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The map label for this gene is aroB

Identifier: 124023259

GI number: 124023259

Start: 1356858

End: 1357976

Strand: Direct

Name: aroB

Synonym: P9303_15571

Alternate gene names: 124023259

Gene position: 1356858-1357976 (Clockwise)

Preceding gene: 124023256

Following gene: 124023261

Centisome position: 50.58

GC content: 53.62

Gene sequence:

>1119_bases
ATGTCCGCTTTCGTGAATATCGACGCCCAACGCATCCCCGTAGCACTGAGCCACCAGCCCTACGAGGTGGTCATTGGGGG
TGAAGGCTTGCGGGGTGTTGGGAAGGAGCTTCGCCGTGCTGGGCTGAAAGAGGGCATCAAGGTATTGGTTGTAAGCAATG
CTGATGTTGCTGAACCATATGGTGATCTTTGCCTCCAAAGCCTTAGTGACAGCGGGTACAGGCCCACTCTGCTGGTGATC
GAGGCCGGAGAAGATCAAAAGACGCCAGTGAGCGTGGCGTTAATTCACGATGCAGCCTATGAAGCAAAGCTAGAAAGAGG
ATCCTTGATGGTTGCTCTTGGCGGTGGGGTCGTGGGCGACATGACTGGATTTGCAGCAGCCACTTGGCTAAGAGGTATCT
CGGTGGTGCAACTTCCTACAACCCTTCTGGCAATGGTGGATGCCGCGATTGGTGGCAAGACAGGCGTTAATCACCCGGGC
GGGAAAAATCTGATCGGAGCATTTCACCAACCAAGGCTTGTATTAATCGATCCCTCAACTCTGAATACATTGCCGGAACG
TGAATTCCGGGCAGGGATGGCCGAGGTGATCAAATACGGGGTGATCGGTGATGCAGCACTTTTTCAACTCCTAGAAGGCA
TTCCAGAACTGAACACACCATCACAACTCCATGCAGACCTACTGGAGAAAATTCTCGAACGTTCAGCACTCGCGAAGTCG
AGAGTGGTGAGCTCAGATGAACGAGAGGGCGGGCTGCGCGCCATCCTTAACTACGGGCACACCTTCGGGCATGTGGTGGA
AACCCTCTGCGGCTATGGAACCTGGCTGCATGGTGAAGCTGTCGCCATCGGCATGGTGGCTGTTGGGGAGCTGGCGGTGT
TGCGACAGAGCTGGAACAGGGATGATGCCAACAGGCAAAAGTCTCTGATCGCAAAGGCAGGGCTGCCGATTGCTTGGCCC
AAGCTTGATCCAGAGGAGGTGCTGTATACCCTGCAAGGGGATAAAAAGGTCAAAGATGGAAAGCTTCGCTTTGTGATTCC
CACCGGCATTGGCAACGTCGAAATCAAAAATGACGTAAGCAGAGAAGAAATCCGAAAATGCCTATCAGAGCTCAGCTAA

Upstream 100 bases:

>100_bases
ACAGAGGGCCAGCCATCACCACAATGCCTGTACTGACAGGAGATTACGTGGGAGCGTTTGATGCCACCCGGCAAACTGAG
ATCAGCAGACTTGCTCTTTC

Downstream 100 bases:

>100_bases
CTGGTTCCTCTAGGAACCGGCAGCGAAGTTCACCGACCTTGGCCTCAACAGAAGGTTTGGGCCTCAACTCAAATGCCAAC
CAACGAAACTCTCCCAAACC

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSAFVNIDAQRIPVALSHQPYEVVIGGEGLRGVGKELRRAGLKEGIKVLVVSNADVAEPYGDLCLQSLSDSGYRPTLLVI
EAGEDQKTPVSVALIHDAAYEAKLERGSLMVALGGGVVGDMTGFAAATWLRGISVVQLPTTLLAMVDAAIGGKTGVNHPG
GKNLIGAFHQPRLVLIDPSTLNTLPEREFRAGMAEVIKYGVIGDAALFQLLEGIPELNTPSQLHADLLEKILERSALAKS
RVVSSDEREGGLRAILNYGHTFGHVVETLCGYGTWLHGEAVAIGMVAVGELAVLRQSWNRDDANRQKSLIAKAGLPIAWP
KLDPEEVLYTLQGDKKVKDGKLRFVIPTGIGNVEIKNDVSREEIRKCLSELS

Sequences:

