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The map label for this gene is sdhA [H]

Identifier: 124021882

GI number: 124021882

Start: 188621

End: 190537

Strand: Direct

Name: sdhA [H]

Synonym: P9303_01691

Alternate gene names: 124021882

Gene position: 188621-190537 (Clockwise)

Preceding gene: 124021881

Following gene: 124021883

Centisome position: 7.03

GC content: 56.23

Gene sequence:

>1917_bases
ATGAATAGTTTGCCTGATCCTCGCCTCCCATCAGGCACGATCGCCGATGCATGGAACCGCACGCAAGGATCGCTGCCATT
AATCAGCTCATCGCGAAAACGGGAGCTTCAGTTGTTGGTGGTAGGCACGGGGTTGGCTGGGGCTTCGGCGGCGGCAACCT
TGGCCGAGCAGGGCTACCAGGTGCGTGTGATCAGCTTTCACGACAGTCCTCGACGGGCACACTCAGTGGCCGCCCAGGGA
GGCATTAATGCCGCTCGTCCTCGTTCTTTGGATGGTGACAGCGTTAGCCGCCTCTTTGTCGATACCCTTCGCGGCGGTGA
CTTCCGTGCGCGTGAGGCCGGCTGCCAGCGTTTGGCTGAGATCAGTAGCGCGATTATCGATCAGTGCGTTGCTCAGGGGG
TTCCCTTTGCGCGTGAGTACGACGGAACACTTTCGACCAGAAGAATGGGAGGGGCTTCGGTCAGTCGCACCTTTTATGCT
CGCGGTCAGACTGGCCAGCAATTGCTCTGCGGCGCTTATCAGGCGTTGATGCGTCAGGTGGCGCTTGGTCAGGTGGAGTT
GCTTTGTCGTCGCGACGTTTTAGAGCTCATCAAGGTGGATGGCGTGGCCCGAGGGGTGGTGTGCCGTGACCTGCTCAGTG
GTGAATTGGAGGTGCATACCGCTCAGGCTGTTTTGCTAGCGACTGGTGGCTATAGCAACGTCTACTTTCTTTCGACAAAT
GCACTGAAATCGAATGCAAGTGCCATTTGGCGGGCTCATCGTCAGGGAGCTTTATTCGCGAACCCTTGCTTCACCCAGAT
CCACCCAACCTGCATTCCAAGTGGTGATCCCTATCAAAGCAAGCGAACTTTGATGAGCGAGAGCTTGCGTAATGACGGTC
GTGTTTGGCTGCCATCAGATTCTGGAGATCAGCGTTCAGCTGTTGAGATTCCTGAGGCCCAGCGCGATTACTTCCTTGAG
CGTCAGTATCCGGCCTACGGCAACATGGTGCCCAGAGATGTGGCTTCACGCCGTGCCAGGGAGCTCTGCAACTCTGGTTA
TGGTGTGGGTCCTGGTGGCCAAGCATTTTATCTCGACCTGAGCGATGCGATCTCGAGTCAGGGGCGAGAGGTGATTGTGG
AGCGGTACGGCAACCTTTTAGAGATGTATGAGCGAATTACAGGTGAGGATCCGTTGATGACACCAATGTGCATCTCTCCA
GCCCCCCACTACACGATGGGTGGCCTCTGGGTTGACTACTACCTGATGAGTTCGATCCCGGGATTGTTTGTGCTTGGTGA
GGCCAACTTCTCTGAGCATGGTGCGAATCGTCTCGGCGCTAGTGCTCTGATGCAAGGTTTGGCTGATGGCTACTTCATTG
CGCCGGCTACCGTCACTGCTTGGTTGGCAGGCCATACCACCACTCCTGTTGCTAATGATCATTGGGCTTGCCGCGAAGCC
CTGGCGAGAGCTCGTGCTCGCATTGAGCTTTTGCTACAGGGGGCGGGTCAACGGTCGGTTGATTCTTTTCACCGTGAGCT
GGGGGCCGTGATCCTTGATCGCTGCGGCATCAGCCGTGATGCCGAAGGGTTGCGTGTTGGATTGGCAGATGTGGCATTGC
TGGAGCAGCGTTTTCATGCTGAGGTAAGCATCCCTTCTCAAGCTCAGGGACCTAATCCTGAGCTTGAGAAGGGGTTGAGG
GTTGCTGATTTCTTTGGGCTGGCAAAGTTGATGTTGCGCGATGCCTTGGCTAGGGAGGAGTCTTGTGGAGCCCACTTCCG
TGAAGAGCATCAGACAGAAGAAGGCGAAGCTCGGCGTGATGATGAGAACTTTGCCCACATTGCTGCTTGGGAAGATCGTG
AGCAGGCCGAGCCTGTTCGCCATGTTGAGCCGCTCAACTTCACGAGCTTGAAGCCCAGTCAACGTAGTTATCGATGA

Upstream 100 bases:

>100_bases
GTATTCGGCGCGCCTTTCGAATGTTGGCGTTGCTTGTGGGTGGCGGCTTCAGCGTGGTGGCGTTGCTGGTCTCTGCCTCA
GCGTTGCAGATGGGTCAGTG

Downstream 100 bases:

>100_bases
GCTATAAACTTTCGCTCACGCTGCGTATTTGGCGTCAGGCGTCAAGCAACAGTTCCGGTGCTTTCCATGTCTACCGGCTT
GAGCAGATCTCTGCCGACTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MNSLPDPRLPSGTIADAWNRTQGSLPLISSSRKRELQLLVVGTGLAGASAAATLAEQGYQVRVISFHDSPRRAHSVAAQG
GINAARPRSLDGDSVSRLFVDTLRGGDFRAREAGCQRLAEISSAIIDQCVAQGVPFAREYDGTLSTRRMGGASVSRTFYA
RGQTGQQLLCGAYQALMRQVALGQVELLCRRDVLELIKVDGVARGVVCRDLLSGELEVHTAQAVLLATGGYSNVYFLSTN
ALKSNASAIWRAHRQGALFANPCFTQIHPTCIPSGDPYQSKRTLMSESLRNDGRVWLPSDSGDQRSAVEIPEAQRDYFLE
RQYPAYGNMVPRDVASRRARELCNSGYGVGPGGQAFYLDLSDAISSQGREVIVERYGNLLEMYERITGEDPLMTPMCISP
APHYTMGGLWVDYYLMSSIPGLFVLGEANFSEHGANRLGASALMQGLADGYFIAPATVTAWLAGHTTTPVANDHWACREA
LARARARIELLLQGAGQRSVDSFHRELGAVILDRCGISRDAEGLRVGLADVALLEQRFHAEVSIPSQAQGPNPELEKGLR
VADFFGLAKLMLRDALAREESCGAHFREEHQTEEGEARRDDENFAHIAAWEDREQAEPVRHVEPLNFTSLKPSQRSYR

Sequences:

>Translated_638_residues
MNSLPDPRLPSGTIADAWNRTQGSLPLISSSRKRELQLLVVGTGLAGASAAATLAEQGYQVRVISFHDSPRRAHSVAAQG
GINAARPRSLDGDSVSRLFVDTLRGGDFRAREAGCQRLAEISSAIIDQCVAQGVPFAREYDGTLSTRRMGGASVSRTFYA
RGQTGQQLLCGAYQALMRQVALGQVELLCRRDVLELIKVDGVARGVVCRDLLSGELEVHTAQAVLLATGGYSNVYFLSTN
ALKSNASAIWRAHRQGALFANPCFTQIHPTCIPSGDPYQSKRTLMSESLRNDGRVWLPSDSGDQRSAVEIPEAQRDYFLE
RQYPAYGNMVPRDVASRRARELCNSGYGVGPGGQAFYLDLSDAISSQGREVIVERYGNLLEMYERITGEDPLMTPMCISP
APHYTMGGLWVDYYLMSSIPGLFVLGEANFSEHGANRLGASALMQGLADGYFIAPATVTAWLAGHTTTPVANDHWACREA
LARARARIELLLQGAGQRSVDSFHRELGAVILDRCGISRDAEGLRVGLADVALLEQRFHAEVSIPSQAQGPNPELEKGLR
VADFFGLAKLMLRDALAREESCGAHFREEHQTEEGEARRDDENFAHIAAWEDREQAEPVRHVEPLNFTSLKPSQRSYR
>Mature_638_residues
MNSLPDPRLPSGTIADAWNRTQGSLPLISSSRKRELQLLVVGTGLAGASAAATLAEQGYQVRVISFHDSPRRAHSVAAQG
GINAARPRSLDGDSVSRLFVDTLRGGDFRAREAGCQRLAEISSAIIDQCVAQGVPFAREYDGTLSTRRMGGASVSRTFYA
RGQTGQQLLCGAYQALMRQVALGQVELLCRRDVLELIKVDGVARGVVCRDLLSGELEVHTAQAVLLATGGYSNVYFLSTN
ALKSNASAIWRAHRQGALFANPCFTQIHPTCIPSGDPYQSKRTLMSESLRNDGRVWLPSDSGDQRSAVEIPEAQRDYFLE
RQYPAYGNMVPRDVASRRARELCNSGYGVGPGGQAFYLDLSDAISSQGREVIVERYGNLLEMYERITGEDPLMTPMCISP
APHYTMGGLWVDYYLMSSIPGLFVLGEANFSEHGANRLGASALMQGLADGYFIAPATVTAWLAGHTTTPVANDHWACREA
LARARARIELLLQGAGQRSVDSFHRELGAVILDRCGISRDAEGLRVGLADVALLEQRFHAEVSIPSQAQGPNPELEKGLR
VADFFGLAKLMLRDALAREESCGAHFREEHQTEEGEARRDDENFAHIAAWEDREQAEPVRHVEPLNFTSLKPSQRSYR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=557, Percent_Identity=26.032315978456, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=29.0378006872852, Blast_Score=198, Evalue=8e-52,
Organism=Escherichia coli, GI1788928, Length=571, Percent_Identity=26.6199649737303, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786942, Length=431, Percent_Identity=29.0023201856148, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17505833, Length=559, Percent_Identity=27.3703041144902, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17550100, Length=555, Percent_Identity=27.3873873873874, Blast_Score=149, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322701, Length=606, Percent_Identity=28.8778877887789, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322416, Length=617, Percent_Identity=28.0388978930308, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI17137288, Length=578, Percent_Identity=27.8546712802768, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24655642, Length=578, Percent_Identity=27.8546712802768, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24655647, Length=578, Percent_Identity=27.8546712802768, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24663005, Length=584, Percent_Identity=25, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 69752; Mature: 69752

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLPDPRLPSGTIADAWNRTQGSLPLISSSRKRELQLLVVGTGLAGASAAATLAEQGYQ
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCE
VRVISFHDSPRRAHSVAAQGGINAARPRSLDGDSVSRLFVDTLRGGDFRAREAGCQRLAE
EEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ISSAIIDQCVAQGVPFAREYDGTLSTRRMGGASVSRTFYARGQTGQQLLCGAYQALMRQV
HHHHHHHHHHHCCCCCHHHCCCCHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHH
ALGQVELLCRRDVLELIKVDGVARGVVCRDLLSGELEVHTAQAVLLATGGYSNVYFLSTN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCEEEEEECC
ALKSNASAIWRAHRQGALFANPCFTQIHPTCIPSGDPYQSKRTLMSESLRNDGRVWLPSD
CHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCC
SGDQRSAVEIPEAQRDYFLERQYPAYGNMVPRDVASRRARELCNSGYGVGPGGQAFYLDL
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
SDAISSQGREVIVERYGNLLEMYERITGEDPLMTPMCISPAPHYTMGGLWVDYYLMSSIP
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCC
GLFVLGEANFSEHGANRLGASALMQGLADGYFIAPATVTAWLAGHTTTPVANDHWACREA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHH
LARARARIELLLQGAGQRSVDSFHRELGAVILDRCGISRDAEGLRVGLADVALLEQRFHA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHC
EVSIPSQAQGPNPELEKGLRVADFFGLAKLMLRDALAREESCGAHFREEHQTEEGEARRD
EECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
DENFAHIAAWEDREQAEPVRHVEPLNFTSLKPSQRSYR
CCCCEEEEECCCHHHCCHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSLPDPRLPSGTIADAWNRTQGSLPLISSSRKRELQLLVVGTGLAGASAAATLAEQGYQ
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCE
VRVISFHDSPRRAHSVAAQGGINAARPRSLDGDSVSRLFVDTLRGGDFRAREAGCQRLAE
EEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ISSAIIDQCVAQGVPFAREYDGTLSTRRMGGASVSRTFYARGQTGQQLLCGAYQALMRQV
HHHHHHHHHHHCCCCCHHHCCCCHHHHHCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHH
ALGQVELLCRRDVLELIKVDGVARGVVCRDLLSGELEVHTAQAVLLATGGYSNVYFLSTN
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCEEEEEECC
ALKSNASAIWRAHRQGALFANPCFTQIHPTCIPSGDPYQSKRTLMSESLRNDGRVWLPSD
CHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCC
SGDQRSAVEIPEAQRDYFLERQYPAYGNMVPRDVASRRARELCNSGYGVGPGGQAFYLDL
CCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
SDAISSQGREVIVERYGNLLEMYERITGEDPLMTPMCISPAPHYTMGGLWVDYYLMSSIP
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCC
GLFVLGEANFSEHGANRLGASALMQGLADGYFIAPATVTAWLAGHTTTPVANDHWACREA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHH
LARARARIELLLQGAGQRSVDSFHRELGAVILDRCGISRDAEGLRVGLADVALLEQRFHA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHC
EVSIPSQAQGPNPELEKGLRVADFFGLAKLMLRDALAREESCGAHFREEHQTEEGEARRD
EECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
DENFAHIAAWEDREQAEPVRHVEPLNFTSLKPSQRSYR
CCCCEEEEECCCHHHCCHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]