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The map label for this gene is cumB [H]

Identifier: 124023348

GI number: 124023348

Start: 1439421

End: 1439912

Strand: Reverse

Name: cumB [H]

Synonym: P9303_16461

Alternate gene names: 124023348

Gene position: 1439912-1439421 (Counterclockwise)

Preceding gene: 124023350

Following gene: 124023346

Centisome position: 53.67

GC content: 55.89

Gene sequence:

>492_bases
ATGCAATGCCGCTGTTGGATGTTGCGGCTACTGACTCGAGCAAAACAACTCGGCGGTCTTGGAGAAGTTCCTGTGAGTGC
CGTAGTACTGGATGCCGACGGCCGCTGTATCGGCCATGGCAGCAACCAAAGGCATCGAGGACGTGATCCATTAGGCCATG
CAGAACTGATCGCACTCCGACAGGCGGCCTGGCTCAGAAGTGATTGGCGATTTAATGACTGCACCCTGATTGTCACTCTG
GAACCCTGCCCGATGTGCGCGGGAGCCCTAACACAAGCGCGCATGGGCCAGGTGATCTTTGCTGCACACGACCCCAAGCG
AGGCGGGCTTGGTAGCACAATCAATCTGGGGGACCACCCCAGTGCGCATCATAAAATGCGTGTTCTAGGCGGTGTGATGG
AAGTTGAAGCCAGGCAGCAGCTAGAAGCCTGGTTCAAGCAGCAACGGCAACGTTTTCACGAAAACGAGGTAACTCTGACT
CGAACAGATTGA

Upstream 100 bases:

>100_bases
ACGCTCGTCATACAAGTTCCATTCTCCCTCCTGATGGCATTGTTTGATCAGGAGCTGCCACTTAGCGGTGCCTTTAGCGA
AACCTGTTGAACTAACCAAC

Downstream 100 bases:

>100_bases
GCAACAGCTCAACGTTTTTAGGGGTGGAGTTGTATCCCATCAAGCCAATCCTCCAGATTTTGCCAGCCAGGCTTCCTAAG
CCGCCGCCGATTTCAATGCC

Product: cytidine/deoxycytidylate deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MQCRCWMLRLLTRAKQLGGLGEVPVSAVVLDADGRCIGHGSNQRHRGRDPLGHAELIALRQAAWLRSDWRFNDCTLIVTL
EPCPMCAGALTQARMGQVIFAAHDPKRGGLGSTINLGDHPSAHHKMRVLGGVMEVEARQQLEAWFKQQRQRFHENEVTLT
RTD

Sequences:

>Translated_163_residues
MQCRCWMLRLLTRAKQLGGLGEVPVSAVVLDADGRCIGHGSNQRHRGRDPLGHAELIALRQAAWLRSDWRFNDCTLIVTL
EPCPMCAGALTQARMGQVIFAAHDPKRGGLGSTINLGDHPSAHHKMRVLGGVMEVEARQQLEAWFKQQRQRFHENEVTLT
RTD
>Mature_163_residues
MQCRCWMLRLLTRAKQLGGLGEVPVSAVVLDADGRCIGHGSNQRHRGRDPLGHAELIALRQAAWLRSDWRFNDCTLIVTL
EPCPMCAGALTQARMGQVIFAAHDPKRGGLGSTINLGDHPSAHHKMRVLGGVMEVEARQQLEAWFKQQRQRFHENEVTLT
RTD

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=160, Percent_Identity=28.125, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI145693172, Length=158, Percent_Identity=39.2405063291139, Blast_Score=115, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 18242; Mature: 18242

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCRCWMLRLLTRAKQLGGLGEVPVSAVVLDADGRCIGHGSNQRHRGRDPLGHAELIALR
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHH
QAAWLRSDWRFNDCTLIVTLEPCPMCAGALTQARMGQVIFAAHDPKRGGLGSTINLGDHP
HHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCC
SAHHKMRVLGGVMEVEARQQLEAWFKQQRQRFHENEVTLTRTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MQCRCWMLRLLTRAKQLGGLGEVPVSAVVLDADGRCIGHGSNQRHRGRDPLGHAELIALR
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHH
QAAWLRSDWRFNDCTLIVTLEPCPMCAGALTQARMGQVIFAAHDPKRGGLGSTINLGDHP
HHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEECCCCC
SAHHKMRVLGGVMEVEARQQLEAWFKQQRQRFHENEVTLTRTD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]