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The map label for this gene is cobH [H]

Identifier: 124021799

GI number: 124021799

Start: 83240

End: 83875

Strand: Direct

Name: cobH [H]

Synonym: P9303_00841

Alternate gene names: 124021799

Gene position: 83240-83875 (Clockwise)

Preceding gene: 124021796

Following gene: 124021804

Centisome position: 3.1

GC content: 55.97

Gene sequence:

>636_bases
GTGAAGTCGCTTGATCATCCGATCTTCACGGAAAGCATTCGCCGCATTCGGGAGCAGTTGGGTGTAACGGGTTTGGATCC
CTTGCAGCAGCAGGTGTTGGAGCGTTTGATTCACAGCAGTGGGGATTTTGGCCTAACTCCTTTGCTGCGTTTTACTCCAG
AGGCTTGTGAGCTTGGGCTGGCTGCTTTGCAGGCCGGAGCGCCAATTATCACCGATACGGCCATGGCGGCTGTAGCAGTG
CAGCCTATGGCGCGACGCACACTCAAGACATCAGTTCGCTGCGTGCTGGAGTGGGCGCCGGATGTGGCACCAAACGGTTC
CACGCGAACAGCCGAGGGTTTGCGATGCGCATGGCAAGAATTGGCGACTCAATATGTGGATCAACAAGCGCCGATTGTGT
TGATTGGTAGTGCACCTACGGCCCTGGATGCATTACTGGAGCTTGTCTCATCAGGTTCACCTCCTCCTAGTTTGATCATC
GGCATGCCTGTGGGTTTTGTAGGTGTATCTGACAGCAAGCGGCGGTTAGTTGTTAGCGGACTGGCTCAGATTCGCCTTGA
GGGCAGTCGTGGTGGGGCTGGTCTGGTTGCAGCGACGGTCAATGCTCTGTTGCGGGCGTCACAGTTGCCTAAGTGA

Upstream 100 bases:

>100_bases
GCGGCATCATCGCCCCAGAAGAGATGGATCGGCATTGCAGCGGCAGACCGAAGATCGTTATCTGATGATGCTTGATGTCT
ATCGGGCTTAAGGCAGAAAC

Downstream 100 bases:

>100_bases
ATCGGTTTTACTCTGGAACTGGCCAAGCAGTAGTTGTAAATAGCTCACACTGCGCAGTTTGATATTTGCAGTGAGCGACA
TTCCTACTTGCAAGGGAAGC

Product: precorrin-8X methylmutase CobH

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MKSLDHPIFTESIRRIREQLGVTGLDPLQQQVLERLIHSSGDFGLTPLLRFTPEACELGLAALQAGAPIITDTAMAAVAV
QPMARRTLKTSVRCVLEWAPDVAPNGSTRTAEGLRCAWQELATQYVDQQAPIVLIGSAPTALDALLELVSSGSPPPSLII
GMPVGFVGVSDSKRRLVVSGLAQIRLEGSRGGAGLVAATVNALLRASQLPK

Sequences:

>Translated_211_residues
MKSLDHPIFTESIRRIREQLGVTGLDPLQQQVLERLIHSSGDFGLTPLLRFTPEACELGLAALQAGAPIITDTAMAAVAV
QPMARRTLKTSVRCVLEWAPDVAPNGSTRTAEGLRCAWQELATQYVDQQAPIVLIGSAPTALDALLELVSSGSPPPSLII
GMPVGFVGVSDSKRRLVVSGLAQIRLEGSRGGAGLVAATVNALLRASQLPK
>Mature_211_residues
MKSLDHPIFTESIRRIREQLGVTGLDPLQQQVLERLIHSSGDFGLTPLLRFTPEACELGLAALQAGAPIITDTAMAAVAV
QPMARRTLKTSVRCVLEWAPDVAPNGSTRTAEGLRCAWQELATQYVDQQAPIVLIGSAPTALDALLELVSSGSPPPSLII
GMPVGFVGVSDSKRRLVVSGLAQIRLEGSRGGAGLVAATVNALLRASQLPK

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 22264; Mature: 22264

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLDHPIFTESIRRIREQLGVTGLDPLQQQVLERLIHSSGDFGLTPLLRFTPEACELGL
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHH
AALQAGAPIITDTAMAAVAVQPMARRTLKTSVRCVLEWAPDVAPNGSTRTAEGLRCAWQE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LATQYVDQQAPIVLIGSAPTALDALLELVSSGSPPPSLIIGMPVGFVGVSDSKRRLVVSG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCHHHHHHH
LAQIRLEGSRGGAGLVAATVNALLRASQLPK
HHHHEECCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKSLDHPIFTESIRRIREQLGVTGLDPLQQQVLERLIHSSGDFGLTPLLRFTPEACELGL
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHH
AALQAGAPIITDTAMAAVAVQPMARRTLKTSVRCVLEWAPDVAPNGSTRTAEGLRCAWQE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LATQYVDQQAPIVLIGSAPTALDALLELVSSGSPPPSLIIGMPVGFVGVSDSKRRLVVSG
HHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCHHHHHHH
LAQIRLEGSRGGAGLVAATVNALLRASQLPK
HHHHEECCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]