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The map label for this gene is gcvT

Identifier: 124026866

GI number: 124026866

Start: 1817099

End: 1818217

Strand: Direct

Name: gcvT

Synonym: NATL1_21611

Alternate gene names: 124026866

Gene position: 1817099-1818217 (Clockwise)

Preceding gene: 124026864

Following gene: 124026867

Centisome position: 97.45

GC content: 37.18

Gene sequence:

>1119_bases
ATGAAATTACTACAAACTCCTCTTTATCAAGAATGCAAAGAATTAGGCGGTAAAATGGTCCCTTTTGCAAATTGGGAAAT
GCCTGTTAGTTTTTCTGGGTTAATAGAAGAACACAATGCAGTAAGAAAAAATGTTGGAATGTTCGACATATCTCACATGG
GTGTTGTGCAATTAAAAGGTAAAAATATCAAAAGCGCATTACAAAATTTAGTTCCCTCAGACGTGTTTCGGATAGGACCT
AGTGAAGCGTGTTATACAGTTTTTTTAAAAGAGAATGGAGGAATTCAAGACGATCTAATCATTTATGACCAAGGAGTTTT
AGATACAAATGAAGAGAGTGTAGTTCTAGTTATTAATGCGGCAAGAAAAGAATCTGACGTTGAATGGTTGAGTTCAAATC
TTTCTAAAAAGGAAATCACAATATCCGAATTCATGCCAGAGGGTGCATTAATTGCGATCCAAGGTCCAGAATCTATCAGT
ACACTTGAGAAAATTCTCGAAGAGCCTTTATCTAATTTGCCACGTTTTGGTCACAGAACTATCACTTCAAATCCCAATCT
AATAAACTCACAAGAATCAATTTTTATTGCACGAACTGGTTATACAGGAGAGGAAGGTTTCGAATTCTTGTCATCTCCTG
AAACAGCAAAGTCTATCTGGAAGAGTCTAATTGCGTCGGGAGTTACTCCATGCGGGCTAGGAGCAAGAGATACACTGCGG
TTAGAGGCTTCTATGCATTTATATGGCAACGATATCAACCTAGATACAACTCCCTTTGAAGCTGGCTTGGGTTGGTTAGT
TCATTTAGAAATGCCTAATGATTTCATAGGTAGGAAAGCTCTAGAAAAACAAGCCGAAGTTGGAACGCAAAAAAAACTTG
TTGGTATTCAAGTCCTTGATAAAGGAATTGCAAGAAAAGGATATCCAGTTCTATACAACAGCGAAACTGTAGGAATAGTC
ACTAGCGGAACATGGTCTCCAACATTGCAAAAACCCATAGCTCTTGCTTATGTGCCAAGCGAAATTGCAAAAGTCAATAC
TCAAATAGAAGTAGAAATTAGAGGAAAAAAACATCCTGCAATAATCGTAAAAAGACCATTCTATCGAAAAGGTTTTTGA

Upstream 100 bases:

>100_bases
AAAACTTTCCGGATCGAGCCACAAAGCATTAAATTTAGTTTTAGAAATTCTTATAAGTTCACGGTATTAATTGTGAATTT
CTTTTACCGTTCAACAAAAA

Downstream 100 bases:

>100_bases
GCAAGTAGAAACTGTGTTGTGCATAAAAGCCGGTCTTTGTGGGAAACTCATTATTCATGATGATTGAGAATTTTATGCGC
AATAAGACTTGTGGAGAACT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKGKNIKSALQNLVPSDVFRIGP
SEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINAARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESIS
TLEKILEEPLSNLPRFGHRTITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLR
LEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLDKGIARKGYPVLYNSETVGIV
TSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPAIIVKRPFYRKGF

Sequences:

>Translated_372_residues
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKGKNIKSALQNLVPSDVFRIGP
SEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINAARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESIS
TLEKILEEPLSNLPRFGHRTITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLR
LEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLDKGIARKGYPVLYNSETVGIV
TSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPAIIVKRPFYRKGF
>Mature_372_residues
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKGKNIKSALQNLVPSDVFRIGP
SEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINAARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESIS
TLEKILEEPLSNLPRFGHRTITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLR
LEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLDKGIARKGYPVLYNSETVGIV
TSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPAIIVKRPFYRKGF

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=32.8877005347594, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI257796258, Length=360, Percent_Identity=32.5, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=29.9191374663073, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI24797151, Length=352, Percent_Identity=27.8409090909091, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI257796256, Length=309, Percent_Identity=32.3624595469256, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI197927446, Length=334, Percent_Identity=25.1497005988024, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI21361378, Length=334, Percent_Identity=25.1497005988024, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI194306651, Length=325, Percent_Identity=23.3846153846154, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789272, Length=380, Percent_Identity=38.9473684210526, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17560118, Length=378, Percent_Identity=35.1851851851852, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71994052, Length=392, Percent_Identity=26.7857142857143, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71994045, Length=392, Percent_Identity=26.7857142857143, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32563613, Length=352, Percent_Identity=24.7159090909091, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=385, Percent_Identity=36.3636363636364, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20129441, Length=382, Percent_Identity=33.7696335078534, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI20130091, Length=352, Percent_Identity=25.8522727272727, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28571104, Length=327, Percent_Identity=23.5474006116208, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_PROM1 (A2C5F7)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015981.1
- ProteinModelPortal:   A2C5F7
- SMR:   A2C5F7
- STRING:   A2C5F7
- GeneID:   4780581
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_21611
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   NDISKPP
- ProtClustDB:   PRK00389
- BioCyc:   PMAR167555:NATL1_21611-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 41079; Mature: 41079

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKG
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEECC
KNIKSALQNLVPSDVFRIGPSEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINA
CCHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEC
ARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESISTLEKILEEPLSNLPRFGHRT
CCCCCHHHHHHCCCCCCEEEHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
ITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLR
ECCCCCEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
LEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLD
EEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHEEHHHHHH
KGIARKGYPVLYNSETVGIVTSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPA
HHHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCCCCE
IIVKRPFYRKGF
EEEECCHHCCCC
>Mature Secondary Structure
MKLLQTPLYQECKELGGKMVPFANWEMPVSFSGLIEEHNAVRKNVGMFDISHMGVVQLKG
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEECC
KNIKSALQNLVPSDVFRIGPSEACYTVFLKENGGIQDDLIIYDQGVLDTNEESVVLVINA
CCHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEC
ARKESDVEWLSSNLSKKEITISEFMPEGALIAIQGPESISTLEKILEEPLSNLPRFGHRT
CCCCCHHHHHHCCCCCCEEEHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEE
ITSNPNLINSQESIFIARTGYTGEEGFEFLSSPETAKSIWKSLIASGVTPCGLGARDTLR
ECCCCCEECCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
LEASMHLYGNDINLDTTPFEAGLGWLVHLEMPNDFIGRKALEKQAEVGTQKKLVGIQVLD
EEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHHEEHHHHHH
KGIARKGYPVLYNSETVGIVTSGTWSPTLQKPIALAYVPSEIAKVNTQIEVEIRGKKHPA
HHHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEEECCHHHHHCCCEEEEEECCCCCCE
IIVKRPFYRKGF
EEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA