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The map label for this gene is dnaX [H]

Identifier: 124021779

GI number: 124021779

Start: 59989

End: 61803

Strand: Reverse

Name: dnaX [H]

Synonym: P9303_00641

Alternate gene names: 124021779

Gene position: 61803-59989 (Counterclockwise)

Preceding gene: 124021780

Following gene: 124021775

Centisome position: 2.3

GC content: 56.03

Gene sequence:

>1815_bases
ATGAGCCAGGCCTACCAGCCGCTGCATCACAAATATCGACCACAGCGCTTCGATGCCCTGGTGGGGCAGGACGCGATCGC
CGCGACCCTCAGTCATGCCTTGCGCAGCAGCCGGATCGCACCGGCCTATCTATTCAGCGGTCCACGAGGCACTGGTAAAA
CCTCCAGTGCTCGCATCCTGGCCCGATCACTCAACTGCTTGAACTGCGACCAGCCAACACCCGAGCCATGCGGAAACTGT
GAGCTCTGCAAAAGCATTGCCGCCGGCACAGCACTAGACGTGATCGAAATCGACGCCGCCTCCAACACCGGCGTAGACAA
CATTCGCGAACTGATCGAACGCTCCCGCTTTGCCCCGGTACAAGCCCGCTGGAAGGTGTATGTGGTTGACGAATGCCACA
TGCTCTCAACCGCCGCCTTCAATGCCCTACTGAAGACCCTTGAAGAACCACCGCCACGGGTGGTGTTCGTACTAGCAACA
ACCGATCCACAGCGAGTGCTGCCGACCATCCTCAGCCGTTGTCAGCGTTTTGATTTCAGGCGGATTCCACTGGAAGCCCT
TGAAAAACACCTAGAGATGATCGCCACTCGTGAAGCCATTCCGATTAACCCCGAAGCCCTGCATGTCGTAGCCCAGCGAG
CCCAGGGAGGGCTTCGAGATGCGGAAAGCTTGCTTGATCAGCTCAGCCTGCTGCCAGGGCCCATCAAAGCAGAAGCTGTA
TGGGAGTTGATGGGAGCCGTGCCAGAGCAAGAGCTGCTGAAACTAGCCGCAGCCTTGGCCCAAGCCGATCCACTCTGCTT
ATTGGAAACCTGCCGAAACCTGCTGAATCGAGGCCGTGATCCAGGTGCACTTCTGCAAGGGCTGGCAGCGGTGTTGCGAG
ATTTGGTGCTCATGACTGCCGCACCCGATCGCCCTGAACTCACAAGTGTTTCTCCACAATTCCGCAATCAATTGCCGCCC
CTAGCCAGCCAAATAGGTCGTCATCAGCTTTTGCAATGGCAGGTCCAACTCAAAGGAAGCGAAAGTCAGCTGCGTCACAG
CGTTCAACCCCGTCTCTGGCTTGAAGTGCTTCTGCTGGGTCTGCTGGCCGAACCACCTTCCAGTGAAGCTGTAACCGCAG
TGCCAATAACAAAGACAGCTCAACCAATAAACCCAGCTGCGCAGGCGATCACTGCCAACGCATTGACCCCGACAACACAA
ATCCAACAACCCCCTTCTAGATCAACGACGACCCACGATCCAGTCTCAGCAATCACCCCAAACGCAGAACCCGATCCACC
TCCAGCCCAGAGAACCCCTAACAACAATCTGCAGGAGTTATGGCAACAAATACTTGGCAGTTTGGAATTACCTTCCACAC
GCATGTTGCTCTCTCAGCAAGCCCAGCTAGTGCGCCTTGATGACCATCGCGCCGTGGTTCAAGTTGCCGGCAACTGGATG
GGAATGGTGCAAAGCCGTGCAACCCTCCTGGAACAAGCAATAGCAAAAGCCCTGGGAAATTCCAGACAGCTTGTTCTCGA
AAGCCAAAGCGGAAGTGCCACACCAATGCCCAGCCCACACAAAACGGGTGCGGCACCAACACCAAACACATCCGCTTCCA
CTGCTGAACCATCACCACCACAACAAGTTCAATCCAGCTCTACAGGCGCTTATCCCCCAGATCCTGCAACCAGCGCCGCC
ATCACAGACCAGCAAAAGCCTCTAGAGGAGGATTCTCCTCCGACTCAGCCCACTTCCTCTTTAGAACCCATCGACAGCAA
AGCAAAGCGACTAGCTGACTTCTTCAACGGCAAAGTGCTGGACGTGGACCTTTAA

Upstream 100 bases:

>100_bases
ATGAACTAGCAGCAATAGAAGATCTAGAAGCCCGCATCACTGCATTGCTCGACGAACCAAAAGCCAAGCCTGAGTAACCT
CAACATCCCGCCAGCAGCGC

Downstream 100 bases:

>100_bases
ACATTCAAACCTGAACAGGCTGTTGGCCATGATGACTGGTCTTGGCCCACACCAAACTCTTCGGGAACAGTGCCATCCGT
ACTGTGACCCAAGGGATGAC

Product: DNA polymerase, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSQAYQPLHHKYRPQRFDALVGQDAIAATLSHALRSSRIAPAYLFSGPRGTGKTSSARILARSLNCLNCDQPTPEPCGNC
ELCKSIAAGTALDVIEIDAASNTGVDNIRELIERSRFAPVQARWKVYVVDECHMLSTAAFNALLKTLEEPPPRVVFVLAT
TDPQRVLPTILSRCQRFDFRRIPLEALEKHLEMIATREAIPINPEALHVVAQRAQGGLRDAESLLDQLSLLPGPIKAEAV
WELMGAVPEQELLKLAAALAQADPLCLLETCRNLLNRGRDPGALLQGLAAVLRDLVLMTAAPDRPELTSVSPQFRNQLPP
LASQIGRHQLLQWQVQLKGSESQLRHSVQPRLWLEVLLLGLLAEPPSSEAVTAVPITKTAQPINPAAQAITANALTPTTQ
IQQPPSRSTTTHDPVSAITPNAEPDPPPAQRTPNNNLQELWQQILGSLELPSTRMLLSQQAQLVRLDDHRAVVQVAGNWM
GMVQSRATLLEQAIAKALGNSRQLVLESQSGSATPMPSPHKTGAAPTPNTSASTAEPSPPQQVQSSSTGAYPPDPATSAA
ITDQQKPLEEDSPPTQPTSSLEPIDSKAKRLADFFNGKVLDVDL

Sequences:

>Translated_604_residues
MSQAYQPLHHKYRPQRFDALVGQDAIAATLSHALRSSRIAPAYLFSGPRGTGKTSSARILARSLNCLNCDQPTPEPCGNC
ELCKSIAAGTALDVIEIDAASNTGVDNIRELIERSRFAPVQARWKVYVVDECHMLSTAAFNALLKTLEEPPPRVVFVLAT
TDPQRVLPTILSRCQRFDFRRIPLEALEKHLEMIATREAIPINPEALHVVAQRAQGGLRDAESLLDQLSLLPGPIKAEAV
WELMGAVPEQELLKLAAALAQADPLCLLETCRNLLNRGRDPGALLQGLAAVLRDLVLMTAAPDRPELTSVSPQFRNQLPP
LASQIGRHQLLQWQVQLKGSESQLRHSVQPRLWLEVLLLGLLAEPPSSEAVTAVPITKTAQPINPAAQAITANALTPTTQ
IQQPPSRSTTTHDPVSAITPNAEPDPPPAQRTPNNNLQELWQQILGSLELPSTRMLLSQQAQLVRLDDHRAVVQVAGNWM
GMVQSRATLLEQAIAKALGNSRQLVLESQSGSATPMPSPHKTGAAPTPNTSASTAEPSPPQQVQSSSTGAYPPDPATSAA
ITDQQKPLEEDSPPTQPTSSLEPIDSKAKRLADFFNGKVLDVDL
>Mature_603_residues
SQAYQPLHHKYRPQRFDALVGQDAIAATLSHALRSSRIAPAYLFSGPRGTGKTSSARILARSLNCLNCDQPTPEPCGNCE
LCKSIAAGTALDVIEIDAASNTGVDNIRELIERSRFAPVQARWKVYVVDECHMLSTAAFNALLKTLEEPPPRVVFVLATT
DPQRVLPTILSRCQRFDFRRIPLEALEKHLEMIATREAIPINPEALHVVAQRAQGGLRDAESLLDQLSLLPGPIKAEAVW
ELMGAVPEQELLKLAAALAQADPLCLLETCRNLLNRGRDPGALLQGLAAVLRDLVLMTAAPDRPELTSVSPQFRNQLPPL
ASQIGRHQLLQWQVQLKGSESQLRHSVQPRLWLEVLLLGLLAEPPSSEAVTAVPITKTAQPINPAAQAITANALTPTTQI
QQPPSRSTTTHDPVSAITPNAEPDPPPAQRTPNNNLQELWQQILGSLELPSTRMLLSQQAQLVRLDDHRAVVQVAGNWMG
MVQSRATLLEQAIAKALGNSRQLVLESQSGSATPMPSPHKTGAAPTPNTSASTAEPSPPQQVQSSSTGAYPPDPATSAAI
TDQQKPLEEDSPPTQPTSSLEPIDSKAKRLADFFNGKVLDVDL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=299, Percent_Identity=25.4180602006689, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI31881687, Length=299, Percent_Identity=25.4180602006689, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI6677723, Length=241, Percent_Identity=27.3858921161826, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI194306571, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI194306567, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI31563534, Length=242, Percent_Identity=25.2066115702479, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1786676, Length=369, Percent_Identity=39.2953929539295, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1787341, Length=147, Percent_Identity=37.4149659863946, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=309, Percent_Identity=24.9190938511327, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17554730, Length=227, Percent_Identity=27.7533039647577, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324039, Length=305, Percent_Identity=25.5737704918033, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6322528, Length=282, Percent_Identity=26.5957446808511, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=239, Percent_Identity=24.6861924686192, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921076, Length=264, Percent_Identity=25.7575757575758, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17647857, Length=246, Percent_Identity=26.0162601626016, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65336; Mature: 65205

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQAYQPLHHKYRPQRFDALVGQDAIAATLSHALRSSRIAPAYLFSGPRGTGKTSSARIL
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHH
ARSLNCLNCDQPTPEPCGNCELCKSIAAGTALDVIEIDAASNTGVDNIRELIERSRFAPV
HHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
QARWKVYVVDECHMLSTAAFNALLKTLEEPPPRVVFVLATTDPQRVLPTILSRCQRFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC
RIPLEALEKHLEMIATREAIPINPEALHVVAQRAQGGLRDAESLLDQLSLLPGPIKAEAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
WELMGAVPEQELLKLAAALAQADPLCLLETCRNLLNRGRDPGALLQGLAAVLRDLVLMTA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
APDRPELTSVSPQFRNQLPPLASQIGRHQLLQWQVQLKGSESQLRHSVQPRLWLEVLLLG
CCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHCCHHHHHHHHHHH
LLAEPPSSEAVTAVPITKTAQPINPAAQAITANALTPTTQIQQPPSRSTTTHDPVSAITP
HHCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCHHCCC
NAEPDPPPAQRTPNNNLQELWQQILGSLELPSTRMLLSQQAQLVRLDDHRAVVQVAGNWM
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHH
GMVQSRATLLEQAIAKALGNSRQLVLESQSGSATPMPSPHKTGAAPTPNTSASTAEPSPP
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QQVQSSSTGAYPPDPATSAAITDQQKPLEEDSPPTQPTSSLEPIDSKAKRLADFFNGKVL
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
DVDL
EECC
>Mature Secondary Structure 
SQAYQPLHHKYRPQRFDALVGQDAIAATLSHALRSSRIAPAYLFSGPRGTGKTSSARIL
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHH
ARSLNCLNCDQPTPEPCGNCELCKSIAAGTALDVIEIDAASNTGVDNIRELIERSRFAPV
HHHCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCC
QARWKVYVVDECHMLSTAAFNALLKTLEEPPPRVVFVLATTDPQRVLPTILSRCQRFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC
RIPLEALEKHLEMIATREAIPINPEALHVVAQRAQGGLRDAESLLDQLSLLPGPIKAEAV
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
WELMGAVPEQELLKLAAALAQADPLCLLETCRNLLNRGRDPGALLQGLAAVLRDLVLMTA
HHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
APDRPELTSVSPQFRNQLPPLASQIGRHQLLQWQVQLKGSESQLRHSVQPRLWLEVLLLG
CCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHEEEEEECCCHHHHHHHCCHHHHHHHHHHH
LLAEPPSSEAVTAVPITKTAQPINPAAQAITANALTPTTQIQQPPSRSTTTHDPVSAITP
HHCCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCHHCCC
NAEPDPPPAQRTPNNNLQELWQQILGSLELPSTRMLLSQQAQLVRLDDHRAVVQVAGNWM
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHEEECCHHHHHHHHHHHH
GMVQSRATLLEQAIAKALGNSRQLVLESQSGSATPMPSPHKTGAAPTPNTSASTAEPSPP
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QQVQSSSTGAYPPDPATSAAITDQQKPLEEDSPPTQPTSSLEPIDSKAKRLADFFNGKVL
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEE
DVDL
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]