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The map label for this gene is phoP [H]

Identifier: 124026776

GI number: 124026776

Start: 1715525

End: 1716265

Strand: Reverse

Name: phoP [H]

Synonym: NATL1_20711

Alternate gene names: 124026776

Gene position: 1716265-1715525 (Counterclockwise)

Preceding gene: 124026777

Following gene: 124026775

Centisome position: 92.04

GC content: 43.18

Gene sequence:

>741_bases
ATGACCTGCATTTTGGTTGTAGATGATGAACCAGCAGTATTGAAAGTCTTGGTAACGAGGCTAAATCTTGCTGGTTATCA
AGTTTTATCTGCACAGGATGGAGAGCAAGCACTAGAGGTTTTTCACAAAGAAGCTCCAGACTTAGTGGTTCTAGATGTCA
TGCTCCCTAAGATGGATGGCTTTGCAGTTTGTCGAAGAATTAGAGCTGAGTCTTGCGTTCCAATAATATTCTTGACTGCT
CTTGAAGCGATTTCAGAAAGAGTAGCAGGTTTGGATTTAGGCGCTGATGATTACCTGGCTAAACCATTTAGCCCCAAGGA
GTTAGAAGCTAGAATAGCGACGATTTTGAGACGAGTGGGACCTGCTCCAACTATTGATGAACCAAGAGAAGTCCCGTCAG
GTCAAGGAGTAATGAAGCTTGGTGATCTTGTTGTAGACACCAATAGAAGGCAAGTCAGTAGAGGAGGAGAAAGGATAGGC
TTAACATATACAGAATTTAGCTTGCTGGAATTATTATTTCGTGATCCTGGCCGTGTTGTACCTCGAGCAGAAATTCTGGA
ACAGCTTTGGGGTTATCCTCCAAGAAGAGCGGCGGATTTAAGAGTTGTAGATGTCTACGTAGCTCGTTTAAGAGGGAAGC
TTGAACCAGATCCTAGGAATCCTGAGTTGATTTTGACTGTCAGAGGTATTGGCTACGCTTCTCAAAGAATTGGAGAATTT
CCTACTGCTATTGCCAGTTAA

Upstream 100 bases:

>100_bases
GGCTTTGAATACCATACTTGAAGATGATATCGTCATATAACAATAAGCCATTTTGATGTAAAATTTCGATGCTCCTGTCA
CCAAGGCAACAGCTAATCTC

Downstream 100 bases:

>100_bases
AGATTAATAGCTCAAAATTGATAGGTTTGCATTTGAAATTGTTTATTCTTGTTGTATGTACCCATTGCCTTGTCTGAATT
AAGAGATACCCGCCTCGAGA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MTCILVVDDEPAVLKVLVTRLNLAGYQVLSAQDGEQALEVFHKEAPDLVVLDVMLPKMDGFAVCRRIRAESCVPIIFLTA
LEAISERVAGLDLGADDYLAKPFSPKELEARIATILRRVGPAPTIDEPREVPSGQGVMKLGDLVVDTNRRQVSRGGERIG
LTYTEFSLLELLFRDPGRVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRIGEF
PTAIAS

Sequences:

>Translated_246_residues
MTCILVVDDEPAVLKVLVTRLNLAGYQVLSAQDGEQALEVFHKEAPDLVVLDVMLPKMDGFAVCRRIRAESCVPIIFLTA
LEAISERVAGLDLGADDYLAKPFSPKELEARIATILRRVGPAPTIDEPREVPSGQGVMKLGDLVVDTNRRQVSRGGERIG
LTYTEFSLLELLFRDPGRVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRIGEF
PTAIAS
>Mature_245_residues
TCILVVDDEPAVLKVLVTRLNLAGYQVLSAQDGEQALEVFHKEAPDLVVLDVMLPKMDGFAVCRRIRAESCVPIIFLTAL
EAISERVAGLDLGADDYLAKPFSPKELEARIATILRRVGPAPTIDEPREVPSGQGVMKLGDLVVDTNRRQVSRGGERIGL
TYTEFSLLELLFRDPGRVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRIGEFP
TAIAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=43.0434782608696, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=38.7931034482759, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=38.4279475982533, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=36.2068965517241, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=37.1794871794872, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=36.0869565217391, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=236, Percent_Identity=36.0169491525424, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=32.1739130434783, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=38.1974248927039, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=34.6320346320346, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=35.4978354978355, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=35.1931330472103, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=33.4763948497854, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=34.3347639484979, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=36.2903225806452, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=117, Percent_Identity=36.7521367521368, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=30.2325581395349, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=121, Percent_Identity=38.0165289256198, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788905, Length=120, Percent_Identity=35.8333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789149, Length=202, Percent_Identity=28.2178217821782, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27168; Mature: 27037

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCILVVDDEPAVLKVLVTRLNLAGYQVLSAQDGEQALEVFHKEAPDLVVLDVMLPKMDG
CEEEEEECCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEEEHHCCCCH
FAVCRRIRAESCVPIIFLTALEAISERVAGLDLGADDYLAKPFSPKELEARIATILRRVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCC
PAPTIDEPREVPSGQGVMKLGDLVVDTNRRQVSRGGERIGLTYTEFSLLELLFRDPGRVV
CCCCCCCCCCCCCCCCHHHHCCEEECCCHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCC
PRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRIGEF
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHCC
PTAIAS
CHHHCC
>Mature Secondary Structure 
TCILVVDDEPAVLKVLVTRLNLAGYQVLSAQDGEQALEVFHKEAPDLVVLDVMLPKMDG
EEEEEECCCCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCEEEEEEHHCCCCH
FAVCRRIRAESCVPIIFLTALEAISERVAGLDLGADDYLAKPFSPKELEARIATILRRVG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCC
PAPTIDEPREVPSGQGVMKLGDLVVDTNRRQVSRGGERIGLTYTEFSLLELLFRDPGRVV
CCCCCCCCCCCCCCCCHHHHCCEEECCCHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCC
PRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRIGEF
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHCC
PTAIAS
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]