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The map label for this gene is mrdB [H]

Identifier: 124026731

GI number: 124026731

Start: 1671538

End: 1672812

Strand: Reverse

Name: mrdB [H]

Synonym: NATL1_20261

Alternate gene names: 124026731

Gene position: 1672812-1671538 (Counterclockwise)

Preceding gene: 124026732

Following gene: 124026730

Centisome position: 89.71

GC content: 32.78

Gene sequence:

>1275_bases
ATGATGGGTTTTGGTCGCAATAAAATATCTTCTTTTAAAATAGTAAGAAACAAAAAGATTTGGAGAGATATAGATTTAGT
AATTTGGATCGTGCCTTTTATTTTAGTACATTTATCTTGTTTTTTAATTGCGAGCACTCAGAGAAATCTTGGAATTACAG
ATTGGTATCAACATGCAATTATTGCTTATATAGGTGCATTAATTGTTTATTTTTTAGCTCAAGTTCCTTTGCAAGATTTA
CGAAAATATACTCTAACAATATATTTTTTGACTATTTCAACACTTTTATATGTGAATTTTAGTGGTACTTCTGCCTTGGG
AGCAAAAAGATGGTTGAGCTTTGCTGGCTTATATATTCAACCCTCTGAGTTTGCAAAATTAACCTTAATACTTGCCTTGG
CTTCTATCTTAGATCAAAAAAGGTTTTCAGATTTATCCCATTTAATGAAACCTTTATTCGTTTCCTTTTTGCCTTGGATT
TTGGTTTTTATACAACCTGATCTTGGTACATCTCTTGTTTTTGGGGCCATACTTCTTGGAATGTTGTATTGGGCGGGGAT
GCCATATGAGTGGGCATTTATTATTTTGGCTACTTTTGTTACGGGATTACTTGCATACTTATATCATTTTGGACTTTTTA
TTTGGATCCCAATCATTGGTTTTTTGTCTTATAAGTCTCTGCCACATCAAAAAAAATTACTAACTTTATTAGTTGTCTTT
TTTCATTCATTAATAGCGAAAATCTCTCCTTGGATTTGGGAATCTGTTTTAAGAGATTACCAAAAAGATCGACTAATCCT
TTTTCTTAATCCTAGCCAAGATCCTTTAGGTGGTGGATATCACATGCTTCAAAGCAAAATAGGCATTGGATCTGGAGGAT
TGCTGGGATCAGGTCTGATGCAAGGTCAATTAACTAAATTAAAATTTATTCCAGAGCAACATACAGATTTCATTTTTAGT
GCTCTTGGAGAAGAGACAGGCTTTTTAGGAACTTTATTGGTCTCATTTTTATTTTTTATTCTAATCTTTAGATTAATAAA
GATAGCTATTGAGGCGCGTACTGATTTTGAATCCTTGATTGTGATTGGAATAACTTCAATGTTTATCTTTCAAATTATGG
TCAATATATTTATGACTATTGGCCTAGGCCCTGTGACTGGAATCCCTTTACCTTTTATGAGCTATGGAAGAACTGCGTTA
TTTGTCAATTTTATTAGTCTGGGCTTTTGTTTATCAGTGTCTAGACGAGGTCAGTCAGTAAGAAGAAATCTTTGA

Upstream 100 bases:

>100_bases
TGTCGTTCATACATCTAGAGATTCAATAACAGCAAAAGTATTTTTAGAACTTGCTGGAACTTTGTGTAATGCATTATCTG
TTAAACAGTGATTTAAATTA

Downstream 100 bases:

>100_bases
CTAGATATTTTTGCTTAGGTGTTTTTCTAAACGCATTTAGTTAGTCAAAATAGAGCCTTCAGTATAATTAGGGTTAATAC
CAATACCATCTTGAGGTTAA

Product: cell division membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MMGFGRNKISSFKIVRNKKIWRDIDLVIWIVPFILVHLSCFLIASTQRNLGITDWYQHAIIAYIGALIVYFLAQVPLQDL
RKYTLTIYFLTISTLLYVNFSGTSALGAKRWLSFAGLYIQPSEFAKLTLILALASILDQKRFSDLSHLMKPLFVSFLPWI
LVFIQPDLGTSLVFGAILLGMLYWAGMPYEWAFIILATFVTGLLAYLYHFGLFIWIPIIGFLSYKSLPHQKKLLTLLVVF
FHSLIAKISPWIWESVLRDYQKDRLILFLNPSQDPLGGGYHMLQSKIGIGSGGLLGSGLMQGQLTKLKFIPEQHTDFIFS
ALGEETGFLGTLLVSFLFFILIFRLIKIAIEARTDFESLIVIGITSMFIFQIMVNIFMTIGLGPVTGIPLPFMSYGRTAL
FVNFISLGFCLSVSRRGQSVRRNL

Sequences:

>Translated_424_residues
MMGFGRNKISSFKIVRNKKIWRDIDLVIWIVPFILVHLSCFLIASTQRNLGITDWYQHAIIAYIGALIVYFLAQVPLQDL
RKYTLTIYFLTISTLLYVNFSGTSALGAKRWLSFAGLYIQPSEFAKLTLILALASILDQKRFSDLSHLMKPLFVSFLPWI
LVFIQPDLGTSLVFGAILLGMLYWAGMPYEWAFIILATFVTGLLAYLYHFGLFIWIPIIGFLSYKSLPHQKKLLTLLVVF
FHSLIAKISPWIWESVLRDYQKDRLILFLNPSQDPLGGGYHMLQSKIGIGSGGLLGSGLMQGQLTKLKFIPEQHTDFIFS
ALGEETGFLGTLLVSFLFFILIFRLIKIAIEARTDFESLIVIGITSMFIFQIMVNIFMTIGLGPVTGIPLPFMSYGRTAL
FVNFISLGFCLSVSRRGQSVRRNL
>Mature_424_residues
MMGFGRNKISSFKIVRNKKIWRDIDLVIWIVPFILVHLSCFLIASTQRNLGITDWYQHAIIAYIGALIVYFLAQVPLQDL
RKYTLTIYFLTISTLLYVNFSGTSALGAKRWLSFAGLYIQPSEFAKLTLILALASILDQKRFSDLSHLMKPLFVSFLPWI
LVFIQPDLGTSLVFGAILLGMLYWAGMPYEWAFIILATFVTGLLAYLYHFGLFIWIPIIGFLSYKSLPHQKKLLTLLVVF
FHSLIAKISPWIWESVLRDYQKDRLILFLNPSQDPLGGGYHMLQSKIGIGSGGLLGSGLMQGQLTKLKFIPEQHTDFIFS
ALGEETGFLGTLLVSFLFFILIFRLIKIAIEARTDFESLIVIGITSMFIFQIMVNIFMTIGLGPVTGIPLPFMSYGRTAL
FVNFISLGFCLSVSRRGQSVRRNL

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=362, Percent_Identity=32.3204419889503, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1786277, Length=352, Percent_Identity=31.5340909090909, Blast_Score=141, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 48068; Mature: 48068

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCC
>Mature Secondary Structure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HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]