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The map label for this gene is groEL [H]

Identifier: 124022214

GI number: 124022214

Start: 495716

End: 497350

Strand: Direct

Name: groEL [H]

Synonym: P9303_05041

Alternate gene names: 124022214

Gene position: 495716-497350 (Clockwise)

Preceding gene: 124022213

Following gene: 124022219

Centisome position: 18.48

GC content: 55.41

Gene sequence:

>1635_bases
ATGGCTAAGCGCATTATTTACAACGAGCAAGCTCGACGTGCCCTTGAGCGCGGCATTGACATCCTGGCCGAATCCGTGGC
CGTCACACTGGGGCCCAAAGGCCGCAATGTGGTGCTTGAGAAAAAGTTTGGTGCACCCCAAATCATCAATGATGGCGTCA
CCATCGCCAAAGAGATTGAGCTTGAAGATCACATTGAGAACACCGGTGTTGCTCTGATCCGTCAGGCAGCTTCGAAGACC
AATGACGCTGCAGGTGATGGCACGACCACAGCCACTGTTTTGGCCCATGCCATGGTGAAGGCCGGCTTGCGCAATGTGGC
TGCTGGTGCCAATGCAATCTCCTTGAAGAAGGGGATCGACAAGGCTTCCGACTTCCTCGTTTCCAAGATTGAGGAGCTGG
CCAAGCCGATCAGTGACAGCAACGCCATTGCTCAGTGTGGAACCATTGCTGCCGGCAACGACGAGGAAGTGGGTCAGATG
ATTGCTGACGCCATGGACAAAGTTGGCAAGGAAGGTGTGATCTCTCTTGAAGAGGGCAAGTCGATGACCACTGAACTGGA
GGTCACCGAGGGGATGCGTTTCGATAAGGGCTACATCTCCCCTTACTTCGCCACTGACACTGAGCGGATGGAGGCTGTGC
TGGATGAGCCCTACATTCTCCTCACTGATAAGAAGATTGGCTTGGTACAGGATCTGGTGCCTGTGCTTGAACAGATTGCC
CGCACTGGCAAGCCCCTGCTGATCATTGCTGAGGACATTGAGAAGGAAGCTCTCGCAACCTTGGTGGTCAATCGTCTGCG
TGGTGTGCTGAATGTGGCTGCCGTGAAGGCGCCTGGGTTTGGTGATCGCCGTAAGGCCATGCTCGAAGACATGGCAGTGC
TGACCAATGGTCAGTTGATCACTGAAGACGCCGGTCTTAAATTGGACAATGCCAAGCTGGAAATGCTTGGTACAGCGCGC
CGTGTGACCATTAATAAGGACACCACAACCATCGTTGCCGAAGGCAATGAGACGGCGGTGAAAGGGCGTTGCGAGCAGAT
CAAAAAGCAGATGGACGAGACTGACTCGACCTACGACAAGGAGAAGCTGCAGGAACGACTGGCCAAGTTGGCCGGTGGCG
TTGCTGTTGTGAAGGTGGGTGCTGCTACCGAAACCGAGATGAAGGACAAGAAGCTCCGTCTTGAAGACGCCATCAACGCC
ACCAAGGCAGCAGTTGAGGAAGGCATCGTCCCAGGTGGTGGCACCACACTGACTCATCTCGCTGCTGATCTGCAGAAGTG
GGCCAATAGCAACCTCAGCGGTGAGGAGCTGATCGGTGCCAACATCGTGGAGGCTTCCCTGGCTGCTCCCTTGATGCGCA
TTGCTGAGAATGCCGGCGCCAATGGTGCTGTCGTGGCCGAGAACGTTAAGAGCAGGCCCATCAGTGACGGCTATAACGCT
GCTACTGGGGATTACATCGACATGCTTGCTGCAGGCATTGTTGACCCTGCCAAAGTCACCCGTTCTGGTTTGCAGAATGC
GGCCTCGATTGCTGGCATGGTGCTGACCACTGAGTGCATCGTTGCTGATTTGCCAGAGAAGAAGGAGGCAGCTCCTGCAG
GCGGTGGCGGCATGGGTGGTGACTTCGACTACTGA

Upstream 100 bases:

>100_bases
CCTTGCTGTCGTCAACTGAGCTTTGCGGCTGACTCTGACTTTCAGCTGACACCGGCTTTCAACTGACCAAATCCATCATT
TTTAAAGGACAACGCCTCCC

Downstream 100 bases:

>100_bases
TCAAAGCCGGGACTCTTCGGAGTCCCACAAGTCACAAGTCACATGTCATCAAGAACAGATCAAAAGCACCCTTCTGGGTG
CTTTTTTTTGGCCGATATCA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAISLKKGIDKASDFLVSKIEELAKPISDSNAIAQCGTIAAGNDEEVGQM
IADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQIA
RTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLDNAKLEMLGTAR
RVTINKDTTTIVAEGNETAVKGRCEQIKKQMDETDSTYDKEKLQERLAKLAGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLTHLAADLQKWANSNLSGEELIGANIVEASLAAPLMRIAENAGANGAVVAENVKSRPISDGYNA
ATGDYIDMLAAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKEAAPAGGGGMGGDFDY

Sequences:

>Translated_544_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAISLKKGIDKASDFLVSKIEELAKPISDSNAIAQCGTIAAGNDEEVGQM
IADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQIA
RTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLDNAKLEMLGTAR
RVTINKDTTTIVAEGNETAVKGRCEQIKKQMDETDSTYDKEKLQERLAKLAGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLTHLAADLQKWANSNLSGEELIGANIVEASLAAPLMRIAENAGANGAVVAENVKSRPISDGYNA
ATGDYIDMLAAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKEAAPAGGGGMGGDFDY
>Mature_543_residues
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAMVKAGLRNVAAGANAISLKKGIDKASDFLVSKIEELAKPISDSNAIAQCGTIAAGNDEEVGQMI
ADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQIAR
TGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLDNAKLEMLGTARR
VTINKDTTTIVAEGNETAVKGRCEQIKKQMDETDSTYDKEKLQERLAKLAGGVAVVKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLTHLAADLQKWANSNLSGEELIGANIVEASLAAPLMRIAENAGANGAVVAENVKSRPISDGYNAA
TGDYIDMLAAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKEAAPAGGGGMGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=533, Percent_Identity=43.9024390243902, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI31542947, Length=533, Percent_Identity=43.9024390243902, Blast_Score=455, Evalue=1e-128,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=57.4387947269303, Blast_Score=591, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17555558, Length=532, Percent_Identity=44.5488721804511, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI193210679, Length=219, Percent_Identity=42.9223744292237, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=47.5285171102662, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322524, Length=147, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=45.8333333333333, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=45.8333333333333, Blast_Score=470, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=43.1558935361217, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=43.1558935361217, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=43.1558935361217, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17864606, Length=543, Percent_Identity=37.9373848987109, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.5283018867924, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.5283018867924, Blast_Score=292, Evalue=5e-79,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57365; Mature: 57234

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCCEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAISLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
KASDFLVSKIEELAKPISDSNAIAQCGTIAAGNDEEVGQMIADAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH
RTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLDNAKLEMLGTARRVTINKDTTTIVAEGNETAVKGRCEQIKKQMDETDSTYDK
ECCCCCEECCCHHHEECCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLTHL
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AADLQKWANSNLSGEELIGANIVEASLAAPLMRIAENAGANGAVVAENVKSRPISDGYNA
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGDYIDMLAAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKEAAPAGGGGMGG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
DFDY
CCCC
>Mature Secondary Structure 
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAISLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
KASDFLVSKIEELAKPISDSNAIAQCGTIAAGNDEEVGQMIADAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH
RTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLDNAKLEMLGTARRVTINKDTTTIVAEGNETAVKGRCEQIKKQMDETDSTYDK
ECCCCCEECCCHHHEECCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCH
EKLQERLAKLAGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLTHL
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AADLQKWANSNLSGEELIGANIVEASLAAPLMRIAENAGANGAVVAENVKSRPISDGYNA
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGDYIDMLAAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKEAAPAGGGGMGG
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCC
DFDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA