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The map label for this gene is hemA

Identifier: 124023386

GI number: 124023386

Start: 1472861

End: 1474171

Strand: Direct

Name: hemA

Synonym: P9303_16841

Alternate gene names: 124023386

Gene position: 1472861-1474171 (Clockwise)

Preceding gene: 124023385

Following gene: 124023387

Centisome position: 54.9

GC content: 52.48

Gene sequence:

>1311_bases
ATGCACATTGCCGTCGTCGGCTTAAGTCATCGCACGGCGCCGGTGGAAATCCGTGAAAAGCTCAGCATCCCTGAGCAAAC
CATGGAGACCTCCCTGCAAACTCTTCGCGGCAACGATCAAGTCCTTGAGGTTTCGATCCTTAGCACCTGCAATCGGCTTG
AGATTTACACCTTGGTTCGTCATCCTGAACGAGGTATCTCAGCCATCAGTGATTTTCTAGGCCAACATTCTGGTTTGGCA
GCGGAAGATCTTTCCCCCCATCTGTTCAACTTTCATCACGATGAAGCAGTAGCCCACTTGATGAGGGTTGCTGCGGGTCT
GGACAGTCTGGTTTTAGGAGAAGGGCAGATCCTTTCCCAGGTGAAGAAGATGGTGCGATTGGGGCAGGAGCACAAATCCA
TGGGCCCGATTCTTAACCGTCTGCTCACTCAGGCAGTGAGTACTGGCAAACGAGTTCGCAGTGAAACCAATCTGGGTACG
GGGGCTGTCTCAATTAGTTCTGCGGCGGTGGAGTTAGCCCAACTGAAACTTGGCCAGGCGCAAGGGGAAGATCAGTTGAT
GACTCTGGAATCTGAGTTGGTCGCAGTGGTGGGTGCGGGCCGGATGAGCCGACTACTGCTTCAACATCTTCAGGCGAAAG
GTTGTTCTGGGGTGATGTTGCTGAACCGCACGCGGCAAAGAGCTGAGGATCTATCGGCTGATTTCCCTGAGCTCCCCGTT
GAGTGTCGACCCCTTGATGATTTGAACCATTGTCTAAGTACCTGTTCACTGGTATTTACCAGTACGGCTGCTGACGATCC
GATTGTTGATGCATCTCTGCTCAAGCAGCTCAAGCGCCGCAGTTTTCTTCGTCTGATTGACATCGGCGTGCCGCGCAACA
TCGCCTCAGATGTTGTCGATTTACCCGGTGTTGAGTCCCATGATGTGGATGATTTGCATGAGGTGGTGTCTCGTAATCAG
GAGGCCCGCCAACAGATGGCCAAAGAAGCAGAGGTTGTGCTCCAGGAAGAGACGCGTCTATTTTTAGAGTGGTGGGACAG
TCTGGAAGCTGTGCCAACCATTAATCGCTTGAGGGCAACCCTTGAGGCGATTCGTGCAGAGGAATTACAAAAAGCGCTCA
GTCGTATGGGGCCTGATTTCTCTGCTCGTGAGCGCAAAGTAGTTGAGGCTTTAAGCAAAGGAATCATTAACAAAATTCTC
CATACCCCCGTCACTCAGCTACGCGCTCCTCAGGCTCGTCAAGAGCGGCAACAGGCTCTGCGTGTGGTGGCGTGTTTGTT
TGAGTTAGATCCACCACTAGAGGATGGTTAG

Upstream 100 bases:

>100_bases
GACAACACAGCTCGGTTTACCAATACCGTGCATATCAAGGATGGAGCTAAGAGCATCGCTCTTAGCTAACCATCCAAGAC
AAGATCTAAGGGACGTCTCC

Downstream 100 bases:

>100_bases
TTCTATGCCAAATGCTGGTTGCGTCTTGATTTGCAGAAGTCTTGTTGGATCTTCGCAGCAGACAGCTTTAGAAGATGGCC
AACCGTCCGGTAGGTTTGCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQVLEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
AEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDLPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARQERQQALRVVACLFELDPPLEDG

Sequences:

>Translated_436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQVLEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
AEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDLPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARQERQQALRVVACLFELDPPLEDG
>Mature_436_residues
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQVLEVSILSTCNRLEIYTLVRHPERGISAISDFLGQHSGLA
AEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQVKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGT
GAVSISSAAVELAQLKLGQAQGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVDLPGVESHDVDDLHEVVSRNQ
EARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRATLEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKIL
HTPVTQLRAPQARQERQQALRVVACLFELDPPLEDG

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=429, Percent_Identity=33.7995337995338, Blast_Score=205, Evalue=6e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PROM3 (A2CAB8)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017693.1
- ProteinModelPortal:   A2CAB8
- STRING:   A2CAB8
- GeneID:   4777406
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_16841
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48167; Mature: 48167

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQVLEVSILSTCNRLEIYTLVR
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHH
HPERGISAISDFLGQHSGLAAEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHH
VKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
QGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
LPGVESHDVDDLHEVVSRNQEARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRAT
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTQLRAPQARQERQQAL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
RVVACLFELDPPLEDG
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHIAVVGLSHRTAPVEIREKLSIPEQTMETSLQTLRGNDQVLEVSILSTCNRLEIYTLVR
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHH
HPERGISAISDFLGQHSGLAAEDLSPHLFNFHHDEAVAHLMRVAAGLDSLVLGEGQILSQ
CCCHHHHHHHHHHHCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHCCCCHHHHH
VKKMVRLGQEHKSMGPILNRLLTQAVSTGKRVRSETNLGTGAVSISSAAVELAQLKLGQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
QGEDQLMTLESELVAVVGAGRMSRLLLQHLQAKGCSGVMLLNRTRQRAEDLSADFPELPV
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
ECRPLDDLNHCLSTCSLVFTSTAADDPIVDASLLKQLKRRSFLRLIDIGVPRNIASDVVD
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
LPGVESHDVDDLHEVVSRNQEARQQMAKEAEVVLQEETRLFLEWWDSLEAVPTINRLRAT
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEAIRAEELQKALSRMGPDFSARERKVVEALSKGIINKILHTPVTQLRAPQARQERQQAL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHH
RVVACLFELDPPLEDG
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA