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The map label for this gene is dxr [H]

Identifier: 124022574

GI number: 124022574

Start: 781978

End: 783216

Strand: Reverse

Name: dxr [H]

Synonym: P9303_08651

Alternate gene names: 124022574

Gene position: 783216-781978 (Counterclockwise)

Preceding gene: 124022576

Following gene: 124022573

Centisome position: 29.2

GC content: 58.27

Gene sequence:

>1239_bases
GTGCTGGGCTCCACAGGTTCGATCGGTACTCAAACCCTCGAGATTGCCGAAGAATTCCCTGAGCGCTTCCGGGTGGTGGC
ACTCACTGCCGGCACGAACGTCTCTCTTGTCGTGGAGCAGATCAAGCGACACCATCCGGAGGTTGTAGCGCTCGCCGACG
CGTCGCTGCTGCCACAACTGAAGCAGCAGCTCAACGCACTGCCTAGCGAGCAACAACCACCTCACTTACCTCAGTTGTTA
GCGGGCCCCGAAGGGCTCAATGTGGCTGCCTCATGGGATAGCGCTGATCTCGTGGTCAGCGGCATCGTCGGCTGTGCTGG
GCTACTGCCAACACTGGCAGCAATCAAAGCCGGCAAGGATCTTGCCCTCGCCAACAAAGAAACTCTGATCGCTGCTGCAC
CTGTCGTGCTGCCGGAGTTGAAACGCAGCGGCAGTCGGCTGCTTCCAGCAGATTCTGAACACTCGGCCATTTTCCAGTGT
CTGCAAGGAACACCCTGGGCTGAGAACGCCCGCCTCTCAACGGGAGTTCCTACCCCTGGGCTGCGCCACATCCAGCTCAC
AGCATCTGGGGGTGCCTTCCGCGACTGGTCAGCAAAAGATCTCGAGAAAGCCACCATTGCCGATGCAACCAGCCACCCCA
ACTGGAGCATGGGACGCAAAATCACCGTGGATTCAGCCACCTTGATGAATAAAGGGCTAGAGGTCATCGAAGCCCATTAC
CTCTTTGGCATCGACTACGACCAAATCGAGATCGTGATCCACCCTCAAAGCATCATCCACTCGATGATCGAGCTGGCTGA
TTCCTCCGTGCTTGCGCAACTCGGCTGGCCTGACATGAAACTACCTATCCTCTACTGCCTGAGCTGGCCGGAGCGGCTCG
AAACACCTTGGCGGCGCCTGAATCTCGCCGAAGTAGGCGAACTCACCTTCCGCGCCCCTGATACCAAAAAATACCCCTGC
ATGGAACTTGCCTACGCCGCAGGACGGGCCGGCGGAACCATGCCAGCCGTTCTCAATGCTGCCAATGAAGAAGCAGTGGC
CCAGTTCCTTGAGGAGCGCATCCATTTTCTTGACATCCCGGAAGTTATCGAGGCTGCCTGTGAACGCCACAAGCCCGACC
TGCAGACACAACCCCAGCTTGATGACGTGCTTGCTGTAGATGCATGGGCACGCAAGGCCGTACAAGAGCAGGTAACACGG
GGCACCCGTCGCCTACCACTGCTAGCCCTGAAAGCATGA

Upstream 100 bases:

>100_bases
CTGCCATGTCTGGAGCTCCTTGTTAAGACAAGCTTGCCAGTGTCTGGCCATCTAGTGGGAGACTGGCTTCAACTGCCGGA
ACAGTGTGAAAGCCATCAGC

Downstream 100 bases:

>100_bases
ATTTCAAGGTGAGTCATCACCTACTGCTTTGCGCAACACCCAACAAGGCGGCCTGTTGCAGTGCAGCTGTCGGCAACGCT
AGCTGGGCCAATCTCAAAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIKRHHPEVVALADASLLPQLKQQLNALPSEQQPPHLPQLL
AGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQC
LQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEVIEAHY
LFGIDYDQIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDTKKYPC
MELAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVTR
GTRRLPLLALKA

Sequences:

>Translated_412_residues
MLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIKRHHPEVVALADASLLPQLKQQLNALPSEQQPPHLPQLL
AGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQC
LQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEVIEAHY
LFGIDYDQIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDTKKYPC
MELAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVTR
GTRRLPLLALKA
>Mature_412_residues
MLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIKRHHPEVVALADASLLPQLKQQLNALPSEQQPPHLPQLL
AGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKDLALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQC
LQGTPWAENARLSTGVPTPGLRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEVIEAHY
LFGIDYDQIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRLNLAEVGELTFRAPDTKKYPC
MELAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIPEVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVTR
GTRRLPLLALKA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=45.75, Blast_Score=318, Evalue=6e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 44700; Mature: 44700

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIKRHHPEVVALADASLLPQL
CCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHH
KQQLNALPSEQQPPHLPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKD
HHHHHCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQCLQGTPWAENARLSTGVPTPG
EEECCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCC
LRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEVIEAHY
CEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHCHHHHHHHH
LFGIDYDQIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRL
HEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCHHHHCCHHHHC
NLAEVGELTFRAPDTKKYPCMELAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIP
CHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCH
EVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVTRGTRRLPLLALKA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEECC
>Mature Secondary Structure
MLGSTGSIGTQTLEIAEEFPERFRVVALTAGTNVSLVVEQIKRHHPEVVALADASLLPQL
CCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHH
KQQLNALPSEQQPPHLPQLLAGPEGLNVAASWDSADLVVSGIVGCAGLLPTLAAIKAGKD
HHHHHCCCCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LALANKETLIAAAPVVLPELKRSGSRLLPADSEHSAIFQCLQGTPWAENARLSTGVPTPG
EEECCCCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECCCCCCCC
LRHIQLTASGGAFRDWSAKDLEKATIADATSHPNWSMGRKITVDSATLMNKGLEVIEAHY
CEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHCHHHHHHHH
LFGIDYDQIEIVIHPQSIIHSMIELADSSVLAQLGWPDMKLPILYCLSWPERLETPWRRL
HEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEECCCHHHHCCHHHHC
NLAEVGELTFRAPDTKKYPCMELAYAAGRAGGTMPAVLNAANEEAVAQFLEERIHFLDIP
CHHHHCCEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCH
EVIEAACERHKPDLQTQPQLDDVLAVDAWARKAVQEQVTRGTRRLPLLALKA
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]