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The map label for this gene is degP [C]

Identifier: 124022141

GI number: 124022141

Start: 432194

End: 433282

Strand: Direct

Name: degP [C]

Synonym: P9303_04311

Alternate gene names: 124022141

Gene position: 432194-433282 (Clockwise)

Preceding gene: 124022140

Following gene: 124022142

Centisome position: 16.11

GC content: 54.91

Gene sequence:

>1089_bases
ATGTCCGTGCTGTTCCCTCTTGCAGCCGGGGTTCAGCCTGTTTGGGCTTTGTCTGGTTTAGATGGGACGACTAGCCATAA
CTTCGTTGCTGATGCAGTAAGTCAGGTGGCGCCCGCAGTGGTTCGCATCGATACGGAACGCACTGTGCAACGTCAGCCCT
TTGATCCCACGCTGATTGATCCCTTGCTCAGAGATCTCTTGGGCGAGCCAGGAATTGGGCCAGAGCGTGAGCGGGGTCAG
GGTTCGGGTGTCGTGATCGATGACCAGGGGTTGGTGCTGACCAATGCCCACGTGGTTGAACGGGTGGATGCGGTCAGCGT
CACCCTTGCCGATGGAGATCAACACGATGGTTCGGTTGTTGGGACGGATCCTGTTACTGATCTGGCTCTTGTGCGACTGG
ATGGGGGCACACGTCCTGAGGCCGCCCCTCTTGGAGATTCTGATGCGCTTGAGGTAGGCGATTGGGCGATCGCTCTTGGT
ACTCCCTATGGCCTTGAACGCACCGTCACCCTTGGCATTGTTAGCAGCCTGCATCGCAATATCAGCAGCCTTGGCTTCTC
TGATAAACGTCTGGATTTGATTCAGACCGATGCCGCGATTAACCCTGGTAATTCCGGTGGTCCACTGGTGAATGGTCGTG
GTGAGGTGATCGGTATCAACACACTGGTTCGTTCTGGTCCAGGCGCTGGTTTGGGATTTGCTATTCCGATCAATTTGGCT
CGACATGTTTCTGAGCAGCTTTTGACCAGTGGGGAGGTGGTGCATCCTTATTTGGGTGTCCAATTGGTGCCGCTGACAGC
TCGTATTGCCAGGGAGCACAATCGTGATCCGAATTCGCTGGTGGAATTACCCGAACGCTTGGGGGCGCTTGTGCAGAGTG
TTTTGCCGGATAGCCCGGCGGAACGAGCTGGTTTGCGGCGTGGTGATCTTGTGATTGCGGCAGCTGAAACATCAGTCTCT
GATCCACAAATGCTGCTTAAACAGGTTGATCAGGCTGAGATCGGTGTCCCCTTCTCATTAAGGATCATGCGCAATGGTCA
AGAGATGAGCCTTTCGGTTAATCCAGCCGCATTACCTGGCCTTAGTTGA

Upstream 100 bases:

>100_bases
TGCTCCTCTGTTTCGGCTTAGCCTCGCGGTCATGATCTCTTTCAGACTGTTGCTGCAACAGGGTTGCATTGTTTTGAAGC
GCTTTTGGGGATTGTTTTTG

Downstream 100 bases:

>100_bases
AACCCTTGCCCTTGCTACCGTCGCGCCGATGATTCAGAAACGATGGCGGACCTTCAAACTCAGATGAAGCAAGCGGTGGC
GGCAGCCGCTGTGGAGCAGA

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVLFPLAAGVQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPTLIDPLLRDLLGEPGIGPERERGQ
GSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAIALG
TPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVIGINTLVRSGPGAGLGFAIPINLA
RHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERLGALVQSVLPDSPAERAGLRRGDLVIAAAETSVS
DPQMLLKQVDQAEIGVPFSLRIMRNGQEMSLSVNPAALPGLS

Sequences:

>Translated_362_residues
MSVLFPLAAGVQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPTLIDPLLRDLLGEPGIGPERERGQ
GSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAIALG
TPYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVIGINTLVRSGPGAGLGFAIPINLA
RHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERLGALVQSVLPDSPAERAGLRRGDLVIAAAETSVS
DPQMLLKQVDQAEIGVPFSLRIMRNGQEMSLSVNPAALPGLS
>Mature_361_residues
SVLFPLAAGVQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPTLIDPLLRDLLGEPGIGPERERGQG
SGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVVGTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAIALGT
PYGLERTVTLGIVSSLHRNISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVIGINTLVRSGPGAGLGFAIPINLAR
HVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERLGALVQSVLPDSPAERAGLRRGDLVIAAAETSVSD
PQMLLKQVDQAEIGVPFSLRIMRNGQEMSLSVNPAALPGLS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=303, Percent_Identity=36.3036303630363, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI7019477, Length=339, Percent_Identity=36.8731563421829, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=32.7433628318584, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI24308541, Length=356, Percent_Identity=30.3370786516854, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786356, Length=276, Percent_Identity=39.8550724637681, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1789629, Length=358, Percent_Identity=35.195530726257, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789630, Length=291, Percent_Identity=33.6769759450172, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24646839, Length=358, Percent_Identity=32.6815642458101, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37900; Mature: 37769

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLFPLAAGVQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPTLID
CCEEECHHCCCCCEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHH
PLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVV
HHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEECHHHHHHCCEEEEEEECCCCCCCCEE
GTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAIALGTPYGLERTVTLGIVSSLHRN
CCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHHH
ISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVIGINTLVRSGPGAGLGFAIPINLA
HHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEHHHHHCCCCCCCEEEEHHHHH
RHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERLGALVQSVLPDSPA
HHHHHHHHHCCCEECCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCH
ERAGLRRGDLVIAAAETSVSDPQMLLKQVDQAEIGVPFSLRIMRNGQEMSLSVNPAALPG
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCC
LS
CC
>Mature Secondary Structure 
SVLFPLAAGVQPVWALSGLDGTTSHNFVADAVSQVAPAVVRIDTERTVQRQPFDPTLID
CEEECHHCCCCCEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHCCCCCCCHHHH
PLLRDLLGEPGIGPERERGQGSGVVIDDQGLVLTNAHVVERVDAVSVTLADGDQHDGSVV
HHHHHHHCCCCCCCCCCCCCCCCEEECCCCEEEECHHHHHHCCEEEEEEECCCCCCCCEE
GTDPVTDLALVRLDGGTRPEAAPLGDSDALEVGDWAIALGTPYGLERTVTLGIVSSLHRN
CCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHHH
ISSLGFSDKRLDLIQTDAAINPGNSGGPLVNGRGEVIGINTLVRSGPGAGLGFAIPINLA
HHHCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCEEEEHHHHHCCCCCCCEEEEHHHHH
RHVSEQLLTSGEVVHPYLGVQLVPLTARIAREHNRDPNSLVELPERLGALVQSVLPDSPA
HHHHHHHHHCCCEECCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCH
ERAGLRRGDLVIAAAETSVSDPQMLLKQVDQAEIGVPFSLRIMRNGQEMSLSVNPAALPG
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCCCCC
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA