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The map label for this gene is parC [H]

Identifier: 124021719

GI number: 124021719

Start: 6146

End: 8635

Strand: Reverse

Name: parC [H]

Synonym: P9303_00041

Alternate gene names: 124021719

Gene position: 8635-6146 (Counterclockwise)

Preceding gene: 124021720

Following gene: NA

Centisome position: 0.32

GC content: 48.43

Gene sequence:

>2490_bases
ATGGCCGAGGAGCGCCTTCAACCAATCGCGTTGCATCAAGAGATGCAACGCTCCTATCTCGAATACGCGATGAGCGTAAT
CGTAGGAAGAGCATTGCCCGATGCCCGGGATGGCCTCAAGCCAGTTCAGAGGCGCATCCTATTTGCAATGCACGAGCTAG
GCCTGACGCCAGATCGTCCCTATAGAAAATGCGCCCGTGTTGTTGGAGATGTCCTAGGGAAATATCACCCTCATGGCGAT
CAAGCCGTTTACGACGCACTCGTTCGACTCGTTCAGAACTTTTCAAGCCGTTTCCCAGTGTTGGATGGACACGGCAACTT
CGGGTCCGTTGATGACGATCCGCCTGCGGCCATGCGTTACACAGAAACGCGTCTGGCTTCAATCGCCCATATGGCGTTGT
TGGATGAAATCGGTGAGGAAACAGTTGATTTTACTGCGAATTTTGATGGCTCCCAACAGGAACCCTCAGTACTGCCAGCC
CAACTTCCCTTCCTACTACTAAATGGTTGTTCGGGAATCGCCGTGGGTATGGCGACCAGCATTCCACCCCACAACCTTGG
CGAAGTGGTCGATGGATTGATTGCCCTGATACGCAAGCCCGATCTCAGTGACGACAAATTACTTGGTCTAATTCCTGGCC
CAGACTTTCCAACTGGTGGAGAGATCCTGCTGGGCACTGGCATCCATGAGACCTACCTCAAAGGACGCGGCAGCATCCCA
ATGCGTGGCGTGGCCCATGTCGAAGAAATACAACCTGGAAAGGGTCGGCACCGCCGAAGTGCTGTTGTCGTCACTGAATT
GCCCTATCAACTCAGCAAAGCTGGCTGGATCGAAAAACTGGCAGATCTTGTTAACAATGGAAAAATCGGTGGCATTGCCG
ATATTCGCGACGAAAGCGACCGAGAAGGAATGAGGATAGTGGTGGAACTGCGCCGAGATGCCAACCCAGAGAATGTTCTC
GGCGATCTGCATCGACGCACCTCCCTACAAAGCAATTTCGGTGCAATTCTTCTGGCTCTTGTTAACGGCCAACCACAACA
ACTTTCGCTGAGAAAATTGCTACAAACCTTTCTCGAGTACCGAGAACTCACAGTTATCCGAAGAACCAACCATGCCCTAG
GAAAAACAAAAACTCGCCTGGAAGTGGTGGAAGGATTGATCACAGCATTGAACGCACTACAAGCTGTCATTGCAATGATC
CAAGAGGCTGCCGATGCTGCTGCTGCAAGAGCCCGTCTGATGGTGCAATTAGATCTAAATGAAAAGCAAGCCGACGCTGT
TTTGGCAATGCCACTACGACGACTTACGAGTCTGGAACAAAGCAGTTTGAGGCAAGAAGCCAAAGAACTGCAAGGCAAAC
AAGAACAACTTCAATTCCTTCTCGAAAATCGAGAAAGCATGCTGGAAGTACTCATTCAAGAACTTCGACAGCTCAAAAAG
CGCTTTAACAACCCCCGCCGAACTCGCCTTGTGGAGGGTGGCGATGATCTGGTCGCTGAGCGAGCGGCAAACCAAAGACC
GAATGCTGAAGTTCAACGACAACAAGCACTATCCGCCCTGCCAAGTGATGGACGAATACTCATCCAACAAGACAGCCAGG
TCAAAGTAATGAGCCCACAAATCCTCGGTCGACTTCACCTCAACGAAGCCTGCAAACTCGGCGATGGACCTTCGCCAGCC
AGATTGATCTTGCCAATTGAACCAGCCCCACGTCTACTTGCGGTGACAAACAATGGTCGAGTAGCTCTAGTCCGCTGGGA
ATTTGCAGGGCAACAACCCGGGTCGCTGGAACGCTTCCTACCAGGAGGATTAGAAAAAGAAACATTGATCAACATATTCC
CCTTGCCCGTAGATCAAAACCTAAGCCTAGGTCTACTGAGCAGCGATGGACGCTTCAAACGATTACCTTTAGAAGAAGTG
ATGGAACTTTCCGGAAGAGCAGCAACCATTGTTAAATTAAAAGATGGTGTTGTATTAAAATCAGCATTCATTTGCAAAGC
AAATGATGATGTCATTTTAGCAAGTAGCATAGGAAGAGTAATCAGAATTAATGTTAATAACGACAGCATGCCATTGATGG
GAAAATTAGCTCAGGGGCCTATGACAATGCGACTATTACCAGAAGAAATGGTCGTTGGAGCAATTTCTTGTCCACCAAAC
TGTGAAAGCACTGTATTACTTGTCACACGCCTAGGTAAATTCGCCAAGCTATTGGTCTCTTCGATAAGAGTCTGCCAGAG
AGGAGATTTAGGCGAAATTGGGTTAACAATAAAAGATTCAAGCCGAGATCAAGATCGAGTCGTTGACATCTGTAATGGCA
ATAGGTTGGTCGGCCTAGTAAGTAGCCAAGGTCGCCATGGCCGTATCGAAGCTGGAGAACTGGAACTGACCATGCCTATC
AAACCAAATCTAAACATTATGGAATTAAAAGACAACGAAGAAATTCAAAAACTCGTGCCACTAATCACGACTAATAATAT
TATAGATTAA

Upstream 100 bases:

>100_bases
CCAACGCTGATACAAACCAATAGGCACTGATCAACAGTGCTGGTATCCGCTAAGTAGATCTGTAGGCTGAGCGCTTTAAG
CCCTCTAATCCCAAATCTGG

Downstream 100 bases:

>100_bases
GCATTTAACACTTAAGGCCTTGATAATCACCTTTATTAAGACAATTGTGTGCGTTCTATCCAATCGAGATATTCAGAAGT
AACTGTCCCTGTAATATACT

Product: DNA gyrase/topoisomerase IV, subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 829; Mature: 828

Protein sequence:

>829_residues
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPA
QLPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVL
GDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALGKTKTRLEVVEGLITALNALQAVIAMI
QEAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQGKQEQLQFLLENRESMLEVLIQELRQLKK
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLGDGPSPA
RLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPLEEV
MELSGRAATIVKLKDGVVLKSAFICKANDDVILASSIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAISCPPN
CESTVLLVTRLGKFAKLLVSSIRVCQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGELELTMPI
KPNLNIMELKDNEEIQKLVPLITTNNIID

Sequences:

>Translated_829_residues
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGD
QAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPA
QLPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVL
GDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALGKTKTRLEVVEGLITALNALQAVIAMI
QEAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQGKQEQLQFLLENRESMLEVLIQELRQLKK
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLGDGPSPA
RLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPLEEV
MELSGRAATIVKLKDGVVLKSAFICKANDDVILASSIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAISCPPN
CESTVLLVTRLGKFAKLLVSSIRVCQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGELELTMPI
KPNLNIMELKDNEEIQKLVPLITTNNIID
>Mature_828_residues
AEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQ
AVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQ
LPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIPM
RGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVLG
DLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALGKTKTRLEVVEGLITALNALQAVIAMIQ
EAADAAAARARLMVQLDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQGKQEQLQFLLENRESMLEVLIQELRQLKKR
FNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRLHLNEACKLGDGPSPAR
LILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFLPGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPLEEVM
ELSGRAATIVKLKDGVVLKSAFICKANDDVILASSIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAISCPPNC
ESTVLLVTRLGKFAKLLVSSIRVCQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLVSSQGRHGRIEAGELELTMPIK
PNLNIMELKDNEEIQKLVPLITTNNIID

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=25.2906976744186, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI19913406, Length=351, Percent_Identity=24.5014245014245, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788562, Length=803, Percent_Identity=36.3636363636364, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789396, Length=489, Percent_Identity=43.3537832310838, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI212645845, Length=509, Percent_Identity=23.7721021611002, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=184, Percent_Identity=30.9782608695652, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17136538, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 91241; Mature: 91110

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
YRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHH
TETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQLPFLLLNGCSGIAVGMATS
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCHHCCHHHHCCCCCEEEHHCCC
IPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCC
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESD
CCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
REGMRIVVELRRDANPENVLGDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEY
CCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RELTVIRRTNHALGKTKTRLEVVEGLITALNALQAVIAMIQEAADAAAARARLMVQLDLN
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
EKQADAVLAMPLRRLTSLEQSSLRQEAKELQGKQEQLQFLLENRESMLEVLIQELRQLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQ
HHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHH
ILGRLHLNEACKLGDGPSPARLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFL
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHC
PGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPLEEVMELSGRAATIVKLKDGVVLK
CCCCCCCCEEEEECCCCCCCCCEEEECCCCCEEECCHHHHHHHCCCEEEEEEECCCEEEE
SAFICKANDDVILASSIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAISCPPN
EEEEEECCCCEEEEECCCCEEEEEECCCCCCHHHHHCCCCEEEEECCHHHHEEEECCCCC
CESTVLLVTRLGKFAKLLVSSIRVCQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SSQGRHGRIEAGELELTMPIKPNLNIMELKDNEEIQKLVPLITTNNIID
CCCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AEERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRP
CCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
YRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHH
TETRLASIAHMALLDEIGEETVDFTANFDGSQQEPSVLPAQLPFLLLNGCSGIAVGMATS
HHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCCCCHHCCHHHHCCCCCEEEHHCCC
IPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIP
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCC
MRGVAHVEEIQPGKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESD
CCCCHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCC
REGMRIVVELRRDANPENVLGDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEY
CCCCEEEEEEHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RELTVIRRTNHALGKTKTRLEVVEGLITALNALQAVIAMIQEAADAAAARARLMVQLDLN
HHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECC
EKQADAVLAMPLRRLTSLEQSSLRQEAKELQGKQEQLQFLLENRESMLEVLIQELRQLKK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFNNPRRTRLVEGGDDLVAERAANQRPNAEVQRQQALSALPSDGRILIQQDSQVKVMSPQ
HHCCCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEECHH
ILGRLHLNEACKLGDGPSPARLILPIEPAPRLLAVTNNGRVALVRWEFAGQQPGSLERFL
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHC
PGGLEKETLINIFPLPVDQNLSLGLLSSDGRFKRLPLEEVMELSGRAATIVKLKDGVVLK
CCCCCCCCEEEEECCCCCCCCCEEEECCCCCEEECCHHHHHHHCCCEEEEEEECCCEEEE
SAFICKANDDVILASSIGRVIRINVNNDSMPLMGKLAQGPMTMRLLPEEMVVGAISCPPN
EEEEEECCCCEEEEECCCCEEEEEECCCCCCHHHHHCCCCEEEEECCHHHHEEEECCCCC
CESTVLLVTRLGKFAKLLVSSIRVCQRGDLGEIGLTIKDSSRDQDRVVDICNGNRLVGLV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SSQGRHGRIEAGELELTMPIKPNLNIMELKDNEEIQKLVPLITTNNIID
CCCCCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]