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The map label for this gene is lysS [H]

Identifier: 124026775

GI number: 124026775

Start: 1713935

End: 1715476

Strand: Reverse

Name: lysS [H]

Synonym: NATL1_20701

Alternate gene names: 124026775

Gene position: 1715476-1713935 (Counterclockwise)

Preceding gene: 124026776

Following gene: 124026774

Centisome position: 92.0

GC content: 38.0

Gene sequence:

>1542_bases
TTGTTGTATGTACCCATTGCCTTGTCTGAATTAAGAGATACCCGCCTCGAGAAGGCAAAAGCACTAAAAACCCTTGGGAA
AGGTCCCTATGGTTTGAATTTTCGACCTACTGACTCTGCCGCTGTTTTGCAGGGAAAATATAAAGACTTGCCAAATGGCG
AAGAAAAAAAAGACGAAGTATCTATTGCAGGGCGAGTAACTTCTAGAAGAGTGATGGGGAAACTTGCTTTTTTTACTCTT
TCCGATGAAACAGGCATAATTCAACTCTTTTTGGAAAAGGCGACCTTAAATCGGAATGAAGATAGTGAGAATCCAAAGAA
TAATTTTGAGAACATTACCTCTCTGGTTGACTCTGGTGATTGGATAGGAGTCAGTGGAATATTAAGGAGAACTGATAGAG
GTGAACTTTCTATAAAGGTTTTCGAATGGTCAATGCTATCAAAATCTTTACAACCCCTACCAGATAAATGGCATGGACTT
GCCGATGTAGAAAAGCGCTATAGACAAAGATATTTAGATTTAATTGTAAATCCACAGTCAAGAAAAACTTTTCGAACTAG
GGCTTTATTAGTTAGTTCAATTCGACGTTGGTTAGATGAAAAAGACTTTCTTGAAATCGAGACTCCAGTTTTACAATCAG
AAGCTGGAGGAGCGGATGCAAGGCCTTTCATAACTCATCACAACACGCTCGATTTACCTTTGTATCTGAGGATTGCAACA
GAATTGCATCTTAAAAGACTTGTGGTGGGTGGATTTCAAAGGGTCTATGAACTTGGAAGAATTTTTAGAAATGAAGGGAT
TAGCACTAGGCATAATCCTGAATTTACTTCTGTTGAAATTTATGAGGCCTTTGCAGATTATTTCGACATGATGGATTTAA
CAGAAAAATTACTTTCTTCAGTTTGCGAAAAGATTTGTGGATCGACCAAAATTAATTATCAAGAGCAAGAAATAGATTTG
CAACCTCCTTGGAGAAGGGCCACGATGCATGACTTAGTTAAGGAATTTACTGGAATAGATTTTGAATTATTTGGAGACAA
TGCTGATGATGCTAAGGCTGAAATGAGTCGAGAGGGGCTTCAAGTGCCCGATAAGGCTGATACTGTTGGAATCCTATTAA
ATGAAGCTTTTGAACAAGCAGTAGAGCCTGAGCTGATTCAGCCTACATTTGTGATGGATTATCCAATTGAGATTTCTCCA
TTGGCTAGAAAACACAGAACTAAAAAAGGTTTAGTGGAAAGATTTGAACTTTTTATTGTTGGTAGAGAAACTGCCAATGC
TTTTAGCGAATTAATTGACCCTATTGATCAAAGAGAACGTTTACTTTTACAGCAAGCGAAAAAAGAAGCAGGTGATCTTG
AGGCTCAAAGCTTGGATGAGGATTTTATCAATGCTCTTGAAGTCGGAATGCCTCCAACAGGAGGTCTCGGAATAGGAATA
GATAGGTTTGTAATGTTGTTAACAGATAGTCCTTCCATAAGAGATGTAATAGCTTTTCCACTTTTACGACCAGAAGCAAA
TTTAAAACAAACTGGAAAGTGA

Upstream 100 bases:

>100_bases
TGGCTACGCTTCTCAAAGAATTGGAGAATTTCCTACTGCTATTGCCAGTTAAAGATTAATAGCTCAAAATTGATAGGTTT
GCATTTGAAATTGTTTATTC

Downstream 100 bases:

>100_bases
CCCATCAGAGTGGATAATAGGCAAGTAAGTATTTTGTTCAGATGAGCGGCGAGAGAGTTGGTTTCCGTTTCAAGCACGCA
GATGCTGTTGTGAAAAGGAA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MLYVPIALSELRDTRLEKAKALKTLGKGPYGLNFRPTDSAAVLQGKYKDLPNGEEKKDEVSIAGRVTSRRVMGKLAFFTL
SDETGIIQLFLEKATLNRNEDSENPKNNFENITSLVDSGDWIGVSGILRRTDRGELSIKVFEWSMLSKSLQPLPDKWHGL
ADVEKRYRQRYLDLIVNPQSRKTFRTRALLVSSIRRWLDEKDFLEIETPVLQSEAGGADARPFITHHNTLDLPLYLRIAT
ELHLKRLVVGGFQRVYELGRIFRNEGISTRHNPEFTSVEIYEAFADYFDMMDLTEKLLSSVCEKICGSTKINYQEQEIDL
QPPWRRATMHDLVKEFTGIDFELFGDNADDAKAEMSREGLQVPDKADTVGILLNEAFEQAVEPELIQPTFVMDYPIEISP
LARKHRTKKGLVERFELFIVGRETANAFSELIDPIDQRERLLLQQAKKEAGDLEAQSLDEDFINALEVGMPPTGGLGIGI
DRFVMLLTDSPSIRDVIAFPLLRPEANLKQTGK

Sequences:

>Translated_513_residues
MLYVPIALSELRDTRLEKAKALKTLGKGPYGLNFRPTDSAAVLQGKYKDLPNGEEKKDEVSIAGRVTSRRVMGKLAFFTL
SDETGIIQLFLEKATLNRNEDSENPKNNFENITSLVDSGDWIGVSGILRRTDRGELSIKVFEWSMLSKSLQPLPDKWHGL
ADVEKRYRQRYLDLIVNPQSRKTFRTRALLVSSIRRWLDEKDFLEIETPVLQSEAGGADARPFITHHNTLDLPLYLRIAT
ELHLKRLVVGGFQRVYELGRIFRNEGISTRHNPEFTSVEIYEAFADYFDMMDLTEKLLSSVCEKICGSTKINYQEQEIDL
QPPWRRATMHDLVKEFTGIDFELFGDNADDAKAEMSREGLQVPDKADTVGILLNEAFEQAVEPELIQPTFVMDYPIEISP
LARKHRTKKGLVERFELFIVGRETANAFSELIDPIDQRERLLLQQAKKEAGDLEAQSLDEDFINALEVGMPPTGGLGIGI
DRFVMLLTDSPSIRDVIAFPLLRPEANLKQTGK
>Mature_513_residues
MLYVPIALSELRDTRLEKAKALKTLGKGPYGLNFRPTDSAAVLQGKYKDLPNGEEKKDEVSIAGRVTSRRVMGKLAFFTL
SDETGIIQLFLEKATLNRNEDSENPKNNFENITSLVDSGDWIGVSGILRRTDRGELSIKVFEWSMLSKSLQPLPDKWHGL
ADVEKRYRQRYLDLIVNPQSRKTFRTRALLVSSIRRWLDEKDFLEIETPVLQSEAGGADARPFITHHNTLDLPLYLRIAT
ELHLKRLVVGGFQRVYELGRIFRNEGISTRHNPEFTSVEIYEAFADYFDMMDLTEKLLSSVCEKICGSTKINYQEQEIDL
QPPWRRATMHDLVKEFTGIDFELFGDNADDAKAEMSREGLQVPDKADTVGILLNEAFEQAVEPELIQPTFVMDYPIEISP
LARKHRTKKGLVERFELFIVGRETANAFSELIDPIDQRERLLLQQAKKEAGDLEAQSLDEDFINALEVGMPPTGGLGIGI
DRFVMLLTDSPSIRDVIAFPLLRPEANLKQTGK

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=511, Percent_Identity=43.2485322896282, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI194272210, Length=511, Percent_Identity=43.2485322896282, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI1790571, Length=498, Percent_Identity=48.1927710843374, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=48.0730223123732, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI87082379, Length=326, Percent_Identity=31.9018404907975, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788173, Length=322, Percent_Identity=25.776397515528, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17535925, Length=509, Percent_Identity=42.6326129666012, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17535927, Length=509, Percent_Identity=42.6326129666012, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71994340, Length=504, Percent_Identity=42.8571428571429, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI32566633, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=525, Percent_Identity=41.5238095238095, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324256, Length=478, Percent_Identity=30.5439330543933, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=537, Percent_Identity=25.1396648044693, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325153, Length=141, Percent_Identity=31.2056737588652, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640849, Length=493, Percent_Identity=43.4077079107505, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640851, Length=493, Percent_Identity=43.4077079107505, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI17136276, Length=477, Percent_Identity=24.1090146750524, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58265; Mature: 58265

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYVPIALSELRDTRLEKAKALKTLGKGPYGLNFRPTDSAAVLQGKYKDLPNGEEKKDEV
CEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHH
SIAGRVTSRRVMGKLAFFTLSDETGIIQLFLEKATLNRNEDSENPKNNFENITSLVDSGD
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
WIGVSGILRRTDRGELSIKVFEWSMLSKSLQPLPDKWHGLADVEKRYRQRYLDLIVNPQS
EECHHHHHHCCCCCCEEEEEEEHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCC
RKTFRTRALLVSSIRRWLDEKDFLEIETPVLQSEAGGADARPFITHHNTLDLPLYLRIAT
HHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCCEEECCCCCCCCCHHHHHH
ELHLKRLVVGGFQRVYELGRIFRNEGISTRHNPEFTSVEIYEAFADYFDMMDLTEKLLSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VCEKICGSTKINYQEQEIDLQPPWRRATMHDLVKEFTGIDFELFGDNADDAKAEMSREGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCC
QVPDKADTVGILLNEAFEQAVEPELIQPTFVMDYPIEISPLARKHRTKKGLVERFELFIV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEE
GRETANAFSELIDPIDQRERLLLQQAKKEAGDLEAQSLDEDFINALEVGMPPTGGLGIGI
ECHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCCCCCCCCH
DRFVMLLTDSPSIRDVIAFPLLRPEANLKQTGK
HHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLYVPIALSELRDTRLEKAKALKTLGKGPYGLNFRPTDSAAVLQGKYKDLPNGEEKKDEV
CEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHH
SIAGRVTSRRVMGKLAFFTLSDETGIIQLFLEKATLNRNEDSENPKNNFENITSLVDSGD
HHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
WIGVSGILRRTDRGELSIKVFEWSMLSKSLQPLPDKWHGLADVEKRYRQRYLDLIVNPQS
EECHHHHHHCCCCCCEEEEEEEHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCC
RKTFRTRALLVSSIRRWLDEKDFLEIETPVLQSEAGGADARPFITHHNTLDLPLYLRIAT
HHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHCCCCCCCCCCEEECCCCCCCCCHHHHHH
ELHLKRLVVGGFQRVYELGRIFRNEGISTRHNPEFTSVEIYEAFADYFDMMDLTEKLLSS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VCEKICGSTKINYQEQEIDLQPPWRRATMHDLVKEFTGIDFELFGDNADDAKAEMSREGL
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCC
QVPDKADTVGILLNEAFEQAVEPELIQPTFVMDYPIEISPLARKHRTKKGLVERFELFIV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEE
GRETANAFSELIDPIDQRERLLLQQAKKEAGDLEAQSLDEDFINALEVGMPPTGGLGIGI
ECHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHCCCCCCCCCCCCH
DRFVMLLTDSPSIRDVIAFPLLRPEANLKQTGK
HHEEEEEECCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA