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The map label for this gene is nlpI [C]

Identifier: 124023008

GI number: 124023008

Start: 1113981

End: 1114901

Strand: Direct

Name: nlpI [C]

Synonym: P9303_13031

Alternate gene names: 124023008

Gene position: 1113981-1114901 (Clockwise)

Preceding gene: 124023007

Following gene: 124023011

Centisome position: 41.53

GC content: 42.02

Gene sequence:

>921_bases
TTGGCCACTGGTGTGGTGCTTCTTTCAACCCAGGCAGCAGATGCTCAAAGTGCTGTTTTCTACAAAAAGAGCGGTAATGC
AAAGGTTAGATCAGAAGATTATCAAGGAGCAATTGCTGATTACAGCAAGGCAATTGCAATTAATCCAAAGGATGCCGATG
CATACAATAACCGTGGTCTTGCCAAGAGTAAGTCAGGAGATAATCAAGGAGCAATTGCTGATTTCAACAAGGCAATAGAG
ATTAATCCGCAGGATGCCCGTGCTTATAACAACCGTGGTCTTGCCAAGAGTAAGTTAGGCGATTATCAAGGGGCAATTGC
TGATTACAATAGGGCAATAGAAATTAATCCGGTGTATTTATATGGATTTCTCAATCGTGGTCTTGCCAAGAAAAATCTCA
ACAAATATCAAGAAGCAATTGCTGATTACAACAATGCAATTGCAATCAACCCTCAACTTGCTGCTGCCTACAACAAGCGT
GGTCTTGCAAAGGTTGATTTAAAGGATTATCAAGGGGCTATTGCTGATTACAACAAGGCAATCGCAATTAATCCCAAGGA
TGCCGCTGCCTACAACAACCGAGGGGCTGTTAAGGGTAAATCAGGAGATAATCAAGGAGCAGTTGCTGATTTCAATAAGG
CAATTGAGATTGATCTGCAATATGCCGATGCCTACATCAACCGTGGCCTTACACAGTATAATTTAGGAGATAATCAAGGA
GCAATTGCTGATTACAGCGAGGCAATACAGATTGATCCGCAGGATGTCTTCGCCTATAACAATCGTGGTTATGCCACGTG
GAAATTAAAAGATTATCAAAGTGCTTGTAATGACTTCAAGAAAGCAGCATCTCTTGGAAGTCAATCAACAGCACAATGGT
TAAACAAAGAAGATGGTGCCTGGTGCCGCAATATGCGATGA

Upstream 100 bases:

>100_bases
CAGCAGCAAATACCTGATGTCACGGAAAAGAACTGCACTTGCTGCTGCCCTGTCATTGCTGTAGCTGGGTCAACCGCTGC
TACTGGGATCTACTGCTGCT

Downstream 100 bases:

>100_bases
GGACATAAAATAACAGCACCTAGAGACCCAATCAGACCTCCCACTTACCCTTAACCAGCAGCAACTCCCAGCAGATGCCA
CGCAGAAGAACGGCACTTGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MATGVVLLSTQAADAQSAVFYKKSGNAKVRSEDYQGAIADYSKAIAINPKDADAYNNRGLAKSKSGDNQGAIADFNKAIE
INPQDARAYNNRGLAKSKLGDYQGAIADYNRAIEINPVYLYGFLNRGLAKKNLNKYQEAIADYNNAIAINPQLAAAYNKR
GLAKVDLKDYQGAIADYNKAIAINPKDAAAYNNRGAVKGKSGDNQGAVADFNKAIEIDLQYADAYINRGLTQYNLGDNQG
AIADYSEAIQIDPQDVFAYNNRGYATWKLKDYQSACNDFKKAASLGSQSTAQWLNKEDGAWCRNMR

Sequences:

>Translated_306_residues
MATGVVLLSTQAADAQSAVFYKKSGNAKVRSEDYQGAIADYSKAIAINPKDADAYNNRGLAKSKSGDNQGAIADFNKAIE
INPQDARAYNNRGLAKSKLGDYQGAIADYNRAIEINPVYLYGFLNRGLAKKNLNKYQEAIADYNNAIAINPQLAAAYNKR
GLAKVDLKDYQGAIADYNKAIAINPKDAAAYNNRGAVKGKSGDNQGAVADFNKAIEIDLQYADAYINRGLTQYNLGDNQG
AIADYSEAIQIDPQDVFAYNNRGYATWKLKDYQSACNDFKKAASLGSQSTAQWLNKEDGAWCRNMR
>Mature_305_residues
ATGVVLLSTQAADAQSAVFYKKSGNAKVRSEDYQGAIADYSKAIAINPKDADAYNNRGLAKSKSGDNQGAIADFNKAIEI
NPQDARAYNNRGLAKSKLGDYQGAIADYNRAIEINPVYLYGFLNRGLAKKNLNKYQEAIADYNNAIAINPQLAAAYNKRG
LAKVDLKDYQGAIADYNKAIAINPKDAAAYNNRGAVKGKSGDNQGAVADFNKAIEIDLQYADAYINRGLTQYNLGDNQGA
IADYSEAIQIDPQDVFAYNNRGYATWKLKDYQSACNDFKKAASLGSQSTAQWLNKEDGAWCRNMR

Specific function: May Be Involved In Cell Division. Overexpression Of Nlpi Results In The Loss Of The Rod Morphology And The Formation Of Single Prolate Ellipsoids And Pairs Of Prolate Ellipsoids Joined By Partial Constrictions. [C]

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Attached To The Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI32307148, Length=225, Percent_Identity=32, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI32307150, Length=225, Percent_Identity=32, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI310110582, Length=219, Percent_Identity=31.5068493150685, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI310131789, Length=219, Percent_Identity=31.5068493150685, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI310123097, Length=219, Percent_Identity=31.5068493150685, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI170784867, Length=255, Percent_Identity=24.3137254901961, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI167466177, Length=228, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI167466175, Length=228, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4506921, Length=104, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI301336134, Length=242, Percent_Identity=26.0330578512397, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI83415184, Length=242, Percent_Identity=26.0330578512397, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI54607135, Length=242, Percent_Identity=25.6198347107438, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI5803181, Length=279, Percent_Identity=25.4480286738351, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI118766328, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI118766330, Length=241, Percent_Identity=26.9709543568465, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI24308141, Length=96, Percent_Identity=36.4583333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI296531396, Length=198, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI7706671, Length=246, Percent_Identity=22.7642276422764, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115532692, Length=191, Percent_Identity=32.9842931937173, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115532690, Length=191, Percent_Identity=32.9842931937173, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563052, Length=237, Percent_Identity=25.7383966244726, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147174, Length=266, Percent_Identity=21.0526315789474, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319387, Length=194, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324601, Length=233, Percent_Identity=27.4678111587983, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17647755, Length=229, Percent_Identity=31.4410480349345, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585827, Length=229, Percent_Identity=31.4410480349345, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585829, Length=229, Percent_Identity=31.4410480349345, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656717, Length=274, Percent_Identity=26.6423357664234, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18110006, Length=274, Percent_Identity=26.6423357664234, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137540, Length=239, Percent_Identity=25.1046025104602, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24647123, Length=274, Percent_Identity=21.1678832116788, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF00515 TPR_1 [H]

EC number: NA

Molecular weight: Translated: 33342; Mature: 33211

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGVVLLSTQAADAQSAVFYKKSGNAKVRSEDYQGAIADYSKAIAINPKDADAYNNRGL
CCCCEEEEEECCCCCCCEEEEEECCCCEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCC
AKSKSGDNQGAIADFNKAIEINPQDARAYNNRGLAKSKLGDYQGAIADYNRAIEINPVYL
CCCCCCCCCCCEECCCCEEEECCHHHHHHCCCCCCHHHCCCCCCHHHCCCCEEEECCEEE
YGFLNRGLAKKNLNKYQEAIADYNNAIAINPQLAAAYNKRGLAKVDLKDYQGAIADYNKA
EEEHHCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEEHHHHCCHHHCCCCE
IAINPKDAAAYNNRGAVKGKSGDNQGAVADFNKAIEIDLQYADAYINRGLTQYNLGDNQG
EEECCHHHHCCCCCCCEECCCCCCCCCEECCCCEEEEEEEHHHHHHHCCCEEECCCCCCC
AIADYSEAIQIDPQDVFAYNNRGYATWKLKDYQSACNDFKKAASLGSQSTAQWLNKEDGA
CCCCCCHHEEECHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
WCRNMR
HHCCCC
>Mature Secondary Structure 
ATGVVLLSTQAADAQSAVFYKKSGNAKVRSEDYQGAIADYSKAIAINPKDADAYNNRGL
CCCEEEEEECCCCCCCEEEEEECCCCEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCC
AKSKSGDNQGAIADFNKAIEINPQDARAYNNRGLAKSKLGDYQGAIADYNRAIEINPVYL
CCCCCCCCCCCEECCCCEEEECCHHHHHHCCCCCCHHHCCCCCCHHHCCCCEEEECCEEE
YGFLNRGLAKKNLNKYQEAIADYNNAIAINPQLAAAYNKRGLAKVDLKDYQGAIADYNKA
EEEHHCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCCEEEEHHHHCCHHHCCCCE
IAINPKDAAAYNNRGAVKGKSGDNQGAVADFNKAIEIDLQYADAYINRGLTQYNLGDNQG
EEECCHHHHCCCCCCCEECCCCCCCCCEECCCCEEEEEEEHHHHHHHCCCEEECCCCCCC
AIADYSEAIQIDPQDVFAYNNRGYATWKLKDYQSACNDFKKAASLGSQSTAQWLNKEDGA
CCCCCCHHEEECHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
WCRNMR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1368342; 8905231 [H]