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The map label for this gene is ubiB [C]

Identifier: 124026903

GI number: 124026903

Start: 1860996

End: 1862855

Strand: Direct

Name: ubiB [C]

Synonym: NATL1_21981

Alternate gene names: 124026903

Gene position: 1860996-1862855 (Clockwise)

Preceding gene: 124026899

Following gene: 124026904

Centisome position: 99.8

GC content: 31.94

Gene sequence:

>1860_bases
ATGGCCGAAGAATTAAGCGATTTTATTGAAGCCTCAGGTCTACTTTCGTATGACCCGGTGGCTATTGACTCAATCTACAA
AAAAAATCCAATTCGTCTACTTCGAAGACTCTGGCAGACACTTTTACCAATTGGATTATTTTTACTAGGTGTTGGATGGG
AAAAGTTGATTGGTTCTCTAGACAAAGATGAAAGAAAAACTTTTAGGGCGAAAGAATTTACAAACCTACTGGTAGATCTA
GGACCAGCATTCATTAAAGCTGGACAAGCACTCTCAACTAGGCCAGACATTGTTCCGCCAACTGTTTTAGAAGAATTAGC
ACAACTTCAAGATCAACTACCTGGCTTTGAAAGTAAGCTCGCAATGGCTTGTATTGAACAAGATTTAGATAATAAAATAG
AGAACATATTTGAAGAGATAGATAAAGAACCGATTTCAGCTGCATCTTTAGGTCAAGTACATAAAGCAAAACTCAAAAGT
GGAGAACAAGTTGCTGTAAAAATTCAAAGACCAGGATTAAGAGAACAAATAACTTTAGATTTATACATAGTAAGAAATAT
AGCAATCTGGTTTAAAAATAATATAGGGATTATTAGAAGTGATCTAGTTGCATTAATAGACGAACTAGGTAAGAGAATAT
TTGAAGAAATGGACTACATTAATGAAGCAAATAATGCAGAAAAATTTAAAGAACTTCATAGCGGAAATGATAAAATTGCA
GTACCAAAAATTTACAGAAAAGCAACAAGTAGAAGAGTGCTTACAATGGAATGGATCGATGGGACAAAATTAACAAATAT
AGAAGCTGTAAAAAATTTAGGAATTAATCCAAATGAGATGGTGGAAATTGGAGTTAGTTGTAGTCTTCAGCAACTTATTG
AGCACGGTTTTTTTCACGCCGATCCACACCCAGGGAACATCTTGGCAATGAAAGATGGACGATTATGTTATTTAGATTTT
GGAATGATGAGTGATATTACGCAACAATCTAGGGTTGGATTAATTAGAGCAGTTGTTCATCTTGTCAACAGGAGATTTGA
TAAACTTTCTAATGATTTTGTTCAACTAGGATTTCTTTCTGAAGATGTTGATTTAACTCCAATTGCGCCAGCATTTGAAA
GTGTATTTACCACCGCTTTGGAAATAGGCGTAAACAAAATGGACTTTAAAGCCGTAACAGATGATATGTCTGGAATTATG
TATAAATTTCCTTTTAAATTACCACCTTATTATGCACTAATAATCAGATCTTTAATTACTTTAGAAGGCATAGCACTAAG
TGTTGACCCTAATTTTAAAATACTAGGAGCTGCATATCCTTATTTCGCAAGAAGACTAATGGAAGATGAAAATCCAGAAT
TAAGAAATAGTTTAAAAGAAATGCTTTTTGATGAAAATACTCTAAAATTAGAGAGATTAGACGATCTTCTAAAAAGCGCT
ACAAAGGAAAAACAACTTGATGGCGAAAAAATATTAGATCAAACAATTGATTTTTTATTTTCTAAAAAGGGTCTTGTTCT
TAGAAATGAATTAGTAAATATCCTAGCTTCAAAAATAGACTCTGTTGGTTGGAAAACTATAATTAGATTAAATGAAAAGT
TACCGTCGAAAATTCGTTCAAAAACAATAGAAAAATCATATAAAATTAATAATAAACAACTTTTAAATATATCTTCAATA
AAGAAAATATTTAAAGTGTCAAAAATGAAATCTGGTTTTAAAAGAAAAATATTTTTTAAAAAATTACCAAGAATTCTAAT
AACTAAAGATACGTATCGGATGGGCTTAGGGTTAATGCAAAAAACCTCAGAAAAAGGGATAATTAGGTTAGTCAAAGTTG
CCGCTGGCGTAAGGCAATAA

Upstream 100 bases:

>100_bases
TTTGAAAACGAAGACTGTTTAACATAAATCAAAGCAACCAAAAAGACGCAAACTGAGAGTAAAATGAACTAGAAGAGACG
TAGAACATTGCCATAATAAA

Downstream 100 bases:

>100_bases
ATGAAATTTAAATATATTATTCTTTTAATATTATTTTTCAATCAAAGCGCTAAAGGGGCAGAAAACCTCTTTCTTTATAA
AGGAACATTTAGTAGAAGCA

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MAEELSDFIEASGLLSYDPVAIDSIYKKNPIRLLRRLWQTLLPIGLFLLGVGWEKLIGSLDKDERKTFRAKEFTNLLVDL
GPAFIKAGQALSTRPDIVPPTVLEELAQLQDQLPGFESKLAMACIEQDLDNKIENIFEEIDKEPISAASLGQVHKAKLKS
GEQVAVKIQRPGLREQITLDLYIVRNIAIWFKNNIGIIRSDLVALIDELGKRIFEEMDYINEANNAEKFKELHSGNDKIA
VPKIYRKATSRRVLTMEWIDGTKLTNIEAVKNLGINPNEMVEIGVSCSLQQLIEHGFFHADPHPGNILAMKDGRLCYLDF
GMMSDITQQSRVGLIRAVVHLVNRRFDKLSNDFVQLGFLSEDVDLTPIAPAFESVFTTALEIGVNKMDFKAVTDDMSGIM
YKFPFKLPPYYALIIRSLITLEGIALSVDPNFKILGAAYPYFARRLMEDENPELRNSLKEMLFDENTLKLERLDDLLKSA
TKEKQLDGEKILDQTIDFLFSKKGLVLRNELVNILASKIDSVGWKTIIRLNEKLPSKIRSKTIEKSYKINNKQLLNISSI
KKIFKVSKMKSGFKRKIFFKKLPRILITKDTYRMGLGLMQKTSEKGIIRLVKVAAGVRQ

Sequences:

>Translated_619_residues
MAEELSDFIEASGLLSYDPVAIDSIYKKNPIRLLRRLWQTLLPIGLFLLGVGWEKLIGSLDKDERKTFRAKEFTNLLVDL
GPAFIKAGQALSTRPDIVPPTVLEELAQLQDQLPGFESKLAMACIEQDLDNKIENIFEEIDKEPISAASLGQVHKAKLKS
GEQVAVKIQRPGLREQITLDLYIVRNIAIWFKNNIGIIRSDLVALIDELGKRIFEEMDYINEANNAEKFKELHSGNDKIA
VPKIYRKATSRRVLTMEWIDGTKLTNIEAVKNLGINPNEMVEIGVSCSLQQLIEHGFFHADPHPGNILAMKDGRLCYLDF
GMMSDITQQSRVGLIRAVVHLVNRRFDKLSNDFVQLGFLSEDVDLTPIAPAFESVFTTALEIGVNKMDFKAVTDDMSGIM
YKFPFKLPPYYALIIRSLITLEGIALSVDPNFKILGAAYPYFARRLMEDENPELRNSLKEMLFDENTLKLERLDDLLKSA
TKEKQLDGEKILDQTIDFLFSKKGLVLRNELVNILASKIDSVGWKTIIRLNEKLPSKIRSKTIEKSYKINNKQLLNISSI
KKIFKVSKMKSGFKRKIFFKKLPRILITKDTYRMGLGLMQKTSEKGIIRLVKVAAGVRQ
>Mature_618_residues
AEELSDFIEASGLLSYDPVAIDSIYKKNPIRLLRRLWQTLLPIGLFLLGVGWEKLIGSLDKDERKTFRAKEFTNLLVDLG
PAFIKAGQALSTRPDIVPPTVLEELAQLQDQLPGFESKLAMACIEQDLDNKIENIFEEIDKEPISAASLGQVHKAKLKSG
EQVAVKIQRPGLREQITLDLYIVRNIAIWFKNNIGIIRSDLVALIDELGKRIFEEMDYINEANNAEKFKELHSGNDKIAV
PKIYRKATSRRVLTMEWIDGTKLTNIEAVKNLGINPNEMVEIGVSCSLQQLIEHGFFHADPHPGNILAMKDGRLCYLDFG
MMSDITQQSRVGLIRAVVHLVNRRFDKLSNDFVQLGFLSEDVDLTPIAPAFESVFTTALEIGVNKMDFKAVTDDMSGIMY
KFPFKLPPYYALIIRSLITLEGIALSVDPNFKILGAAYPYFARRLMEDENPELRNSLKEMLFDENTLKLERLDDLLKSAT
KEKQLDGEKILDQTIDFLFSKKGLVLRNELVNILASKIDSVGWKTIIRLNEKLPSKIRSKTIEKSYKINNKQLLNISSIK
KIFKVSKMKSGFKRKIFFKKLPRILITKDTYRMGLGLMQKTSEKGIIRLVKVAAGVRQ

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=268, Percent_Identity=30.5970149253731, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI41393593, Length=268, Percent_Identity=30.2238805970149, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI217035081, Length=209, Percent_Identity=32.5358851674641, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI34147522, Length=259, Percent_Identity=32.046332046332, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI27363457, Length=263, Percent_Identity=28.1368821292776, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI217416386, Length=227, Percent_Identity=28.6343612334802, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI2367309, Length=392, Percent_Identity=27.0408163265306, Blast_Score=166, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17559152, Length=258, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32565180, Length=248, Percent_Identity=29.0322580645161, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323282, Length=244, Percent_Identity=32.7868852459016, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=23.394495412844, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=325, Percent_Identity=25.5384615384615, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24662575, Length=262, Percent_Identity=32.824427480916, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI22024280, Length=259, Percent_Identity=32.4324324324324, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18859849, Length=262, Percent_Identity=29.0076335877863, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 70269; Mature: 70138

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEELSDFIEASGLLSYDPVAIDSIYKKNPIRLLRRLWQTLLPIGLFLLGVGWEKLIGSL
CCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
DKDERKTFRAKEFTNLLVDLGPAFIKAGQALSTRPDIVPPTVLEELAQLQDQLPGFESKL
CHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
AMACIEQDLDNKIENIFEEIDKEPISAASLGQVHKAKLKSGEQVAVKIQRPGLREQITLD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHEEE
LYIVRNIAIWFKNNIGIIRSDLVALIDELGKRIFEEMDYINEANNAEKFKELHSGNDKIA
EEEEHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
VPKIYRKATSRRVLTMEWIDGTKLTNIEAVKNLGINPNEMVEIGVSCSLQQLIEHGFFHA
CHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHEEECCCCCHHHHHHCCCCCC
DPHPGNILAMKDGRLCYLDFGMMSDITQQSRVGLIRAVVHLVNRRFDKLSNDFVQLGFLS
CCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCC
EDVDLTPIAPAFESVFTTALEIGVNKMDFKAVTDDMSGIMYKFPFKLPPYYALIIRSLIT
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LEGIALSVDPNFKILGAAYPYFARRLMEDENPELRNSLKEMLFDENTLKLERLDDLLKSA
HCCEEEEECCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TKEKQLDGEKILDQTIDFLFSKKGLVLRNELVNILASKIDSVGWKTIIRLNEKLPSKIRS
HHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KTIEKSYKINNKQLLNISSIKKIFKVSKMKSGFKRKIFFKKLPRILITKDTYRMGLGLMQ
HHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHH
KTSEKGIIRLVKVAAGVRQ
HCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEELSDFIEASGLLSYDPVAIDSIYKKNPIRLLRRLWQTLLPIGLFLLGVGWEKLIGSL
CHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
DKDERKTFRAKEFTNLLVDLGPAFIKAGQALSTRPDIVPPTVLEELAQLQDQLPGFESKL
CHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHH
AMACIEQDLDNKIENIFEEIDKEPISAASLGQVHKAKLKSGEQVAVKIQRPGLREQITLD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHEEE
LYIVRNIAIWFKNNIGIIRSDLVALIDELGKRIFEEMDYINEANNAEKFKELHSGNDKIA
EEEEHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEE
VPKIYRKATSRRVLTMEWIDGTKLTNIEAVKNLGINPNEMVEIGVSCSLQQLIEHGFFHA
CHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHEEECCCCCHHHHHHCCCCCC
DPHPGNILAMKDGRLCYLDFGMMSDITQQSRVGLIRAVVHLVNRRFDKLSNDFVQLGFLS
CCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCC
EDVDLTPIAPAFESVFTTALEIGVNKMDFKAVTDDMSGIMYKFPFKLPPYYALIIRSLIT
CCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
LEGIALSVDPNFKILGAAYPYFARRLMEDENPELRNSLKEMLFDENTLKLERLDDLLKSA
HCCEEEEECCCEEEEECHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TKEKQLDGEKILDQTIDFLFSKKGLVLRNELVNILASKIDSVGWKTIIRLNEKLPSKIRS
HHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KTIEKSYKINNKQLLNISSIKKIFKVSKMKSGFKRKIFFKKLPRILITKDTYRMGLGLMQ
HHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHHH
KTSEKGIIRLVKVAAGVRQ
HCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]