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The map label for this gene is purK [H]

Identifier: 124023257

GI number: 124023257

Start: 1354626

End: 1355837

Strand: Reverse

Name: purK [H]

Synonym: P9303_15551

Alternate gene names: 124023257

Gene position: 1355837-1354626 (Counterclockwise)

Preceding gene: 124023258

Following gene: 124023253

Centisome position: 50.54

GC content: 52.06

Gene sequence:

>1212_bases
TTGCAGGATTGCGTGATTGATTCTCTCTGCATGAGCAGCGTTACAAGCCCAATGATTGGGGTCGTCGGTGGTGGTCAGTT
GGCTCAGATGTTGGCGCAAGCAGCAAAAAGACGCGCTGTGGATGTTGTCGTGCAGTCGGGATCGGCAATCGATCCCGCTG
CTGTTGAAGCAACTCGACTTGTTTTGGCTGACCCAGTCGATGTAGAAGCTACTAGCAAGCTCGTGCAGGGCTGTTGTGGC
GTCACGTTTGAGAACGAATGGGTCGATATTGAAGCTCTGATTCCCCTTGAACAACAAGGGGTGTGTTTTTCTCCGTCTCT
TACTGCGCTTGCTCCATTGGTCGACAAAATCTCGCAGCGTCAGTTGCTTCGTGAGCTTGATCTTCCTAGCCCTGATTGGA
CTTTGCTGAGTTCGATTTCTTTTGATCAGCCCGAGCTTCCTACGGAGTGGAACTTTCCGGTGATGGCCAAGTCAAGCCGG
TGGGGATATGACGGCAAAGGAACCAAGGTTCTCAAGAGTGTCGAGGATTTGTCGCAACTTCAGCGCTCAGTGGATCCAAC
TCAATGGCTGCTTGAGAGCTGGGTGCCGTTCGAAAAGGAATTAGCCATTGTTGTTAGTCGAGATGCTCAGGGCCGTGTTC
GTAGCCTGCCACTTGCTGAGACTCATCAGTTCCAACAGGTGTGTGATTGGGTGATAGCACCTGCGAGTGTTGATCATGCT
GTGGAAATGATGGCCTACAACATGGCAGCGTCTCTTCTAACAGAGCTCAATTACGTGGGCGTGCTTGCTGTTGAATTTTT
CTACGGACCAGAGGGACTGCAGGTCAATGAAGTTGCACCTCGCACTCACAATTCCGCACATTTTTCGATCGAAGCCTGCA
GCAGCAGCCAGTTTGATCAACAACTTTGTATCGCGGCGGGCTTGCCAGTGCCTGCAACCGATCTCCATGCACCTGGCGCC
TTAATGGTGAACCTTCTAGGTTTGCAAAAAGGGGTTGAGCCCTCTCTAGATGAGCGCCTAGCGAAGCTGCGTAGTTGTGA
TCGCTTCCATTTGCACTGGTATGGAAAAGATTGTGAAACTCCAGGACGCAAGCTCGGTCATGTGACCGTGCTGCTTCATG
GTGTTGATGCGCCCAGCCGTCAGCTCGAGGCGGAAACTGCCTTAAAGCATATTCGCTCAATCTGGCCGACGCAGGACACC
GTTTGCGCTTAA

Upstream 100 bases:

>100_bases
GGCGCTTTTCCTTTTGGTCTTGTTGCTCACTGCTGTGCGTTTGACCTTCGCTGGCGATCAGGGCTTGCTCTGAAATCTCA
ATTTTGTTGGGATGCAATGC

Downstream 100 bases:

>100_bases
ATTCTGTTTGAACTGCTGTGTTGGTGACGGCCTTTTTCTAGTGCTCTGATCTGACTCTCTTTCGATTTGGGGAGGCTGTC
GTGAAGGTGACGTAGACCGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQDCVIDSLCMSSVTSPMIGVVGGGQLAQMLAQAAKRRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATSKLVQGCCG
VTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRELDLPSPDWTLLSSISFDQPELPTEWNFPVMAKSSR
WGYDGKGTKVLKSVEDLSQLQRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHA
VEMMAYNMAASLLTELNYVGVLAVEFFYGPEGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPATDLHAPGA
LMVNLLGLQKGVEPSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLHGVDAPSRQLEAETALKHIRSIWPTQDT
VCA

Sequences:

>Translated_403_residues
MQDCVIDSLCMSSVTSPMIGVVGGGQLAQMLAQAAKRRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATSKLVQGCCG
VTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRELDLPSPDWTLLSSISFDQPELPTEWNFPVMAKSSR
WGYDGKGTKVLKSVEDLSQLQRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHA
VEMMAYNMAASLLTELNYVGVLAVEFFYGPEGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPATDLHAPGA
LMVNLLGLQKGVEPSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLHGVDAPSRQLEAETALKHIRSIWPTQDT
VCA
>Mature_403_residues
MQDCVIDSLCMSSVTSPMIGVVGGGQLAQMLAQAAKRRAVDVVVQSGSAIDPAAVEATRLVLADPVDVEATSKLVQGCCG
VTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQRQLLRELDLPSPDWTLLSSISFDQPELPTEWNFPVMAKSSR
WGYDGKGTKVLKSVEDLSQLQRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHA
VEMMAYNMAASLLTELNYVGVLAVEFFYGPEGLQVNEVAPRTHNSAHFSIEACSSSQFDQQLCIAAGLPVPATDLHAPGA
LMVNLLGLQKGVEPSLDERLAKLRSCDRFHLHWYGKDCETPGRKLGHVTVLLHGVDAPSRQLEAETALKHIRSIWPTQDT
VCA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=353, Percent_Identity=29.7450424929178, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=412, Percent_Identity=29.126213592233, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 44021; Mature: 44021

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDCVIDSLCMSSVTSPMIGVVGGGQLAQMLAQAAKRRAVDVVVQSGSAIDPAAVEATRL
CCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHEE
VLADPVDVEATSKLVQGCCGVTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQR
EEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHH
QLLRELDLPSPDWTLLSSISFDQPELPTEWNFPVMAKSSRWGYDGKGTKVLKSVEDLSQL
HHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
QRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHA
HHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHH
VEMMAYNMAASLLTELNYVGVLAVEFFYGPEGLQVNEVAPRTHNSAHFSIEACSSSQFDQ
HHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEECCCCCCCCCCCEEEEEECCCCCHHH
QLCIAAGLPVPATDLHAPGALMVNLLGLQKGVEPSLDERLAKLRSCDRFHLHWYGKDCET
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
PGRKLGHVTVLLHGVDAPSRQLEAETALKHIRSIWPTQDTVCA
CCCHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQDCVIDSLCMSSVTSPMIGVVGGGQLAQMLAQAAKRRAVDVVVQSGSAIDPAAVEATRL
CCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHEE
VLADPVDVEATSKLVQGCCGVTFENEWVDIEALIPLEQQGVCFSPSLTALAPLVDKISQR
EEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHH
QLLRELDLPSPDWTLLSSISFDQPELPTEWNFPVMAKSSRWGYDGKGTKVLKSVEDLSQL
HHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
QRSVDPTQWLLESWVPFEKELAIVVSRDAQGRVRSLPLAETHQFQQVCDWVIAPASVDHA
HHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHCCCCHHHH
VEMMAYNMAASLLTELNYVGVLAVEFFYGPEGLQVNEVAPRTHNSAHFSIEACSSSQFDQ
HHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCEECCCCCCCCCCCEEEEEECCCCCHHH
QLCIAAGLPVPATDLHAPGALMVNLLGLQKGVEPSLDERLAKLRSCDRFHLHWYGKDCET
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
PGRKLGHVTVLLHGVDAPSRQLEAETALKHIRSIWPTQDTVCA
CCCHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA