLHLPSIAQIWKGGCIIRSRLLQRIQDAFNADPQLSNLLIDPWFAEQ
VNRRLPGLAKVVAGAAEAGIPVPCFSSTLDYINSYRTARLPQNLVQAMRDCFGSHTYQRVDKEGTFHTEWLD
>Mature_471_residues
SKAHFGLIGLGVMGENLVLNAERNGFSSVVYNRTYAKTEEFLKGRGADKAIQGAKDLQDFVDKLERPRRILMMIKAGSAI
DAVIEQISPYLQEGDLLIDGGNSEFRDTERRVAELESKSFGYIGMGVSGGAKGALEGPSMMPGGTKTSYEAIESLVCKMA
AQVEDGPCVTYIGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVGGMTGTQMADVFAHWNATEELTSYLVEITEVCLR
TKDPDDGSDLVEKILDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKPQRIAAEQILHGSAIRPFDLGSSADG
MAPLMDAVVLSCMASYAQGMELLRIASAEYNYNLHLPSIAQIWKGGCIIRSRLLQRIQDAFNADPQLSNLLIDPWFAEQV
NRRLPGLAKVVAGAAEAGIPVPCFSSTLDYINSYRTARLPQNLVQAMRDCFGSHTYQRVDKEGTFHTEWLD

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=46.1864406779661, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788341, Length=473, Percent_Identity=49.2600422832981, Blast_Score=467, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=43.4322033898305, Blast_Score=400, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321695, Length=469, Percent_Identity=45.2025586353945, Blast_Score=420, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=46.8131868131868, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24639279, Length=469, Percent_Identity=44.5628997867804, Blast_Score=398, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51299; Mature: 51168

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVYNRTYAKTEEFLKGRGADKAIQGAKDLQD
CCCCCCCEEEECCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
FVDKLERPRRILMMIKAGSAIDAVIEQISPYLQEGDLLIDGGNSEFRDTERRVAELESKS
HHHHHHCCHHEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKTSYEAIESLVCKMAAQVEDGPCVTYIGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVGGMTGTQMADVFAHWNATEELTSYLVEITEVCL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RTKDPDDGSDLVEKILDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKPQRIA
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHCCCHHHHH
AEQILHGSAIRPFDLGSSADGMAPLMDAVVLSCMASYAQGMELLRIASAEYNYNLHLPSI
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHH
AQIWKGGCIIRSRLLQRIQDAFNADPQLSNLLIDPWFAEQVNRRLPGLAKVVAGAAEAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
PVPCFSSTLDYINSYRTARLPQNLVQAMRDCFGSHTYQRVDKEGTFHTEWLD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCCCCEECCCCC
>Mature Secondary Structure 
SKAHFGLIGLGVMGENLVLNAERNGFSSVVYNRTYAKTEEFLKGRGADKAIQGAKDLQD
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
FVDKLERPRRILMMIKAGSAIDAVIEQISPYLQEGDLLIDGGNSEFRDTERRVAELESKS
HHHHHHCCHHEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKTSYEAIESLVCKMAAQVEDGPCVTYIGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVGGMTGTQMADVFAHWNATEELTSYLVEITEVCL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RTKDPDDGSDLVEKILDKAGQKGTGLWTVVSALELGASVPTIYASLNGRVMSSMKPQRIA
HCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHCCCHHHHCCCHHHHH
AEQILHGSAIRPFDLGSSADGMAPLMDAVVLSCMASYAQGMELLRIASAEYNYNLHLPSI
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHH
AQIWKGGCIIRSRLLQRIQDAFNADPQLSNLLIDPWFAEQVNRRLPGLAKVVAGAAEAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCC
PVPCFSSTLDYINSYRTARLPQNLVQAMRDCFGSHTYQRVDKEGTFHTEWLD
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]