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The map label for this gene is lldD [H]

Identifier: 124026752

GI number: 124026752

Start: 1690320

End: 1691516

Strand: Reverse

Name: lldD [H]

Synonym: NATL1_20471

Alternate gene names: 124026752

Gene position: 1691516-1690320 (Counterclockwise)

Preceding gene: 124026753

Following gene: 124026751

Centisome position: 90.71

GC content: 40.85

Gene sequence:

>1197_bases
ATGTTAGGAGCAGATGTTTCCTCTCCTGGGGTACTTAATATTGATGACCTCAGGTCTAGAGCTAAAAATCGTCTGCCGGC
GATGGTTTTTAACTATATAGATAGTGGTGCAGATAGAGAACAAACACTTTCGCAAAATTGCAACGCATATAATGAAATTT
TATTTAGACCTAGATGTGCAGTTTCTGTTCCATCGTGTGAGCTTGGAATATCTGTTTTAGATCAGCAATTTCAACTTCCT
TTCTTGTTGGGACCAGTAGGGAGTAGCAGAATGTTCTATCCTCAAGGAGAAGTTGTTGCAGCTAGAGAGGCAGGAAAAGC
TGGAACTGGATATACCTTGTCGATTCTCTCAGGTTGTTTATTAGAAGACGTTAAAGCTGCTACAAACGGACCAGCTTGGT
ATCAGCTTTATTTACTTGGTGGTAAAGAAGTCGCTTTAAAAACAATTGCTAGAGCTAAAGAAGCTGGATTCTCAGCAATA
GTTGTAACTATTGATACACCCGTATCTGGTTTGAGGGAAAGAGATATGCGATCAGGAACCCAACAGCTTTTATCAATGAA
TCCTTTGGAGATGCTTCCTTATATTCCTCAAATATTAGTTAAACCATGCTGGATGACTCAATGGTTAAGTGATGGAGGCT
TAATGAGTTTTCCTAATGTTCAACTAGATGATGGCCCTATGGGATACACGGCAATTGGTCCTGCTTTAGAGCAATCAGTG
GTTACTTGGGATGATCTTCAATGGATAAGAGAAGCGTGGGGTGGAAAAATTATTGTTAAGGGTATACATATTGGCGATGA
CGCAAAAAAAGCGGTAGAGCTAGGGGCTGATGCGATCGTTATTTCTAATCATGGAGCCAGGCAACTTGATAGCGTTGCTC
CCACGATCCGTGTTTTGCCCGAAATTTTAGCTGCAGTTGATGGGAAAATAGATGTGTTGCTAGATGGAGGTATTCGCAGG
GGTAGTGATGTTGTTAAAGCATTATGTCTTGGAGCGAAAGGAGTTTTGATCGGTAGAGCATATGCGTATGGACTTGCTGC
TGCAGGAGGGAAAGGCGTTGCCAGAGCTATAGAAATTCTTCAAACAGATATAGTGAGAACTATGAAACTATTGGGATGTG
GGTCTGTTGCCGATTTAAATAAATCTTATATTCAAGTTCCTGAAAGTTGGGAGAGATTCGAAAAAATCTTTGATTGA

Upstream 100 bases:

>100_bases
TTTATAGCTTTTTGTATCACAAATATTTCAATATTTTGTTCATTTTTGCAACTATGTTCAATATATTATAGATTCGTAAT
TCATGAATTTGTGATGAATA

Downstream 100 bases:

>100_bases
ATAATAGATTTATTTTCTATGAAAATAATTATTTTTGATGATGATCCAACTGGATCTCAAACTGTTTATGGATGCCCATT
ATTATTAAATTGGGATGAAC

Product: L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLGADVSSPGVLNIDDLRSRAKNRLPAMVFNYIDSGADREQTLSQNCNAYNEILFRPRCAVSVPSCELGISVLDQQFQLP
FLLGPVGSSRMFYPQGEVVAAREAGKAGTGYTLSILSGCLLEDVKAATNGPAWYQLYLLGGKEVALKTIARAKEAGFSAI
VVTIDTPVSGLRERDMRSGTQQLLSMNPLEMLPYIPQILVKPCWMTQWLSDGGLMSFPNVQLDDGPMGYTAIGPALEQSV
VTWDDLQWIREAWGGKIIVKGIHIGDDAKKAVELGADAIVISNHGARQLDSVAPTIRVLPEILAAVDGKIDVLLDGGIRR
GSDVVKALCLGAKGVLIGRAYAYGLAAAGGKGVARAIEILQTDIVRTMKLLGCGSVADLNKSYIQVPESWERFEKIFD

Sequences:

>Translated_398_residues
MLGADVSSPGVLNIDDLRSRAKNRLPAMVFNYIDSGADREQTLSQNCNAYNEILFRPRCAVSVPSCELGISVLDQQFQLP
FLLGPVGSSRMFYPQGEVVAAREAGKAGTGYTLSILSGCLLEDVKAATNGPAWYQLYLLGGKEVALKTIARAKEAGFSAI
VVTIDTPVSGLRERDMRSGTQQLLSMNPLEMLPYIPQILVKPCWMTQWLSDGGLMSFPNVQLDDGPMGYTAIGPALEQSV
VTWDDLQWIREAWGGKIIVKGIHIGDDAKKAVELGADAIVISNHGARQLDSVAPTIRVLPEILAAVDGKIDVLLDGGIRR
GSDVVKALCLGAKGVLIGRAYAYGLAAAGGKGVARAIEILQTDIVRTMKLLGCGSVADLNKSYIQVPESWERFEKIFD
>Mature_398_residues
MLGADVSSPGVLNIDDLRSRAKNRLPAMVFNYIDSGADREQTLSQNCNAYNEILFRPRCAVSVPSCELGISVLDQQFQLP
FLLGPVGSSRMFYPQGEVVAAREAGKAGTGYTLSILSGCLLEDVKAATNGPAWYQLYLLGGKEVALKTIARAKEAGFSAI
VVTIDTPVSGLRERDMRSGTQQLLSMNPLEMLPYIPQILVKPCWMTQWLSDGGLMSFPNVQLDDGPMGYTAIGPALEQSV
VTWDDLQWIREAWGGKIIVKGIHIGDDAKKAVELGADAIVISNHGARQLDSVAPTIRVLPEILAAVDGKIDVLLDGGIRR
GSDVVKALCLGAKGVLIGRAYAYGLAAAGGKGVARAIEILQTDIVRTMKLLGCGSVADLNKSYIQVPESWERFEKIFD

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=380, Percent_Identity=38.9473684210526, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI54234014, Length=373, Percent_Identity=34.8525469168901, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI7705393, Length=373, Percent_Identity=34.8525469168901, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=37.9310344827586, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI193208036, Length=382, Percent_Identity=32.9842931937173, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566217, Length=301, Percent_Identity=29.5681063122924, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323587, Length=381, Percent_Identity=30.4461942257218, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281363140, Length=391, Percent_Identity=34.2710997442455, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI78707190, Length=391, Percent_Identity=34.2710997442455, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI78707188, Length=383, Percent_Identity=34.9869451697128, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42840; Mature: 42840

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGADVSSPGVLNIDDLRSRAKNRLPAMVFNYIDSGADREQTLSQNCNAYNEILFRPRCA
CCCCCCCCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCC
VSVPSCELGISVLDQQFQLPFLLGPVGSSRMFYPQGEVVAAREAGKAGTGYTLSILSGCL
EECCCHHHHHHHHHHCCCCCEEECCCCCCCEECCCCCEEEECCCCCCCCCEEHHHHHHHH
LEDVKAATNGPAWYQLYLLGGKEVALKTIARAKEAGFSAIVVTIDTPVSGLRERDMRSGT
HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
QQLLSMNPLEMLPYIPQILVKPCWMTQWLSDGGLMSFPNVQLDDGPMGYTAIGPALEQSV
HHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCCEECCCCCEECCCCCCHHHHCHHHHHCC
VTWDDLQWIREAWGGKIIVKGIHIGDDAKKAVELGADAIVISNHGARQLDSVAPTIRVLP
CCHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
EILAAVDGKIDVLLDGGIRRGSDVVKALCLGAKGVLIGRAYAYGLAAAGGKGVARAIEIL
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHHH
QTDIVRTMKLLGCGSVADLNKSYIQVPESWERFEKIFD
HHHHHHHHHHHCCCCHHHCCHHHEECCHHHHHHHHHCC
>Mature Secondary Structure
MLGADVSSPGVLNIDDLRSRAKNRLPAMVFNYIDSGADREQTLSQNCNAYNEILFRPRCA
CCCCCCCCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHCCCCCC
VSVPSCELGISVLDQQFQLPFLLGPVGSSRMFYPQGEVVAAREAGKAGTGYTLSILSGCL
EECCCHHHHHHHHHHCCCCCEEECCCCCCCEECCCCCEEEECCCCCCCCCEEHHHHHHHH
LEDVKAATNGPAWYQLYLLGGKEVALKTIARAKEAGFSAIVVTIDTPVSGLRERDMRSGT
HHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
QQLLSMNPLEMLPYIPQILVKPCWMTQWLSDGGLMSFPNVQLDDGPMGYTAIGPALEQSV
HHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCCEECCCCCEECCCCCCHHHHCHHHHHCC
VTWDDLQWIREAWGGKIIVKGIHIGDDAKKAVELGADAIVISNHGARQLDSVAPTIRVLP
CCHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
EILAAVDGKIDVLLDGGIRRGSDVVKALCLGAKGVLIGRAYAYGLAAAGGKGVARAIEIL
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHHH
QTDIVRTMKLLGCGSVADLNKSYIQVPESWERFEKIFD
HHHHHHHHHHHCCCCHHHCCHHHEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA