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The map label for this gene is tktA [H]

Identifier: 124026767

GI number: 124026767

Start: 1706093

End: 1708105

Strand: Direct

Name: tktA [H]

Synonym: NATL1_20621

Alternate gene names: 124026767

Gene position: 1706093-1708105 (Clockwise)

Preceding gene: 124026766

Following gene: 124026773

Centisome position: 91.49

GC content: 40.59

Gene sequence:

>2013_bases
ATGGTTGCCTTGACTACTTCCCTAGACACACTTTGCATCAACAGCATCAGGATGCTCGCTGTTGATGCAATTAATAAATC
CAAAAGTGGTCACCCAGGTTTACCTATGGGTTGCGCACCTATGGGTTATGCATTATGGGACAAGCACTTACGACACAATC
CAAAAAACCCGAAATGGTTTAATCGAGACAGATTTGTTCTTTCAGCGGGACATGGATGCATGCTTTTGTATGCTCTCTTG
CATTTGACTGGCTATGACTCTGTCACCATTGAAGATATAAAAGAATTTAGACAGTGGGGAGCTAAAACTCCAGGGCATCC
AGAAACCTTCGAAACTCCGGGAGTTGAAGTAACTGCAGGACCTTTGGGAGCAGGAATTTCAAATGCAGTTGGATTAGCTA
TTGCGGAAGCTCACCTTGCTGCAAAATTCAACAAACCTGATTCAACAGTTGTAGACCATTACACCTATGTGATCATGGGG
GATGGATGTAATCAAGAAGGTATTTCCTCAGAAGCATGTTCTCTTGCTGGGCATTTAAAACTTGGAAAATTAATAGCTCT
CTATGACGATAATCACATAACTATTGATGGAAGAACTGATGTCTCATTTACAGAGGATGTCTTAAAAAGATATGAAGCAT
ATGGATGGCATGTACAAGAAATTCCTGAGGGGAATACAGATGTTGAAGGCATATCTCAAGCAATCGAAAAGGCCAAATCA
GTCACTGATAAGCCATCCATCATCAAAGTAACAACAACTATCGGTTACGGTTCTCCAAATAAAAGTGATACTGCAGGTAT
TCACGGCGCCCCATTGGGCGAAGAAGAGGCAGAGCTCACTAGAAAACAATTAGGTTGGTCATACAAACCTTTCGAGGTTC
CCCAAGATGCTTATGATCAATATCGACAAGCCATTCAAAAAGGTGCACAGCTAGAAGAAGAGTGGAATCAAAGCCTAGCT
AAATACAAAGAAAAATATCCTAATGAAGCAACTCAATTTGAGCGCATGTTGAGAGGTGAGCTCCCTGAAGGCTGGGATAA
AGATTTACCTACCTATACATCCGATGATAAAGGGGTTGCTACTAGAAAACATTCTCAAATATGTCTAGGTGCTCTTGGTC
CAAACATCCCTGAACTAATAGGAGGTTCTGCTGATTTAACTCATTCAAACTACACAGATATAAAAGGAGAAACTGGATCT
TTTCAATATGAAAGTCCTGAAAAACGTTATTTACATTTTGGTGTCAGAGAGCATGCTATGGCAGCCATATTGAATGGCAT
TGCTTATCACGACAGTGGTTTAATTCCTTATGGTGGAACCTTCTTAGTCTTCGCAGATTACATGAGAGGATCGATGCGTC
TTTCTGCTCTTAGTGAGCTTGGAGTTATTTATGTTTTAACCCATGATTCCATAGGTGTTGGTGAAGATGGCCCAACACAT
CAACCTATAGAAACCATCCCATCATTGAGAGCAATGCCAAATATGATGGTTTTCCGTCCTGGCGATGGCAATGAAACCAG
TGGTGCTTATAAAGTTGCAATTAAAAATCGTAAGAGACCAAGTTCCTTATGCCTAAGTAGGCAGGGTATGGCAAATCAAC
AAAATTCATCCGTAGACAAAGTTGCTTTAGGTGGATATGTACTTGAGGAGTGCGATGGCACCCCAGAACTAATACTTATC
GGAACCGGAACTGAACTTGATTTATGTGTTCAAGCAGCGAAAAAGTTAACTAAGGAAGGTCGAAAAGTGCGTGTTGTTTC
TATGCCATGCGTTGAACTTTTTGAAGAACAAAGCGATAGTTATAAAGAAGAAGTTTTGCCTTCAAATATCAGAAAACGCC
TAGTAGTTGAAGCCGCAGAGAGTTTCGGATGGCACAAATATATTGGTCTTGATGGTGACAGCGTAACTATGAATAGCTTT
GGAGCATCTGCTCCAGGTGGATTATGTATGGAAAAATTTGGATTTACAGTTGAAAACGTACTAGAAAAATCTAAAAGTCT
GCTCAACAAATAA

Upstream 100 bases:

>100_bases
GGCGGTCACAATGTCTGTCTAGCTTTTCGACAAATGATCTAAATCAATTTCATTTTCGCTTTCCACTTAAATTTCTTATC
CCCCCACTCACTAATTCAAA

Downstream 100 bases:

>100_bases
AATTAATTATTTAACTACAAATAGTTATTACAGAAAAAGTTAAACAAAGAACTAGTTTTCTTTGTTTAACTTTACTGGAG
TTAATTCAGCTGCACCTTTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MVALTTSLDTLCINSIRMLAVDAINKSKSGHPGLPMGCAPMGYALWDKHLRHNPKNPKWFNRDRFVLSAGHGCMLLYALL
HLTGYDSVTIEDIKEFRQWGAKTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPDSTVVDHYTYVIMG
DGCNQEGISSEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQEIPEGNTDVEGISQAIEKAKS
VTDKPSIIKVTTTIGYGSPNKSDTAGIHGAPLGEEEAELTRKQLGWSYKPFEVPQDAYDQYRQAIQKGAQLEEEWNQSLA
KYKEKYPNEATQFERMLRGELPEGWDKDLPTYTSDDKGVATRKHSQICLGALGPNIPELIGGSADLTHSNYTDIKGETGS
FQYESPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMMVFRPGDGNETSGAYKVAIKNRKRPSSLCLSRQGMANQQNSSVDKVALGGYVLEECDGTPELILI
GTGTELDLCVQAAKKLTKEGRKVRVVSMPCVELFEEQSDSYKEEVLPSNIRKRLVVEAAESFGWHKYIGLDGDSVTMNSF
GASAPGGLCMEKFGFTVENVLEKSKSLLNK

Sequences:

>Translated_670_residues
MVALTTSLDTLCINSIRMLAVDAINKSKSGHPGLPMGCAPMGYALWDKHLRHNPKNPKWFNRDRFVLSAGHGCMLLYALL
HLTGYDSVTIEDIKEFRQWGAKTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPDSTVVDHYTYVIMG
DGCNQEGISSEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQEIPEGNTDVEGISQAIEKAKS
VTDKPSIIKVTTTIGYGSPNKSDTAGIHGAPLGEEEAELTRKQLGWSYKPFEVPQDAYDQYRQAIQKGAQLEEEWNQSLA
KYKEKYPNEATQFERMLRGELPEGWDKDLPTYTSDDKGVATRKHSQICLGALGPNIPELIGGSADLTHSNYTDIKGETGS
FQYESPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMMVFRPGDGNETSGAYKVAIKNRKRPSSLCLSRQGMANQQNSSVDKVALGGYVLEECDGTPELILI
GTGTELDLCVQAAKKLTKEGRKVRVVSMPCVELFEEQSDSYKEEVLPSNIRKRLVVEAAESFGWHKYIGLDGDSVTMNSF
GASAPGGLCMEKFGFTVENVLEKSKSLLNK
>Mature_670_residues
MVALTTSLDTLCINSIRMLAVDAINKSKSGHPGLPMGCAPMGYALWDKHLRHNPKNPKWFNRDRFVLSAGHGCMLLYALL
HLTGYDSVTIEDIKEFRQWGAKTPGHPETFETPGVEVTAGPLGAGISNAVGLAIAEAHLAAKFNKPDSTVVDHYTYVIMG
DGCNQEGISSEACSLAGHLKLGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQEIPEGNTDVEGISQAIEKAKS
VTDKPSIIKVTTTIGYGSPNKSDTAGIHGAPLGEEEAELTRKQLGWSYKPFEVPQDAYDQYRQAIQKGAQLEEEWNQSLA
KYKEKYPNEATQFERMLRGELPEGWDKDLPTYTSDDKGVATRKHSQICLGALGPNIPELIGGSADLTHSNYTDIKGETGS
FQYESPEKRYLHFGVREHAMAAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMMVFRPGDGNETSGAYKVAIKNRKRPSSLCLSRQGMANQQNSSVDKVALGGYVLEECDGTPELILI
GTGTELDLCVQAAKKLTKEGRKVRVVSMPCVELFEEQSDSYKEEVLPSNIRKRLVVEAAESFGWHKYIGLDGDSVTMNSF
GASAPGGLCMEKFGFTVENVLEKSKSLLNK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=575, Percent_Identity=27.8260869565217, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI4507521, Length=575, Percent_Identity=27.8260869565217, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=25.3012048192771, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI225637459, Length=579, Percent_Identity=21.4162348877375, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI225637463, Length=478, Percent_Identity=23.2217573221757, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI225637461, Length=478, Percent_Identity=23.0125523012552, Blast_Score=113, Evalue=7e-25,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=51.7397881996974, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=50.6807866868381, Blast_Score=677, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=580, Percent_Identity=24.6551724137931, Blast_Score=142, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=51.4925373134328, Blast_Score=675, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=678, Percent_Identity=49.1150442477876, Blast_Score=650, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=576, Percent_Identity=27.4305555555556, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45550715, Length=576, Percent_Identity=27.4305555555556, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24645119, Length=547, Percent_Identity=27.2394881170018, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=25.2577319587629, Blast_Score=147, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73357; Mature: 73357

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALTTSLDTLCINSIRMLAVDAINKSKSGHPGLPMGCAPMGYALWDKHLRHNPKNPKWF
CEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYALLHLTGYDSVTIEDIKEFRQWGAKTPGHPETFETPGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGAGISNAVGLAIAEAHLAAKFNKPDSTVVDHYTYVIMGDGCNQEGISSEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHCCCC
LGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQEIPEGNTDVEGISQAIEKAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VTDKPSIIKVTTTIGYGSPNKSDTAGIHGAPLGEEEAELTRKQLGWSYKPFEVPQDAYDQ
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
YRQAIQKGAQLEEEWNQSLAKYKEKYPNEATQFERMLRGELPEGWDKDLPTYTSDDKGVA
HHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNIPELIGGSADLTHSNYTDIKGETGSFQYESPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEECCHHHHHH
AAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHHHEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMMVFRPGDGNETSGAYKVAIKNRKRPSSLCLSRQGMANQQNSSVDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCH
VALGGYVLEECDGTPELILIGTGTELDLCVQAAKKLTKEGRKVRVVSMPCVELFEEQSDS
HHHCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
YKEEVLPSNIRKRLVVEAAESFGWHKYIGLDGDSVTMNSFGASAPGGLCMEKFGFTVENV
HHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCHHHH
LEKSKSLLNK
HHHHHHHHCC
>Mature Secondary Structure
MVALTTSLDTLCINSIRMLAVDAINKSKSGHPGLPMGCAPMGYALWDKHLRHNPKNPKWF
CEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYALLHLTGYDSVTIEDIKEFRQWGAKTPGHPETFETPGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGAGISNAVGLAIAEAHLAAKFNKPDSTVVDHYTYVIMGDGCNQEGISSEACSLAGHLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHCCCC
LGKLIALYDDNHITIDGRTDVSFTEDVLKRYEAYGWHVQEIPEGNTDVEGISQAIEKAKS
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VTDKPSIIKVTTTIGYGSPNKSDTAGIHGAPLGEEEAELTRKQLGWSYKPFEVPQDAYDQ
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
YRQAIQKGAQLEEEWNQSLAKYKEKYPNEATQFERMLRGELPEGWDKDLPTYTSDDKGVA
HHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCE
TRKHSQICLGALGPNIPELIGGSADLTHSNYTDIKGETGSFQYESPEKRYLHFGVREHAM
ECCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEECCHHHHHH
AAILNGIAYHDSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHHHEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMMVFRPGDGNETSGAYKVAIKNRKRPSSLCLSRQGMANQQNSSVDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCH
VALGGYVLEECDGTPELILIGTGTELDLCVQAAKKLTKEGRKVRVVSMPCVELFEEQSDS
HHHCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
YKEEVLPSNIRKRLVVEAAESFGWHKYIGLDGDSVTMNSFGASAPGGLCMEKFGFTVENV
HHHHHCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCHHHHHHCCCHHHH
LEKSKSLLNK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]