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The map label for this gene is glmS [H]

Identifier: 124026763

GI number: 124026763

Start: 1702185

End: 1704089

Strand: Reverse

Name: glmS [H]

Synonym: NATL1_20581

Alternate gene names: 124026763

Gene position: 1704089-1702185 (Counterclockwise)

Preceding gene: 124026764

Following gene: 124026760

Centisome position: 91.39

GC content: 37.95

Gene sequence:

>1905_bases
ATGTGTGGCATATTTGCTGTTATTGGATCAAGGGAAGTTTCTTCTTTACTTATTGATGGATTAAGAAAATTGGAATATCG
AGGTTATGACTCTGCAGGTATAGCAACAATTGACAATTTAAATAACGATCAAATTGGACAACTAAATGTCACAAAAGCAA
AAGGAAAGTTAATTAATCTATCAAACTTAATTAAAAAAAAGCCTCCAAAAGGTCATGTTGGTATCGCCCATACTAGATGG
GCTACTCACGGTAAGCCTAATGAAAGAAATGCCCATCCTCATCTTGATTTCTCAGGGCAAATTGCAGTTGTGCAAAATGG
GATTATCGAGAATTACAGAGATTTATCTAACAGCCTGAAACTTAAAGGAATCAAATTAACTTCGGAAACTGACACTGAAA
TAATTCCGCATTTAATCGGTCTAGAGATAGAACACTCTCTTGCAAATGGACTGTCTTCTAATGAACAAACATTATTAATC
GCTGTTCAAAAAGTTTTGACTTTATTAGAAGGGACTTATTCCATAGCTGTGATTTGGTCCAAGGCACCCAATGCTCTTGT
GGTTGCTAGAGGACAAGCACCATTAGTTCTTGGCTTTGGCGAGGGTGAGTTTTTTTGTGCAAGTGATACTCCAGCATTAA
CAGGATTTACTCGTACATTTTTACCTTTGAGGGATCACGAAAGTGCACTCTTAACTCCACTAGGAATTGAAATATATGAT
GATGATGGAAAGAGGCAGCATAGAGCACCGTCGATCTTACAGGGCACGGAATTTTTTGCGGATAAAAGAAATTTCCGTCA
TTACATGCTTAAAGAAATTTATGAGCAGCCAGAGACTGCACAACAATGGATAGATAGATTTTTGCCAATGGACTTGCCCT
CCGAAAATCAAATAGCTTTTCCGGTATCTAAATCGATCCTTGAGAATATAGAACAAATACAAATACTTGCCTGTGGCACC
AGCAGACACGCAGGTATGGTTGGTGCTTATTTGTTGGAACAGTTTGCAGGAGTTCCTACAAAGGTATATTTCGCGAGTGA
ATTTCGGTATGCTCCCCCTCCACTTTCCCCCCATACTTTGACAATAGGAGTAAGTCAATCAGGTGAAACGGCAGACACGT
TAGCTGCCTTAAGGATGGAAAAGGAGAGAAGAGATTCGACTCAAGATCCTAATTTTTCTTTTCATCAATTGGGAATTACT
AATAGGGTTGATAGTTCATTTGGTCGTGAACTAGAAAATGTTATTGATATTGGATCAGGCATCGAAATAGGTGTTGCAGC
CACCAAAACCTTTCTGGGTCAAATGTTGTCCTTTTATGGTTTGACACTTGTATTTGCATCACATAGACAAAAAAGAAAAT
CTCAAGAAATTTTAGATCTCTCTAATGATTTGAGGTTAATTCCTAAACAGCTAACAAATCTCATAAAAAAACATGATTCT
CTCTCTAAGGAAATAGCACATTTGTTTGTTGAAACAAAGGATGTAATTTTCTTGGGTAGAGGAATAAATTATCCAATTGC
ACTTGAAGGTGCTCTTAAACTTAAGGAAATAAGCTACATCCATGCGCAAGGCTATCCAGCTGGAGAGCTAAAACACGGAC
CAATAGCACTTTTAGATCAACATGTTCCAGTGGTATCTATAGCTGTCCCGGGGATCGTTTATGAAAAGGTACTTAGTAAC
TCGCAAGAGGCTAAAGCTAGAGATGCCCGTTTAATTGGGGTGTCTACACATCGATCTGAATCGGAAATGTTTGATGAATT
ATTTACTATTCCAAAAGTTAGTGAATGGGTAAGCCCCCTATTAACTGTTGTACCTTTACAGCTATTTAGTTATCACATAG
CAGCTCATAAAGGGTTAGATGTTGATCAGCCGAGGAATTTAGCTAAAAGTGTAACCGTTGAATAA

Upstream 100 bases:

>100_bases
ATGAAACAACTAGAAGTATGGGATTGGCTTACTAAAAATTAGTGTTTTTCTTAACTAAGGTTTATTTTATATAAATAATT
TGTGACGTTAATTTAAATAT

Downstream 100 bases:

>100_bases
ATAAAGCTTTTTTATTAATTCTGATTTTTTATTCTGCCATAAGAATCTTCAAAACGAATGATGTCTTCTTCGCCTAAATA
CGTTCCGCTTTGAACTTCAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MCGIFAVIGSREVSSLLIDGLRKLEYRGYDSAGIATIDNLNNDQIGQLNVTKAKGKLINLSNLIKKKPPKGHVGIAHTRW
ATHGKPNERNAHPHLDFSGQIAVVQNGIIENYRDLSNSLKLKGIKLTSETDTEIIPHLIGLEIEHSLANGLSSNEQTLLI
AVQKVLTLLEGTYSIAVIWSKAPNALVVARGQAPLVLGFGEGEFFCASDTPALTGFTRTFLPLRDHESALLTPLGIEIYD
DDGKRQHRAPSILQGTEFFADKRNFRHYMLKEIYEQPETAQQWIDRFLPMDLPSENQIAFPVSKSILENIEQIQILACGT
SRHAGMVGAYLLEQFAGVPTKVYFASEFRYAPPPLSPHTLTIGVSQSGETADTLAALRMEKERRDSTQDPNFSFHQLGIT
NRVDSSFGRELENVIDIGSGIEIGVAATKTFLGQMLSFYGLTLVFASHRQKRKSQEILDLSNDLRLIPKQLTNLIKKHDS
LSKEIAHLFVETKDVIFLGRGINYPIALEGALKLKEISYIHAQGYPAGELKHGPIALLDQHVPVVSIAVPGIVYEKVLSN
SQEAKARDARLIGVSTHRSESEMFDELFTIPKVSEWVSPLLTVVPLQLFSYHIAAHKGLDVDQPRNLAKSVTVE

Sequences:

>Translated_634_residues
MCGIFAVIGSREVSSLLIDGLRKLEYRGYDSAGIATIDNLNNDQIGQLNVTKAKGKLINLSNLIKKKPPKGHVGIAHTRW
ATHGKPNERNAHPHLDFSGQIAVVQNGIIENYRDLSNSLKLKGIKLTSETDTEIIPHLIGLEIEHSLANGLSSNEQTLLI
AVQKVLTLLEGTYSIAVIWSKAPNALVVARGQAPLVLGFGEGEFFCASDTPALTGFTRTFLPLRDHESALLTPLGIEIYD
DDGKRQHRAPSILQGTEFFADKRNFRHYMLKEIYEQPETAQQWIDRFLPMDLPSENQIAFPVSKSILENIEQIQILACGT
SRHAGMVGAYLLEQFAGVPTKVYFASEFRYAPPPLSPHTLTIGVSQSGETADTLAALRMEKERRDSTQDPNFSFHQLGIT
NRVDSSFGRELENVIDIGSGIEIGVAATKTFLGQMLSFYGLTLVFASHRQKRKSQEILDLSNDLRLIPKQLTNLIKKHDS
LSKEIAHLFVETKDVIFLGRGINYPIALEGALKLKEISYIHAQGYPAGELKHGPIALLDQHVPVVSIAVPGIVYEKVLSN
SQEAKARDARLIGVSTHRSESEMFDELFTIPKVSEWVSPLLTVVPLQLFSYHIAAHKGLDVDQPRNLAKSVTVE
>Mature_634_residues
MCGIFAVIGSREVSSLLIDGLRKLEYRGYDSAGIATIDNLNNDQIGQLNVTKAKGKLINLSNLIKKKPPKGHVGIAHTRW
ATHGKPNERNAHPHLDFSGQIAVVQNGIIENYRDLSNSLKLKGIKLTSETDTEIIPHLIGLEIEHSLANGLSSNEQTLLI
AVQKVLTLLEGTYSIAVIWSKAPNALVVARGQAPLVLGFGEGEFFCASDTPALTGFTRTFLPLRDHESALLTPLGIEIYD
DDGKRQHRAPSILQGTEFFADKRNFRHYMLKEIYEQPETAQQWIDRFLPMDLPSENQIAFPVSKSILENIEQIQILACGT
SRHAGMVGAYLLEQFAGVPTKVYFASEFRYAPPPLSPHTLTIGVSQSGETADTLAALRMEKERRDSTQDPNFSFHQLGIT
NRVDSSFGRELENVIDIGSGIEIGVAATKTFLGQMLSFYGLTLVFASHRQKRKSQEILDLSNDLRLIPKQLTNLIKKHDS
LSKEIAHLFVETKDVIFLGRGINYPIALEGALKLKEISYIHAQGYPAGELKHGPIALLDQHVPVVSIAVPGIVYEKVLSN
SQEAKARDARLIGVSTHRSESEMFDELFTIPKVSEWVSPLLTVVPLQLFSYHIAAHKGLDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=703, Percent_Identity=33.9971550497866, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI4826742, Length=717, Percent_Identity=34.3096234309623, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1790167, Length=638, Percent_Identity=42.6332288401254, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI87082251, Length=353, Percent_Identity=21.5297450424929, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788651, Length=231, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=448, Percent_Identity=36.8303571428571, Blast_Score=248, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17532897, Length=448, Percent_Identity=36.8303571428571, Blast_Score=248, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17539970, Length=447, Percent_Identity=35.7941834451902, Blast_Score=244, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=33.1081081081081, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323730, Length=211, Percent_Identity=39.3364928909953, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323731, Length=456, Percent_Identity=25, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=710, Percent_Identity=33.8028169014084, Blast_Score=341, Evalue=7e-94,
Organism=Drosophila melanogaster, GI24659598, Length=206, Percent_Identity=27.1844660194175, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573187, Length=142, Percent_Identity=30.2816901408451, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 70109; Mature: 70109

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIFAVIGSREVSSLLIDGLRKLEYRGYDSAGIATIDNLNNDQIGQLNVTKAKGKLINL
CCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEECCCCCEECH
SNLIKKKPPKGHVGIAHTRWATHGKPNERNAHPHLDFSGQIAVVQNGIIENYRDLSNSLK
HHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCE
LKGIKLTSETDTEIIPHLIGLEIEHSLANGLSSNEQTLLIAVQKVLTLLEGTYSIAVIWS
EEEEEECCCCCHHHHHHHHCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
KAPNALVVARGQAPLVLGFGEGEFFCASDTPALTGFTRTFLPLRDHESALLTPLGIEIYD
CCCCEEEEECCCCCEEEEECCCCEEECCCCCCCCCCHHHCCCCCCCCCCEECEECEEEEC
DDGKRQHRAPSILQGTEFFADKRNFRHYMLKEIYEQPETAQQWIDRFLPMDLPSENQIAF
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEC
PVSKSILENIEQIQILACGTSRHAGMVGAYLLEQFAGVPTKVYFASEFRYAPPPLSPHTL
HHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEE
TIGVSQSGETADTLAALRMEKERRDSTQDPNFSFHQLGITNRVDSSFGRELENVIDIGSG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCC
IEIGVAATKTFLGQMLSFYGLTLVFASHRQKRKSQEILDLSNDLRLIPKQLTNLIKKHDS
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LSKEIAHLFVETKDVIFLGRGINYPIALEGALKLKEISYIHAQGYPAGELKHGPIALLDQ
HHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEHEEEEEECCCCCCCCCCCCEEEECC
HVPVVSIAVPGIVYEKVLSNSQEAKARDARLIGVSTHRSESEMFDELFTIPKVSEWVSPL
CCCEEEEECCHHHHHHHHCCCHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
LTVVPLQLFSYHIAAHKGLDVDQPRNLAKSVTVE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIFAVIGSREVSSLLIDGLRKLEYRGYDSAGIATIDNLNNDQIGQLNVTKAKGKLINL
CCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEECCCCCEECH
SNLIKKKPPKGHVGIAHTRWATHGKPNERNAHPHLDFSGQIAVVQNGIIENYRDLSNSLK
HHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCE
LKGIKLTSETDTEIIPHLIGLEIEHSLANGLSSNEQTLLIAVQKVLTLLEGTYSIAVIWS
EEEEEECCCCCHHHHHHHHCCEEHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
KAPNALVVARGQAPLVLGFGEGEFFCASDTPALTGFTRTFLPLRDHESALLTPLGIEIYD
CCCCEEEEECCCCCEEEEECCCCEEECCCCCCCCCCHHHCCCCCCCCCCEECEECEEEEC
DDGKRQHRAPSILQGTEFFADKRNFRHYMLKEIYEQPETAQQWIDRFLPMDLPSENQIAF
CCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEC
PVSKSILENIEQIQILACGTSRHAGMVGAYLLEQFAGVPTKVYFASEFRYAPPPLSPHTL
HHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEE
TIGVSQSGETADTLAALRMEKERRDSTQDPNFSFHQLGITNRVDSSFGRELENVIDIGSG
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCC
IEIGVAATKTFLGQMLSFYGLTLVFASHRQKRKSQEILDLSNDLRLIPKQLTNLIKKHDS
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LSKEIAHLFVETKDVIFLGRGINYPIALEGALKLKEISYIHAQGYPAGELKHGPIALLDQ
HHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEHEEEEEECCCCCCCCCCCCEEEECC
HVPVVSIAVPGIVYEKVLSNSQEAKARDARLIGVSTHRSESEMFDELFTIPKVSEWVSPL
CCCEEEEECCHHHHHHHHCCCHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
LTVVPLQLFSYHIAAHKGLDVDQPRNLAKSVTVE
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]