>Translated_372_residues
MSAFVNIDAQRIPVALSHQPYEVVIGGEGLRGVGKELRRAGLKEGIKVLVVSNADVAEPYGDLCLQSLSDSGYRPTLLVI
EAGEDQKTPVSVALIHDAAYEAKLERGSLMVALGGGVVGDMTGFAAATWLRGISVVQLPTTLLAMVDAAIGGKTGVNHPG
GKNLIGAFHQPRLVLIDPSTLNTLPEREFRAGMAEVIKYGVIGDAALFQLLEGIPELNTPSQLHADLLEKILERSALAKS
RVVSSDEREGGLRAILNYGHTFGHVVETLCGYGTWLHGEAVAIGMVAVGELAVLRQSWNRDDANRQKSLIAKAGLPIAWP
KLDPEEVLYTLQGDKKVKDGKLRFVIPTGIGNVEIKNDVSREEIRKCLSELS
>Mature_371_residues
SAFVNIDAQRIPVALSHQPYEVVIGGEGLRGVGKELRRAGLKEGIKVLVVSNADVAEPYGDLCLQSLSDSGYRPTLLVIE
AGEDQKTPVSVALIHDAAYEAKLERGSLMVALGGGVVGDMTGFAAATWLRGISVVQLPTTLLAMVDAAIGGKTGVNHPGG
KNLIGAFHQPRLVLIDPSTLNTLPEREFRAGMAEVIKYGVIGDAALFQLLEGIPELNTPSQLHADLLEKILERSALAKSR
VVSSDEREGGLRAILNYGHTFGHVVETLCGYGTWLHGEAVAIGMVAVGELAVLRQSWNRDDANRQKSLIAKAGLPIAWPK
LDPEEVLYTLQGDKKVKDGKLRFVIPTGIGNVEIKNDVSREEIRKCLSELS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family

Homologues:

Organism=Escherichia coli, GI1789791, Length=362, Percent_Identity=40.6077348066298, Blast_Score=247, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6320332, Length=337, Percent_Identity=38.5756676557863, Blast_Score=189, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROB_PROM3 (A2C9Z1)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001017566.1
- ProteinModelPortal:   A2C9Z1
- SMR:   A2C9Z1
- STRING:   A2C9Z1
- GeneID:   4776024
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_15571
- eggNOG:   COG0337
- HOGENOM:   HBG632303
- OMA:   GWIDESI
- ProtClustDB:   PRK00002
- GO:   GO:0005737
- HAMAP:   MF_00110
- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037
- PANTHER:   PTHR21090:SF1
- PIRSF:   PIRSF001455
- TIGRFAMs:   TIGR01357

Pfam domain/function: PF01761 DHQ_synthase

EC number: =4.2.3.4

Molecular weight: Translated: 39877; Mature: 39746

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFVNIDAQRIPVALSHQPYEVVIGGEGLRGVGKELRRAGLKEGIKVLVVSNADVAEPY
CCCEEECCHHHCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
GDLCLQSLSDSGYRPTLLVIEAGEDQKTPVSVALIHDAAYEAKLERGSLMVALGGGVVGD
HHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEECCCCHHH
MTGFAAATWLRGISVVQLPTTLLAMVDAAIGGKTGVNHPGGKNLIGAFHQPRLVLIDPST
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCEEEEECCHH
LNTLPEREFRAGMAEVIKYGVIGDAALFQLLEGIPELNTPSQLHADLLEKILERSALAKS
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RVVSSDEREGGLRAILNYGHTFGHVVETLCGYGTWLHGEAVAIGMVAVGELAVLRQSWNR
HHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHEEHHHHHHHHHHHHHHCCC
DDANRQKSLIAKAGLPIAWPKLDPEEVLYTLQGDKKVKDGKLRFVIPTGIGNVEIKNDVS
CCHHHHHHHHHHCCCCEECCCCCHHHHEEEECCCCEECCCEEEEEEECCCCCEEECCCCC
REEIRKCLSELS
HHHHHHHHHHCC
>Mature Secondary Structure 
SAFVNIDAQRIPVALSHQPYEVVIGGEGLRGVGKELRRAGLKEGIKVLVVSNADVAEPY
CCEEECCHHHCCEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
GDLCLQSLSDSGYRPTLLVIEAGEDQKTPVSVALIHDAAYEAKLERGSLMVALGGGVVGD
HHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEECCCCHHH
MTGFAAATWLRGISVVQLPTTLLAMVDAAIGGKTGVNHPGGKNLIGAFHQPRLVLIDPST
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCEEEEECCHH
LNTLPEREFRAGMAEVIKYGVIGDAALFQLLEGIPELNTPSQLHADLLEKILERSALAKS
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RVVSSDEREGGLRAILNYGHTFGHVVETLCGYGTWLHGEAVAIGMVAVGELAVLRQSWNR
HHCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHEEHHHHHHHHHHHHHHCCC
DDANRQKSLIAKAGLPIAWPKLDPEEVLYTLQGDKKVKDGKLRFVIPTGIGNVEIKNDVS
CCHHHHHHHHHHCCCCEECCCCCHHHHEEEECCCCEECCCEEEEEEECCCCCEEECCCCC
REEIRKCLSELS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA