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The map label for this gene is murC

Identifier: 124021741

GI number: 124021741

Start: 29295

End: 30761

Strand: Reverse

Name: murC

Synonym: P9303_00261

Alternate gene names: 124021741

Gene position: 30761-29295 (Counterclockwise)

Preceding gene: 124021743

Following gene: 124021740

Centisome position: 1.15

GC content: 54.67

Gene sequence:

>1467_bases
TTGAGCCTATGGTTTTGCCCATTGACCAGCACGCTCAGCCGCCAGCAACCCATCCACTTCATAGGTGTTGGCGGCATCGG
CATGTCTGCCCTAGCTCTCATTCTGGTGAATCGAGGTCATATTGTCTCCGGCTCAGACCCACGCGAAAACACTACCGTTG
AGCGCCTGCGAGCTCAAGGAGTAAGGGTCTTCCGCGATCAGAGCGCCGCAAACATCAATGCCATTTGTAGCAACGTAGAT
CTCCTTCCTTTGGTGGTGATCAGCACAGCCATTCCCAAGAGCAATCCTGAGCTCAAGGCAGCCAAGCTGTCTCAATTGAA
AATCTTGCATCGCTCAGACCTCCTTGCTGCCTTGATTCAGGCACAACCATCCATCGCAGTAGCCGGGAGCCATGGCAAAA
CCACAACCAGCACCCTGCTCACCACACTGCTGGCCACAACCGATCAAGACCCAACAGCTGTGATTGGTGGTGTCGTGCCT
TACTACGACAGCAACGGCCATGCGGGCAAAGGGCGACTGCTAGTAGCAGAAGCTGATGAATCTGATGGCTCTCTCGTCAA
GTTTCAGGCAACGCTCGGCGTGATCACCAATTTGGAGTTAGATCACACCGATCACTACGCCGATCTTGATGAACTGATCA
ACACCATGAAGCGGTTCGGCCGAGGTTGCCGACGACTACTCGCCAACTTCGACTGCCCAATCCTCAAGGAGCATTTCGAT
GCCACAGCTTGGTGGTCAGTCAAAACCTCAGCGGGTGTTGATTTTGCAGCTTTACCAATTTGCCTCAATGGCGATCAAAC
AATTGCGGACATTTACGAGCAGGGCAAACGGATGGGTCAAATCACACTGCCGATGCCCGGACTTCACAACCTCAGCAACG
CTATGGCCGCCATAGCAGCCTGCAGACTCGCAGGACTGTCCTTTGAGGACCTGCAACAAGGTCTGGCTGACCTGCAGCCT
CCTGGGCGCCGTTTCGACTTCCGAGGCACCTGGGAGGGTCGCCAAATCGTTGATGATTACGCCCACCATCCCAGCGAAGT
CAGCGCCACGCTCGCAATGGCGCGCCTGATAGTAACTAGCGGTCGTAGCCAACTACCGAGCCCACCCAAACGCATTTTGG
CCGTGTTCCAGCCTCATCGATACAGCCGTACAAACGAATTTCTCTACGAGTTCGCAAGGGCACTCGGTGAAGCGGATGCT
GTTCTGCTAGCACCCGTTTACAGCGCCGGAGAGAACCCTATTCAGGGAGCCACGAGTGAGAGCCTGGCTAATGCGATCAG
AATCCAGCACCCCAACCTGCCAGTCGCCGTAGCTGAAAACTTTAATCAGCTAACCCTATTGGTGCAAAAACACAGCCTCA
AAGGTGACCTAGTCCTCGCCATGGGTGCAGGCAATATCAACAATCTATGGAGACAACTGACACGTCTTGACAACGCAAAG
ACATGCCCACCCTCCCTGGCCGCCTGA

Upstream 100 bases:

>100_bases
CGGATGAGGAGGCGGCCCATACCTGGCACAAGGTCAACCCCGGCTGGACCTCTCCAAAACATAAGAATCACGGGCTTTCA
GCCCAAGACTGGCTTATCTT

Downstream 100 bases:

>100_bases
CCATAGTGAAGGGGATCAAGCCCCAACCACTGGTTTCTCTTGCCAACTTCACGAGCTGGCGCGTCGGAGGGCCTGCGGAA
TGGTTTGCATCGCCCAGCAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSLWFCPLTSTLSRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDPRENTTVERLRAQGVRVFRDQSAANINAICSNVD
LLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVP
YYDSNGHAGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYADLDELINTMKRFGRGCRRLLANFDCPILKEHFD
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLAGLSFEDLQQGLADLQP
PGRRFDFRGTWEGRQIVDDYAHHPSEVSATLAMARLIVTSGRSQLPSPPKRILAVFQPHRYSRTNEFLYEFARALGEADA
VLLAPVYSAGENPIQGATSESLANAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTRLDNAK
TCPPSLAA

Sequences:

>Translated_488_residues
MSLWFCPLTSTLSRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDPRENTTVERLRAQGVRVFRDQSAANINAICSNVD
LLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVP
YYDSNGHAGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYADLDELINTMKRFGRGCRRLLANFDCPILKEHFD
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLAGLSFEDLQQGLADLQP
PGRRFDFRGTWEGRQIVDDYAHHPSEVSATLAMARLIVTSGRSQLPSPPKRILAVFQPHRYSRTNEFLYEFARALGEADA
VLLAPVYSAGENPIQGATSESLANAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTRLDNAK
TCPPSLAA
>Mature_487_residues
SLWFCPLTSTLSRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDPRENTTVERLRAQGVRVFRDQSAANINAICSNVDL
LPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQAQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPY
YDSNGHAGKGRLLVAEADESDGSLVKFQATLGVITNLELDHTDHYADLDELINTMKRFGRGCRRLLANFDCPILKEHFDA
TAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAACRLAGLSFEDLQQGLADLQPP
GRRFDFRGTWEGRQIVDDYAHHPSEVSATLAMARLIVTSGRSQLPSPPKRILAVFQPHRYSRTNEFLYEFARALGEADAV
LLAPVYSAGENPIQGATSESLANAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTRLDNAKT
CPPSLAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=497, Percent_Identity=34.6076458752515, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790680, Length=478, Percent_Identity=28.0334728033473, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PROM3 (A2C5M3)

Other databases:

- EMBL:   CP000554
- RefSeq:   YP_001016048.1
- ProteinModelPortal:   A2C5M3
- SMR:   A2C5M3
- STRING:   A2C5M3
- GeneID:   4778438
- GenomeReviews:   CP000554_GR
- KEGG:   pmf:P9303_00261
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52707; Mature: 52576

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWFCPLTSTLSRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDPRENTTVERLRAQG
CCEEEECCHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCC
VRVFRDQSAANINAICSNVDLLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQ
HHEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPYYDSNGHAGKGRLLVAEADE
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCEEEEEECCC
SDGSLVKFQATLGVITNLELDHTDHYADLDELINTMKRFGRGCRRLLANFDCPILKEHFD
CCCCEEEEEEEEEEHEECEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAA
CEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHCCHHCCEEECCCCCHHHHHHHHHHHHH
CRLAGLSFEDLQQGLADLQPPGRRFDFRGTWEGRQIVDDYAHHPSEVSATLAMARLIVTS
HHHCCCCHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRSQLPSPPKRILAVFQPHRYSRTNEFLYEFARALGEADAVLLAPVYSAGENPIQGATSE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHH
SLANAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTRLDNAK
HHHHHHEEECCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
TCPPSLAA
CCCCCCCC
>Mature Secondary Structure 
SLWFCPLTSTLSRQQPIHFIGVGGIGMSALALILVNRGHIVSGSDPRENTTVERLRAQG
CEEEECCHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHCC
VRVFRDQSAANINAICSNVDLLPLVVISTAIPKSNPELKAAKLSQLKILHRSDLLAALIQ
HHEECCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQPSIAVAGSHGKTTTSTLLTTLLATTDQDPTAVIGGVVPYYDSNGHAGKGRLLVAEADE
CCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEECCCCCCCCCEEEEEECCC
SDGSLVKFQATLGVITNLELDHTDHYADLDELINTMKRFGRGCRRLLANFDCPILKEHFD
CCCCEEEEEEEEEEHEECEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCC
ATAWWSVKTSAGVDFAALPICLNGDQTIADIYEQGKRMGQITLPMPGLHNLSNAMAAIAA
CEEEEEEECCCCCCEEEEEEEECCCHHHHHHHHCCHHCCEEECCCCCHHHHHHHHHHHHH
CRLAGLSFEDLQQGLADLQPPGRRFDFRGTWEGRQIVDDYAHHPSEVSATLAMARLIVTS
HHHCCCCHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRSQLPSPPKRILAVFQPHRYSRTNEFLYEFARALGEADAVLLAPVYSAGENPIQGATSE
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHH
SLANAIRIQHPNLPVAVAENFNQLTLLVQKHSLKGDLVLAMGAGNINNLWRQLTRLDNAK
HHHHHHEEECCCCCCHHHCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
TCPPSLAA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA