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The map label for this gene is ilvA [H]

Identifier: 124023240

GI number: 124023240

Start: 1340963

End: 1342507

Strand: Direct

Name: ilvA [H]

Synonym: P9303_15381

Alternate gene names: 124023240

Gene position: 1340963-1342507 (Clockwise)

Preceding gene: 124023237

Following gene: 124023241

Centisome position: 49.99

GC content: 52.1

Gene sequence:

>1545_bases
ATGGACGATTATCTACAGAGGATTCTGAGGGCACGTGTCTATGACGTAGCCCATGAAACCCCCCTGGAACTGGCAAAAAA
CCTCAGTCGCCGTCTTCAGAACAAGATCTGGTTGAAACGTGAGGACCTACAGCCAGTCTTCTCCTTCAAGCTTCGTGGTG
CGTATAACCGCATGTCCCTTCTCAGTAAAGAGGAGTTGCAGCGTGGCGTGATTGCTTCAAGTGCTGGAAACCACGCTCAG
GGAGTGGCACTGAGCGCCTCTTATCTCAATTGCAGAGCTGTGATTGTGATGCCGATCACCACACCCGAAATGAAAGTACG
CGCAGTCCGTGCTCTTGGCGCTGAAGTCGCACTTCATGGAGAGACCTACGACGAGGCCTATCAAGAGGCCATGCGTCGAA
GCGAAAAAGATGGACTCACATTTATCCACCCGTTTGATGATCCAGAGGTGATTGCTGGGCAAGGGACGATTGCTCTAGAA
ATCCTGCGCCAGATCCAAGATCCACCAGATGCAATCTATGTCGCAGTTGGCGGTGGCGGACTGATCGGCGGGATTGCCAC
TTATGTCAAAAGCTTGTGGCCGCAAGTCGAAATTATTGGTGTCGAGCCCCACGACGCTGCAGCAATGACGCTCTCTCTTG
AAGCTGGTGAACGCATTCAGCTGCCAAAAGTAGGTCTATTTGCCGACGGAGTCGCTGTACGTCAAGTAGGCAAACACACC
TTCTCATTAGCTCAGATGCACGTAGACGCGATGGTGACGGTAAGCACTGATGAAATCTGTGCAGCGATCAAAGATGTTTT
TGAAGATACCCGCTCAATTCTTGAACCAGCTGGCGCACTGGCAATTGCTGGCATGAAGGCAGATATCGCCAAACGTGATC
TTCAAGACCGCACTCTTGTGGCCGTGGCCTGTGGCGCAAACATGAACTTTGAACGGCTCCGTTTTGTCGCCGAAAGAGCA
GAGCTAGGGGAAGAAAGGGAAGCAATACTCGCGGTAGAGATCCCAGAGCAGGCAGGCAGCCTGCGAAAGCTCTGCAACGT
CCTAGCGGGAAAAAATCTCACCGAATTCAGTTACCGAATGGCAGAGGGGGATAGAGCCCAAATATTCATCGGGGTGCAGG
TTTTAGACCTCAATGATCGAACCAAACTTTTAACGCGACTGCAGTCGTCAGGATTCCCATGCCTTGATCTCAGCAACGAC
GAGCTGACCAAAGGGCACCTTCGTCACATGGTGGGTGGCCGGCTTCCTGCCTCAGCAAAAACCCTTTGCCGAGATGGATG
TCGCGAACTGCTCTATCGCTTTGAGTTCCCTGAGCGCCCAGGAGCTCTTATGACCTTTGTTAGTGCCCTTCACCCCGAAT
GGAGTATCAGCATCTTCCACTACCGCAATCACGGAGCAGATGTCGGCAGGATCGTTGTAGGTGTGTTGGTCCAGGACAAC
GAAATGAAAAATTGGCAGCGCTTTCTTGATGATCTGGGCTATCCAAACTGGGAAGAAACCAACAACCCCGCCTACTGCTT
ATTTCTGGGTGCACAGACCGTTTGA

Upstream 100 bases:

>100_bases
TCCAACCCATTCAATCTAGGTCTTCTCAGCTATAGAACGGCGAAAGCAACCCTGGCAAGTGCAAACAGTTGCCGGATCTG
AATATTGCAAGACTGGCGTG

Downstream 100 bases:

>100_bases
TCGCGGTAACTTGGCATATTCCATAGCAGGGCCTGCCATGGCCACCGATTCCCCAGCTCAAGAGAGGGATGAGGTCTCTA
GCTTCTCCTTACCAGCACGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRLQNKIWLKREDLQPVFSFKLRGAYNRMSLLSKEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPHDAAAMTLSLEAGERIQLPKVGLFADGVAVRQVGKHT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLNDRTKLLTRLQSSGFPCLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMKNWQRFLDDLGYPNWEETNNPAYCLFLGAQTV

Sequences:

>Translated_514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRLQNKIWLKREDLQPVFSFKLRGAYNRMSLLSKEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPHDAAAMTLSLEAGERIQLPKVGLFADGVAVRQVGKHT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLNDRTKLLTRLQSSGFPCLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMKNWQRFLDDLGYPNWEETNNPAYCLFLGAQTV
>Mature_514_residues
MDDYLQRILRARVYDVAHETPLELAKNLSRRLQNKIWLKREDLQPVFSFKLRGAYNRMSLLSKEELQRGVIASSAGNHAQ
GVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHGETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALE
ILRQIQDPPDAIYVAVGGGGLIGGIATYVKSLWPQVEIIGVEPHDAAAMTLSLEAGERIQLPKVGLFADGVAVRQVGKHT
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLVAVACGANMNFERLRFVAERA
ELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRMAEGDRAQIFIGVQVLDLNDRTKLLTRLQSSGFPCLDLSND
ELTKGHLRHMVGGRLPASAKTLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
EMKNWQRFLDDLGYPNWEETNNPAYCLFLGAQTV

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=282, Percent_Identity=35.4609929078014, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=31.1897106109325, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI19923959, Length=314, Percent_Identity=29.9363057324841, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1790207, Length=508, Percent_Identity=50, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=38.0952380952381, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=330, Percent_Identity=35.1515151515151, Blast_Score=161, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=325, Percent_Identity=36, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17508781, Length=301, Percent_Identity=29.2358803986711, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320930, Length=524, Percent_Identity=47.7099236641221, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=35.8803986710963, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=319, Percent_Identity=25.705329153605, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355833, Length=378, Percent_Identity=33.8624338624339, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645328, Length=316, Percent_Identity=32.9113924050633, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56960; Mature: 56960

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDYLQRILRARVYDVAHETPLELAKNLSRRLQNKIWLKREDLQPVFSFKLRGAYNRMSL
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHH
LSKEELQRGVIASSAGNHAQGVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHG
HHHHHHHHCHHHCCCCCCCCCEEEEEEEECEEEEEEEECCCCHHHHHHHHHHCCEEEECC
ETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALEILRQIQDPPDAIYVAVGGGG
CHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCC
LIGGIATYVKSLWPQVEIIGVEPHDAAAMTLSLEAGERIQLPKVGLFADGVAVRQVGKHT
HHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCEECCCCCCEEECCHHHHHHHHHH
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLV
HHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEE
AVACGANMNFERLRFVAERAELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHH
AEGDRAQIFIGVQVLDLNDRTKLLTRLQSSGFPCLDLSNDELTKGHLRHMVGGRLPASAK
CCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCHHH
TLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEEEEEEECC
EMKNWQRFLDDLGYPNWEETNNPAYCLFLGAQTV
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MDDYLQRILRARVYDVAHETPLELAKNLSRRLQNKIWLKREDLQPVFSFKLRGAYNRMSL
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHH
LSKEELQRGVIASSAGNHAQGVALSASYLNCRAVIVMPITTPEMKVRAVRALGAEVALHG
HHHHHHHHCHHHCCCCCCCCCEEEEEEEECEEEEEEEECCCCHHHHHHHHHHCCEEEECC
ETYDEAYQEAMRRSEKDGLTFIHPFDDPEVIAGQGTIALEILRQIQDPPDAIYVAVGGGG
CHHHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCC
LIGGIATYVKSLWPQVEIIGVEPHDAAAMTLSLEAGERIQLPKVGLFADGVAVRQVGKHT
HHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCEECCCCCCEEECCHHHHHHHHHH
FSLAQMHVDAMVTVSTDEICAAIKDVFEDTRSILEPAGALAIAGMKADIAKRDLQDRTLV
HHHHHHEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEE
AVACGANMNFERLRFVAERAELGEEREAILAVEIPEQAGSLRKLCNVLAGKNLTEFSYRM
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHH
AEGDRAQIFIGVQVLDLNDRTKLLTRLQSSGFPCLDLSNDELTKGHLRHMVGGRLPASAK
CCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCCCHHH
TLCRDGCRELLYRFEFPERPGALMTFVSALHPEWSISIFHYRNHGADVGRIVVGVLVQDN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEEEEEEECC
EMKNWQRFLDDLGYPNWEETNNPAYCLFLGAQTV
CHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA