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The map label for this gene is fabF [H]

Identifier: 124026766

GI number: 124026766

Start: 1704787

End: 1706034

Strand: Direct

Name: fabF [H]

Synonym: NATL1_20611

Alternate gene names: 124026766

Gene position: 1704787-1706034 (Clockwise)

Preceding gene: 124026765

Following gene: 124026767

Centisome position: 91.42

GC content: 42.47

Gene sequence:

>1248_bases
ATGATGGAGAAACTCCATCGAGTTGTTATTACAGGTCTTGGCGCCATTACTCCAATTGGCAACGACCTCGAAAGTTACCT
CAAAGGGCTTCAATCCGGGAAAAATGGGGTAGATCAAATAACACTCTTTGATGCCTCATCCCATGCATGCAGATTTGCAG
CAGAGGTGAAAAGTTTTGATCCTACTGGCAAATTAGAGCCAAAAGAATCCAAACGATGGGATCGTTTTTCAAAATTTGGA
GTCATTGCAGCAAAAGAAGCCTTGAATCATTCAGGTCTAATAATTGACAACTCAAATTCTGGAAGAATTGGTGTGATTAT
TGGTTCTGGAGTTGGCGGATTGCTGACTATGGAAACCCAAGCTCATGTTTTAGAGAACAAGGGAGCAAGTCGAGTTAGTC
CTTTTACTGTTCCCATGATGATTCCCAACATGGCTACAGGGTTAGCAGCTATTGCACTAGGTGCTAAAGGTCCAAGTTCA
GCAGTTTCAACTGCTTGTGCCGCCGGATCAAATGCTATAGGTGATGCATTCAGACTGCTCCAATTAGGCAAAGCAGATGC
AATGGTTTGCGGTGGAGCAGAAGCAAGTATCACTCCTCTAGGAGTAGCAGGATTTGCTAGTGCAAAAGCTTTATCCTTCA
GAAATGATGATCCATCTACCGCAAGTAGACCTTTTGATTCTCAACGAGATGGATTTGTAATTGGAGAAGGGGCCGGAGTA
CTAATTTTAGAAACTCTTGATCATGCATTAAAAAGAGACGCAACAATCCATGCAGAGATCATTGGTTATGGAACCACTTG
TGATGCTCATCACATTACCTCTCCTACACCTGGTGGAGTGGGAGGGGCAGAAGCTATGAAACTTGCATTAATTGATGGAC
AAATTAATCCCGAAGAAGTCGATTACATTAATGCTCACGGAACTAGCACTCCAGCCAATGACAGCAATGAAACATCTGCT
ATAAAAGCTGCTTTGGGAAATCATGCGTATCAAGTACCTACAAGCTCAACCAAATCTATGACTGGGCACTTACTAGGAGG
GTCTGGTGGAATCGAAGCTGTTGCTTGTGCTCTGGCAATAAAACATGAAATAATTCCGCCAACAATTAATTATTCCAATC
CAGACCCAAATTGTGATCTTGATTATGTGCCCAACAAAGCAAGAGAAAAGAAATTAGGTGTCGTACTATCTAACTCATTC
GGGTTTGGCGGTCACAATGTCTGTCTAGCTTTTCGACAAATGATCTAA

Upstream 100 bases:

>100_bases
GAGGCATTTGACATAGAAATCCCCGACGAGGCTGCTGAAGGCATTGCCACTGTTGGTGATGCAGTCAAATACATCGAAGA
AAAACAGTCTTGAGGTTCAA

Downstream 100 bases:

>100_bases
ATCAATTTCATTTTCGCTTTCCACTTAAATTTCTTATCCCCCCACTCACTAATTCAAAATGGTTGCCTTGACTACTTCCC
TAGACACACTTTGCATCAAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MMEKLHRVVITGLGAITPIGNDLESYLKGLQSGKNGVDQITLFDASSHACRFAAEVKSFDPTGKLEPKESKRWDRFSKFG
VIAAKEALNHSGLIIDNSNSGRIGVIIGSGVGGLLTMETQAHVLENKGASRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVSTACAAGSNAIGDAFRLLQLGKADAMVCGGAEASITPLGVAGFASAKALSFRNDDPSTASRPFDSQRDGFVIGEGAGV
LILETLDHALKRDATIHAEIIGYGTTCDAHHITSPTPGGVGGAEAMKLALIDGQINPEEVDYINAHGTSTPANDSNETSA
IKAALGNHAYQVPTSSTKSMTGHLLGGSGGIEAVACALAIKHEIIPPTINYSNPDPNCDLDYVPNKAREKKLGVVLSNSF
GFGGHNVCLAFRQMI

Sequences:

>Translated_415_residues
MMEKLHRVVITGLGAITPIGNDLESYLKGLQSGKNGVDQITLFDASSHACRFAAEVKSFDPTGKLEPKESKRWDRFSKFG
VIAAKEALNHSGLIIDNSNSGRIGVIIGSGVGGLLTMETQAHVLENKGASRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVSTACAAGSNAIGDAFRLLQLGKADAMVCGGAEASITPLGVAGFASAKALSFRNDDPSTASRPFDSQRDGFVIGEGAGV
LILETLDHALKRDATIHAEIIGYGTTCDAHHITSPTPGGVGGAEAMKLALIDGQINPEEVDYINAHGTSTPANDSNETSA
IKAALGNHAYQVPTSSTKSMTGHLLGGSGGIEAVACALAIKHEIIPPTINYSNPDPNCDLDYVPNKAREKKLGVVLSNSF
GFGGHNVCLAFRQMI
>Mature_415_residues
MMEKLHRVVITGLGAITPIGNDLESYLKGLQSGKNGVDQITLFDASSHACRFAAEVKSFDPTGKLEPKESKRWDRFSKFG
VIAAKEALNHSGLIIDNSNSGRIGVIIGSGVGGLLTMETQAHVLENKGASRVSPFTVPMMIPNMATGLAAIALGAKGPSS
AVSTACAAGSNAIGDAFRLLQLGKADAMVCGGAEASITPLGVAGFASAKALSFRNDDPSTASRPFDSQRDGFVIGEGAGV
LILETLDHALKRDATIHAEIIGYGTTCDAHHITSPTPGGVGGAEAMKLALIDGQINPEEVDYINAHGTSTPANDSNETSA
IKAALGNHAYQVPTSSTKSMTGHLLGGSGGIEAVACALAIKHEIIPPTINYSNPDPNCDLDYVPNKAREKKLGVVLSNSF
GFGGHNVCLAFRQMI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=43.1279620853081, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=49.3243243243243, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI41872631, Length=424, Percent_Identity=26.6509433962264, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=48.780487804878, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=34.8668280871671, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=32.3040380047506, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=35.6060606060606, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=25.1396648044693, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=27.0758122743682, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=36.036036036036, Blast_Score=255, Evalue=8e-69,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=41.9664268585132, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=25.5813953488372, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19920632, Length=330, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221330659, Length=330, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42991; Mature: 42991

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEKLHRVVITGLGAITPIGNDLESYLKGLQSGKNGVDQITLFDASSHACRFAAEVKSFD
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCC
PTGKLEPKESKRWDRFSKFGVIAAKEALNHSGLIIDNSNSGRIGVIIGSGVGGLLTMETQ
CCCCCCCCHHHHHHHHHHCCCEEEHHHCCCCCEEEECCCCCEEEEEEECCCCCEEEECHH
AHVLENKGASRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVSTACAAGSNAIGDAFRLL
HHHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHH
QLGKADAMVCGGAEASITPLGVAGFASAKALSFRNDDPSTASRPFDSQRDGFVIGEGAGV
HCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCE
LILETLDHALKRDATIHAEIIGYGTTCDAHHITSPTPGGVGGAEAMKLALIDGQINPEEV
EEEHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCHHHE
DYINAHGTSTPANDSNETSAIKAALGNHAYQVPTSSTKSMTGHLLGGSGGIEAVACALAI
EEEECCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHH
KHEIIPPTINYSNPDPNCDLDYVPNKAREKKLGVVLSNSFGFGGHNVCLAFRQMI
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MMEKLHRVVITGLGAITPIGNDLESYLKGLQSGKNGVDQITLFDASSHACRFAAEVKSFD
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCC
PTGKLEPKESKRWDRFSKFGVIAAKEALNHSGLIIDNSNSGRIGVIIGSGVGGLLTMETQ
CCCCCCCCHHHHHHHHHHCCCEEEHHHCCCCCEEEECCCCCEEEEEEECCCCCEEEECHH
AHVLENKGASRVSPFTVPMMIPNMATGLAAIALGAKGPSSAVSTACAAGSNAIGDAFRLL
HHHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCHHHHHHHHHCCCCHHHHHHHHH
QLGKADAMVCGGAEASITPLGVAGFASAKALSFRNDDPSTASRPFDSQRDGFVIGEGAGV
HCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCE
LILETLDHALKRDATIHAEIIGYGTTCDAHHITSPTPGGVGGAEAMKLALIDGQINPEEV
EEEHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHEEEEEECCCCCHHHE
DYINAHGTSTPANDSNETSAIKAALGNHAYQVPTSSTKSMTGHLLGGSGGIEAVACALAI
EEEECCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCHHHHHHHHHH
KHEIIPPTINYSNPDPNCDLDYVPNKAREKKLGVVLSNSFGFGGHNVCLAFRQMI
HHHCCCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]