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The map label for this gene is cysG [H]

Identifier: 124026873

GI number: 124026873

Start: 1825439

End: 1826224

Strand: Reverse

Name: cysG [H]

Synonym: NATL1_21681

Alternate gene names: 124026873

Gene position: 1826224-1825439 (Counterclockwise)

Preceding gene: 124026874

Following gene: 124026865

Centisome position: 97.93

GC content: 39.69

Gene sequence:

>786_bases
ATGAATACAAATCAGTTTGGCACTGTGCATCTTGTCGGAGCAGGTCCTGGTGATCCCGATTTATTAACAGTTAAAGCGCA
AAAACTAATTAGTAAATGTGATGCGCTTGTATACGACTCTTTAGTTCCTATAGAGCTACTTGAATTAGTTTCTTCAAATT
GTCAACTTCATTCAGTGGGTAAGAGGCGTGGTCATCATTCGGTTCCTCAGAGGACAACGAATGATATTTTATTTGATTTA
GCAAAGAGTTATTCTTGTATTGTTAGATTAAAAGGTGGTGATCCATTTTTGTTTGGTAGAGGTGCGGAAGAAGCTTCTTA
TCTTCATAAAAAAGGGGTTCCAGTACAAGTAGTACCTGGGGTTACATCAGGTATAGCTGCTCCTGCCTATGTTGGGATAC
CTATTACTCATAGACGTGCTGGATCTTCAGTCACTTTTGTGACTGGACATGAGGGGATTGATAAAAAACGCCCAGCTGTA
AATTGGCGGTCTTTAGCCAAATCCAGTGATGGAATCGTTATATATATGGGTGTTCATAATTTAAAATTTATCTCAGCAGA
GTTGATTGCTGGTGGTATGAATCCTGAGACGTCTGCGGCAGTAATTGAGCAGGGTACTGTTATTGGTCAACGTCATATTA
AGAGCCCTTTGGTAAAGCTTTTTGACCGAGTTCAAGAAGAAAATTTAAGGTCTCCTGCGATTGTTGTAATAGGTTCAGTT
GTGGATTTTCAAGTAGAAGCTTGCTCTCCAAAGCCAGCTGAAGTGACATTTCCAATTCCTATATAG

Upstream 100 bases:

>100_bases
ACAAAAATGTAGAAATTGATAGTAAAGGAGAGCAGCTTAAATCTTTGCTTGAGATTGATATTATTCATCGTGGTCTTGTT
AATATTTTGGGTAACTTGCC

Downstream 100 bases:

>100_bases
ATAGTATGTCCGATATTATTTTTTAGATTTTTAACAAACTCAGCCAAAATTCTTTGGGGTTAGTTGATATTTTTAATTCT
TTTTTGTTTATTTTTTGAAT

Product: putative uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNTNQFGTVHLVGAGPGDPDLLTVKAQKLISKCDALVYDSLVPIELLELVSSNCQLHSVGKRRGHHSVPQRTTNDILFDL
AKSYSCIVRLKGGDPFLFGRGAEEASYLHKKGVPVQVVPGVTSGIAAPAYVGIPITHRRAGSSVTFVTGHEGIDKKRPAV
NWRSLAKSSDGIVIYMGVHNLKFISAELIAGGMNPETSAAVIEQGTVIGQRHIKSPLVKLFDRVQEENLRSPAIVVIGSV
VDFQVEACSPKPAEVTFPIPI

Sequences:

>Translated_261_residues
MNTNQFGTVHLVGAGPGDPDLLTVKAQKLISKCDALVYDSLVPIELLELVSSNCQLHSVGKRRGHHSVPQRTTNDILFDL
AKSYSCIVRLKGGDPFLFGRGAEEASYLHKKGVPVQVVPGVTSGIAAPAYVGIPITHRRAGSSVTFVTGHEGIDKKRPAV
NWRSLAKSSDGIVIYMGVHNLKFISAELIAGGMNPETSAAVIEQGTVIGQRHIKSPLVKLFDRVQEENLRSPAIVVIGSV
VDFQVEACSPKPAEVTFPIPI
>Mature_261_residues
MNTNQFGTVHLVGAGPGDPDLLTVKAQKLISKCDALVYDSLVPIELLELVSSNCQLHSVGKRRGHHSVPQRTTNDILFDL
AKSYSCIVRLKGGDPFLFGRGAEEASYLHKKGVPVQVVPGVTSGIAAPAYVGIPITHRRAGSSVTFVTGHEGIDKKRPAV
NWRSLAKSSDGIVIYMGVHNLKFISAELIAGGMNPETSAAVIEQGTVIGQRHIKSPLVKLFDRVQEENLRSPAIVVIGSV
VDFQVEACSPKPAEVTFPIPI

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=235, Percent_Identity=43.8297872340426, Blast_Score=189, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322922, Length=245, Percent_Identity=29.3877551020408, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27977; Mature: 27977

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNQFGTVHLVGAGPGDPDLLTVKAQKLISKCDALVYDSLVPIELLELVSSNCQLHSVG
CCCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEHH
KRRGHHSVPQRTTNDILFDLAKSYSCIVRLKGGDPFLFGRGAEEASYLHKKGVPVQVVPG
HHCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHCCCCEEEECC
VTSGIAAPAYVGIPITHRRAGSSVTFVTGHEGIDKKRPAVNWRSLAKSSDGIVIYMGVHN
CCCCCCCCEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEECCC
LKFISAELIAGGMNPETSAAVIEQGTVIGQRHIKSPLVKLFDRVQEENLRSPAIVVIGSV
CEEEEHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VDFQVEACSPKPAEVTFPIPI
EEEEEECCCCCCCEEEECCCC
>Mature Secondary Structure
MNTNQFGTVHLVGAGPGDPDLLTVKAQKLISKCDALVYDSLVPIELLELVSSNCQLHSVG
CCCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEHH
KRRGHHSVPQRTTNDILFDLAKSYSCIVRLKGGDPFLFGRGAEEASYLHKKGVPVQVVPG
HHCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCHHHHHHHHCCCCEEEECC
VTSGIAAPAYVGIPITHRRAGSSVTFVTGHEGIDKKRPAVNWRSLAKSSDGIVIYMGVHN
CCCCCCCCEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEECCC
LKFISAELIAGGMNPETSAAVIEQGTVIGQRHIKSPLVKLFDRVQEENLRSPAIVVIGSV
CEEEEHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VDFQVEACSPKPAEVTFPIPI
EEEEEECCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]