Click here to switch to the map view.

The map label for this gene is nadA

Identifier: 124023265

GI number: 124023265

Start: 1363089

End: 1364090

Strand: Direct

Name: nadA

Synonym: P9303_15631

Alternate gene names: 124023265

Gene position: 1363089-1364090 (Clockwise)

Preceding gene: 124023261

Following gene: 124023268

Centisome position: 50.81

GC content: 46.51

Gene sequence:

>1002_bases
ATGGTCCGAATGACCGCTGTTTGCACCGCCAAGACGGTCTCTCCAGTGCCATCAACTAGAAAAGAATTCAAGGGTGCCAT
TGCTGAGCTACGCAAAAAACTCAATGCCGTGATCCTGGCTCACTACTACCAGGATCCAGAGATACAAGACATCGCCGATT
TCATTGGCGACTCCCTGGAACTCTCACGTAGAGCTGCTAGCACAAATGCTGATGTGATCGTGTTCTGCGGGGTGCACTTC
ATGGCAGAAACAGCAAAGATTCTCAGCCCGGAAAAAATTGTATTGCTACCGGATCTCGAAGCGGGGTGCTCCCTTGCTGA
TGACTGCCCTGCCGATGAGTTTGCTGCTTTCAGAGACAAGCACCCAGACCACATTGTGGTGAGCTATATCAACTGCACAG
CTGCTGTTAAAGCCCAAAGCGATCTGATCTGCACGAGTAGCAATGCTGTAGCTCTTGTAAGCCAATTACCAAAGGATCGA
CCGATCCTATTTGCACCGGATCAAAACCTGGGAAGGTGGGTTCAAAAGCAGAGCGGAAGAGAACTGACGATCTGGCCTGG
ACGCTGCATGGTGCATGAAACATTCAGCGAAGAAGCTCTGCTAAAACTAAAAATGATGCACCCCGAAGCTAAAGTAATAG
CTCATCCGGAGTGCCTAGAAAGGCTACTAGAATTAGCGGATTATGTTGGCTCTACCAGCAAATTACTTGAATATACAGAA
ACAAACCCTGGCACAAAGTTTATCGTACTAACAGAGCCAGGCATCCTGCACCAGATGAAACAGAGGATGCCAAACAAAGA
ATTTATGGATGTTCCAGGTATTGACGGTTGCAGCTGCAATGAATGCCCTTATATGAGACTAAATACACTAGAAAAACTCT
GGAGATGCTTAAGCACAATGAAGCCATCAATAGAAATTGAAGAGGGAGTACGTCAAAAGGCGCTTATTCCGATTCAACGC
ATGTTAAACATGAAAGAAAAACAGGAGGCTAGTCAACATTAA

Upstream 100 bases:

>100_bases
ATACTGATCATCAGGAGTCCATACACCATGGAGATCTCCAACGATGGCGAGGCTCTGGTGTGACAGGGCAAATGTCTAGG
CTATGGCCATACTGCCCTAG

Downstream 100 bases:

>100_bases
TTATTCGATATCGAGTTGAAAATCAACACAACAAGAGACAGCCATGAAAGAAAGTTCTTACAGATTTTAAAATAGGTTGG
GCAAAACTAAAAAATTCAGT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVRMTAVCTAKTVSPVPSTRKEFKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLELSRRAASTNADVIVFCGVHF
MAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDKHPDHIVVSYINCTAAVKAQSDLICTSSNAVALVSQLPKDR
PILFAPDQNLGRWVQKQSGRELTIWPGRCMVHETFSEEALLKLKMMHPEAKVIAHPECLERLLELADYVGSTSKLLEYTE
TNPGTKFIVLTEPGILHQMKQRMPNKEFMDVPGIDGCSCNECPYMRLNTLEKLWRCLSTMKPSIEIEEGVRQKALIPIQR
MLNMKEKQEASQH

Sequences:

>Translated_333_residues
MVRMTAVCTAKTVSPVPSTRKEFKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLELSRRAASTNADVIVFCGVHF
MAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDKHPDHIVVSYINCTAAVKAQSDLICTSSNAVALVSQLPKDR
PILFAPDQNLGRWVQKQSGRELTIWPGRCMVHETFSEEALLKLKMMHPEAKVIAHPECLERLLELADYVGSTSKLLEYTE
TNPGTKFIVLTEPGILHQMKQRMPNKEFMDVPGIDGCSCNECPYMRLNTLEKLWRCLSTMKPSIEIEEGVRQKALIPIQR
MLNMKEKQEASQH
>Mature_333_residues
MVRMTAVCTAKTVSPVPSTRKEFKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLELSRRAASTNADVIVFCGVHF
MAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDKHPDHIVVSYINCTAAVKAQSDLICTSSNAVALVSQLPKDR
PILFAPDQNLGRWVQKQSGRELTIWPGRCMVHETFSEEALLKLKMMHPEAKVIAHPECLERLLELADYVGSTSKLLEYTE
TNPGTKFIVLTEPGILHQMKQRMPNKEFMDVPGIDGCSCNECPYMRLNTLEKLWRCLSTMKPSIEIEEGVRQKALIPIQR
MLNMKEKQEASQH

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=313, Percent_Identity=43.4504792332268, Blast_Score=268, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_PROM3 (A2C9Z7)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017572.1
- STRING:   A2C9Z7
- GeneID:   4776050
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_15631
- eggNOG:   COG0379
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 37300; Mature: 37300

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: BINDING 41-41 BINDING 58-58 BINDING 129-129 BINDING 146-146 BINDING 215-215 BINDING 232-232

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRMTAVCTAKTVSPVPSTRKEFKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLE
CEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCHHH
LSRRAASTNADVIVFCGVHFMAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDK
HHHHHCCCCCCEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCC
HPDHIVVSYINCTAAVKAQSDLICTSSNAVALVSQLPKDRPILFAPDQNLGRWVQKQSGR
CCCEEEEEEEEEEEEEECCCCEEEECCCCHHHHHHCCCCCCEEECCCCHHHHHHHHCCCC
ELTIWPGRCMVHETFSEEALLKLKMMHPEAKVIAHPECLERLLELADYVGSTSKLLEYTE
EEEEECCCEEEEHHCCHHHHHHHHHCCCCHHEEECHHHHHHHHHHHHHHCCHHHHHHHHC
TNPGTKFIVLTEPGILHQMKQRMPNKEFMDVPGIDGCSCNECPYMRLNTLEKLWRCLSTM
CCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
KPSIEIEEGVRQKALIPIQRMLNMKEKQEASQH
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MVRMTAVCTAKTVSPVPSTRKEFKGAIAELRKKLNAVILAHYYQDPEIQDIADFIGDSLE
CEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCHHH
LSRRAASTNADVIVFCGVHFMAETAKILSPEKIVLLPDLEAGCSLADDCPADEFAAFRDK
HHHHHCCCCCCEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCC
HPDHIVVSYINCTAAVKAQSDLICTSSNAVALVSQLPKDRPILFAPDQNLGRWVQKQSGR
CCCEEEEEEEEEEEEEECCCCEEEECCCCHHHHHHCCCCCCEEECCCCHHHHHHHHCCCC
ELTIWPGRCMVHETFSEEALLKLKMMHPEAKVIAHPECLERLLELADYVGSTSKLLEYTE
EEEEECCCEEEEHHCCHHHHHHHHHCCCCHHEEECHHHHHHHHHHHHHHCCHHHHHHHHC
TNPGTKFIVLTEPGILHQMKQRMPNKEFMDVPGIDGCSCNECPYMRLNTLEKLWRCLSTM
CCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
KPSIEIEEGVRQKALIPIQRMLNMKEKQEASQH
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA